Milan Holecek

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. ncbi Relation between glutamine, branched-chain amino acids, and protein metabolism
    Milan Holecek
    Department of Physiology, Charles University School of Medicine, Hradec Kralove, Czech Republic
    Nutrition 18:130-3. 2002
  2. ncbi Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions
    Milan Holecek
    Department of Physiology, Charles University, Medical Faculty, Hradec Kralove, Czech Republic
    JPEN J Parenter Enteral Nutr 30:467-73. 2006
  3. ncbi Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver
    Milan Holecek
    Department of Physiology, Charles University Prague, Hradec Kralove, Czech Republic
    Int J Exp Pathol 84:185-90. 2003
  4. ncbi Protein metabolism in guanethidine-treated rats
    Milan Holecek
    Department of Physiology, Charles University School of Medicine, , Czech Republic
    Int J Exp Pathol 85:257-64. 2004
  5. ncbi Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis
    Roman Safranek
    Department of Physiology, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic
    Ann Nutr Metab 50:361-7. 2006
  6. ncbi Effects of ?-hydroxy-?-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats
    Miroslav Kovarik
    Department of Physiology, Faculty of Medicine, Charles University, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    J Physiol Biochem 66:311-9. 2010
  7. ncbi Protein metabolism in slow- and fast-twitch skeletal muscle during turpentine-induced inflammation
    Tomas Muthny
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Int J Exp Pathol 89:64-71. 2008
  8. ncbi Modulation of inflammatory response in sepsis by proteasome inhibition
    Roman Safranek
    Department of Surgery, School of Medicine, Kurume University, Kurume, Japan
    Int J Exp Pathol 87:369-72. 2006
  9. ncbi Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats
    Jana Kadlcikova
    Department of Pharmacology, Faculty of Pharmacy, Charles University, Heyrovského 1230, 500 05 Hradec Kralove, Czech Republic
    Int J Exp Pathol 85:365-71. 2004
  10. ncbi Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle
    Milan Holecek
    Department of Physiology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    Amino Acids 40:575-84. 2011

Detail Information

Publications14

  1. ncbi Relation between glutamine, branched-chain amino acids, and protein metabolism
    Milan Holecek
    Department of Physiology, Charles University School of Medicine, Hradec Kralove, Czech Republic
    Nutrition 18:130-3. 2002
    ..In conclusion some favorable effects of BCAA supply can be explained by its role in the synthesis of glutamine and some positive effects of glutamine exogenous supply can be explained by its effect on metabolism of BCAA...
  2. ncbi Simultaneous infusion of glutamine and branched-chain amino acids (BCAA) to septic rats does not have more favorable effect on protein synthesis in muscle, liver, and small intestine than separate infusions
    Milan Holecek
    Department of Physiology, Charles University, Medical Faculty, Hradec Kralove, Czech Republic
    JPEN J Parenter Enteral Nutr 30:467-73. 2006
    ..In the present study, we evaluated their effect on protein synthesis in skeletal muscle, liver, and jejunum of septic rats...
  3. ncbi Acute effects of acidosis on protein and amino acid metabolism in perfused rat liver
    Milan Holecek
    Department of Physiology, Charles University Prague, Hradec Kralove, Czech Republic
    Int J Exp Pathol 84:185-90. 2003
    ....
  4. ncbi Protein metabolism in guanethidine-treated rats
    Milan Holecek
    Department of Physiology, Charles University School of Medicine, , Czech Republic
    Int J Exp Pathol 85:257-64. 2004
    ..These changes may also be induced by administration of other sympathetic blocking agents, e.g. in treatment of hypertension...
  5. ncbi Aspects of protein and amino acid metabolism in a model of severe glutamine deficiency in sepsis
    Roman Safranek
    Department of Physiology, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic
    Ann Nutr Metab 50:361-7. 2006
    ..The aim was to investigate the effects of glutamine deficiency in sepsis with and without GH treatment on protein and amino acid metabolism...
  6. ncbi Effects of ?-hydroxy-?-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats
    Miroslav Kovarik
    Department of Physiology, Faculty of Medicine, Charles University, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    J Physiol Biochem 66:311-9. 2010
    ..The action of HMB was mediated by attenuation of proteasome activity and protein breakdown, not by stimulation of protein synthesis. More pronounced effect of the HMB treatment on myofibrillar proteolysis was observed in the SOL...
  7. ncbi Protein metabolism in slow- and fast-twitch skeletal muscle during turpentine-induced inflammation
    Tomas Muthny
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Int J Exp Pathol 89:64-71. 2008
    ..Release of leucine was inhibited significantly more in SOL. We conclude that turpentine-induced inflammation affects more CHTLA, protein synthesis and leucine release in EDL compared to SOL...
  8. ncbi Modulation of inflammatory response in sepsis by proteasome inhibition
    Roman Safranek
    Department of Surgery, School of Medicine, Kurume University, Kurume, Japan
    Int J Exp Pathol 87:369-72. 2006
    ..IL-6 was not significantly affected. A mortality study revealed prolonged survival in MG-132 treated mice. We conclude that MG-132 treatment decreases inflammatory response and prolongs survival in the CLP model of sepsis...
  9. ncbi Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats
    Jana Kadlcikova
    Department of Pharmacology, Faculty of Pharmacy, Charles University, Heyrovského 1230, 500 05 Hradec Kralove, Czech Republic
    Int J Exp Pathol 85:365-71. 2004
    ..Leucine oxidation was increased by AdaAhx(3)L(3)VS in the septic EDL muscle and decreased by MG132 in intact EDL muscle. We conclude that MG132 and AdaAhx(3)L(3)VS reversed protein catabolism in septic rat muscles...
  10. ncbi Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle
    Milan Holecek
    Department of Physiology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic
    Amino Acids 40:575-84. 2011
    ..These metabolic changes are not directly associated with marked changes in protein turnover. The effect of ammonia is more pronounced in muscles with high content of white fibres...
  11. ncbi Acute effects of decreased glutamine supply on protein and amino acid metabolism in hepatic tissue: a study using isolated perfused rat liver
    Milan Holecek
    Department of Physiology, Charles Unviersity Prague, Medical Faculty, Hradec Kralove, Czech Republic
    Metabolism 52:1062-7. 2003
    ....
  12. ncbi Proteasome inhibitor MG-132 enhances whole-body protein turnover in rat
    Milan Holecek
    Department of Physiology, Charles University, Medical Faculty, Hradec Kralove, Czech Republic
    Biochem Biophys Res Commun 345:38-42. 2006
    ....
  13. ncbi Three targets of branched-chain amino acid supplementation in the treatment of liver disease
    Milan Holecek
    Department of Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic
    Nutrition 26:482-90. 2010
    ..An important task for clinical research is to identify groups of patients for whom BCAA treatment can significantly improve the health-related quality of life and the prognosis of hepatic disease...
  14. ncbi Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet - effect of starvation
    Milan Holecek
    Department of Physiology, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
    Food Chem Toxicol 49:3336-42. 2011
    ....