Research Topics
Genomes and GenesSpecies | Helena Tlaskalova-HogenovaSummaryAffiliation: Academy of Sciences of the Czech Republic Country: Czech Republic Publications
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Publications
The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseasesHelena Tlaskalova-Hogenova
Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Prague, Czech Republic
Cell Mol Immunol 8:110-20. 2011..g., probiotics and prebiotics) whose administration may aid in disease prevention and treatment...- Involvement of innate immunity in the development of inflammatory and autoimmune diseasesHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 1st Faculty of Medicine, Charles University, Víde ská 1083, Prague 4, Czech Republic
Ann N Y Acad Sci 1051:787-98. 2005..Activation of innate immunity cells by food proteins or components from gut microbiota thus could participate in the impairment of intestinal mucosa and the development of intestinal and/or systemic inflammation... - Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseasesHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
Immunol Lett 93:97-108. 2004..Regulation of microflora composition (e.g. by probiotics and prebiotics) offers the possibility to influence the development of mucosal and systemic immunity but it can play a role also in prevention and treatment of some diseases... - Colorectal carcinoma: Importance of colonic environment for anti-cancer response and systemic immunityLuca Vannucci
Laboratory of Natural Cell Immunity, Institute of Microbiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Immunotoxicol 6:217-26. 2009.... - Lysate of probiotic Lactobacillus casei DN-114 001 ameliorates colitis by strengthening the gut barrier function and changing the gut microenvironmentZuzana Zakostelska
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
PLoS ONE 6:e27961. 2011..Our aim was to investigate if lysate of probiotic bacterium L. casei DN-114 001 (Lc) could decrease the severity of intestinal inflammation in a murine model of IBD... - The prevalence of coeliac disease in Libyan children with type 1 diabetes mellitusAbdelhakim Ashabani
Department of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Videnska, Prague, Czech Republic
Diabetes Metab Res Rev 19:69-75. 2003..There are no data on the prevalence of CD in the Libyan population and Libyan DM patients. The aim of this study was to test the occurrence of CD-related markers in a group of Libyan children with DM... - Similarity of fine specificity of IgA anti-gliadin antibodies between patients with celiac disease and humanized ?1KI miceDaniel Sanchez
Department of Immunology, Institute of Microbiology, v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Agric Food Chem 59:3092-100. 2011.... - Mucosal immunity: its role in defense and allergyHelena Tlaskalova-Hogenova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Science of the Czech Republic, Prague, Czech Republic
Int Arch Allergy Immunol 128:77-89. 2002.... - Detection of galectin-3 in patients with inflammatory bowel diseases: new serum marker of active forms of IBD?Lenka Frol'ová
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, v v i, Videnska 1083, Prague 4 142 20, Czech Republic
Inflamm Res 58:503-12. 2009..It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease... - Safety and efficacy of the immunosuppressive agent 6-tioguanine in murine model of acute and chronic colitisMiloslav Kverka
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
BMC Gastroenterol 11:47. 2011..Here, we examine the efficacy and toxicity of oral treatment with 6-tioguanine (6-TG) and azathioprine (AZA) in a murine model of IBD... - Colorectal carcinogenesis in germ-free and conventionally reared rats: different intestinal environments affect the systemic immunityLuca Vannucci
Laboratory of Natural Cell Immunity, Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 14220 Prague 4, Czech Republic
Int J Oncol 32:609-17. 2008..The different levels of tolerance/regulatory mechanisms in GF versus the CV animals may modulate the anticancer response not only at the mucosal but also at the systemic immunity level... - Activation of macrophages by gliadin fragments: isolation and characterization of active peptideLudmila Tuckova
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Leukoc Biol 71:625-31. 2002..In contrast, C-terminally shortened peptides had a lower ability to stimulate macrophages than the native form... - Epitopes of calreticulin recognised by IgA autoantibodies from patients with hepatic and coeliac diseaseDaniel Sanchez
Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, 142204 Prague, Czech Republic
J Autoimmun 21:383-92. 2003..Identification of disease specific CRT epitopes contributes to clarification of autoreactivity against this molecule... - Gliadin peptides activate blood monocytes from patients with celiac diseaseJana Cinova
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Clin Immunol 27:201-9. 2007..Thus, gliadin activation of HLA-DQ2(+) monocytes leading to chemokine and proinflammatory cytokine production may contribute to the host innate immune response in celiac disease... - Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaBLenka Jelínková
Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
FEBS Lett 571:81-5. 2004..We propose that gliadin-induced activation of monocytes/macrophages can participate in mechanisms leading to the impairment of intestinal mucosa in coeliac patients... - Specificity analysis of anti-gliadin mouse monoclonal antibodies used for detection of gliadin in food for gluten-free dietDaniel Sanchez
Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, Prague 4, 142 20 Czech Republic
J Agric Food Chem 55:2627-32. 2007..The comparison of data obtained using the newly developed ELISA kit and commercially available ones indicated that Abs selection on the basis of their fine specificity to gliadin is useful for sensitive detection of gliadin in foods... - Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cellsRenata Stepankova
Laboratory of Gnotobiology, Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, Novy Hradek, Czech Republic
Inflamm Bowel Dis 13:1202-11. 2007.... - Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free miceTomas Hrncir
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague and Novy Hradek, Czech Republic
BMC Immunol 9:65. 2008.... - Oral administration of probiotic Escherichia coli after birth reduces frequency of allergies and repeated infections later in life (after 10 and 20 years)Raja Lodinova-Zadnikova
Institute for Care of Mother and Child, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Int Arch Allergy Immunol 131:209-11. 2003.... - Cytokine profiling in human colostrum and milk by protein arrayMiloslav Kverka
Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Clin Chem 53:955-62. 2007..Human colostrum and milk contain components that influence development. Our aim was to use a protein array to determine the cytokine profile of human lacteal secretions and changes that occur during the early postpartum period... - Experimentally induced gluten enteropathy and protective effect of epidermal growth factor in artificially fed neonatal ratsRenata Stepankova
Laboratory of Electron Microscopy, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
J Pediatr Gastroenterol Nutr 36:96-104. 2003.... - Effect of bacterial monoassociation on brush-border enzyme activities in ex-germ-free piglets: comparison of commensal and pathogenic Escherichia coli strainsHana Kozakova
Institute of Microbiology, Department of Immunology and Gnotobiology, Academy of Sciences of the Czech Republic, 549 22 Novy Hradek, Czech Republic
Microbes Infect 8:2629-39. 2006..coli strains. In conclusion, germ-free piglets represent a valuable tool to study the consequences of colonization of the immature sterile gut with defined strains of bacteria... - Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetesDavid P Funda
Division of Immunology and Gnotobiology, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic
Diabetes Metab Res Rev 24:59-63. 2008..In this study we tested hypothesis that early introduction of gluten-enriched (gluten+) diet may increase diabetes incidence in NOD mice... - Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol dietRenata Stepankova
Department of Immunology and Gnotobiology, Institute of Microbiology, vvi, Czech Academy of Sciences, Praque, Czech Republic
J Atheroscler Thromb 17:796-804. 2010..The aim of our work was to determine the influence of intestinal bacteria on the development of atherosclerotic lesions using apolipoprotein E (ApoE)-deficient knockout mice... - Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitisLenka Frolova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
J Histochem Cytochem 56:267-74. 2008..Hence, dysregulation of TLR2, TLR4, and CD14 expression in different parts of the intestinal mucosa may be crucial in IBD pathogenesis...