L Fugger

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men
    L Fugger
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Denmark
    Arthritis Res 2:208-11. 2000
  2. ncbi Human autoimmunity genes in mice
    L Fugger
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, DK 8200 N, Aarhus, Denmark
    Curr Opin Immunol 12:698-703. 2000
  3. ncbi Humanized animal models for autoimmune diseases
    J W Gregersen
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, N Aarhus, Denmark
    Tissue Antigens 63:383-94. 2004
  4. ncbi The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients. A combined analysis of data available in the literature
    L Fugger
    Department of Clinical Immunology, National University Hospital, Copenhagen, Denmark
    Tissue Antigens 50:494-500. 1997
  5. ncbi Technical aspects of typing for HLA-DP alleles using allele-specific DNA in vitro amplification and sequence-specific oligonucleotide probes. Detection of single base mismatches
    L Fugger
    Department of Clinical Immunology, State University Hospital, Copenhagen, Denmark
    J Immunol Methods 129:175-85. 1990
  6. ncbi Immunological studies in acquired immunodeficiency syndrome: effect of TCGF and indomethacine on the in vitro lymphocyte response
    B Hofmann
    Department of Clinical Immunology, University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark
    Cancer Detect Prev Suppl 1:619-26. 1987
  7. ncbi Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
  8. ncbi Identification of 4 different alternatively spliced HLA-A transcripts
    L Norgaard
    Department of Clinical Immunology, University Hospital of Copenhagen Rigshospitalet, Denmark
    Tissue Antigens 54:370-8. 1999

Collaborators

  • A Svejgaard
  • L Norgaard
  • J W Gregersen
  • L Madsen
  • S Holmes
  • C Benoist
  • D Mathis
  • A Dierich
  • J Engberg
  • N Labrecque
  • B Hofmann
  • J Gaub
  • L P Ryder
  • J Gerstoft
  • P Platz
  • N Odum

Detail Information

Publications8

  1. ncbi Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men
    L Fugger
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Denmark
    Arthritis Res 2:208-11. 2000
    ..Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed...
  2. ncbi Human autoimmunity genes in mice
    L Fugger
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, DK 8200 N, Aarhus, Denmark
    Curr Opin Immunol 12:698-703. 2000
    ....
  3. ncbi Humanized animal models for autoimmune diseases
    J W Gregersen
    Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, N Aarhus, Denmark
    Tissue Antigens 63:383-94. 2004
    ....
  4. ncbi The HLA-DQ7 and -DQ8 associations in DR4-positive rheumatoid arthritis patients. A combined analysis of data available in the literature
    L Fugger
    Department of Clinical Immunology, National University Hospital, Copenhagen, Denmark
    Tissue Antigens 50:494-500. 1997
    ..Our analyses provide strong evidence against the hypothesis that HLA-DQ molecules play a major role in the general susceptibility to RA. Thus, the strongest association in rheumatoid arthritis is with DRB1 genes rather than DQB1 genes...
  5. ncbi Technical aspects of typing for HLA-DP alleles using allele-specific DNA in vitro amplification and sequence-specific oligonucleotide probes. Detection of single base mismatches
    L Fugger
    Department of Clinical Immunology, State University Hospital, Copenhagen, Denmark
    J Immunol Methods 129:175-85. 1990
    ..Thus, single base mismatches may be detected in the PCR and typing for HLA-DP gene variants, which differ for only one base, may be performed...
  6. ncbi Immunological studies in acquired immunodeficiency syndrome: effect of TCGF and indomethacine on the in vitro lymphocyte response
    B Hofmann
    Department of Clinical Immunology, University Hospital Rigshospitalet and State Serum Institute, Copenhagen, Denmark
    Cancer Detect Prev Suppl 1:619-26. 1987
    ..No differences were found between the three groups: the responses to PHA were slightly increased and those to Con A were unchanged...
  7. ncbi Mice lacking all conventional MHC class II genes
    L Madsen
    Department of Clinical Immunology, Rigshospitalet, 2200 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 96:10338-43. 1999
    ..Therefore, they should be invaluable for engineering "humanized" mouse models of human MHC-II-associated autoimmune disorders...
  8. ncbi Identification of 4 different alternatively spliced HLA-A transcripts
    L Norgaard
    Department of Clinical Immunology, University Hospital of Copenhagen Rigshospitalet, Denmark
    Tissue Antigens 54:370-8. 1999
    ..Nevertheless, our findings indicate that alternative splicing of the HLA-A transcript may take place to a small extent in virtually all cells, and it is possible that their generation promote escape from immune surveillance...