Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flowSilvio Danese
Division of Gastroenterology, Laboratory of Inflammation and Immunology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Curr Opin Gastroenterol 23:384-9. 2007
..Inflammatory bowel disease pathogenesis involves the interplay of multiple biological factors, among which nonimmune cells, including the endothelium, represent a crucial component of disease pathogenesis...
- Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle
Daniela Paclik
Medizinische Klinik m S Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
PLoS ONE 3:e2629. 2008
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- Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation
Silvio Danese
Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy
J Immunol 178:6017-22. 2007
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- Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease
Franco Scaldaferri
Division of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
J Clin Invest 117:1951-60. 2007
..Restoring the PC pathway may represent a new therapeutic approach to suppress intestinal inflammation in IBD...
- Proteomic analysis of the inflamed intestinal mucosa reveals distinctive immune response profiles in Crohn's disease and ulcerative colitis
Uta Berndt
Division of Gastroenterology and Hepatology, Department of Medicine, Charite Campus Virchow Clinic, Universitatsmedizin Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
J Immunol 179:295-304. 2007
..Thus, topological proteomic analysis may help to unravel the pathogenesis of inflammatory bowel disease by defining distinct immunopathogenic profiles in CrD and UC...
- New therapies for inflammatory bowel disease: from the bench to the bedside
Silvio Danese
IBD Center, Division of Gastroenterology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Gut 61:918-32. 2012
..This study systematically reviews the mechanisms of action, efficacy and safety of new and emerging therapies that are currently in clinical trials and discusses future directions in the treatment of IBD...
- Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies
Giuseppina Bonanno
Department of Hematology, Catholic University Med, School, Rome, Italy
J Transl Med 8:114. 2010
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- PAI-1 and TAFI in inflammatory bowel disease: the yin and yang of the fibrinolytic system
Silvio Danese
Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Eur J Gastroenterol Hepatol 20:826-8. 2008
..Recent studies have shown an imbalance of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor, suggesting that these molecules might contribute to thromboembolic events in both forms of IBD...
- TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease
Silvio Danese
Department of Internal Medicine, Catholic University, Rome, Italy
J Immunol 176:2617-24. 2006
..Thus, in addition to neutralizing TNF-alpha and inducing T cell death, the therapeutic effects of infliximab in CD appear to be also mediated by inhibition of vascular inflammation in the gut...
- Extraintestinal manifestations in inflammatory bowel disease
Silvio Danese
Department of Internal Medicine, Catholic University School of Medicine, L go Vito 1, Rome 00168, Italy
World J Gastroenterol 11:7227-36. 2005
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- Oral beclomethasone: a review of its use in inflammatory bowel disease
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas IRCCS in Gastroenterology, Viale Manzoni, Rozzano, Milan, Italy
Mini Rev Med Chem 8:1459-63. 2008
..Aim of this paper is to review mechanisms of action, safety and efficacy of beclomethasone dipropionate, a steroid with enhanced topical intestinal activity and low systemic activity, in the treatment of inflammatory bowel disease...
- Chemokines in inflammatory bowel disease
S Danese
Department of Internal Medicine, Gemelli Hospital, Catholic University, Rome I-00168, Italy
J Clin Pathol 58:1025-7. 2005
- Adhesion molecules in inflammatory bowel disease: therapeutic implications for gut inflammation
S Danese
Department of Internal Medicine, Catholic University School of Medicine, L go Vito 1, 00168 Rome, Italy
Dig Liver Dis 37:811-8. 2005
..This paper reviews the major molecules that mediate leukocyte-endothelial interactions, and summarises the results of the most recent clinical trials targeting adhesion molecules in inflammatory bowel disease...
- Platelet activation and the CD40/CD40 ligand pathway: mechanisms and implications for human disease
Silvio Danese
Department of Internal Medicine, Catholic University of Rome, Rome, Italy
Crit Rev Immunol 25:103-21. 2005
..The clinical profit to be gained from blocking this molecular pair will be determined by results in humans with conditions in which the platelet CD40/CD40 ligand pathway is crucially involved in disease pathogenesis...
- Homocysteine triggers mucosal microvascular activation in inflammatory bowel disease
Silvio Danese
Department of Internal Medicine, Institute of General Pathology, Catholic University, Rome, Italy
Am J Gastroenterol 100:886-95. 2005
..Our aims were to study the levels of plasma and mucosal homocysteine in IBD patients and to assess whether homocysteine can trigger an inflammatory reaction on human intestinal microvascular endothelial cells (HIMECs)...
- Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Gastroenterology 130:2060-73. 2006
..We assessed mucosal vascularization, expression of endothelial alphaVbeta3 integrin, angiogenic factors, and their bioactivity in Crohn's disease (CD) and ulcerative colitis (UC) mucosa...
- Biological therapies for inflammatory bowel disease: research drives clinics
Silvio Danese
IBD, Division of Gastroenterology, Istituto Clinico Humanitas IRCCS in Gastroenterology, Viale Manzoni 56, 20089, Rozzano, Milan, Italy
Mini Rev Med Chem 6:771-84. 2006
..Aim of this article is to review the biological compounds and their efficacy in IBD...
- Cytapheresis in inflammatory bowel diseases: current evidence and perspectives
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, University of Milan, Rozzano Milan, Italy
Digestion 77:96-107. 2008
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- Tumor necrosis factor-alpha monoclonal antibodies for Crohn's disease: tipping the balance
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Curr Med Chem 14:1489-97. 2007
..The aim of this paper is to critically review the rationale and state-of-the art for the use TNF- alpha inhibitors in the treatment of CD...
- VEGF in inflammatory bowel disease: a master regulator of mucosal immune-driven angiogenesis
S Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Dig Liver Dis 40:680-3. 2008
- Negative regulators of angiogenesis in inflammatory bowel disease: thrombospondin in the spotlight
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano, Italy
Pathobiology 75:22-4. 2008
..In addition, recombinant thrombospondin-1 may inhibit pathological angiogenesis and may offer a new therapeutic approach to intestinal inflammation...
- Biological agents for ulcerative colitis: hypes and hopes
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Med Res Rev 28:201-18. 2008
..However, the recent introduction of biological therapies has led to promising changes in the management of UC patients. Aim of this paper is to review the recent advances and future perspectives for the use of biological agents in UC...
- Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease
S Danese
Division of Gastroenterology, Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Gut 56:1248-56. 2007
..The present study evaluated the role of the CD40-CD40L interaction in the promotion of immune-mediated angiogenesis in IBD...
- Angiogenesis blockade as a new therapeutic approach to experimental colitis
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Milan 20089, Italy
Gut 56:855-62. 2007
..Neoangiogenesis is a critical component of chronic inflammatory disorders. Inhibition of angiogenesis is an effective treatment in animal models of inflammation, but has not been tested in experimental colitis...
- Nonimmune cells in inflammatory bowel disease: from victim to villain
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan 20089, Italy
Trends Immunol 29:555-64. 2008
..I describe the current knowledge of the roles played by nonimmune cells in the pathogenesis of IBD, as they emerge as crucial alternative targets for therapeutic intervention...
- The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Silvio Danese
IBD Unit, Division of Gastroenterology, Istituto Clinico Humanitas IRCCS, Rozzano, Italy
Blood 115:1121-30. 2010
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- Review article: infliximab for Crohn's disease treatment--shifting therapeutic strategies after 10 years of clinical experience
S Danese
Division of Gastroenterology, Instituto Clinico Humanitas, IRCCS in Gastroenterology, Via Manzoni 56, Rozzano, Milan, Italy
Aliment Pharmacol Ther 33:857-69. 2011
..Over 10 years of clinical data and experience have demonstrated these therapies to be highly effective in Crohn's disease...
- IBD: of mice and men-shedding new light on IL-13 activity in IBD
Silvio Danese
IBD Center, IRCCS Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy
Nat Rev Gastroenterol Hepatol 8:128-9. 2011
..the decoyreceptor Il?13r?2 inhibits this protective effect, suggesting blockade of Il?13r?2 as a potential therapy for patients with IBD...
- Immune and nonimmune components orchestrate the pathogenesis of inflammatory bowel disease
Silvio Danese
IBD Center, Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Am J Physiol Gastrointest Liver Physiol 300:G716-22. 2011
..The aim of this review is to summarize the current role played by each cell type in IBD pathogenesis...
- Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: a pilot study
Silvio Danese
Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan 20089, Italy
World J Gastroenterol 16:2396-400. 2010
..To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients...
- Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
S Danese
Inflammatory Bowel Disease Unit, Division of Gastroenterology, Milan, Italy
Oncogene 29:3313-23. 2010
..Dissection of molecular pathways involved in colitis-associated cancer may offer opportunities for innovative therapeutic strategies...
- Mechanisms of action of infliximab in inflammatory bowel disease: an anti-inflammatory multitasker
S Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Dig Liver Dis 40:S225-8. 2008
..Infliximab, a monoclonal antibody against TNF-alpha has been proved highly effective in the clinical management of both forms of IBD. Aim of this paper is to review the mechanisms of action of infliximab in IBD...
- New and emerging biologics in the treatment of inflammatory bowel disease: quo vadis?
S Danese
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Gastroenterol Clin Biol 33:S217-27. 2009
..This paper systematically reviews the mechanismof-action, efficacy, short-term and, where available, long-term safety of biological agents that target molecules other than tumor necrosis factor alpha, in IBD...
- Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'
Silvio Danese
Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Gut 60:998-1008. 2011
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- VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
Franco Scaldaferri
Division of Gastroenterology, Istituto Clinico Humanitas, University of Milan, Milan Department of Internal Medicine, Catholic University, Rome, Italy
Gastroenterology 136:585-95.e5. 2009
..Vascular endothelial growth factor A (VEGF-A) mediates angiogenesis and might also have a role in inflammation and immunity. We examined whether VEGF-A signaling has a role in inflammatory bowel disease (IBD)...
- The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6
Stefania Vetrano
Division of Gastroenterology, Istituto Clinico Humanitas IRCCS, Milan, Italy
Gut 59:197-206. 2010
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- Infliximab therapy inhibits inflammation-induced angiogenesis in the mucosa of patients with Crohn's disease
Sergio Rutella
Department of Hematology, Catholic University Medical School, Rome, Italy
Am J Gastroenterol 106:762-70. 2011
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- The role of MAPK in governing lymphocyte adhesion to and migration across the microvasculature in inflammatory bowel disease
Franco Scaldaferri
Istituto Clinico Humanitas IRCCS in Gastroenterology, University of Milan, Rozzano, Milan
Eur J Immunol 39:290-300. 2009
..05) HIMEC monolayers. These findings suggest a critical role for MAPK in governing lymphocyte influx into the gut in IBD patients, and their blockade may offer a molecular target for blockade of leukocyte recruitment to the intestine...
- Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature
Sergio Rutella
Department of Hematology, Catholic University Medical School, Rome, Italy
J Cell Mol Med 15:625-34. 2011
..These findings suggest that inflamed HIMEC may recruit PLT which, upon release of pro-angiogenic factors, actively contribute to inflammation-induced angiogenesis...
- New insights into inflammatory bowel disease pathophysiology: paving the way for novel therapeutic targets
Tommaso Stefanelli
Division of Gastroenterology, Istituto Clinico Humanitas, Milan, Italy
Curr Drug Targets 9:413-8. 2008
..Aim of this review is to summarize the recent advances in IBD pathophysiology and the new therapeutic targets and drugs that are changing the IBD clinical management...
- Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
Stefania Vetrano
Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
Gastroenterology 135:173-84. 2008
..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
- Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation
Stefania Vetrano
IBD Unit, Division of Gastroenterology, Istituto Clinico Humanitas IRCCS, Rozzano 20089 Milan, Italy
Proc Natl Acad Sci U S A 108:19830-5. 2011
..Taken together, these findings demonstrate that the PC pathway is a unique system involved in controlling intestinal homeostasis and inflammation by regulating epithelial barrier function...
- Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a Jack of all trades
Livija Deban
Division of Gastroenterology, Istituto Clinico Humanitas IRCCS in Gastroenterology, Viale Manzoni, Rozzano, Milan, Italy
Am J Pathol 172:1457-66. 2008
..In particular, we assess the multiple roles of the microvascular endothelium in innate immunity, leukocyte recruitment, coagulation and perfusion, and immune-driven angiogenesis in IBD...
- Emerging biologics in the treatment of inflammatory bowel disease: what is around the corner?
Gionata Fiorino
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
Curr Drug Targets 11:249-60. 2010
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- Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications
Silvio Danese
Catholic University of Rome, Rome, Italy
Am J Gastroenterol 99:938-45. 2004
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- Molecular signaling blockade as a new approach to inhibit leukocyte-endothelial interactions for inflammatory bowel disease treatment
Franco Scaldaferri
Department of Internal Medicine, Catholic University, Rome, Italy
Cell Adh Migr 3:296-9. 2009
..Specific local inhibition of MAPK activity on endothelial cells and fibroblasts may provide a new mechanism to control mucosal inflammation and leukocyte recruitment into the intestine of active IBD patients...
- Tolerance in intestinal inflammation and cancer
Marisa Vulcano
Laboratory of Gastroenterology and Immunopathology, Division of Gastroenterology, Instituto Clinico Humanitas, Milan, Italy
Curr Drug Targets 9:404-12. 2008
..Nevertheless, antigen uptake and presentation seems to be a crucial factor in this issue. In this review, we will discuss the key role of immune intestinal cells in the development of mucosal immunity, tolerance and disease...
- Leukocyte traffic control: a novel therapeutic strategy for inflammatory bowel disease
Gionata Fiorino
IBD Unit, Division of Gastroenterology and Digestive Endoscopy, IRCCS Humanitas, Rozzano, Milan, Italy
Expert Rev Clin Immunol 6:567-72. 2010
..The development of a new specific molecule, vedolizumab, is currently under investigation in a large clinical trial. This novel specific anti-integrin drug seems to hold promise in the treatment of gut inflammation...
- Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease
Gilles Laverny
BioXell S p a, Milan, Italy
Immunol Lett 131:49-58. 2010
..These results confirm the therapeutic efficacy of VDR agonists in experimental colitis, and suggest BXL-62 as a promising compound for IBD treatment...
- Mucosal biomarkers in inflammatory bowel disease: key pathogenic players or disease predictors?
Franco Scaldaferri
Division of Gastroenterology, IRCCS, Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
World J Gastroenterol 16:2616-25. 2010
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- Anti-adhesion molecule therapies in inflammatory bowel disease: touch and go
Tommaso Stefanelli
Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Viale M lt anzoni, Rozzano, Milan, Italy
Autoimmun Rev 7:364-9. 2008
..This review outlines the scientific basis behind this therapeutic approach, and describes the principal clinical studies that have been carried out on these new molecules in patients with IBD...
- Inflammation and coagulation in inflammatory bowel disease: The clot thickens
Silvio Danese
Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Am J Gastroenterol 102:174-86. 2007
..Overall, an overview is provided that the coagulation system represents an important, though previously underestimated, component of IBD pathogenesis, and may be a possible target for therapeutic intervention...
- Risk of postoperative recurrence and postoperative management of Crohn's disease
Antonino Spinelli
Department and Chair of General Surgery, University of Milan, Istituto Clinico Humanitas IRCCS, Via Manzoni 5620089, Rozzano, Milan, Italy
World J Gastroenterol 17:3213-9. 2011
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- The role of JAM-A in inflammatory bowel disease: unrevealing the ties that bind
Stefania Vetrano
Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
Ann N Y Acad Sci 1165:308-13. 2009
..This review focuses on the role of JAM-A in controlling mucosal homeostasis by regulating the integrity and permeability of epithelial barrier function...
- Vascular involvement in inflammatory bowel disease: pathogenesis and clinical aspects
Alfredo Papa
Department of Internal Medicine, Division of Gastroenterology, Catholic University of Rome, Rome, Italy
Dig Dis 26:149-55. 2008
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- Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa
S Danese
Dept. of Clinical Chemistry, Gemelli Hospital, Catholic University, Rome, Italy
Scand J Gastroenterol 36:247-50. 2001
..Assessment of CagA status might be useful to discriminate patients in which H. pylori eradication is advisable...
- Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds
Tiziana Di Pucchio
Istituto Superiore di Sanita, Department of Cell Biology and Neurosciences, Rome, Italy
Expert Opin Ther Pat 20:229-50. 2010
..Recently, IDO has been implicated in B-cell stimulation and autoantibody production in experimental models of autoimmune diseases...
- Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance
Sergio Rutella
Department of Hematology, Laboratory of Immunology, Catholic University School of Medicine, Rome, Italy
J Immunol 175:7085-91. 2005
..This review summarizes the growing body of evidence that supports a critical role for G-CSF as a novel mediator of T cell tolerance...
- Review article: inherited thrombophilia in inflammatory bowel disease
Alfredo Papa
Department of Internal Medicine, Catholic University of Rome, Rome, Italy
Am J Gastroenterol 98:1247-51. 2003
..In the last few years, a great amount of literature has focused on the prevalence of such genetic mutations and their role in determining thrombosis in IBD patients. In this review, we summarize the results of these studies...
- Biological therapy for ulcerative colitis: what is after anti-TNF
Gionata Fiorino
IBD Center, Gastroenterology, IRCCS Humanitas, Rozzano, Milan, Italy
Curr Drug Targets 12:1433-9. 2011
..They include anti TNF-? agents, anti adhesion molecules, anti IL-12/23, anti IL-6R and more. We review the recent advances in biological therapy for UC treatment beyond the anti-TNFs...
- A novel pathogenic role for microvasculature in inflammatory bowel disease
S Danese
Department of Internal Medicine, Catholic University of Rome, Rome, Italy
Eur Rev Med Pharmacol Sci 10:3-5. 2006
..Interestingly, endothelium has become one of the major areas of investigation in gut inflammation...
- MRI in Crohn's disease--current and future clinical applications
Gionata Fiorino
Division of Gastroenterology and Digestive Endoscopy, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy
Nat Rev Gastroenterol Hepatol 9:23-31. 2012
..This damage-driven therapeutic approach could potentially change the course of Crohn's disease...
- Thrombopoietin serum levels in patients with inflammatory bowel disease with and without previous thromboembolic events
Alfredo Papa
Department of Internal Medicine, Catholic University of Rome, Italy
Hepatogastroenterology 50:132-5. 2003
..However, the available data are not conclusive. The aim of this study was to assess thrombopoietin serum levels in inflammatory bowel disease patients according to platelet counts, disease activity and previous thrombotic events...
- Regulation of leukocyte recruitment by the long pentraxin PTX3
Livija Deban
Laboratory for Immunology and Inflammation, Instituto di Ricovero e Cura a Carattere Scientifico Istituto Clinico Humanitas, Rozzano, Italy
Nat Immunol 11:328-34. 2010
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- Intestinal microbiota in inflammatory bowel disease: friend of foe?
Francesca Fava
Inflammatory Bowel Disease Unit, Istituto Clinico Humanitas, Via Manzoni 113, 20089 Rozzano, Milano, Italy
World J Gastroenterol 17:557-66. 2011
..Studies looking at gut microbial composition, epithelial integrity and mucosal immune markers in genotyped IBD populations are therefore warranted to shed light on this obscure pathogenesis...
- Helicobacter pylori eradication down-regulates matrix metalloproteinase-9 expression in chronic gastritis and gastric ulcer
Silvio Danese
Department of Internal Medicine, , Rome, Italy
Gastroenterology 126:369-71. 2004
- Budesonide: teaching an old dog new tricks for inflammatory bowel disease treatment
Erika Angelucci
Division of Gastroenterology, Policlinico Umberto I, Universita Sapienza, Rome, Italy
Curr Med Chem 15:2527-35. 2008
..e. MMX-budesonide), have also been developed to allow uniform release along the length of the colon. This paper reviews the mechanism-of-action, safety and efficacy of budesonide in the treatment of inflammatory bowel disease...
- Balanced propofol sedation administered by nonanesthesiologists: The first Italian experience
Alessandro Repici
Department of Gastroenterology, IRCCS Istituto Clinico Humanitas, Via Manzoni 56 20089 Rozzano, Milan, Italy
World J Gastroenterol 17:3818-23. 2011
..To assess the efficacy and safety of a balanced approach using midazolam in combination with propofol, administered by non-anesthesiologists, in a large series of diagnostic colonoscopies...
- Review article: potential therapeutic applications and mechanisms of action of heparin in inflammatory bowel disease
A Papa
Department of Internal Medicine, Catholic University of Rome, Italy
Aliment Pharmacol Ther 14:1403-9. 2000
..In conclusion, unfractioned heparin may represent a safe therapeutic option for severe, steroid-resistant ulcerative colitis, although randomized, controlled trials are needed to confirm these data...
- Role of Helicobacter pylori CagA+ infection in determining oxidative DNA damage in gastric mucosa
A Papa
Institute of Internal Medicine, Giovanni XXIII Cancer Research Center and Institute of General Pathology, Institute of Pathology, Catholic University of Rome, Italy
Scand J Gastroenterol 37:409-13. 2002
..pylori status and cytotoxic associated gene product A (CagA); 2) to determine the relationship between ROS generation and amount of 8-OHdG...
- Metal stents for malignant colorectal obstruction
Alessandro Repici
Department of Gastroenterology, Digestive Endoscopy Unit, IRCCS Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
Minim Invasive Ther Allied Technol 15:331-8. 2006
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- Adalimumab in ulcerative colitis: hypes and hopes
Gionata Fiorino
IBD Unit, Gastroenterology, IRCCS Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Expert Opin Biol Ther 11:109-16. 2011
..Adalimumab is a fully human anti-TNF-? antibody that is effective and safe for the treatment of luminal and fistulising CD...
- Laparoscopic surgery for recurrent Crohn's disease
Antonino Spinelli
Dipartimento e Cattedra di Chirurgia Generale, Istituto Clinico Humanitas IRCCS, Universita degli Studi di Milano, Rozzano, Milano, Italy
Gastroenterol Res Pract 2012:381017. 2012
..The reported results indicate that laparoscopy may be safely applied even in selected recurrent CD cases in hands of IBD surgeons with broad laparoscopic experience...
- The CD40/CD40L costimulatory pathway in inflammatory bowel disease
S Danese
Department of Internal Medicine, Catholic University, Rome, Italy
Gut 53:1035-43. 2004
- Prevalence of the K469E polymorphism of intercellular adhesion molecule 1 gene in Italian patients with inflammatory bowel disease
A Papa
Department of Internal Medicine, Gastroenterology Unit, Catholic University of Rome, A Gemelli University Hospital, Largo A Gemelli 8, 00168 Rome, Italy
Dig Liver Dis 36:528-32. 2004
..Intercellular adhesion molecule 1 gene lies on chromosome 19p13, implicated in determining susceptibility to inflammatory bowel disease. Recently, the polymorphism K469E of intercellular adhesion molecule 1 gene has been identified...
- Helicobacter pylori infection affects eosinophilic cationic protein in the gastric juice of patients with idiopathic chronic urticaria
V Ojetti
Department of Internal Medicine, Catholic University, Rome, Italy
Int Arch Allergy Immunol 125:66-72. 2001
..CONCLUSIONS: Although H. pylori infection affects gastric juice ECP and eosinophil infiltration of ICU patients, the role of the bacterium in the pathogenesis of this skin disorder still remains uncertain...
- Review article: anti TNF-alpha induced psoriasis in patients with inflammatory bowel disease
G Fiorino
GI Unit, Dipartimento di Scienze Cliniche, Policlinico Umberto I, Rome, Italy
Aliment Pharmacol Ther 29:921-7. 2009
..An emerging challenge is the increasing incidence of anti TNF-alpha induced psoriasis. A total of 120 cases have been currently reported, of whom 18 patients were treated with biological agents for IBD...
- Colifagina, a novel preparation of 8 lysed bacteria ameliorates experimental colitis
S Vetrano
Laboratory of Immunology and Inflammation and Division of Gastroenterology, Istituto Clinico Humanitas, Viale Manzoni, Rozzano, Milan, Italy
Int J Immunopathol Pharmacol 21:401-7. 2008
..MIP-1, MIP-2 and RANTES concentrations in colonic organ culture were significantly lower in colifagina-treated mice than in the placebo group. The use of colifagina is effective in amelioration of murine colitis...
- Etiopathogenesis of inflammatory bowel diseases
Silvio Danese
Division of Gastroenterology, Istituto Clinico Humanitas-IRCCS in Gastroenterology, Milan, Italy
World J Gastroenterol 12:4807-12. 2006
..Gut inflammation is mediated by cells of the innate as well as adaptive immune systems, with the additional contribution of non-immune cells, such as epithelial, mesenchymal and endothelial cells, and platelets...
- High prevalence of celiac disease in patients with lactose intolerance
Veronica Ojetti
Internal Medicine, Catholic University, Rome, Italy
Digestion 71:106-10. 2005
..In these subjects lactase deficiency seems to be the only manifestation of celiac disease. We suggest serologic screening for celiac disease in all patients with a positive H2-lactose breath test before beginning a milk-exclusion diet...
- Efficacy and tolerability of antibiotics in patients undergoing H. pylori eradication
S Danese
Internal Medicine Department, Gemelli Hospital, Catholic University, Rome, Italy
Hepatogastroenterology 48:465-7. 2001
..Quadruple therapy, which appear highly efficacious as a second line therapy, is associated with a significantly higher incidence of side effects when compared to first-line treatment...
- Early atherosclerosis in patients with inflammatory bowel disease
A Papa
Department of Internal Medicine, Gastroenterology Unit, Catholic University of Rome, Italy
Eur Rev Med Pharmacol Sci 10:7-11. 2006
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- Prevalence of and risk factors for Helicobacter pylori infection among healthcare workers at a teaching hospital in Rome: the Catholic University Epidemiological Study
A Gasbarrini
Department of Medical Pathology, Gemelli Hospital, Catholic University, Rome, Italy
Eur J Gastroenterol Hepatol 13:185-9. 2001
..To evaluate the prevalence of and the risk factors for Helicobacter pylori in a population of medical and non-medical workers at a teaching hospital in Rome, Italy...
- Increased carotid intima-media thickness in patients with inflammatory bowel disease
A Papa
Department of Internal Medicine, Gastroenterology Unit, Catholic University of Rome, Rome, Italy
Aliment Pharmacol Ther 22:839-46. 2005
..Patients with inflammatory bowel disease have an increased risk of thrombotic complications; moreover, mesenteric microvascular thrombosis has been hypothesized as a contributing factor in the pathogenesis of inflammatory bowel disease...
- Antibodies to Saccharomyces cerevisiae: are they useful in clinical practice?
M Candelli
Department of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy
Hepatogastroenterology 50:718-20. 2003
..CONCLUSIONS: Our data show an association between Crohn's disease and antibodies to Saccharomyces cerevisiae. However, it does not seem useful in discriminating between ulcerative colitis and colic Crohn's disease...
- Adalimumab in Crohn's disease: tips and tricks after 5 years of clinical experience
G Fiorino
IBD Unit, Gastroenterology, IRCCS Humanitas, Rozzano, Milan, Italy
Curr Med Chem 18:1230-8. 2011
..Adalimumab, a fully human anti TNF-? antibody, demonstrates similar treatment efficacy as infliximab and certolizumab, and can easily be self-administered at home...
- Assessment of thrombin-activatable fibrinolysis inhibitor (TAFI) plasma levels in inflammatory bowel diseases
S Saibeni
Gastroenterology and Gastrointestinal Endoscopy Service and Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital, University of Milan, Via Pace 9, 20122 Milan, Italy
Am J Gastroenterol 99:1966-70. 2004
..CONCLUSIONS: TAFI plasma levels are increased in IBD patients and correlate with acute-phase reactants. Increased TAFI plasma levels might contribute to the prothrombotic state observed in IBD through the induction of hypofibrinolysis...
- Review article: anti-fibrotic agents for the treatment of Crohn's disease - lessons learnt from other diseases
H Szabo
Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
Aliment Pharmacol Ther 31:189-201. 2010
..The current therapies for Crohn's disease (CD) are mainly focused on blockade of inflammation. Fibrosis remains one of the major complications of CD often leading to surgery, affecting patients' quality-of-life...
- Endoclipping for gastric perforation secondary to second session of EMRC in locally residual early gastric cancer: a case report
G De Caro
Department of Gastroenterology and Digestive Endoscopy Unit, IRCCS, Istituto Clinico Humanitas, Rozzano, MI, Italy
Dig Liver Dis 41:e32-4. 2009
..A perforation in the site of endoscopic resection was immediately observed. The complication was treated successfully by the application of seven clips...
- Hyperhomocysteinemia and prevalence of polymorphisms of homocysteine metabolism-related enzymes in patients with inflammatory bowel disease
A Papa
Department of Internal Medicine, Catholic University of Rome, Italy
Am J Gastroenterol 96:2677-82. 2001
....
- New drug delivery systems in inflammatory bowel disease: MMX and tailored delivery to the gut
G Fiorino
Gastroenterology Unit, Istituto Clinico Humanitas, Rozzano, Milan, Italy
Curr Med Chem 17:1851-7. 2010
..This new delivery technology has been used to modify some commonly used drugs, including mesalamine and budesonide, as well as heparin, which are now being investigated for their utility in the management of IBD...
- Genetic and nutritional predictors of hyperhomocysteinemia in inflammatory bowel disease
Alfredo Papa
Am J Gastroenterol 97:490-1. 2002
- Assessment and grading of mucosal inflammation in colonic diverticular disease
Antonio Tursi
Digestive Endoscopy Unit, Lorenzo Bonomo Hospital, Andria, BA, Italy
J Clin Gastroenterol 42:699-703. 2008
..The aim of this study was to assess and grade the mucosal inflammatory infiltrate in different degrees of diverticular disease (DD) and to compare them with healthy matched controls...
- Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease
Miquel Sans
Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Gastroenterology 132:139-53. 2007
..We investigated FKN production by the mucosal microvasculature in inflammatory bowel disease (IBD), its capacity for leukocyte recruitment into the gut, and the number of CX3CR1+ cells in the circulation and mucosa of IBD patients...
- Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
Nature 446:557-61. 2007
....
- CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration
Jon D Vogel
Division of Gastroenterology, University Hospitals of Cleveland, Case Western University School of Medicine, Cleveland, OH 44106, USA
Gastroenterology 126:63-80. 2004
....
- Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features
Sergio Rutella
Department of Hematology, Laboratory of Immunology, Catholic University Medical School, Largo A Gemelli 8 00168 Rome, Italy
Blood 108:218-27. 2006
..Collectively, our findings point to a novel role for HGF in the regulation of monocyte/DC functions that might be exploited therapeutically...
- Atherosclerosis and inflammatory bowel disease: sharing a common pathogenic pathway?
Silvio Danese
Circulation 107:e52. 2003
- Antibody to alpha4beta7 integrin for ulcerative colitis
Silvio Danese
N Engl J Med 353:1180-1; author reply 1180-1. 2005
- Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients
Silvio Danese
Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Ohio 44106, USA
Gastroenterology 124:1249-64. 2003
..CONCLUSIONS: These results show that platelets can actively contribute to mucosal inflammation and represent a previously unrecognized component of IBD pathogenesis...
- CD40L-positive platelets induce CD40L expression de novo in endothelial cells: adding a loop to microvascular inflammation
Silvio Danese
Arterioscler Thromb Vasc Biol 24:e162. 2004
