Troels S Jensen

..This review briefly discusses the definition and clinical presentation of neuropathic pain and highlights recent advances in the treatment of neuropathic pain...

..This brief review focuses on the increasing evidence for effective treatments and discusses an evidence-based algorithm for treating neuropathic pain conditions...

..This article presents epidemiological, clinical and pathophysiological aspects of chronic postoperative pain and offers suggestions for pain management and prophylaxis...

..Central pain usually develops within months after the stroke and is located within the area of sensory abnormality corresponding to the CNS region damaged by the stroke...

..Irrespective of which treatment is offered, only about one third of patients are likely to achieve more than 50% pain relief. Further research to improve the diagnosis and management of DPNP is needed...

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..One-year prospective study of 141 acute whiplash patients (WLP) and 40 acute ankle-injured controls...

..04) but not an increased response to capsaicin in patients with central pain. These results suggest that SCI patients with below-level pain have increased responses to some but not all sensory input at the level of injury...

..These results suggest a peripheral mediated decrease in cold sensation following TPRV1 receptor activation...

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..Surgical removal of third molars may carry a risk of developing persistent orofacial pain, and central sensitization appears to play an important role in the transition from acute to chronic pain...

..The current study examines the analgesic effect of the sodium channel blocker lidocaine on neuropathic pain in patients with spinal cord injury and the predictive role of concomitant evoked pain on pain relief with lidocaine...

..The present review summarizes mechanisms of neuropathic pain, targets of currently used drugs, and measures used in neuropathic pain trials...

..Personal characteristics before the collision are important for recovery and attention to pre-collision characteristics may contribute to the prevention of poor recovery after acute whiplash trauma...

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..The findings suggest that different mechanisms are responsible for the development of mood disorders in the two patient groups...

..However, it is not yet possible to identify mechanisms in individual patients, and present knowledge of drug effects builds on diagnosis. An algorithm for treatment of NP is presented...

..Chronic hip pain after total hip arthroplasty (THA) is a significant problem, but the aetiology remains unclear...

..02) and trapezius muscles (p<0.04) after 384 days. This study shows early mechano-sensitization after an acute whiplash injury and the development of further sensitization in patients with long-term disability...

..The aim of this prospective study was therefore to study the role of surgery and other possible predictors for pain 4 months after hysterectomy...

..Adverse events, including dizziness, were more frequent with dronabinol than with placebo during the first week of treatment...

..The authors studied systemic autonomic and hemodynamic function in CRPS patients during rest, and during orthostatic and mental arithmetic stress...

..Present suggestions for anticonvulsant treatment of CP are lamotrigine as the first choice, followed by gabapentin or carbamazepine/oxcarbazepine. These compounds are considered as effective as the antidepressant amitriptyline...

..In the present review we discuss the role of botulinum neurotoxins (BoNTs) in the management of different pain conditions, with evidence-based data on the toxins' efficacy on pain and its mechanisms...

..The effect of surgical excision has remained controversial. Here we report a prospective study on the effect of neuroma removal on pain...

..The recommended dose for intravenous (IV) paracetamol injection in adults is 1g, however pharmacokinetic and pharmacodynamic findings suggest that a better analgesia could be obtained with a 2 g starting dose...

..The concentration-effect relationship is similar for patients with central and peripheral neuropathic pain. Further studies are needed to document if TDM improves pain relief; however, TDM reduces the risk for toxicity...

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..To prospectively examine the course of pain and other neurologic complaints in patients with acute whiplash injury and in controls with acute ankle injury...

..The purpose of this article is to discuss an evidence-based algorithm that can be implemented by the primary care physician in his/her daily clinical practice for the treatment of patients with neuropathic pain conditions...

..006) in female Fabry patients. This indicates that female Fabry patients have a significant loss of small-fibre function and demonstrates that it is possible to evaluate this by a non-invasive method...

..This nationwide questionnaire and database study describes pain and identifies risk factors for chronic postsurgical pain 1 yr after hysterectomy for benign indications...

..Persistent postsurgical pain has been reported following cosmetic breast augmentation, but little is known about the underlying mechanisms...

..Although treatment of CPSP is difficult, the most effective approaches are those that target the increased neuronal hyperexcitability...

..Methods depending on cortical structures, as the PEAP, are therefore optimal endpoints in animal models of central pain...

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..If symptoms persist and conservative treatments are chosen, these should be active and they should focus on sustaining or regaining usual activities...

..Possible mechanisms underlying the pathophysiology of depression and pain could be involvement of the monoamines (5-HT and NA) and the HPA axis...

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..Tissue injury is accompanied by pain and results in increased energy expenditure, which may promote catabolism. The extent to which pain contributes to this sequence of events is not known...

..Pain after amputation is common but difficult to treat. Therefore, the authors examined whether postoperative treatment with gabapentin could reduce postamputation stump and phantom pain...

..Muscle fiber hypertrophy and/or altered central drive may account for our results, but there was no indication of changes in muscle fiber excitability...

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..The differential effect of painful HTS on ongoing pain and area of brush-evoked allodynia suggest that separate mechanisms are involved...

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..This Review will stress the importance of recognizing neurological symptoms for the diagnosis of Fabry's disease. The possible pathophysiological background will also be discussed...

..The clinical manifestation of aftersensations can be mimicked in an experimental pain model so aftersensations may be another useful parameter in assessment of central sensitization...

..Optimal pain control and counselling of patients may be achievable through research into the genetic mechanisms involved in pain...

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..Pregabalin is suitable for patients on multiple drugs although there may be additive CNS-related side-effects. Thus, pregabalin has a primary role in central pain patients...

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..The aim of the present study was to assess pain and sensorimotor function in the craniofacial region in an unselected group of patients sustaining a motor vehicle accident involving a rear collision...

..We propose distinct mechanisms for local lidocaine and ketamine based on the differential effects of local lidocaine and ketamine on flux and pain...

..A higher density of muscle nociceptors in the vicinity of the motor endplate region may account for the observed differences in pain. These findings may have clinical implications for the treatment of musculoskeletal pain conditions...

..0 (2.3-6.0) vs. 5.0 (4.0-6.4), median (25th-75th percentiles), p = 0.02). Though dronabinol's analgesic effect is modest, its use should be evaluated considering the general difficulty in treating central pain...

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..Pain is an important symptom in patients with multiple sclerosis (MS). The estimated pain prevalence varies between 30% and 90%. To our knowledge, previous studies do not include a whole population sample of patients with MS...

..Acute stimulation of muscle nociceptors thus produced a fatiguelike change in the interference pattern during MVC, possibly due to a decrease in motoneuron firing rate and increased muscle fatigability...

..The pathophysiology is unclear. Most research groups favor a multifactorial pathophysiology similar to that observed for other chronic pain conditions without a clear nociceptive or neuropathic component...

..Pain induced decrease of mean RR during mental stress may be caused by the release of catecholamines into the systemic circulation...

..To investigate the degree and duration of neuronal hyperexcitability due to local inflammatory trauma after surgical removal of an impacted mandibular third molar...

..Furthermore, the authors aimed to describe the sensitivity, specificity, and positive predictive values (PPV) of the techniques if group differences could be established...

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..The results suggest that pain in MS is central in more than half of the patients and is associated with mechanical or thermal hyperalgesia...

..Randomized, parallel-group trial...

..Furthermore, in contrast to studies on various neuropathic pain conditions, fentanyl and S-ketamine in the present doses failed to attenuate AO pain...