Research Topics
Species | O H NielsenSummaryAffiliation: University of Copenhagen Country: Denmark Publications
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Detail Information
Publications
[Mesalamine in the treatment of Crohn disease?]Ole Haagen Nielsen
Ugeskr Laeger 167:1656-7. 2005
Drug insight: aminosalicylates for the treatment of IBDOle H Nielsen
Department of Gastroenterology C112, Herlev Hospital, 75 Herlev Ringvej, DK 2730 Herlev, Denmark
Nat Clin Pract Gastroenterol Hepatol 4:160-70. 2007..Furthermore, evidence is lacking that mesalazine per se is a chemoprophylactic agent...
[Induction of remission with TNF-alpha inhibitor in Crohn disease. An analysis of a systematic Cochrane review]Ole Haagen Nielsen
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C
Ugeskr Laeger 166:4248-51. 2004
[New guidelines on good scientific practice]Ole Haagen Nielsen
Gastroenheden, Medicinsk Sektion, Herlev Hospital, DK 2730 Herlev
Ugeskr Laeger 171:1847-9. 2009..These guidelines are intended to help Danish researchers avoid any discreditability of their scientific work, and especially to improve the general standard of their research...
Diagnosis and management of fistulizing Crohn's diseaseOle Haagen Nielsen
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, 75 Herlev Ringvej, Herlev, Denmark
Nat Clin Pract Gastroenterol Hepatol 6:92-106. 2009..Available therapeutic options, including novel therapies, are discussed. Wherever possible, practical and evidence-based treatment regimens for Crohn's disease-associated fistulas are provided...
Non-IBD and noninfectious colitisOle Haagen Nielsen
Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Nat Clin Pract Gastroenterol Hepatol 5:28-39. 2008..Practical guidelines for the diagnosis and therapy of these more recently characterized and rarer forms of colitis are given where possible...
Upregulation of interleukin-12 and -17 in active inflammatory bowel diseaseO H Nielsen
Dept of Gastroenterology C, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Scand J Gastroenterol 38:180-5. 2003..Interleukin (IL)-12 and IL-17 are potent immunoregulatory cytokines whose roles in the pathogenesis of IBD are unknown. The aim of this study was to evaluate the colonic expression of IL-12 and IL-17 genes in IBD...
[Treatment of collagenous colitis. An analysis of a systematic Cochrane review]Ole Haagen Nielsen
Medicinsk Gastroenterologisk Afdeling C, Amtssygehuset i Herlev, DK 2730 Herlev
Ugeskr Laeger 165:3154-6. 2003..Treatment has been based mainly on anecdotal evidence. This review was performed to identify therapies for collagenous colitis that have been proven in randomized trials...
Systematic review: coxibs, non-steroidal anti-inflammatory drugs or no cyclooxygenase inhibitors in gastroenterological high-risk patients?O H Nielsen
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Aliment Pharmacol Ther 23:27-33. 2006..An evidence-based algorithm for treatment of a chronic arthritis patient with one or more gastrointestinal risk factors is presented...
[Microscopic colitis--a missed diagnosis?--a secondary publication]Ole Haagen Nielsen
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C
Ugeskr Laeger 167:51-2. 2005
Microscopic colitis: a missed diagnosis?Ole Haagen Nielsen
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
Lancet 364:2055-7. 2004....
Influence of smoking on colonic gene expression profile in Crohn's diseaseOle Haagen Nielsen
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 4:e6210. 2009..Several genes are involved in the pathogenesis of CD, and in this study the gene expression differences of the descending colonic mucosa were investigated in CD (smokers or never smokers) and controls (smokers or never smokers)...
Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprineO H Nielsen
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Aliment Pharmacol Ther 15:1699-708. 2001..The purpose of this comprehensive review is to suggest guidelines for the application of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease...
Gastric mucosal interleukin-8 and IL-8 antibody concentrations related to prevailing Helicobacter pylori infections. A Danish-Albanian studyO H Nielsen
Department of Medicine, Glostrup Hospital, University of Copenhagen
Dan Med Bull 46:249-52. 1999..The aim was to study the correlation between H. pylori infection and IL-8, together with IL-8 autoantibodies in two different populations from a developed and a developing country...
Use of biological molecules in the treatment of inflammatory bowel diseaseO H Nielsen
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK 2730Herlev, Denmark
J Intern Med 270:15-28. 2011..Finally, the need for an appropriate strategy for stopping biological treatment is discussed...
Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel diseaseB Vainer
Department of Medicine M, Division of Gastroenterology, Glostrup Hospital, University of Copenhagen, Denmark
Cytokine 12:1531-6. 2000..02). Conclusion: Active UC is associated with decreased colonic IL-13 suggesting that IL-13 levels are diminished as a part of UC exacerbations, or that exacerbations follow active downregulation of IL-13...
Chemotactic properties of ICAM-1 and PECAM-1 on neutrophil granulocytes in ulcerative colitis: effects of prednisolone and mesalazineB Vainer
Department of Medicine M, Division of Gastroenterology, Glostrup Hospital, University of Copenhagen, Denmark
Aliment Pharmacol Ther 14:1023-31. 2000..ICAM-1 seems to exhibit effects other than passive leucocyte/endothelial interaction...
Changed colonic profile of P-selectin, platelet-endothelial cell adhesion molecule-1 (PECAM-1), intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and ICAM-3 in inflammatory bowel diseaseB Vainer
Department of Medicine M, Division of Gastroenterology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
Clin Exp Immunol 121:242-7. 2000..The observed differences in the CAM concentrations in UC and CD support the hypothesis that UC and CD are two distinct disease entities with separate pathogenic mechanisms...
Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), beta2 integrins (LFA-1, Mac-1, and p150,95), and PECAM-1 in ulcerative colitis and Crohn's diseaseB Vainer
Department of Medicine, Glostrup Hospital, Denmark
Am J Surg Pathol 24:1115-24. 2000..Differentiated upregulation of cell adhesion molecules is suggested to be essential for the diversities between UC and CD...
Inflammatory bowel disease: potential therapeutic strategiesO H Nielsen
Department of Gastroenterology F, Glostrup Hospital, University of Copenhagen, Denmark
Cytokines Cell Mol Ther 3:267-81. 1997..Controlled trials of the novel agents mentioned in this review have not yet been performed, however...
Effect of the leukotriene LTD4/LTE4 antagonist, SR 2640, in ulcerative colitis: an open clinical studyO H Nielsen
Department of Internal Medicine, Sct Elisabeth Hospital, University of Copenhagen, Denmark
Prostaglandins Leukot Essent Fatty Acids 42:181-4. 1991..abstract truncated at 250 words)..
Effect of 5-aminosalicylic acid and analogous substances on superoxide generation and intracellular free calcium in human neutrophilic granulocytesO H Nielsen
Dept of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Scand J Gastroenterol 28:527-32. 1993....
A role for interleukin-33 in T(H)2-polarized intestinal inflammation?J B Seidelin
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Mucosal Immunol 4:496-502. 2011..As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC...
Impaired sensitivity to beta 2 integrin-blocking in ICAM-1-mediated neutrophil migration in ulcerative colitisB Vainer
Dept of Medicine M, Division of Gastroenterology, Glostrup Hospital, Nordre Ringvej, DK 2600 Glostrup, Denmark
Scand J Gastroenterol 36:621-9. 2001..ICAM-1 has recently been shown to possess chemotactic properties, and the aim of this study was to evaluate the involvement of beta 2 integrins in this ICAM-1-mediated migration...
Source of endogenous arachidonate and 5-lipoxygenase products in human neutrophils stimulated by bradykinin and A23187O H Nielsen
Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Gut 29:319-24. 1988....
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generationL Ferrero-Miliani
Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Denmark
Clin Exp Immunol 147:227-35. 2007....
Spontaneous aggregation of leukocytes in active ulcerative colitis might be ICAM-1 dependentB Vainer
Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Inflamm Res 53:458-61. 2004..The aim was to assess the spontaneous leukocyte aggregation and the aggregation induced by bacteria-derived products in UC and to evaluate the involvement of ICAM-1 and beta(2)-integrins in this aggregation...
Expression of 5-lipoxygenase mRNA is unchanged in the colon of patients with active inflammatory bowel diseaseJ Hendel
Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
Inflamm Res 51:423-6. 2002..The objective of the present study was to investigate whether de novo synthesis of 5-LO is increased in patients with quiescent IBD, or is induced during acute exacerbations of IBD...
Mitogen activated protein kinases: a role in inflammatory bowel disease?O J Broom
Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Clin Exp Immunol 158:272-80. 2009..This review highlights some of the research into the role for the MAPKs and their related signalling proteins in influencing the progression of IBD...
An open-labeled, randomized study comparing systemic interferon-alpha-2A and prednisolone enemas in the treatment of left-sided ulcerative colitisS M Madsen
Department of Medical Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Am J Gastroenterol 96:1807-15. 2001..Larger, randomized trials are, however, warranted to confirm this finding, owing to possible type II errors in group comparisons...
Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitisN Pedersen
Dept. of Medicine M, Division of Gastroenterology, Glostrup Hospital, University of Copenhagen, Denmark
Scand J Gastroenterol 39:277-82. 2004..The low circulating concentrations of MCP-1 1 and 4 h following alcohol consumption might possibly reflect that this mediator acts locally via autocrine mechanisms...
Clinical phenotype and gene expression profile in Crohn's diseaseClaudio Csillag
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Herlev Ringvej, Herlev DK 2730, Denmark
Am J Physiol Gastrointest Liver Physiol 292:G298-304. 2007....
Expression of ICAM-1 in colon epithelial cells: an ultrastructural study performed on in vivo and in vitro modelsBen Vainer
Department of Pathology, Herlev Hospital, University of Copenhagen, Denmark
Virchows Arch 443:774-81. 2003..Conflicting results exist on epithelial ICAM-1 expression, and the aim of this study was to compare the expression in various models of colonic epithelium...
[Apoptosis in chronic inflammatory bowel disease. The importance for pathogenesis and treatment]Jakob Benedict Seidelin
Medicinsk Gastroenterologisk Afdeling C, Amtssygehuset i Herlev, Herlev Ringvej, DK 2730 Herlev
Ugeskr Laeger 165:790-2. 2003..This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed...
[TNF-alpha antibody treatment and remission induction in ulcerative colitis: a review of a Cochrane review]Jacob Tveiten Bjerrum
Herlev Hospital, Medicinsk-gastroenterologisk Afdeling C, Region Hovedstadens Sygehus Apotek, Herlev
Ugeskr Laeger 169:792-5. 2007
CARD15 status and familial predisposition for Crohn's disease and colonic gene expressionClaudio Csillag
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Herlev Ringvej, DK 2730, Herlev, Denmark
Dig Dis Sci 52:1783-9. 2007..We conclude that gene expression profiling of mucosal biopsies from the descending colon of patients with CD could not be correlated with CARD15 status or with familial disposition for IBD...
Expression of the genes dual oxidase 2, lipocalin 2 and regenerating islet-derived 1 alpha in Crohn's diseaseClaudio Csillag
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Herlev Ringvej, DK 2730 Herlev, Denmark
Scand J Gastroenterol 42:454-63. 2007..A global gene expression profile of non-inflamed colonic mucosal cells from patients with Crohn's disease (CD) and of colonic mucosal cells from controls was performed...
Treatment response and colonic gene expression in patients with Crohn's diseaseClaudio Csillag
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Herlev, Denmark
Scand J Gastroenterol 42:834-40. 2007..Responses and adverse events to medication vary greatly among patients with Crohn's disease (CD). The aim of this study was to investigate whether global gene expression profiles could predict such responses and possible side effects...
[Inflammatory bowel disease--do microorganisms play a role?]Sara Elsøe Nielsen
Medicinsk Gastroenterologisk Afdeling C, Patologisk Anatomisk Institut, Amtssygehuset i Herlev
Ugeskr Laeger 164:5947-50. 2002....
[Biological drugs in the treatment of immunoinflammatory diseases]Ole Haagen Nielsen
Ugeskr Laeger 170:2103. 2008
Subcellular localization of intercellular adhesion molecule-1 in colonic mucosa in ulcerative colitisBen Vainer
Department of Pathology, Herlev Hospital, Copenhagen, Denmark
Ultrastruct Pathol 26:113-21. 2002....
Total levels of tissue inhibitor of metalloproteinases 1 in plasma yield high diagnostic sensitivity and specificity in patients with colon cancerMads N Holten-Andersen
The Finsen Laboratory, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
Clin Cancer Res 8:156-64. 2002....
[Microarray data analysis]Rehannah H A Borup
RH Microarray Center, H S Rigshospitalet, Klinisk Biokemisk Afdeling, København
Ugeskr Laeger 168:2159-62. 2006..This article focuses on the data analysis, from raw data file to marker gene lists used to retrieve knowledge about underlying biological processes...
[Azathioprine and 6-mercaptopurine for maintenance treatment in ulcerative colitis. A survey of a Cochrane review]Jacob Tveiten Bjerrum
Hospital, Medicinsk-gastroenterologisk Afdeling C
Ugeskr Laeger 169:4341-4. 2007
Continuous cytokine exposure of colonic epithelial cells induces DNA damageJakob B Seidelin
Department of Gastroenterology C, Herlev Hospital, Copenhagen University, Herlev, Denmark
Eur J Gastroenterol Hepatol 17:363-9. 2005..NO as well as other ROS are potential DNA damaging agents. The aim was to determine the effect of long-term cytokine exposure on NO formation and DNA damage in epithelial cells...
Comparative studies of superoxide production by microbial wall product-primed neutrophils in ulcerative colitisSara Elsøe Nielsen
Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
Dig Dis Sci 49:878-82. 2004..However, bacterial wall products such as BLP modify neutrophil tissue-destruction mechanisms and might be pivotal for perpetuation of chronic colonic inflammation...
[How far are we from the clinical use of array technology?]Claudio Csillag
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C
Ugeskr Laeger 167:2168-70. 2005
Microarrays and Crohn's disease: collecting reliable informationClaudio Csillag
Department of Gastroenterology C, Herlev Hospital, Denmark
Scand J Gastroenterol 40:369-77. 2005
[Transjugular intrahepatic portosystemic stent-shunts or paracentesis in the treatment of cirrhotic patients with refractory ascites]Mark A Ainsworth
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C, Herlev
Ugeskr Laeger 167:3273-6. 2005
[Magnetic resonance colonography: a new diagnostic tool]Michael Patrick Achiam
Amtssygehuset i Herlev, Afdelingen for Diagnostisk Radiologi, Herlev
Ugeskr Laeger 167:4279-84. 2005..The results of cancer screening have shown MR colonography to be superior to the traditional double-contrast barium enema. In inflammatory bowel disease, MR colonography can be used to assess disease activity, including spreading...
[Transdermal nicotine treatment of ulcerative colitis: a survey of a Cochrane review]Jakob Benedict Seidelin
, Medicinsk afdeling,
Ugeskr Laeger 168:674-7. 2006
Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: a comparative study of inflammatory bowel disease and colonic neoplasmsBen Vainer
Department of Pathology, Herlev Hospital, Herlev, Denmark
Scand J Gastroenterol 41:318-25. 2006..The aim of this study was to assess the ICAM-1 expression in human colonic tissue representing UC, Crohn's disease (CD), adenomas, and adenocarcinomas, with special attention to the epithelium...
[Antibiotic treatment of Clostridium difficile associated diarrhea in adults. A survey of a Cochrane review]Eva Efsen Dahl
, Medicinsk afdeling,
Ugeskr Laeger 168:1631-4. 2006
Insulin-like growth factor binding protein 3 in inflammatory bowel diseaseIrena Kirman
Department of Surgery, Columbia University, New York, New York, USA
Dig Dis Sci 50:780-4. 2005..The level of intact IGFBP-3 is decreased in IBD patients with moderate to severe disease activity. This decrease may be linked to altered IGFBP-3 production or to increased cleavage by proteases other than MMP-9...
[Perioperative blood transfusion and colorectal cancer recurrence: a survey of a Cochrane review]Jacob Tveiten Bjerrum
Amtssygehuset i Herlev, Medicinsk-gastroenterologisk Afdeling C, Herlev
Ugeskr Laeger 168:2798-801. 2006
[Probiotics for treating infectious diarrhea. A survey of a Cochrane review]Eva Efsen Dahl
Finsencentret, epidemiklinikken, H.S.Rigshospitalet,
Ugeskr Laeger 167:1725-8. 2005
[Pharmacogenetics--new therapeutic possibilities]Mark A Ainsworth
Ugeskr Laeger 167:2141. 2005
Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutationNils Milman
Department of Medicine B, Division of Lung Transplantation, Rigshospitalet, University of Copenhagen, Copenhage, Demark
APMIS 114:912-9. 2006..In children, discrimination between early onset sarcoidosis and Blau syndrome should include a CARD15 mutation analysis...
CARD15 single nucleotide polymorphisms 8, 12 and 13 are not increased in ethnic Danes with sarcoidosisNils Milman
Department of Medicine B, Division of Lung Transplantation, Rigshospitalet, Copenhagen University Hospital, Institute of Medical Biochemistry and Genetics, University of Copenhagen, Copenhagen, Denmark
Respiration 74:76-9. 2007..Sarcoidosis is a systemic granulomatous disease with unknown etiology, which shares histological features with Crohn's disease...
[Regulation of cytokine production in inflammatory bowel disease]Laura Ferrero-Miliani
Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C
Ugeskr Laeger 168:1847-50. 2006....
