Research Topics
| Renata StepankovaSummaryCountry: Czech Republic Publications
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Publications
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cellsRenata Stepankova
Laboratory of Gnotobiology, Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, Novy Hradek, Czech Republic
Inflamm Bowel Dis 13:1202-11. 2007....- Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol dietRenata Stepankova
Department of Immunology and Gnotobiology, Institute of Microbiology, vvi, Czech Academy of Sciences, Praque, Czech Republic
J Atheroscler Thromb 17:796-804. 2010..The aim of our work was to determine the influence of intestinal bacteria on the development of atherosclerotic lesions using apolipoprotein E (ApoE)-deficient knockout mice... - The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseasesHelena Tlaskalova-Hogenova
Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
Cell Mol Immunol 8:110-20. 2011..g., probiotics and prebiotics) whose administration may aid in disease prevention and treatment... - Involvement of innate immunity in the development of inflammatory and autoimmune diseasesHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 1st Faculty of Medicine, Charles University, Víde ská 1083, Prague 4, Czech Republic
Ann N Y Acad Sci 1051:787-98. 2005..Activation of innate immunity cells by food proteins or components from gut microbiota thus could participate in the impairment of intestinal mucosa and the development of intestinal and/or systemic inflammation... - Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free miceTomas Hrncir
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague and Novy Hradek, Czech Republic
BMC Immunol 9:65. 2008.... - Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseasesHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
Immunol Lett 93:97-108. 2004..Regulation of microflora composition (e.g. by probiotics and prebiotics) offers the possibility to influence the development of mucosal and systemic immunity but it can play a role also in prevention and treatment of some diseases... - Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free ratsJana Cinova
Department of Immunology, Institute of Microbiology v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
PLoS ONE 6:e16169. 2011..We aimed to study the effects of gliadin and various intestinal bacterial strains on mucosal barrier integrity, gliadin translocation, and cytokine production... - Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunityLuca Vannucci
Laboratory of Natural Cell Immunity, Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic
Int J Oncol 32:609-17. 2008..The different levels of tolerance/regulatory mechanisms in GF versus the CV animals may modulate the anticancer response not only at the mucosal but also at the systemic immunity level... - Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhoea and increased bacterial translocation in gnotobiotic ratsHana Kozakova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Novy Hradek, Czech Republic
Microbes Infect 5:405-11. 2003..e. the colonization state, has a strong influence on triggering the severity of the functional disturbances of the intestinal epithelium, and adds to the clinical manifestations of vitamin A deficiency... - Mucosal immunity: its role in defense and allergyHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Science of the Czech Republic, Prague, Czech Republic
Int Arch Allergy Immunol 128:77-89. 2002.... - Susceptibility to nasal and oral tolerance induction to the major birch pollen allergen Bet v 1 is not dependent on the presence of the microfloraAndreas Repa
Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A 1090 Vienna, Austria
Immunol Lett 117:50-6. 2008..Our findings may challenge the view that the commensal microflora is a key factor for breakdown of physiological tolerance and allergy development... - The effect of weaning on the clonality of alpha beta T-cell receptor T cells in the intestine of GF and SPF miceChristopher S J Probert
Department of Clinical Science at South Bristol, Bristol Royal Infirmary, University of Bristol, Bristol, BS2 8HW, UK
Dev Comp Immunol 31:606-17. 2007..These data show: firstly, that under SPF conditions, the intestine is seeded with a diverse T-cell population that becomes oligoclonal around the time of weaning; secondly, that GF mice were oligoclonal at each time point... - Effects of microflora on the neonatal development of gut mucosal T cells and myeloid cells in the mouseAmanda M Williams
Department of Clinical Science at South Bristol, University of Bristol, Bristol, UK
Immunology 119:470-8. 2006..Their activation status depends on the microbiological status of the dam, and without a commensal flora they remain naive. We propose that these cells regulate antigen responsiveness of the developing mucosal T cell pool... - Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathologyHolm H Uhlig
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK
Immunity 25:309-18. 2006..The differential role of IL-23 in local but not systemic inflammation suggests that it may make a more specific target for the treatment of IBD... - Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat modelBohuslav Dvorak
Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona 85724, USA
Am J Physiol Gastrointest Liver Physiol 282:G156-64. 2002..Enhanced EGF-R expression in the RMS group was localized predominantly in the epithelial cells of injured ileum. These data suggest a new potential therapeutic approach for the prevention and treatment of NEC...