Bodil Cecilie Sondergaard

Summary

Affiliation: Nordic Bioscience
Country: Denmark

Publications

  1. ncbi Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus
    B C Sondergaard
    Cartilage Biology and Biomarker R and D, Nordic Bioscience, Herlev, Denmark
    Osteoarthritis Cartilage 20:136-43. 2012
  2. ncbi Identification of the calcitonin receptor in osteoarthritic chondrocytes
    Toni Segovia-Silvestre
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Res Notes 4:407. 2011
  3. ncbi Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
    Bijue Wang
    Nordic Bioscience A S, Zhongguancun Life Science Park, Beijing 102206, PR China
    BMC Res Notes 2:259. 2009
  4. ncbi Patients with rheumatoid arthritis have an altered circulatory aggrecan profile
    Jean C Rousseau
    Inserm Unit 831, University of Lyon, Pavillon F, Hopital E Herriot, Lyon, France
    BMC Musculoskelet Disord 9:74. 2008
  5. ncbi Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 10:R63. 2008
  6. ncbi MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
    B C Sondergaard
    Nordic Bioscience A S, Herlev, Denmark
    Osteoarthritis Cartilage 18:279-88. 2010
  7. ncbi Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes
    Bodil Cecilie Sondergaard
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Musculoskelet Disord 11:62. 2010
  8. ncbi Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation
    Morten Asser Karsdal
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Arthritis Rheum 56:1549-58. 2007
  9. ncbi Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo
    Suzi Hoegh Madsen
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 15:266-76. 2010
  10. ncbi Biochemical markers of joint tissue turnover
    Anne Christine Bay-Jensen
    Nordic Bioscience A S, Herlev, Denmark
    Assay Drug Dev Technol 8:118-24. 2010

Collaborators

Detail Information

Publications13

  1. ncbi Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus
    B C Sondergaard
    Cartilage Biology and Biomarker R and D, Nordic Bioscience, Herlev, Denmark
    Osteoarthritis Cartilage 20:136-43. 2012
    ..We investigated effects of salmon calcitonin (sCT) on the articular cartilage and bone, after destabilization of the medial meniscus (DMM) in normal and sCT over-expressing mice...
  2. ncbi Identification of the calcitonin receptor in osteoarthritic chondrocytes
    Toni Segovia-Silvestre
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Res Notes 4:407. 2011
    ..abstract:..
  3. ncbi Suppression of MMP activity in bovine cartilage explants cultures has little if any effect on the release of aggrecanase-derived aggrecan fragments
    Bijue Wang
    Nordic Bioscience A S, Zhongguancun Life Science Park, Beijing 102206, PR China
    BMC Res Notes 2:259. 2009
    ....
  4. ncbi Patients with rheumatoid arthritis have an altered circulatory aggrecan profile
    Jean C Rousseau
    Inserm Unit 831, University of Lyon, Pavillon F, Hopital E Herriot, Lyon, France
    BMC Musculoskelet Disord 9:74. 2008
    ..We investigated, whether measurement of aggrecan and fragments thereof in serum, could be used as biomarkers for joint-disease in RA patients and furthermore characterized the fragments found in the circulation...
  5. ncbi Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
    Morten A Karsdal
    Nordic Bioscience A S, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Res Ther 10:R63. 2008
    ..We investigated the capacity of repair of chondrocytes by analyzing their ability to initiate an anabolic response subsequent to three different levels of catabolic stimulation...
  6. ncbi MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
    B C Sondergaard
    Nordic Bioscience A S, Herlev, Denmark
    Osteoarthritis Cartilage 18:279-88. 2010
    ..However, the signaling pathways that results in MMP and/or aggrecanase synthesis and activation are not well understood. We investigated the molecular events leading to MMP- and aggrecanase-mediated cartilage degradation...
  7. ncbi Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes
    Bodil Cecilie Sondergaard
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Musculoskelet Disord 11:62. 2010
    ..We investigated possible direct effects of salmon calcitonin on proteoglycans and collagen-type-II synthesis in osteoarthritic (OA) cartilage...
  8. ncbi Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation
    Morten Asser Karsdal
    Nordic Bioscience Diagnostics, Herlev, Denmark
    Arthritis Rheum 56:1549-58. 2007
    ..One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondrocytes would be chondroprotective...
  9. ncbi Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo
    Suzi Hoegh Madsen
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 15:266-76. 2010
    ..This may have implications for the development of intervention strategies for OA...
  10. ncbi Biochemical markers of joint tissue turnover
    Anne Christine Bay-Jensen
    Nordic Bioscience A S, Herlev, Denmark
    Assay Drug Dev Technol 8:118-24. 2010
    ..Finally, we provide some perspective to future developments in biomarker discovery and discuss the potential impact such technologies could have on the drug development process...
  11. ncbi Molecular serum and urine marker repertoire supporting clinical research on joint diseases
    Per Qvist
    Nordic Bioscience A S, Herlev, Denmark
    Best Pract Res Clin Rheumatol 25:859-72. 2011
    ..This report aims at providing a critical review of biochemical markers applied in clinical research of joint diseases, in particular those markers reflecting the turnover of cartilage tissue...
  12. ncbi Application of biochemical markers in development of drugs for treatment of osteoarthritis
    Per Qvist
    Nordic Bioscience A S, Herlev, Denmark
    Biomarkers 15:1-19. 2010
    ..Finally, we discuss possible directions in future biomarker research...
  13. ncbi The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model
    Bodil Cecilie Sondergaard
    Nordic Bioscience Diagnostics, Herlev Hovedgade 207, DK 2730 Herlev, Denmark
    Arthritis Rheum 56:2674-8. 2007
    ..To investigate whether oral calcitonin treatment influences the increases in type II collagen (CII) degradation and related surface erosions of articular cartilage in ovariectomized rats...