Lars Henrik Heckmann

Summary

Affiliation: National Environmental Research Institute
Country: Denmark

Publications

  1. ncbi A simple and rapid method for preserving RNA of aquatic invertebrates for ecotoxicogenomics
    Lars Henrik Heckmann
    Environmental Biology Section, School of Biological Sciences, The University of Reading, Whiteknights, PO Box 68, Reading, RG6 6BX, UK
    Ecotoxicology 16:445-7. 2007
  2. ncbi Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, Philip Lyle Building, Reading, RG6 6BX, UK
    Genome Biol 9:R40. 2008
  3. ncbi Time is of the essence
    Lars Henrik Heckmann
    National Environmental Research Institute, Aarhus University, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    Environ Toxicol Chem 29:1396-8. 2010
  4. ncbi Outlining eicosanoid biosynthesis in the crustacean Daphnia
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, PO Box 68, Reading, RG6 6BX, UK
    Front Zool 5:11. 2008
  5. ncbi Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, Philip Lyle Building, Reading UK
    Toxicol Lett 172:137-45. 2007
  6. ncbi Expression of target and reference genes in Daphnia magna exposed to ibuprofen
    Lars Henrik Heckmann
    The University of Reading, School of Biological Sciences, Environmental Biology, PO Box 228, RG6 6AJ, UK
    BMC Genomics 7:175. 2006
  7. ncbi Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen
    Yuya Hayashi
    School of Biological Sciences, Environmental Biology, University of Reading, Philip Lyle Building, Whiteknights, Reading RG6 6BX, UK
    Ecotoxicology 17:246-51. 2008
  8. ncbi Linking molecular and population stress responses in Daphnia magna exposed to cadmium
    Richard Connon
    School of Biological Sciences, University of Reading, P O Box 68, Reading RG6 6BX, UK
    Environ Sci Technol 42:2181-8. 2008
  9. ncbi Hsp70 expression and metabolite composition in response to short-term thermal changes in Folsomia candida (Collembola)
    Dorthe Waagner
    Aarhus University, Department of Biological Sciences, Aarhus C, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 157:177-83. 2010
  10. ncbi NORMA-Gene: a simple and robust method for qPCR normalization based on target gene data
    Lars Henrik Heckmann
    National Environmental Research Institute, Aarhus University, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    BMC Bioinformatics 12:250. 2011

Collaborators

Detail Information

Publications10

  1. ncbi A simple and rapid method for preserving RNA of aquatic invertebrates for ecotoxicogenomics
    Lars Henrik Heckmann
    Environmental Biology Section, School of Biological Sciences, The University of Reading, Whiteknights, PO Box 68, Reading, RG6 6BX, UK
    Ecotoxicology 16:445-7. 2007
    ..g. amphipod Gammarus pulex representing an upper size limit. We explain in detail how to apply this new method, named the "Cylindrical Sieve (CS) system", and highlight its advantages and disadvantages...
  2. ncbi Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, Philip Lyle Building, Reading, RG6 6BX, UK
    Genome Biol 9:R40. 2008
    ..Here we report a systems biology study that simultaneously describes the transcriptomic and phenotypic stress responses of the model crustacean Daphnia magna after exposure to ibuprofen...
  3. ncbi Time is of the essence
    Lars Henrik Heckmann
    National Environmental Research Institute, Aarhus University, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    Environ Toxicol Chem 29:1396-8. 2010
    ....
  4. ncbi Outlining eicosanoid biosynthesis in the crustacean Daphnia
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, PO Box 68, Reading, RG6 6BX, UK
    Front Zool 5:11. 2008
    ..However, little is still known about the synthesis and structure of the pathway in invertebrates...
  5. ncbi Chronic toxicity of ibuprofen to Daphnia magna: Effects on life history traits and population dynamics
    Lars Henrik Heckmann
    University of Reading, School of Biological Sciences, Environmental Biology, Philip Lyle Building, Reading UK
    Toxicol Lett 172:137-45. 2007
    ..We discuss our results in relation to recent genomic studies, which suggest that the potential mechanism of toxicity in Daphnia is similar to the mode of action in mammals, where IB inhibits eicosanoid biosynthesis...
  6. ncbi Expression of target and reference genes in Daphnia magna exposed to ibuprofen
    Lars Henrik Heckmann
    The University of Reading, School of Biological Sciences, Environmental Biology, PO Box 228, RG6 6AJ, UK
    BMC Genomics 7:175. 2006
    ..However, reference gene expression can vary between tissues and experimental conditions, which makes it crucial to validate them prior to application...
  7. ncbi Reproduction recovery of the crustacean Daphnia magna after chronic exposure to ibuprofen
    Yuya Hayashi
    School of Biological Sciences, Environmental Biology, University of Reading, Philip Lyle Building, Whiteknights, Reading RG6 6BX, UK
    Ecotoxicology 17:246-51. 2008
    ..Our results suggest a possible theory behind the compensatory fecundity that we referred to as 'catch-up reproduction'...
  8. ncbi Linking molecular and population stress responses in Daphnia magna exposed to cadmium
    Richard Connon
    School of Biological Sciences, University of Reading, P O Box 68, Reading RG6 6BX, UK
    Environ Sci Technol 42:2181-8. 2008
    ..Our production and application of a large Daphnia magna microarray has shown that measured gene responses can be logically linked to the impact of a toxicant such as cadmium on somatic growth and development, and consequently pgr...
  9. ncbi Hsp70 expression and metabolite composition in response to short-term thermal changes in Folsomia candida (Collembola)
    Dorthe Waagner
    Aarhus University, Department of Biological Sciences, Aarhus C, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 157:177-83. 2010
    ..These results, obtained from ecological transcriptomics and metabolomics jointly generated insight on various levels into the combined responses to a changing environment...
  10. ncbi NORMA-Gene: a simple and robust method for qPCR normalization based on target gene data
    Lars Henrik Heckmann
    National Environmental Research Institute, Aarhus University, Department of Terrestrial Ecology, Vejlsøvej 25, DK 8600 Silkeborg, Denmark
    BMC Bioinformatics 12:250. 2011
    ..The currently used normalization approach is based on using one or more reference genes. Yet, this approach extends the experimental work load and suffers from assumptions that may be difficult to meet and to validate...