Introduction of mycophenolate mofetil and cyclosporin reduction in children with chronic transplant nephropathyE David-Neto
Renal Transplantation Unit, Hospital das Clinicas, University of Sao Paulo School of Medicine, 01250 040 São Paulo, Brazil
Pediatr Transplant 5:302-9. 2001
..These findings suggest that MMF is sufficiently powerful to allow a decrease/withdrawal of CsA without the burden of acute rejection in a pediatric population with CTN...
- C4d-positive chronic rejection: a frequent entity with a poor outcome
Elias David-Neto
Renal Transplantation Unit, Division of Urology and Nephrology, Hospital das Clinicas, University of Sao Paulo, Brazil
Transplantation 84:1391-8. 2007
..Some studies have suggested the role of antibodies mediating chronic graft dysfunction. In this context, C4d identification is an important tool to evaluate antibody-mediated rejection...
- The dynamics of glucose metabolism under calcineurin inhibitors in the first year after renal transplantation in nonobese patients
Elias David-Neto
Renal Transplantation Unit, Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Transplantation 84:50-5. 2007
..A lack of information also exists regarding the profile of glucose metabolism during the first year after transplant...
- C4d staining in post-reperfusion renal biopsy is not useful for the early detection of antibody-mediated rejection when CDC crossmatching is negative
Elias David-Neto
Renal Transplantation Service of the Urology Division, School of Medicine, Sao Paulo University, Brazil
Nephrol Dial Transplant 26:1388-92. 2011
..We hypothesized that C4d staining in 1-h post-reperfusion biopsies (1-h Bx) could detect early complement activation in the renal allograft due to preformed donor-specific antibodies...
- The need of mycophenolic acid monitoring in long-term renal transplants
Elias David-Neto
Renal Transplant Unit, Divisions of Urology and Nephrology, Hospital das Clinicas, University of Sao Paulo, School of Medicine, Sao Paulo, Brazil
Clin Transplant 19:19-25. 2005
..There is little information regarding the 12-h mycophenolic acid (MPA) pharmacokinetics (PK), a way to monitor the drug and the need of frequent monitoring, in stable patients...
- Bioequivalence of a new cyclosporine a formulation to Neoral
Elias David-Neto
Unidade de Transplante Renal, Divisão de Clínica Urológica das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Ther Drug Monit 26:53-7. 2004
..mL/h) were within the Neoral bioequivalence interval for the same parameters (+/-204 ng/mL and +/-794 ng x mL/h, respectively). These data demonstrate that the ZinografME CsA formulation is bioequivalent to Neoral...
- Sampling strategy to calculate the cyclosporin-A area under the time-concentration curve
Elias David-Neto
Renal Transplantation Unit, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Brazil
Am J Transplant 2:546-50. 2002
..81). Our data shows that C2 can be safely used to estimate AUC0-4. The C2 equation simplifies CyA monitoring because of its high-predictive value and clinical feasibility...
- Mycophenolic acid pharmacokinetics in stable pediatric renal transplantation
Elias David-Neto
Renal Transplant Unit, Division of Urology and Nephrology, Hospital das Clinicas da Faculdade de Medicina, University of Sao Paulo, Sao Paulo, Brazil
Pediatr Nephrol 18:266-72. 2003
..75) where AUC(0-12)=12.62+(7.78 x C(0))+(0.90 x C(1))+(1.30 x C(2)) (P<0.001). The use of MMF without monitoring MPA blood levels may cause unnecessary overexposure to the drug in stable pediatric recipients...
- A strategy to calculate cyclosporin A area under the time-concentration curve in pediatric renal transplantation
Elias David-Neto
Renal Transplantation Unit and Division of Central Laboratory, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
Pediatr Transplant 6:313-8. 2002
..However, for values above 4,000 ng/h/mL, the formula overestimates the trapezoidal AUC0-4. The C2 equation simplifies the CsA monitoring as a result of its high predictive value and clinical feasibility...
- Dengue in renal transplant patients: a retrospective analysis
Luiz S Azevedo
Hospital das Clinicas, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Transplantation 84:792-4. 2007
..The first episode of dengue in transplanted patients resembled a flu-like syndrome, as in the general population. It did not cause long-term damage to either the patient or the graft...
- Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
Luiz Sergio Azevedo
Renal Transplantation Unit, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil
Rev Inst Med Trop Sao Paulo 47:143-5. 2005
..MMF may have an effective protective role against PCP as no patient under MMF, despite not receiving TMS coverage, developed PCP. A larger, controlled, trial is warranted to consolidate this information...
- Comparison of renal transplantation outcomes in children with and without bladder dysfunction. A customized approach equals the difference
William C Nahas
Department of Urology, University of Sao Paulo Medical School, Sao Paulo, Brazil
J Urol 179:712-6. 2008
..We examined the development of urological abnormalities in a group of pediatric renal transplant recipients...
- Validation of plasma clearance of 51Cr-EDTA in adult renal transplant recipients: comparison with inulin renal clearance
Flávia Silva Reis Medeiros
Division of Nephrology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
Transpl Int 22:323-31. 2009
..8 and 2.7 ml/min, respectively. Two plasma sampling for (51)Cr-EDTA-Cl was a reliable method to measure GFR compared with In-Cl and comprises a suitable method to be used in kidney transplanted patients...
- Strategies to treat children with end-stage renal dysfunction and severe lower urinary tract anomalies for receiving a kidney transplant
Wlliam C Nahas
Division of Urology, Renal Transplant Unit, University of Sao Paulo, Sao Paulo, Brazil
Pediatr Transplant 13:524-35. 2009
..Patients with severe lower urinary tract abnormalities and ESRD may receive a kidney transplant with comparable success...
