Jeffrey R IdleSummaryAffiliation: Charles University Country: Czech Republic Publications
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MetabolomicsJeffrey R Idle
Institute of Pharmacology, 1st Faculty of Medicine, Charles University, 128 00 Praha 2, Czech Republic
Cell Metab 6:348-51. 2007..Here, recent studies using metabolomics in xenobiotic metabolism and genetically modified mice are highlighted...- Christmas gingerbread (Lebkuchen) and Christmas cheer--review of the potential role of mood elevating amphetamine-like compounds formed in vivo and in furnoJ R Idle
Institute of Pharmacology of the First Faculty of Medicine, Charles University, Prague, Czech Republic
Prague Med Rep 106:27-38. 2005..Whether spices have a true pharmacological effect or they act as aromatherapy remains to be elucidated through clinical and laboratory studies... - Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substratesAi Ming Yu
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Drug Metab Rev 36:243-77. 2004..Thus, polymorphic CYP2D6 may play an important role in the interconversions of these psychoactive tryptamines, including a crucial step in a serotonin-melatonin cycle... - Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistanceTing Wang
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Pharmacol Exp Ther 324:674-84. 2008..Other PXR target transporters might also be involved... - Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activationYueying Zhen
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Endocrinol 21:2136-51. 2007..This study underscores the power of mass spectrometry-based metabolomics combined with genetically modified mice in the definition of monogenic metabolic phenotypes... - A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approachChi Chen
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Chem Res Toxicol 20:531-42. 2007.... - Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435TOndrej Slanar
Eur J Clin Pharmacol 63:419-21. 2007 - Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)Xiaochao Ma
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892, USA
Carcinogenesis 28:732-7. 2007..Because of the high inducibility of human CYP1A1, especially in cigarette smokers, the role of lung CYP1A1 in PhIP carcinogenesis should be considered. (237 words)... - 3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratioYueying Zhen
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Drug Metab Dispos 34:1563-74. 2006.... - CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary responseOndrej Slanar
Eur J Clin Pharmacol 62:75-6; author reply 77-8. 2006 - Metabolism of melatonin by human cytochromes p450Xiaochao Ma
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Drug Metab Dispos 33:489-94. 2005.... - Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null miceChi Chen
Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 283:4543-59. 2008....