The basaloid cell is the best tissue marker for human papillomavirus in invasive penile squamous cell carcinoma: a study of 202 cases from ParaguayAntonio L Cubilla
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:104-14. 2010
..Our results also suggest that, in penile SCC, the basaloid cell is the best tissue marker for oncogenic HPV infection...
- Value of p16(INK)?(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases
Antonio L Cubilla
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 35:253-61. 2011
..In this study, we evaluated p16(INK)?(a) immunohistochemical expression, which is simpler and less costly, as a potential marker of high-risk HPV (HR-HPV) infection in penile SCC...
- The role of pathologic prognostic factors in squamous cell carcinoma of the penis
Antonio L Cubilla
Department of Pathology, Facultad de Ciencias Medicas, Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Martín Brizuela 325, Asuncion, Paraguay
World J Urol 27:169-77. 2009
..The aim of this review was to identify prognostic pathologic factors which are independent from other clinical or molecular variables...
- Warty-basaloid carcinoma: clinicopathological features of a distinctive penile neoplasm. Report of 45 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Mod Pathol 23:896-904. 2010
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- Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:385-92. 2010
..Although more studies are necessary to confirm these observations, p16 overexpression seems to be a useful tool for discriminating differentiated from warty, basaloid, and warty-basaloid PeIN...
- Differentiated precursor lesions and low-grade variants of squamous cell carcinomas are frequent findings in foreskins of patients from a region of high penile cancer incidence
Judith Oertell
Instituto de Previsión Social, Asuncion, Paraguay
Histopathology 58:925-33. 2011
..The aims of the present study were to determine the prevalence of various precancerous and cancerous lesions exclusively affecting the foreskin, and to describe their pathological features...
- Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Int J Surg Pathol 18:268-77. 2010
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- Histologic grade in penile squamous cell carcinoma: visual estimation versus digital measurement of proportions of grades, adverse prognosis with any proportion of grade 3 and correlation of a Gleason-like system with nodal metastasis
Alcides Chaux
Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
Am J Surg Pathol 33:1042-8. 2009
..When histologically evaluating penile carcinomas, we recommend a careful search of areas of grade 3. Any focus of grade 3 should be sufficient to grade the neoplasm as a high-grade tumor...
- Warty/basaloid penile intraepithelial neoplasia is more prevalent than differentiated penile intraepithelial neoplasia in nonendemic regions for penile cancer when compared with endemic areas: a comparative study between pathologic series from Paris and P
Ana Soskin
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Hum Pathol 43:190-6. 2012
..Further prospective studies in matched populations and from different geographic regions are needed to further clarify the reasons for this discrepancy...
- Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Am J Surg Pathol 34:223-30. 2010
..Helpful morphologic features for differential diagnosis are provided...
- The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma
Alcides Chaux
Department of Pathology, Instituto de Patologia e Investigacion, Universidad Nacional, Asuncion, Paraguay
Am J Surg Pathol 33:1049-57. 2009
..If sentinel node biopsy cannot be performed for various reasons the Prognostic Index might represent a useful pathologic guide to the clinicians in the often difficult decision to perform an inguinal dissection or not...
- Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases
Alcides Chaux
Instituto de Patologia e Investigacion, Universidad Nacional de Asuncion, Paraguay
Am J Surg Pathol 33:1299-306. 2009
..Re-excision of the recurrent tumor permitted the control of the disease only in one-third of the patients...
- Epithelial lesions associated with invasive penile squamous cell carcinoma: a pathologic study of 288 cases
Antonio L Cubilla
Instituto de Patologia e Investigacion, Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Paraguay
Int J Surg Pathol 12:351-64. 2004
..The association and histologic similarities between high-grade SIL of the basaloid, warty, or mixed forms with their invasive counterparts indicate these lesions are their likely precursors...
- Metastatic tumors to the penis: a report of 17 cases and review of the literature
Alcides Chaux
Instituto de Patologia e Investigacion, Asuncion, Paraguay
Int J Surg Pathol 19:597-606. 2011
..Clinical evidence of penile involvement in a patient with a known malignancy is an ominous sign and should alert the clinicians to the dismal prognosis...
- Developments in the pathology of penile squamous cell carcinomas
Alcides Chaux
Instituto de Patologia e Investigacion, Martín Brizuela 325, Asuncion, Paraguay
Urology 76:S7-S14. 2010
..In addition, recommendations for handling penile cancer specimens, frozen section specimens, and pathology reports are provided...
- Autopsy findings in 14 patients with penile squamous cell carcinoma
Alcides Chaux
Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
Int J Surg Pathol 19:164-9. 2011
..A natural history model for penile cancer routes of spread is proposed: local intrapeneal, regional and systemic nodes, regional skin, liver, lungs, heart, and other multiple sites...
- Carcinoma cuniculatum: a distinctive variant of penile squamous cell carcinoma: report of 7 cases
Jose E Barreto
Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
Am J Surg Pathol 31:71-5. 2007
..Unlike most subtypes of penile SCCs and despite the deep invasion, none of the tumors showed groin or systemic dissemination at time of diagnosis...
- Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinct
Antonio L Cubilla
, Asuncion, Paraguay
Am J Surg Pathol 28:895-900. 2004
..Because it was present in all cases, lichen sclerosus may play a precancerous role...
