A randomized, controlled trial of initial anti-retroviral therapy with abacavir/lamivudine/zidovudine twice-daily compared to atazanavir once-daily with lamivudine/zidovudine twice-daily in HIV-infected patients over 48 weeks (ESS100327, the ACTION Study)Princy N Kumar
Georgetown University Medical Center, Washington, DC, USA
AIDS Res Ther 6:3. 2009
..Both regimens offer benefits in select therapy-naïve subjects. TRIAL REGISTRATION: [Clinical Trials Identifier, NCT00082394]...
Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adultsEdwin DeJesus
Orlando Immunology Center, Orlando, FL, USA
Antivir Ther 15:711-20. 2010
..A pharmacokinetic trial was conducted to evaluate the potential for once-daily etravirine in antiretroviral regimens without and with darunavir/ritonavir...
Use of Dronabinol Improves Appetite and Reverses Weight Loss in HIV/AIDS-Infected PatientsEdwin DeJesus
Orlando Immunology Center, Orlando, Florida
J Int Assoc Physicians AIDS Care (Chic) 6:95-100. 2007
..Objective: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS...
Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patientsEdwin DeJesus
Orlando Immunology Center, Orlando, FL 32803, USA
J Acquir Immune Defic Syndr 51:163-74. 2009
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Safety and efficacy of enfuvirtide in combination with darunavir-ritonavir and an optimized background regimen in treatment-experienced human immunodeficiency virus-infected patients: the below the level of quantification studyEdwin DeJesus
Orlando Immunology Center, 1701 N Mills Avenue, Orlando, FL 32803, USA
Antimicrob Agents Chemother 52:4315-9. 2008
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A randomised comparison of safety and efficacy of nevirapine vs. atazanavir/ritonavir combined with tenofovir/emtricitabine in treatment-naïve patientsE Dejesus
Orlando Immunology Center, Orlando, FL, USA Anthony Mills MD Inc, Los Angeles, CA, USA AIDS Healthcare Foundation, Los Angeles, CA, USA Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USA
Int J Clin Pract 65:1240-9. 2011
..Rates of AEs were similar between the two arms, whereas HDL-C increased and TC:HDL-C decreased significantly more in patients taking NVP than ATV/r...
Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48Roberto Ortiz
Orlando Immunology Center, Orlando, Florida, USA
AIDS 22:1389-97. 2008
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Impact of switching virologically suppressed, HIV-1-infected patients from twice-daily fixed-dose zidovudine/lamivudine to once-daily fixed-dose tenofovir disoproxil fumarate/emtricitabineEdwin DeJesus
Orlando Immunology Center, Orlando, Florida 32803, USA
HIV Clin Trials 9:103-14. 2008
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Interaction between fosamprenavir, with and without ritonavir, and nevirapine in human immunodeficiency virus-infected subjectsEdwin DeJesus
Orlando Immunology Center, Florida, USA
Antimicrob Agents Chemother 50:3157-9. 2006
..A regimen of 700 mg of FPV BID plus 100 mg of RTV BID may be coadministered with NVP without dose adjustment...
Once-daily versus twice-daily lamivudine, in combination with zidovudine and efavirenz, for the treatment of antiretroviral-naive adults with HIV infection: a randomized equivalence trialEdwin DeJesus
IDC Research Initiative, Altamonte Springs, FL, USA
Clin Infect Dis 39:411-8. 2004
..Median increase above baseline in CD4(+) cell count was similar (q.d. group, +144 cells/mm(3); b.i.d. group, +146 cells/mm(3)), and the incidences of adverse events, disease progression, and HIV-associated conditions were comparable...
Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patientsEdwin DeJesus
Orlando Immunology Center, Orlando, FL, USA
J Acquir Immune Defic Syndr 43:1-5. 2006
..CONCLUSIONS: GS-9137 demonstrated substantial short-term antiviral activity and was well tolerated as monotherapy, thus warranting further study...