Research Topics
Species | Jana SmardovaSummaryCountry: Czech Republic Publications
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Publications
Analysis of tumor suppressor p53 status in head and neck squamous cell carcinomaJana Smardova
Department of Anatomy and Pathology, University Hospital Brno, 625 00 Brno, Czech Republic
Oncol Rep 11:923-9. 2004..7%); iv) 2 independent p53 mutations were found in at least 2 of the 36 positive cases; v) no statistically significant relationship was found between p53 aberration and overall survival...- Functional analysis of p53 tumor suppressor in yeastJana Smardova
Department of Pathology and Anatomy, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic
Differentiation 73:261-77. 2005..Understanding the exact impact of p53 mutation on its function is an important prerequisite for establishment of efficient anti-cancer therapies... - Analysis of p53 status in human cell lines using a functional assay in yeast: detection of new non-sense p53 mutation in codon 124Jana Smardova
Department of Pathology and Anatomy, University Hospital Brno, Jihlavska 20, 625 00 Brno, Czech Republic
Oncol Rep 14:901-7. 2005..In acute lymphoid leukemia HPB cell line, we disclosed unknown non-sense mutation in codon 124 of the p53 gene... - An unusual p53 mutation detected in Burkitt's lymphoma: 30 bp duplicationJana Smardova
Department of Pathology, University Hospital, 625 00 Brno, Czech Republic
Oncol Rep 20:773-8. 2008..12155_12184dup30) leading to a repeat of 10 amino acids (Pro-77 to Ala-86) in the p53 protein. Further analyses showed that the mutation was unstable in yeast cells. The FISH analyses did not confer loss of the p53-specific locus 17p13... - Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphomaLenka Stefancikova
Department of Pathology, University Hospital Brno, 625 00 Brno, Czech Republic
Int J Oncol 36:699-706. 2010..3. The p53 mutations were shown to be a negative prognostic marker in MCL... - Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphomaLenka Stefancikova
Department of Pathology, University Hospital, 625 00 Brno, Czech Republic
Int J Oncol 39:1413-20. 2011..p53 aberrations are negative predictors for survival of DLBCL patients treated with R-CHOP... - Transactivation by temperature-dependent p53 mutants in yeast and human cellsJana Slovackova
Department of Pathology, University Hospital, Department of Experimental Biology Faculty of Science, Masaryk University, Brno, Czech Republic
Cell Cycle 9:2141-8. 2010.... - Missense mutations located in structural p53 DNA-binding motifs are associated with extremely poor survival in chronic lymphocytic leukemiaMartin Trbusek
University Hospital Brno, Department of Internal Medicine Hematooncology, Czech Republic
J Clin Oncol 29:2703-8. 2011..There is a distinct connection between TP53 defects and poor prognosis in chronic lymphocytic leukemia (CLL). It remains unclear whether patients harboring TP53 mutations represent a homogenous prognostic group... - The persistence of t(14;18)-bearing cells in lymph nodes of patients with follicular lymphoma in complete remission: the evidence for 'a lymphoma stem cell'Andrea Janikova
Department of Internal Medicine, Hemato Oncology, University Hospital Brno, Czech Republic
Leuk Lymphoma 50:1102-9. 2009..Another three of these patients relapsed a few months after UG-FNA. This study is proof of the principle of the detection of residual t(14;18) bearing cells in previously involved lymph nodes despite patients being in remission...