Michael Sørensen

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumors
    Michael Sørensen
    PET Center, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 62:854-61. 2005
  2. ncbi The potential use of 2-[¹?F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma
    Michael Sørensen
    PET Centre, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 38:1723-31. 2011
  3. ncbi Determination of hepatic galactose elimination capacity using 2-[¹?F]fluoro-2-deoxy-D-galactose PET/CT: reproducibility of the method and metabolic heterogeneity in a normal pig liver model
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    Scand J Gastroenterol 46:98-103. 2011
  4. ncbi Hepatic galactose metabolism quantified in humans using 2-18F-fluoro-2-deoxy-D-galactose PET/CT
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    J Nucl Med 52:1566-72. 2011
  5. ncbi Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    Metab Brain Dis 24:237-42. 2009
  6. ncbi Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomography
    Michael Sørensen
    PET Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 295:G27-G36. 2008
  7. ncbi FDG-PET improves management of patients with colorectal liver metastases allocated for local treatment: a consecutive prospective study
    M Sørensen
    Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
    Scand J Surg 96:209-13. 2007
  8. ncbi New findings on cerebral ammonia uptake in HE using functional (13)N-ammonia PET
    Michael Sørensen
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Metab Brain Dis 22:277-84. 2007
  9. ncbi Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography
    Susanne Keiding
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 43:42-50. 2006
  10. ncbi Human (13)N-ammonia PET studies: the importance of measuring (13)N-ammonia metabolites in blood
    Susanne Keiding
    PET Centre, Aarhus University Hospital, Aarhus, 8000, Denmark
    Metab Brain Dis 25:49-56. 2010

Collaborators

Detail Information

Publications18

  1. ncbi Effect of intratumoral heterogeneity in oxygenation status on FMISO PET, autoradiography, and electrode Po2 measurements in murine tumors
    Michael Sørensen
    PET Center, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 62:854-61. 2005
    ..To explore conflicting results obtained when tumor hypoxia is assessed with Eppendorf electrode Po(2) measurements and with positron emission tomography (PET) by use of [(18)F]fluoromisonidazole (FMISO)...
  2. ncbi The potential use of 2-[¹?F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma
    Michael Sørensen
    PET Centre, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 38:1723-31. 2011
    ..The aim of the study was to evaluate the feasibility of using the hepatocyte-specific positron emission tomography (PET) tracer 2-[(18)F]fluoro-2-deoxy-D-galactose (FDGal) as a tracer for hepatocellular carcinoma (HCC)...
  3. ncbi Determination of hepatic galactose elimination capacity using 2-[¹?F]fluoro-2-deoxy-D-galactose PET/CT: reproducibility of the method and metabolic heterogeneity in a normal pig liver model
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    Scand J Gastroenterol 46:98-103. 2011
    ..The aim of the present study was to determine the reproducibility of the method in pigs before translating it to human studies...
  4. ncbi Hepatic galactose metabolism quantified in humans using 2-18F-fluoro-2-deoxy-D-galactose PET/CT
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    J Nucl Med 52:1566-72. 2011
    ..Here, we quantify hepatic galactose elimination in humans using PET and the galactose analog 2-(18)F-fluoro-2-deoxy-d-galactose ((18)F-FDGal) as the PET tracer...
  5. ncbi Backflux of ammonia from brain to blood in human subjects with and without hepatic encephalopathy
    Michael Sørensen
    PET Centre, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    Metab Brain Dis 24:237-42. 2009
    ..In conclusion, backflux of ammonia from the brain to the blood does indeed occur in both healthy subjects and cirrhotic patients with and without hepatic encephalopathy...
  6. ncbi Hepatic uptake and metabolism of galactose can be quantified in vivo by 2-[18F]fluoro-2-deoxygalactose positron emission tomography
    Michael Sørensen
    PET Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Am J Physiol Gastrointest Liver Physiol 295:G27-G36. 2008
    ..At near-saturated kinetics, the maximal hepatic removal rate of galactose can be calculated from the net metabolic clearance of FDGal and the blood concentration of galactose...
  7. ncbi FDG-PET improves management of patients with colorectal liver metastases allocated for local treatment: a consecutive prospective study
    M Sørensen
    Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
    Scand J Surg 96:209-13. 2007
    ..Proper staging is therefore essential and CT is the standard imaging modality. We examined whether additional FDG-PET improves therapeutic management of patients with colorectal liver metastases...
  8. ncbi New findings on cerebral ammonia uptake in HE using functional (13)N-ammonia PET
    Michael Sørensen
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Metab Brain Dis 22:277-84. 2007
    ..In conclusion, basic brain ammonia kinetics was not changed significantly in patients with cirrhosis +/- HE compared to healthy controls. Blood ammonia seems to be the more important factor for increased brain ammonia uptake in HE...
  9. ncbi Brain metabolism of 13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography
    Susanne Keiding
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Hepatology 43:42-50. 2006
    ..In conclusion, increased cerebral trapping of ammonia in patients with cirrhosis with acute HE was primarily attributable to increased blood ammonia and to a minor extent to changed ammonia kinetics in the brain...
  10. ncbi Human (13)N-ammonia PET studies: the importance of measuring (13)N-ammonia metabolites in blood
    Susanne Keiding
    PET Centre, Aarhus University Hospital, Aarhus, 8000, Denmark
    Metab Brain Dis 25:49-56. 2010
    ....
  11. ncbi Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy
    Renata Leke
    PET Centre, Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark
    J Neurochem 117:824-32. 2011
    ..Since the indirect pathway is associated with synthesis of vesicular GABA, this might explain the increased GABAergic tone in HE...
  12. ncbi Branched-chain amino acids increase arterial blood ammonia in spite of enhanced intrinsic muscle ammonia metabolism in patients with cirrhosis and healthy subjects
    Gitte Dam
    PET Centre, Aarhus University Hospital, Denmark
    Am J Physiol Gastrointest Liver Physiol 301:G269-77. 2011
    ..05; healthy subjects, P = 0.12). In conclusion, BCAA enhanced the intrinsic muscle metabolism of ammonia but not the metabolism of blood-supplied ammonia in both the patients with cirrhosis and in the healthy subjects...
  13. ncbi Hepatic blood perfusion measured by 3-minute dynamic 18F-FDG PET in pigs
    Michael Winterdahl
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    J Nucl Med 52:1119-24. 2011
    ..For this purpose, we examined the possibility of using a 3-min data acquisition and a model-derived dual input calculated from measurements of radioactivity concentrations in a peripheral artery...
  14. ncbi Low cerebral oxygen consumption and blood flow in patients with cirrhosis and an acute episode of hepatic encephalopathy
    Peter Iversen
    PET Centre, Aarhus University Hospital, Aarhus, Denmark
    Gastroenterology 136:863-71. 2009
    ..It is unclear whether patients with hepatic encephalopathy (HE) have disturbed brain oxygen metabolism and blood flow...
  15. ncbi Tracer input for kinetic modelling of liver physiology determined without sampling portal venous blood in pigs
    Michael Winterdahl
    PET Centre, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 38:263-70. 2011
    ..We wished to develop a method for estimating dual tracer input without the necessity to sample PV blood...
  16. ncbi Nucleophilic radiosynthesis of 2-[18F]fluoro-2-deoxy-D-galactose from Talose triflate and biodistribution in a porcine model
    Kim Frisch
    PET Centre, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Nucl Med Biol 38:477-83. 2011
    ..In addition, the biodistribution of FDGal in the pig is presented...
  17. ncbi Hepatic ethanol elimination kinetics in patients with cirrhosis
    Gitte Dam
    Department of Medicine V Hepatology, Aarhus University Hospital, Aarhus, Denmark
    Scand J Gastroenterol 44:867-71. 2009
    ..A further objective was to investigate whether systemic clearance of ethanol at low arterial ethanol concentrations can be used as a measure of hepatic blood flow...