Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?Undurti N Das
Department of Molecular and Clinical Medicine, CARE Hospital, The Institute of Medical Sciences, Banjara Hills, Hyderabad 500 034, India UND Life Sciences, Shaker Heights, OH 44120, USA
J Nutr Biochem 18:701-13. 2007
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- Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies
Undurti N Das
UND Life Sciences, Shaker Heights, OH 42100, USA
Med Sci Monit 13:RA119-31. 2007
..The low neurotoxicity of GLA to normal brain neurons and selective activity against tumor cells suggests that it could be an effective anti-glioma molecule...
- Radiation resistance, invasiveness and metastasis are inflammatory events that could be suppressed by lipoxin A4
Undurti N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 86:3-11. 2012
..Thus, methods designed to enhance endogenous lipoxin A(4) formation or its synthetic analogs may be useful in the management of cancer...
- MicroRNA profile of polyunsaturated fatty acid treated glioma cells reveal apoptosis-specific expression changes
Nóra Faragó
Functional Genomics Laboratory, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary
Lipids Health Dis 10:173. 2011
..Polyunsaturated fatty acids (PUFAs) such as ?-linolenic acid (GLA), arachidonic acid (AA) and docosahexaenoic acid (DHA) have cytotoxic action on glioma cells...
- Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction
Xiaofeng Lu
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310029, P R China
Lipids Health Dis 9:106. 2010
..The relative resistance of LOVO cells to the cytotoxic action of LA is due to a reduction in the activation of caspase-3. Thus, LA induced cancer cell apoptosis by enhancing cellular oxidant status and inducing mitochondrial dysfunction...
- Effect of ?-3 and ?-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model
Andrea Comba
Instituto de Biologia Celular, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina
Lipids Health Dis 9:112. 2010
..We studied the effect of two diets enriched in 6% Walnut and Peanut oils that are rich in ?-3 and ?9 PUFAs respectively on a murine mammary gland adenocarcinoma as compared with the control (C) that received commercial diet...
- Insulin and the critically ill
Undurti N Das
Crit Care 6:262-3. 2002
- Perinatal supplementation of long-chain polyunsaturated fatty acids, immune response and adult diseases
Undurti N Das
UND Life Sciences, Walpole, MA 02081, USA
Med Sci Monit 10:HY19-25. 2004
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- A perinatal strategy to prevent coronary heart disease
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 19:1022-7. 2003
..Based on this evidence, I suggest that provision of LCPUFAs during critical periods of growth, especially from the second trimester of pregnancy to age 5 y, prevents CHD in adult life...
- Essential Fatty acids - a review
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA
Curr Pharm Biotechnol 7:467-82. 2006
..Thus, EFAs and their derivatives have significant clinical implications...
- Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its derivatives
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Curr Pharm Biotechnol 7:457-66. 2006
..Since GLA is an endogenous naturally occurring molecule and has no significant side effects, it calls for more studies to exploit its potential as a novel anti-cancer drug...
- Essential fatty acids: biochemistry, physiology and pathology
Undurti N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
Biotechnol J 1:420-39. 2006
..Thus, EFAs and their derivatives have varied biological actions and seem to be involved in several physiological and pathological processes...
- Is pyruvate an endogenous anti-inflammatory molecule?
Undurti N Das
UND Life Sciences, Shaker Heights, Ohio, USA
Nutrition 22:965-72. 2006
..Similar beneficial actions have been seen in endotoxemia. These and other studies suggest that ethyl pyruvate could be of significant benefit in the treatment of patients who are critically ill and have sepsis/septic shock...
- Effect of gamma-linolenic acid and prostaglandins E1 on gamma-radiation and chemical-induced genetic damage to the bone marrow cells of mice
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 74:165-73. 2006
..PGE1 and its precursor GLA prevented gamma-radiation, DPH, BP, and 4-alpha-phorbol-induced genetic damage...
- COX-2 inhibitors and metabolism of essential fatty acids
Undurti N Das
UND Life Sciences, Cleveland Heights, OH 44106, USA
Med Sci Monit 11:RA233-7. 2005
..EPA, DHA, and AA augment eNO formation that has anti-atherosclerotic action. Hence, combining EFAs with COX-2 inhibitors will prevent thrombotic cardiovascular events...
- Pathophysiology of metabolic syndrome X and its links to the perinatal period
Undurti N Das
UND Life Sciences, Walpole, Massachusetts, USA
Nutrition 21:762-73. 2005
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- Occlusion of infusion vessels on gamma-linolenic acid infusion
Undurti N Das
EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 70:23-32. 2004
..A significant reduction in the size of the tumor was also observed in these patients. LGIOC showed occlusion of tumor-feeding vessels after infusion, and further studies are needed to confirm these preliminary results...
- Anti-inflammatory nature of exercise
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts, USA
Nutrition 20:323-6. 2004
- A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome
Undurti N Das
UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
Prostaglandins Leukot Essent Fatty Acids 72:343-50. 2005
..Thus, calorie restriction or reduced food intake has a role not only in the pathobiology of insulin resistance, but also in other associated conditions such as obesity, type II diabetes mellitus, ageing, and longevity...
- Essential fatty acids in Huntington's disease
Undurti N Das
UND Life Sciences, Walpole, Massachusetts 02081, USA
Nutrition 20:942-7. 2004
..In view of the encouraging results with essential fatty acids in Huntington's disease, it is proposed that their possible use in other neurodegenerative conditions need to be explored...
- From bench to the clinic: gamma-linolenic acid therapy of human gliomas
Undurti N Das
UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA corrected
Prostaglandins Leukot Essent Fatty Acids 70:539-52. 2004
..In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors...
- Do polyunsaturated fatty acids behave like an endogenous "polypill"?
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Med Hypotheses 70:430-4. 2008
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- Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation
Undurti N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
Med Sci Monit 13:RA214-21. 2007
..This suggests that increased plasma and tissue activities of acetylcholinesterase and butyrylcholinesterase seen in various clinical conditions could serve as a marker of low-grade systemic inflammation...
- Essential fatty acids and their metabolites as modulators of stem cell biology with reference to inflammation, cancer, and metastasis
Undurti N Das
School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
Cancer Metastasis Rev 30:311-24. 2011
..Thus, there appears to be a close interaction among essential fatty acids, their bioactive products, and inflammation and cancer growth and its metastasis...
- Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro
Undurti N Das
Jawaharlal Nehru Technological University, Kakinada 533003, India
Lipids Health Dis 10:159. 2011
..Thus, polyunsaturated fatty acids either by themselves or in combination with chemotherapeutic drugs have the potential as anti-cancer molecules...
- Lipoxins as biomarkers of lupus and other inflammatory conditions
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321 Shaker Heights, OH 44120, USA
Lipids Health Dis 10:76. 2011
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- Can vagus nerve stimulation halt or ameliorate rheumatoid arthritis and lupus?
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 10:19. 2011
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- L-arginine, NO and asymmetrical dimethylarginine in hypertension and type 2 diabetes
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321 Shaker Heights, OH 44120, USA
Front Biosci 16:13-20. 2011
..These and other studies suggest that serum ADMA levels could be used to predict the development of hypertension and type 2 diabetes mellitus in those who are at high-risk to develop these diseases...
- Is insulin resistance a disorder of the brain?
Undurti N Das
Jawaharlal Nehru Technological University, Kakinada 533 003, India
Front Biosci 16:1-12. 2011
..These and other evidence suggest that insulin resistance may very well be a disease of the brain...
- Vagus nerve stimulation as a strategy to prevent and manage metabolic syndrome
Undurti N Das
School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
Med Hypotheses 76:429-33. 2011
..Based on these evidences, it is proposed that vagus nerve stimulation could be of significant benefit in the management of the metabolic syndrome...
- A defect in ?6 and ?5 desaturases may be a factor in the initiation and progression of insulin resistance, the metabolic syndrome and ischemic heart disease in South Asians
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 9:130. 2010
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- Lipoxin A4 may function as an endogenous anti-arrhythmic molecule
Undurti N Das
School of Biotechnology, Jawaharlal Nehru Technological University, Kakinada 533 003, India
Med Hypotheses 76:14-6. 2011
..Based on these evidences, I propose that lipoxins, resolvins and protectins function as endogenous anti-arrhythmic molecules and their stable synthetic analogs could be useful in the management of cardiac arrhythmias...
- Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders
Undurti N Das
Jawaharlal Nehru Technological University, Kakinada 533 003, Andhra Pradesh, India
Lipids Health Dis 8:61. 2009
..Identifying the anti-inflammatory compounds from n-3 fatty acids that suppress low-grade systemic inflammatory conditions and understanding their mechanism(s) of action may lead to newer therapeutic strategies...
- Obesity: genes, brain, gut, and environment
Undurti N Das
UND Life Sciences, Shaker Heights, Ohio, USA
Nutrition 26:459-73. 2010
..Thus, there is a cross-talk among the gut, liver, pancreas, adipose tissue, and hypothalamus. Based on these evidences, it is clear that management of obesity needs a multifactorial approach...
- Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 7:37. 2008
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- Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 7:19. 2008
..Thus, beneficial actions of EPA/DHA and aspirin in CHD could be attributed to the formation of LXs, resolvins, protectins, and nitrolipids and suggest that their plasma levels aid in the prediction and prognosis of CHD...
- Can essential fatty acids reduce the burden of disease(s)?
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 7:9. 2008
..Hence, supplementation of EFAs could reduce burden of these disease(s)...
- Gene expression profile in obesity and type 2 diabetes mellitus
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Lipids Health Dis 6:35. 2007
..These results suggest that genes concerned with carbohydrate, lipid and amino acid metabolic pathways, neuronal function and inflammation play a significant role in the pathobiology of obesity and type 2 diabetes...
- Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why?
Undurti N Das
UND Life Sciences, 13800 Fairhill Road 321, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 78:11-9. 2008
..These results suggest that a combination of EPA, DHA, AA and folic acid could be of significant benefit in dementia, depression, and Alzheimer's disease and improve cognitive function...
- Long-chain polyunsaturated fatty acids in memory formation and consolidation: further evidence and discussion
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 19:988-93. 2003
- Essential fatty acids, lipid peroxidation and apoptosis
U N Das
EFA Sciences, Inc, Techlead, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 61:157-63. 1999
..Thus, these long-chain fatty acids may, infact act at the level of gene/oncogene expression in producing their cytotoxic action on tumour cells...
- Nitric oxide as the mediator of the antiosteoporotic actions of estrogen, statins, and essential fatty acids
Undurti N Das
EFA Sciences, Norwood, Massachusetts 02062, USA
Exp Biol Med (Maywood) 227:88-93. 2002
..If so, it will be interesting to study whether nitric oxide donors and/or nitric oxide precursors can be given together with estrogen, statins, or essential fatty acids to potentiate their benefit in osteoporosis...
- Estrogen, statins, and polyunsaturated fatty acids: similarities in their actions and benefits-is there a common link?
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 18:178-88. 2002
..To investigate whether there is any common link between estrogen, statins, and polyunsaturated fatty acids (PUFAs), which have similar actions and benefits...
- Nutritional deficiencies and the prevalence of syndrome X in South Asians
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 18:282. 2002
- Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent diabetes mellitus?
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Eur J Clin Nutr 57:218-26. 2003
..Based on this, it is proposed that provision of adequate amounts of long chain polyunsaturated fatty acids during the critical periods of brain growth and development can prevent or postpone the development diabetes mellitus...
- A radical approach to cancer
Undurti Das
EFA Sciences LLC, Norwood, MA 02062, USA
Med Sci Monit 8:RA79-92. 2002
..Thus, PUFAs, thalidomide and 2-methoxyoestradiol or their derivatives may offer a new radical approach to the treatment of cancer...
- Is type 2 diabetes mellitus a disorder of the brain?
Undurti N Das
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
Nutrition 18:667-72. 2002
..Hence, supplementation of adequate amounts of long-chain polyunsaturated fatty acids during the third trimester of pregnancy to 2 y postterm can prevent or postpone the development of diabetes mellitus...
- The lipids that matter from infant nutrition to insulin resistance
U N Das
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 67:1-12. 2002
..Hence, promoting prolonged breast feeding and/or supplementing LCPUFAs during the critical stages of development may be beneficial in preventing insulin resistance...
- Abrupt and complete occlusion of tumor-feeding vessels by gamma-linolenic acid
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts, USA
Nutrition 18:767-9. 2002
..For legal reasons this article has been removed by the publisher..
- Long-chain polyunsaturated fatty acids in the growth and development of the brain and memory
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 19:62-5. 2003
- Is insulin an endogenous cardioprotector?
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts, USA
Crit Care 6:389-93. 2002
..Adequate attention should be given to maintaining euglycemia (plasma glucose <or= 110 mg/dl) in order to reduce infarct size and improve cardiac function while using a glucose-insulin-potassium cocktail...
- Essential fatty acids as possible enhancers of the beneficial actions of probiotics
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 18:786. 2002
..It is likely that breast-feeding and probiotics are two naturally occurring, appropriate events in early human life that have significant health benefits...
- Is obesity an inflammatory condition?
U N Das
EFA Sciences LLC, Norwood, Massachusets 02062, USA
Nutrition 17:953-66. 2001
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- Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent hypertension in adult life?
U N Das
EFA Sciences LLC, Norwood, MA 02062, USA
Hypertension 38:E6-8. 2001
..It is suggested that adequate provision of long-chain polyunsaturated fatty acids during the critical periods of brain growth prevents the development of hypertension in later life...
- Insulin: an endogenous cardioprotector
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Curr Opin Crit Care 9:375-83. 2003
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- Current advances in sepsis and septic shock with particular emphasis on the role of insulin
Undurti N Das
EFA Sciences LLC, Norwood, MA 02062, USA
Med Sci Monit 9:RA181-92. 2003
..Hence, their combined use may be of significant benefit in sepsis and septic shock...
- Folic acid says NO to vascular diseases
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts, USA
Nutrition 19:686-92. 2003
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- Critical advances in septicemia and septic shock
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Crit Care 4:290-6. 2000
..This suggests that it may be possible to predict the development of septicemia and septic shock in a given individual and take appropriate action both to prevent and treat them adequately...
- Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?
U N Das
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 63:351-62. 2000
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- Nutritional factors in the pathobiology of human essential hypertension
U N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 17:337-46. 2001
..Therefore, alterations in the metabolism of essential fatty acids might be a predisposing factor to the development of essential hypertension and insulin resistance...
- Is insulin an antiinflammatory molecule?
U N Das
From EFA Sciences LLC, Norwood, Massachusetts, USA
Nutrition 17:409-13. 2001
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- Can glucose-insulin-potassium regimen suppress inflammatory bowel disease?
U N Das
EFA Sciences LLC, Suite 266, 1420 Providence Highway, Norwood, MA 02062, USA
Med Hypotheses 57:183-5. 2001
..This suggests that insulin can behave as an anti-inflammatory molecule. In view of this, it is suggested that insulin in combination with glucose and potassium may be of benefit in the management of inflammatory bowel disease...
- Can memory be improved? A discussion on the role of ras, GABA, acetylcholine, NO, insulin, TNF-alpha, and long-chain polyunsaturated fatty acids in memory formation and consolidation
Undurti N Das
EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
Brain Dev 25:251-61. 2003
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- Essential fatty acids as possible mediators of the actions of statins
U N Das
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 65:37-40. 2001
..In view of the similarity in their actions and as statins influence essential fatty acid metabolism, it is suggested that essential fatty acids and their metabolites may serve as second messengers of the actions of statins...
- Hypothesis: can glucose-insulin-potassium regimen in combination with polyunsaturated fatty acids suppress lupus and other inflammatory conditions?
U N Das
EFA Sciences LLC, 1420 Providence Highway, Suite 266, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 65:109-13. 2001
..Hence, it is suggested that a combination of insulin (in the form of glucose-insulin-potassium) and PUFAs may be of benefit in lupus and other inflammatory conditions...
- Is metabolic syndrome X an inflammatory condition?
Undurti N Das
EFA Sciences LLC, Norwood, MA 02062, USA
Exp Biol Med (Maywood) 227:989-97. 2002
..It is suggested that metabolic syndrome X is a low-grade systemic inflammatory condition...
- A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis
Undurti N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 76:251-68. 2007
..In view of this, it is suggested that Delta6 and Delta5 desaturases could serve as biological target(s) for the discovery and development of pharmaceuticals to treat atherosclerosis...
- Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule
Undurti N Das
UND Life Sciences, Shaker Heights, OH, USA
Med Sci Monit 12:RA79-84. 2006
..This may have relevance to the use of glucose-insulin-potassium regimen in these clinical conditions, sepsis, and cancer...
- Can perinatal supplementation of long-chain polyunsaturated fatty acids prevents schizophrenia in adult life?
Undurti N Das
UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
Med Sci Monit 10:HY33-7. 2004
..If this hypothesis is true, it implies that perinatal supplementation of appropriate amounts of LCPUFAs in the right combination is helpful in the prevention of schizophrenia in adult life...
- Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease
Allam A Rao
Department of Computer Sciences and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
Med Hypotheses 69:1272-6. 2007
..In view of this, we propose that butyrylcholinesterase and acetylcholinesterase will not only serve as therapeutic targets but also may serve as markers to predict the development of type 2 diabetes mellitus and Alzheimer's disease...
- Pathobiology of metabolic syndrome X in obese and non-obese South Asian Indians: further discussion and some suggestions
Undurti N Das
Nutrition 19:560-2. 2003
- Metabolic syndrome X: an inflammatory condition?
Undurti N Das
Reflexis Systems, Inc, 1420 Providence Highway, Suite #266, Norwood, MA 02062, USA
Curr Hypertens Rep 6:66-73. 2004
..Hence, instituting anti-inflammatory measures might be beneficial in preventing or halting the progress of metabolic syndrome X in high-risk populations...
- Prevention of chemically induced diabetes mellitus in experimental animals by polyunsaturated fatty acids
I Krishna Mohan
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Nutrition 17:126-51. 2001
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- Nutrition, physical activity, and obesity
Undurti N Das
Lancet 360:1249-50. 2002
- Insulin in the critically ill with focus on cytokines, reactive oxygen species, HLA-DR expression
Undurti N Das
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
J Assoc Physicians India 55:56-65. 2007
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- Differential effect of saturated, monounsaturated, and polyunsaturated fatty acids on alloxan-induced diabetes mellitus
Y Suresh
UND Life Sciences, 13800 Fairhill Road, 321, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 74:199-213. 2006
..Furthermore, AA restored the anti-oxidant status to normal range in various tissues. These results suggest that AA protects pancreatic beta cells against alloxan-induced diabetes in experimental animals by attenuating oxidant stress...
- Insulin and inflammation: further evidence and discussion
Undurti N Das
Nutrition 18:526-7. 2002
- Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study
Christina Chrysohoou
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece
J Am Coll Cardiol 44:152-8. 2004
..This may partly explain the beneficial actions of this diet on the cardiovascular system...
- Is angiotensin-II an endogenous pro-inflammatory molecule?
Undurti N Das
UND Life Sciences, Walpole, MA 02081, USA
Med Sci Monit 11:RA155-162. 2005
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- Metabolic alterations during inflammation and its modulation by central actions of omega-3 fatty acids
Undurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Curr Opin Clin Nutr Metab Care 6:413-9. 2003
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- Glucose, insulin, and acute myocardial infarction
Undurti N Das
Eur Heart J 27:2141-2; author reply 2142-3. 2006
- Diet, exercise, and C-reactive protein levels in people with abdominal obesity: the ATTICA epidemiological study
Christos Pitsavos
Unit of Preventive Cardiology Epidemiology, First Cardiology Clinic, School of Medicine, University of Athens, Greece
Angiology 58:225-33. 2007
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- Exercise and inflammation
Undurti N Das
Eur Heart J 27:1385; author reply 1385-6. 2006
- Bioinformatics analysis of functional protein sequences reveals a role for brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus
Allam Appa Rao
Department of Computer Science and Systems Engineering, Andhra University, Visakhapatnam 530 003, India
Med Hypotheses 70:424-9. 2008
..Hence, methods developed to selectively deliver BDNF to appropriate hypothalamic neurons may form a novel approach in their treatment...
- Angiotensin-II behaves as an endogenous pro-inflammatory molecule
U N Das
UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
J Assoc Physicians India 53:472-6. 2005
..Furthermore, structural analogues of ACE inhibitors and angiotensin-II receptor blockers could be developed that possess anti-inflammatory actions without significant action on the cardiovascular system...
- Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension
U N Das
EFA Sciences LLC, Norwood, MA 02062, USA
Eur J Clin Nutr 58:195-203. 2004
..Hence, it is proposed that availability of adequate amounts of LCPUFAs during the critical periods of growth prevents the development of hypertension in adulthood...
- Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period
U N Das
UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA
J Assoc Physicians India 54:133-42. 2006
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- Insulin in sepsis and septic shock
Undurti N Das
Department of Nutrition and Surgery, SUNY Upstate Medical University Syracause, NY, USA
J Assoc Physicians India 51:695-700. 2003
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- Breast-feeding, atopy, and asthma
Undurti N Das
J Allergy Clin Immunol 113:1002; author reply 1002-3. 2004
- Can perinatal supplementation of long-chain polyunsaturated fatty acids prevent atopy, bronchial asthma and other inflammatory conditions?
Undurti N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
Med Sci Monit 12:RA99-111. 2006
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- Metabolic syndrome X is common in South Asians, but why and how?
Undurti N Das
Nutrition 18:774-6. 2002
- Re: Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene
Undurti N Das
J Natl Cancer Inst 98:718; author reply 718-20. 2006
- Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study
Antonis Zampelas
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece
J Am Coll Cardiol 46:120-4. 2005
..CONCLUSIONS: Fish consumption was independently associated with lower inflammatory markers levels, among healthy adults. The strength and consistency of this finding has implications for public health and should be explored further...
- Breastfeeding prevents type 2 diabetes mellitus: but, how and why?
Undurti N Das
Am J Clin Nutr 85:1436-7. 2007
- Oxidant stress in pre-eclampsia and essential hypertension
C A Kumar
EFA Sciences LLC, 1420 Providence Highway, Suit # 266, Norwood, MA 02062, USA
J Assoc Physicians India 50:1372-5. 2002
..CONCLUSION: These results suggest that oxidants and anti-oxidants are altered in human essential hypertension and pre-eclampsia...
- Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders
U N Das
EFA Sciences LLC, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 65:197-203. 2001
..This suggests that the beneficial actions of corticosteroids and EPA/DHA in glomerular disorders can be attributed to their action on the pro-oxidant and anti-oxidant concentrations and metabolism of essential fatty acids...
- Oxidant stress, anti-oxidants and essential fatty acids in South Indian vegetarians and non-vegetarians
V Manjari
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA
Prostaglandins Leukot Essent Fatty Acids 64:53-9. 2001
..It remains to be seen whether this alterations in the oxidant and anti-oxidant status and n-3 concentrations explains the lower incidence of cardiovascular diseases and lower blood pressure in vegetarians...
- Biological significance of essential fatty acids
U N Das
UND Life Sciences, Shaker Heights, OH 44120, USA
J Assoc Physicians India 54:309-19. 2006
..Thus, EFAs and their derivatives have varied biological actions that may have relevance to their involvement in several physiological and pathological processes...
- Metabolic syndrome X is common in Indians: but, why and how?
U N Das
EFA Sciences LLC, 1420 Providence Highway, Suite # 266, Norwood, MA 02062, USA
J Assoc Physicians India 51:987-98. 2003
..This implies that perinatal to adult life supplementation of long-chain polyunsaturated fatty acids could prevent, arrest or postpone the development of metabolic syndrome X and its complications...
- Effect of prostaglandins against alloxan-induced diabetes mellitus
M M Sailaja Devi
UND Life Sciences, Shaker Heights, OH 44120, USA
Prostaglandins Leukot Essent Fatty Acids 74:39-60. 2006
..These results suggest that PGE(1), PGE(2), PGF(1)(alpha), and PGF(3)(alpha) can abrogate chemically induced diabetes mellitus in experimental animals and attenuate the oxidant stress that occurs in diabetes mellitus...
- Can COX-2 inhibitor-induced increase in cardiovascular disease risk be modified by essential fatty acids?
U N Das
UND Life Sciences, 205, 2477 Overlook Road, Cleveland Heights, OH 44106, USA
J Assoc Physicians India 53:623-7. 2005
..This suggests that COX-2 inhibitors increase cardiovascular and stroke risk by interfering with the formation of eNO, PGI2, LXs, and resolvins and implies that combining EFAs with COX-2 inhibitors could prevent these complications...
