Morten Busk

Summary

Affiliation: Aarhus University Hospital
Country: Denmark

Publications

  1. ncbi Metabolic arrest and its regulation in anoxic eel hepatocytes
    M Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, 8000 Aarhus, Denmark
    Physiol Biochem Zool 78:926-36. 2005
  2. ncbi In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    BMC Cancer 11:63. 2011
  3. ncbi Combretastatin-induced hypertension and the consequences for its combination with other therapies
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Vascul Pharmacol 54:13-7. 2011
  4. ncbi Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Acta Oncol 49:922-33. 2010
  5. ncbi Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Radiother Oncol 92:429-36. 2009
  6. ncbi Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 35:2294-303. 2008
  7. ncbi Resolution in PET hypoxia imaging: voxel size matters
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:1201-10. 2008
  8. ncbi Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 122:2726-34. 2008
  9. ncbi Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 70:1202-12. 2008
  10. ncbi Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:404-11. 2011

Detail Information

Publications13

  1. ncbi Metabolic arrest and its regulation in anoxic eel hepatocytes
    M Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, 8000 Aarhus, Denmark
    Physiol Biochem Zool 78:926-36. 2005
    ..Accordingly, adrenaline elevated anaerobic energy production but, apparently, also elevated ATP consumption because cellular ATP levels during oxygen deprivation were slightly lowered by adrenergic stimulation...
  2. ncbi In vivo identification and specificity assessment of mRNA markers of hypoxia in human and mouse tumors
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    BMC Cancer 11:63. 2011
    ..g., low pH). Here we describe a new technique that by exploiting intratumoral oxygenation heterogeneity allows us to identify and objectively rank the most robust mRNA hypoxia biomarkers...
  3. ncbi Combretastatin-induced hypertension and the consequences for its combination with other therapies
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Vascul Pharmacol 54:13-7. 2011
    ..The aim of this study was to use a mouse model to investigate whether hypertension or its modification influenced the treatment efficacy of CA4P in combination with other therapies...
  4. ncbi Assessing hypoxia in animal tumor models based on pharmocokinetic analysis of dynamic FAZA PET
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Acta Oncol 49:922-33. 2010
    ..Our study demonstrates the potential usefulness of dynamic PET, but also that a simple two-compartment model may be inappropriate in some tumor models...
  5. ncbi Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital AUH, Aarhus, Denmark
    Radiother Oncol 92:429-36. 2009
    ....
  6. ncbi Cellular uptake of PET tracers of glucose metabolism and hypoxia and their linkage
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus C, Denmark
    Eur J Nucl Med Mol Imaging 35:2294-303. 2008
    ..Here, we compare the oxygenation-dependent retention of fluoroazomycin arabinoside ([(18)F]FAZA), a promising but not well-characterised hypoxia-specific tracer, and fluorodeoxyglucose ([(18)F]FDG) in four carcinoma cell lines...
  7. ncbi Resolution in PET hypoxia imaging: voxel size matters
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Acta Oncol 47:1201-10. 2008
    ....
  8. ncbi Aerobic glycolysis in cancers: implications for the usability of oxygen-responsive genes and fluorodeoxyglucose-PET as markers of tissue hypoxia
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Cancer 122:2726-34. 2008
    ..This linkage suggests that multi-tracer imaging combining FDG and hypoxia-specific markers may provide therapeutically relevant information on tumor energetic phenotypes...
  9. ncbi Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
    Int J Radiat Oncol Biol Phys 70:1202-12. 2008
    ..The aim of this study was to examine the in vivo hypoxia selectivity of fluoroazomycin arabinoside ([18F]-FAZA), a promising tracer with improved washout kinetics from oxygenated tissue...
  10. ncbi Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment
    Morten Busk
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:404-11. 2011
    ....
  11. ncbi Accessing radiation response using hypoxia PET imaging and oxygen sensitive electrodes: a preclinical study
    Lise Saksø Mortensen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Radiother Oncol 99:418-23. 2011
    ..The aim of this study was to investigate the prognostic value of hypoxia measured by (18)F-fluoroazomycin arabinoside ((18)F-FAZA) PET or the Eppendorf oxygen electrode in a pre-clinical tumor model...
  12. ncbi Development of a hypoxia gene expression classifier with predictive impact for hypoxic modification of radiotherapy in head and neck cancer
    Kasper Toustrup
    Department of Experimental Clinical Oncology, Aarhus University Hospital and Bioinformatics Research Centre, Aarhus University, Aarhus C, Denmark
    Cancer Res 71:5923-31. 2011
    ..Thus, findings show that the classifier attained both prognostic and predictive impact, and its pretherapeutic use may provide a method to identify those patients who will benefit from hypoxic modification of radiotherapy...
  13. ncbi Imaging tumour physiology and vasculature to predict and assess response to heat
    Steffen L Hokland
    Department of Experimental Clinical Oncology, Aarhus University Hospital NBG, Aarhus, Denmark
    Int J Hyperthermia 26:264-72. 2010
    ..Here we review the various techniques that can be applied to supply this information, especially using non-invasive imaging approaches...