Barbara Guerra

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. ncbi Ability of CK2beta to selectively regulate cellular protein kinases
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark
    Mol Cell Biochem 316:115-26. 2008
  2. ncbi Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    BMC Mol Biol 13:7. 2012
  3. ncbi Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2
    Barbara Guerra
    Division of Biological Sciences 0322, University of California, San Diego, CA 92093 0322, USA
    Oncogene 22:4933-42. 2003
  4. ncbi Protein kinase CK2 subunits are positive regulators of AKT kinase
    Barbara Guerra
    Institute for Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Int J Oncol 28:685-93. 2006
  5. ncbi Protein kinase CK2 in human diseases
    Barbara Guerra
    Institute for Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
    Curr Med Chem 15:1870-86. 2008
  6. ncbi Mapping of the interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2
    Birgitte B Olsen
    Institute of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark
    Int J Oncol 36:1175-82. 2010
  7. ncbi Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site
    Lars P Kristensen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    FEBS Lett 569:217-23. 2004
  8. ncbi Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity
    Jan N Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
    Mol Cell Biochem 356:149-58. 2011
  9. ncbi Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action
    Birgitte B Olsen
    University of Southern Denmark, Institute of Biochemistry and Molecular Biology, Campusvej 55, 5230 Odense M, Denmark
    Int J Biochem Cell Biol 39:227-37. 2007
  10. ncbi The regulatory beta-subunit of protein kinase CK2 accelerates the degradation of CDC25A phosphatase through the checkpoint kinase Chk1
    Jan Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense, Denmark
    Int J Oncol 31:1251-9. 2007

Collaborators

  • Patrizia Diana
  • Anne E Lykkesfeldt
  • Martin R Larsen
  • Nobumoto Watanabe
  • Jean Y Wang
  • Marta Riera
  • Tina Holm
  • Birgitte B Olsen
  • Jan N Kreutzer
  • Olaf Georg Issinger
  • Christina W Yde
  • Olaf-Georg Issinger
  • Tobias Persson
  • Jan Kreutzer
  • Lars P Kristensen
  • Marina Bjørling-Poulsen
  • Daniela Vedaldi
  • Benjamin Pc Chen
  • Alessia Salvador
  • David W Litchfield
  • Shih Ya Wang
  • Tina H Svenstrup
  • Girolamo Cirrincione
  • Karolina Lech
  • Maria Ruzzene
  • Karsten Niefind
  • Martin V Bennetzen
  • Ole G Mouritsen
  • Mathias P Clausen
  • Jakob E Rasmussen
  • Tine L Rasmussen
  • John Nielsen
  • Marina Bjørling Poulsen
  • Peter Højrup
  • Gerhard Seitz

Detail Information

Publications17

  1. ncbi Ability of CK2beta to selectively regulate cellular protein kinases
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark
    Mol Cell Biochem 316:115-26. 2008
    ....
  2. ncbi Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    BMC Mol Biol 13:7. 2012
    ..abstract:..
  3. ncbi Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2
    Barbara Guerra
    Division of Biological Sciences 0322, University of California, San Diego, CA 92093 0322, USA
    Oncogene 22:4933-42. 2003
    ..Collectively, these studies confirm the implication of the regulatory beta-subunit of protein kinase CK2 in cell cycle regulation and identify a novel mechanism for the activation of Chk1 protein kinase...
  4. ncbi Protein kinase CK2 subunits are positive regulators of AKT kinase
    Barbara Guerra
    Institute for Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense, Denmark
    Int J Oncol 28:685-93. 2006
    ....
  5. ncbi Protein kinase CK2 in human diseases
    Barbara Guerra
    Institute for Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
    Curr Med Chem 15:1870-86. 2008
    ..Since not all the aspects of what has been published on CK2 can be covered in this review, we would like to recommend the following reviews; (i) for general information on CK2 [11-18] and (ii) with a focus on aberrant CK2 [19-22]...
  6. ncbi Mapping of the interaction sites between Wee1 kinase and the regulatory beta-subunit of protein kinase CK2
    Birgitte B Olsen
    Institute of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark
    Int J Oncol 36:1175-82. 2010
    ..Taken together, our findings reinforce the notion that CK2beta is a modulator of protein kinases implicated in cell cycle regulation and exerts functions that are independent of CK2 tetramers...
  7. ncbi Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site
    Lars P Kristensen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    FEBS Lett 569:217-23. 2004
    ..Formation of a stable complex between CK2beta and Chk1 is not affected by the modification of Thr213 but it does require the presence of an active Chk1 kinase...
  8. ncbi Role of polyamines in determining the cellular response to chemotherapeutic agents: modulation of protein kinase CK2 expression and activity
    Jan N Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
    Mol Cell Biochem 356:149-58. 2011
    ....
  9. ncbi Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action
    Birgitte B Olsen
    University of Southern Denmark, Institute of Biochemistry and Molecular Biology, Campusvej 55, 5230 Odense M, Denmark
    Int J Biochem Cell Biol 39:227-37. 2007
    ..Taken together, our results highlight a new mechanism by which emodin exerts anti-cancer activity and suggest the further investigation of plant polyphenols, such as emodin, as therapeutic and preventive agents for cancer therapy...
  10. ncbi The regulatory beta-subunit of protein kinase CK2 accelerates the degradation of CDC25A phosphatase through the checkpoint kinase Chk1
    Jan Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense, Denmark
    Int J Oncol 31:1251-9. 2007
    ..These results suggest that protein kinase CK2 is involved in cell cycle regulation and indicate the mechanism by which CDC25A turnover might be regulated by Chk1 in the absence of DNA damage...
  11. ncbi Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells
    Jan N Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    BMC Cancer 10:440. 2010
    ....
  12. ncbi Structural basis of the constitutive activity of protein kinase CK2
    Birgitte B Olsen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    Methods Enzymol 484:515-29. 2010
    ..In this review, we explain (i) its constitutive activity at the intramolecular level, and (ii) come forward with a model how this protein kinase could be regulated in cells by a mechanism involving intermolecular interactions...
  13. ncbi 2-Triazenoazaindoles: ? novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells
    Jan N Kreutzer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    Int J Oncol 40:914-22. 2012
    ....
  14. ncbi The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifen-sensitive and tamoxifen-resistant human breast cancer cells
    Christina W Yde
    Department of Biochemistry and Molecular Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Anticancer Drugs 20:723-35. 2009
    ..This implies that chlorpromazine can change influx properties of membranes hence suggesting that chlorpromazine may be a promising chemosensitizing compound for enhancing the cytotoxic effect of tamoxifen...
  15. ncbi The pro-apoptotic FAS-associated factor 1 is specifically reduced in human gastric carcinomas
    Marina Bjørling-Poulsen
    University of Southern Denmark, Institute for Biochemistry and Molecular Biology, DK 5230 Odense, Denmark
    Int J Oncol 23:1015-23. 2003
    ..Also, the reduction of FAF1 is likely to be specific for gastric cancer, which might be due to the fact that signet ring cells are most frequently found in gastric cancers...
  16. ncbi Pyrazole carboxamides and carboxylic acids as protein kinase inhibitors in aberrant eukaryotic signal transduction: induction of growth arrest in MCF-7 cancer cells
    Tobias Persson
    Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg, Denmark
    Org Biomol Chem 5:3963-70. 2007
    ..Two analogues caused changes in MCF-7 cell growth, one of them through cell cycle arrest demonstrated by cell cycle analysis...
  17. ncbi Purification and characterization of recombinant protein kinase CK2 from Zea mays expressed in Escherichia coli
    Marta Riera
    Departamento de Genetica Molecular, IBMB, CID, C.S.I.C, Jordi Girona 18-26, 08034 Barcelona, Spain
    Protein Expr Purif 29:24-32. 2003
    ..The maize holoenzyme activity is more sensitive towards NaCl concentrations higher than those of rhCK2 and treatment with urea showed that rmCK2 holoenzyme was denatured more readily than the human holoenzyme...