Downbeat nystagmus following classical heat strokeDirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, Doha, Qatar
Clin Neurol Neurosurg 108:102-4. 2005
..g. hypomagnesemia) and follow-up revealed complete reversibility of the ophthalmological abnormality. It reveals that the vestibulocerebellum is particularly vulnerable to thermal injury...
- Schwannoma of the vestibulocochlear nerve presenting as isolated paroxysmal vertigo
Dirk Deleu
Department of Neurology, Hamad Medical Corporation, PO Box 3050, Doha, State of Qatar Fax 974 4392377 E mail
Neurosciences (Riyadh) 10:307-8. 2005
..Hence, recurrent paroxysmal vertigo should therefore prompt the physician to rule out schwannoma of the vestibulocochlear nerve as a potential cause even in the presence of normal hearing tests...
- Hemifacial spasm resulting from vertebral artery dolichoectasia
Dirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, PO Box 3050, Doha, State of Qatar Fax 947 4392273 E mail
Neurosciences (Riyadh) 10:304-6. 2005
..This case demonstrates that MRI/MRA is an essential part of the work-up for hemifacial spasm, and shows that in accordance with the literature, vertebral dolichoectasia is an uncommon cause of hemifacial spasm...
- Pure isolated unilateral internuclear ophthalmoplegia from ischemic origin: report of a case and literature review
D Deleu
Department of Neurology Medicine, Hamad Medical Corporation, P O Box 3050, Doha, State of Qatar
Acta Neurol Belg 105:214-7. 2005
..To report a case of pure isolated unilateral internuclear ophthalmoplegia from ischemic stroke, and to review its literature...
- Segmental left ventricular wall motion abnormalities are associated with lacunar ischemic stroke
Dirk Deleu
Department of Neurology, Hamad Medical Corporation, P O Box 3050, Doha, State of Qatar
Clin Neurol Neurosurg 108:744-9. 2006
..The aim of this study was to determine whether segmental left ventricular wall motion abnormalities (SLVWMA) are a potential cause of ischemic stroke...
- Ethnic variations in risk factor profile, pattern and recurrence of non-cardioembolic ischemic stroke
Dirk Deleu
Department of Neurology, Hamad Medical Corporation, Doha, State of Qatar
Arch Med Res 37:655-62. 2006
..The aim of this study was to identify the risk factor profiles, subtypes and recurrence of non-cardioembolic ischemic stroke for the two largest subpopulations, the Arab and South Asians, at the only stroke-admitting hospital in Qatar...
- Effects of caffeine on levodopa pharmacokinetics and pharmacodynamics in Parkinson disease
D Deleu
Department of Neurology Medicine, Sultan Qaboos University Hospital, Sultanate of Oman
Neurology 67:897-9. 2006
..Caffeine administered before levodopa may improve its pharmacokinetics in some parkinsonian patients...
- Neurogenic stunned myocardium following hemorrhagic cerebral contusion
Dirk Deleu
Department of Neurology, Hamad Medical Corporation, PO Box 3050, Doha, State of Qatar
Saudi Med J 28:283-5. 2007
..This case supports the presumed unifying role of the increased intracranial pressure, probably triggering a vigorous sympathetic outflow hyperactivity leading to NSM...
- Will new injection devices for interferon beta-1a s.c. Affect treatment adherence in patients with multiple sclerosis? An expert opinion in the Middle East
Dirk Deleu
Hamad Medical Corporation, Department of Neurology Medicine, Hamad Medical Corporation, Doha, Qatar
Int J Neurosci 121:171-5. 2011
..The group also considered the possible effects of these changes in drug delivery technology on patient adherence to IFN beta-1a s.c...
- Neurogenic stunned myocardium following hemorrhagic cerebral contusion
Dirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, PO Box 3050, Doha, State of Qatar Tel 974 4392773 Fax 974 4391826 E mail
Neurosciences (Riyadh) 12:65-7. 2007
..This case supports the presumed unifying role of the increased intracranial pressure, probably triggering a vigorous sympathetic outflow hyperactivity leading to NSM...
- Vertical one-and-a-half syndrome with contralesional pseudo-abducens palsy in a patient with thalamomesencephalic stroke
Dirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, P O Box 3050, Doha, Qatar
J Neurol Sci 312:180-3. 2012
..We discuss the clinical topography of both neuroophthalmological findings. This unusual neuroophthalmological finding has not been reported...
- Hemifacial spasm resulting from vertebral artery dolichoectasia
Dirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, Doha, State of Qatar
Saudi Med J 26:1640-2. 2005
..This case demonstrates that MRI/MRA is an essential part of the work-up for hemifacial spasm, and shows that in accordance with the literature, vertebral dolichoectasia is an uncommon cause of hemifacial spasm...
- "Man-in-the-barrel" syndrome as delayed manifestation of extrapontine and central pontine myelinolysis: beneficial effect of intravenous immunoglobulin
Dirk Deleu
Department of Medicine Neurology, Hamad Medical Corporation, P O Box 3050, Doha, State of Qatar
J Neurol Sci 237:103-6. 2005
..This case, reported for its peculiar mode of development, unusual presentation and challenging therapeutic response to intravenous immunoglobulin, highlights the enigmatic and unpredictable aspects of osmotic myelinolysis...
- Levetiracetam in the treatment of idiopathic hemifacial spasm
Dirk Deleu
Department of Neurology (Medicine, Hamad Medical Corporation, Doha, State of Qatar
Neurology 62:2134-5. 2004
- Subtherapeutic free phenytoin levels following fosphenytoin therapy in status epilepticus
Roshan Koul
Department of Child Health, College of Medicine, Sultan Qaboos University, Muscat, Sultanate of Oman
Neurology 58:147-8. 2002
- Ischaemic posterior circulation stroke in State of Qatar
N Akhtar
Division of Neurology Medicine, Hamad Medical Corporation, Doha, State of Qatar
Eur J Neurol 16:1004-9. 2009
..No significant studies or registries have reported on the characteristics and outcomes of PCS in our region...
- [Crossed pattern of sensory loss with left thoracic level in a right dorsolateral medullary infarction]
F Ruiz-Miyares
Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
Rev Neurol 47:361-2. 2008
..Crossed pattern of sensory loss with a sensory level is a quite unusual presentation of lateral medullary infarctions and expresses the involvement of the most external aspect of the spinothalamic tract...
- Population pharmacokinetics of free carbamazepine in adult Omani epileptic patients
D Deleu
Department of Clinical Pharmacology, Sultan Qaboos University Hospital, College of Medicine, Muscat, Sultanate of Oman
Eur J Clin Pharmacol 57:243-8. 2001
..The aim of this study was to define the pharmacokinetic profile of free carbamazepine (F-CBZ) in adult Omani epileptic patients in order to improve on dosing schedules through population pharmacokinetic analysis using the NONMEM program...
- Acute visual dysfunction following phenytoin-induced toxicity
Archana Thakral
Department of Ophthalmology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman
Acta Neurol Belg 103:218-20. 2003
..CONCLUSION: Phenytoin toxicity may result in acute visual dysfunction a previously unreported phenomenon...
- [Hemiparetic ataxia secondary to a lenticulo-capsular infarction with favorable outcome: report of one case]
Dirk Deleu
Departamento de Neurologia, Hamad Medical Corporation, Doha, State of Qatar
Rev Med Chil 138:217-9. 2010
..The magnetic resonance imaging showed a sub acute infarction of the left lenticular nucleus and infernal capsule. The patient was treated with physiotherapy, anti platelet agents and statins and was discharged with an evident recovery...
- Short-term efficacy and safety of valproate sustained-release formulation in newly diagnosed partial epilepsy VIPe-study. A multicenter observational open-label study
Dirk Deleu
Department of Neurology Medicine Hamad Medical Corporation, PO Box 3050, Doha, State of Qatar
Saudi Med J 28:1402-7. 2007
..To evaluate the efficacy and safety of valproate (VPA) sustained-released in monotherapy across all ages in newly-diagnosed epileptic patients with partial seizures (PS) with or without secondary generalization...
- Salivary free concentrations of anti-epileptic drugs: an evaluation in a routine clinical setting
Dirk Deleu
Department of Clinical Pharmacology and Therapeutics, Sultan Qaboos University Hospital, P.O. Box 35, Al-Khod, Muscat-123, Sultanate of Oman
Acta Neurol Belg 103:19-23. 2003
..48 +/- 0.27. CONCLUSION: Monitoring of free salivary concentrations of anti-epileptic drugs, particularly phenytoin and carbamazepine proved to be a realistic alternative in this routine clinical setting...
- Efficacy and tolerability of antiepileptic drugs in an Omani epileptic population
Yolande Hanssens
Department of Pharmacy Clinical Pharmacy Services, Hamad Medical Corporation, PO Box 3050, Doha, Qatar
Clin Neurol Neurosurg 108:532-8. 2006
..The aim of this hospital-based study is to get an insight into the efficacy and tolerability of antiepileptic drugs (AED) in Omani epileptic patients...
- Antibiotic prescribing pattern in a medical intensive care unit in Qatar
Yolande Hanssens
Pharmacy Department, Hamad Medical Corporation, PO Box 3050, Doha State of Qatar
Saudi Med J 26:1269-76. 2005
..A secondary objective was to evaluate the influence of the use of steroid therapy on the development of fungal infections...
- Long-term 24-hour duodenal infusion of levodopa: outcome and dose requirements
Dirk Deleu
Neurology 66:1611-2; author reply 1611-2. 2006
- Subcutaneous apomorphine : an evidence-based review of its use in Parkinson's disease
Dirk Deleu
Department of Neurology Medicine, Hamad Medical Corporation, Doha, State of Qatar
Drugs Aging 21:687-709. 2004
..Continuous subcutaneous apomorphine infusions should be evaluated before more invasive measures or neurosurgical interventions are contemplated...
- Annual direct medical cost and contributing factors to total cost of epilepsy in Oman
Ibrahim Al-Zakwani
Department of Pharmacy, Sultan Qaboos University Hospital, Muscat, Oman
Seizure 12:555-60. 2003
....
- Estimation of population pharmacokinetic parameters of free-phenytoin in adult epileptic patients
Dirk Deleu
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK
Arch Med Res 36:49-53. 2005
..3 mg/L, respectively. The model was prospectively evaluated in a small group (seven) of additional patients. CONCLUSIONS: The recommended daily dose in this population to achieve a F-PHT concentration of 1.5 mg/L is 6.1 mg/kg...
- Eletriptan vs sumatriptan: a double-blind, placebo-controlled, multiple migraine attack study
Dirk Deleu
Neurology 60:1221-2; author reply 1221-2. 2003
- An evidence-based review of dopamine receptor agonists in the treatment of Parkinson's disease
Dirk Deleu
College of Medicine, Sultan Qaboos University Hospital, Sultanate of Oman
Saudi Med J 23:1165-75. 2002
..In addition, their clinical pharmacokinetics, adverse effect profiles and most relevant interactions will be summarized...
- Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease
Dirk Deleu
College of Medicine, Sultan Qaboos University, PO Box 35, Al Khod, Sultanate of Oman
Clin Pharmacokinet 41:261-309. 2002
..Particularly in the advanced stage of the disease, treatment should be individually tailored...
