Research Topics
| A ArguedasSummaryCountry: Costa Rica Publications
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Publications
Prospective epidemiologic surveillance of invasive pneumococcal disease and pneumonia in children in San José, Costa RicaAdriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Vaccine 30:2342-8. 2012....- Prevenar experienceAdriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Vaccine 29:C26-34. 2011.... - Single-dose extended-release azithromycin versus a 10-day regimen of amoxicillin/clavulanate for the treatment of children with acute otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, PO Box 607 1150, La Uruca, San Jose, Costa Rica
Int J Infect Dis 15:e240-8. 2011..4 mg/kg per day in children with acute otitis media at high risk of persistent or recurrent middle ear infection... - Otitis media across nine countries: disease burden and managementA Arguedas
Instituto de Atención Pediátrica and Universidad de Ciencias Médicas, PO Box 607 1150 La Uruca, San Jose, Costa Rica
Int J Pediatr Otorhinolaryngol 74:1419-24. 2010..To assess the perceived disease burden and management of otitis media (OM) among an international cohort of experienced physicians... - Safety and tolerability of ertapenem versus ceftriaxone in a double-blind study performed in children with complicated urinary tract infection, community-acquired pneumonia or skin and soft-tissue infectionAdriano Arguedas
Instituto de Atención Pediátrica, Universidad de Ciencias Medicas, Instituto Costarricense de Investigaciones Clinicas, San Jose, Costa Rica
Int J Antimicrob Agents 33:163-7. 2009..No serious drug-related laboratory AEs were reported. In children aged 3 months to 17 years, ertapenem was well tolerated and had a comparable safety profile to that of ceftriaxone... - An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, Neeman ICIC, Universidad de Ciencias Medicas, San Jose, Costa Rica
Pediatr Infect Dis J 25:1102-9. 2006..Levofloxacin has excellent activity against common respiratory pathogens and therefore is likely to be effective in treating children with persistent or recurrent otitis media... - Safety and immunogenicity of one dose of MenACWY-CRM, an investigational quadrivalent meningococcal glycoconjugate vaccine, when administered to adolescents concomitantly or sequentially with Tdap and HPV vaccinesA Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Vaccine 28:3171-9. 2010..This is the first demonstration that these currently recommended adolescent vaccines could be administered concomitantly without causing increased reactogenicity... - A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infectionAdriano Arguedas
Instituto de Atención Pediátrica, Neeman ICIC, Hospital Nacional de Ninos, San Jose, Costa Rica
Pediatr Infect Dis J 25:211-8. 2006.... - Middle ear fluid Streptococcus pneumoniae serotype distribution in Costa Rican children with otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Pediatr Infect Dis J 24:631-4. 2005..Previous S. pneumoniae middle ear fluid (MEF) data obtained during the period 1999-2001 from Costa Rican children indicated that serotype 19F was the most common type (75%), but more recently other serotypes have become more prevalent... - Single dose azithromycin for the treatment of uncomplicated otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica and Universidad de Ciencias Médicas, San Jose, Costa Rica
Pediatr Infect Dis J 23:S108-14. 2004..001). We conclude that a single dose of azithromycin (30 mg/kg) is safe and effective for the treatment of uncomplicated AOM in children... - Microbiology of otitis media in Costa Rican children, 1999 through 2001Adriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Pediatr Infect Dis J 22:1063-8. 2003.... - A randomized, multicenter, double blind, double dummy trial of single dose azithromycin versus high dose amoxicillin for treatment of uncomplicated acute otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Pediatr Infect Dis J 24:153-61. 2005..Single dose azithromycin (30 mg/kg) is considered an alternative agent for the treatment of AOM... - Microbiology of acute otitis media in Costa Rican childrenA Arguedas
National Children s Hospital, Universidad Autonoma de Ciencias Medicas, San Jose, Costa Rica
Pediatr Infect Dis J 17:680-9. 1998.... - In vitro activities of levofloxacin and comparable agents against middle ear fluid, nasopharyngeal, and oropharyngeal pathogens obtained from Costa Rican children with recurrent otitis media or failing other antibiotic therapyCarolina Soley
, P.O. Box 607-1150, San Jos, Costa Rica
Antimicrob Agents Chemother 49:3056-8. 2005..Levofloxacin proved to be very active against these pathogens and had intermediate activity against Streptococcus pyogenes... - Invasive pneumococcal disease in Costa Rican children: a seven year surveyRolando Ulloa-Gutierrez
Pediatric Infectious Diseases Division, Hospital Nacional de Niños de Costa Rica Dr Carlos Sáenz Herrera, San Jose, Costa Rica
Pediatr Infect Dis J 22:1069-74. 2003..Although morbidity and mortality associated with invasive pneumococcal disease (IPD) are known to be high in Latin American infants, the current situation for Central American children is unclear... - Activity of trimethoprim-sulfamethoxazole against middle ear fluid pathogens obtained from Costa Rican children with otitis mediaAdriano Arguedas
Instituto de Atención Pediátrica, San Jose, Costa Rica
Pediatr Infect Dis J 24:839-41. 2005..A significant increase in the number of TMP-SMX Streptococcus pneumoniae (P = 0.00008)- and Haemophilus influenzae (P = 0.04)-resistant strains was observed during 2002-2003 when compared with strains from 1992-1997... - Comparative trial of 3 days of azithromycin versus 10 days of clarithromycin in the treatment of children with acute otitis media with effusionA Arguedas
National Children s Hospital, San Jose, Costa Rica
J Chemother 9:44-50. 1997..Based on the efficacy and safety results, azithromycin for 3 days and clarithromycin for 10 days are considered to represent an attractive alternative for the treatment of children with acute otitis media... - Seasonal distribution of otitis media pathogens among Costa Rican childrenSilvia Guevara
Instituto de Atención Pediátrica, San Jose, Costa Rica
Pediatr Infect Dis J 27:12-6. 2008..Otitis media is an important cause of pediatric consultation, and knowledge of yearly pathogen distribution might improve antimicrobial selection... - Understanding the link between pneumococcal serotypes and invasive diseaseCarolina Soley
Instituto de Atención Pediátrica, Universidad de Ciencias Medicas, P O Box 607 1150, San Jose, Costa Rica
Vaccine 27:C19-21. 2009..However, due to evolving epidemiology, there is a need to enhance S. pneumoniae serotype coverage in future generation vaccines, complemented by ongoing surveillance of pneumococcal serotypes following vaccine introduction... - Single-dose azithromycin for the treatment of children with acute otitis mediaCarolin A Soley
, , San Jos, Costa Rica
Expert Rev Anti Infect Ther 3:707-17. 2005..pneumoniae macrolide resistance is uncommon, and for those patients that require directly observed therapy or when compliance may be a problem... - Streptococcus pneumoniae serotype 3 among Costa Rican children with otitis media: clinical, epidemiological characteristics and antimicrobial resistance patternsArturo Abdelnour
Instituto de Atención Pediátrica, San Jose, Costa Rica
BMC Pediatr 9:52. 2009..To describe the clinical, epidemiological and antimicrobial resistance patterns of Costa Rican children with otitis media caused by Streptococcus pneumoniae serotype 3... - Open label, multicenter study of gatifloxacin treatment of recurrent otitis media and acute otitis media treatment failureAdriano Arguedas
Hospital Nacional de Niños and Neeman ICIC, Instituto de Atención Pediátrica, PO Box 6071 1150, San Jose, Costa Rica
Pediatr Infect Dis J 22:949-56. 2003..Newer fluoroquinolones have excellent activity against respiratory pathogens, but their use in children has been limited because of concerns about adverse effects... - An open, multicenter clinical trial of piperacillin/tazobactam in the treatment of pediatric patients with intra-abdominal infectionsA Arguedas
Medicine 1 Department, National Children s Hospital, San Jose, Costa Rica
J Chemother 8:130-6. 1996.... - An open-label, double tympanocentesis, single-center study of trimethoprim sulfametoxasole in children with acute otitis mediaCarolina Soley
Instituto de Atención Pediftrica, San Jose, Costa Rica
Pediatr Infect Dis J 26:273-4. 2007..03). In this study, trimethoprim sulfamethoxasole clinical response was unsatisfactory, especially among culture-'positive children... - Comparison of azithromycin pharmacokinetics following single oral doses of extended-release and immediate-release formulations in children with acute otitis mediaPing Liu
Pfizer Inc, Groton, Connecticut, USA
Antimicrob Agents Chemother 55:5022-6. 2011..These results indicated that a 60-mg/kg single dose of ER azithromycin provides similar or greater systemic exposure in children than the 30-mg/kg single dose of IR azithromycin... - 48th ICAAC/46th IDSA Annual Meeting: a pediatric perspectiveRolando Ulloa-Gutierrez
Servicio de Infectología Pediátrica, Hospital Nacional de Niños de Costa Rica Dr Carlos Sáenz Herrera, PO Box 1654 1000, Avenida Paseo Colón, San Jose, Costa Rica
Expert Rev Vaccines 8:143-7. 2009..This illustrates the importance of continuous surveillance in the epidemiology of vaccine-preventable diseases once a vaccine is licensed and introduced in a given population... - High-dose azithromycin versus high-dose amoxicillin-clavulanate for treatment of children with recurrent or persistent acute otitis mediaAntonio Arrieta
Children's Hospital of Orange County, Orange, California, USA
Antimicrob Agents Chemother 47:3179-86. 2003..095). Corresponding compliance rates were 99 and 93%, respectively (P = 0.018). These data demonstrate the efficacy and safety of high-dose azithromycin for treating recurrent or persistent AOM... - Pneumococcal vaccination for acute otitis mediaAdriano Arguedas
Lancet 367:1897-8; author reply 1898. 2006 - Emergence of penicillin-nonsusceptible Streptococcus pneumoniae clones expressing serotypes not present in the antipneumococcal conjugate vaccineNurith Porat
Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel
J Infect Dis 190:2154-61. 2004..Penicillin-nonsusceptible Streptococcus pneumoniae isolates are confined mainly to a few serogroups. Capsular transformation may serve as a mechanism for spreading antibiotic resistance to new serotypes... - A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis mediaGary J Noel
Johnson and Johnson Pharmaceutical Research and Development, L L C, Raritan, NJ 08869, USA
Pediatr Infect Dis J 27:483-9. 2008..The need for alternative antimicrobial therapy for recurrent and persistent acute otitis media (AOM) in children has raised interest in assessing the efficacy and safety of fluoroquinolones for treatment of these infections... - Comparative safety profile of levofloxacin in 2523 children with a focus on four specific musculoskeletal disordersGary J Noel
Johnson and Johnson Pharmaceutical Research and Development LLC, Raritan, NJ 08869, USA
Pediatr Infect Dis J 26:879-91. 2007..A large prospective trial is needed to assess the risks associated with using levofloxacin in children... - Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in childrenLawrence Sher
Peninsula Research Associates, Rolling Hills Estates, CA, USA
Pediatr Infect Dis J 24:301-8. 2005..There was no evidence of arthrotoxicity or emergence of fluoroquinolone-resistant bacteria in gatifloxacin-treated children... - Potential role of fluoroquinolone therapy in childhood otitis mediaRon Dagan
Pediatric Infectious Disease Unit, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 23:390-8. 2004..Newer 8-methoxyfluoroquinolones may have a role in selected cases associated with multidrug-resistant pathogens... - Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failureMichael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, New York 14642, USA
Clin Infect Dis 41:470-8. 2005..This study describes the safety and efficacy of gatifloxacin when used for treatment of children with recurrent acute otitis media (ROM) or acute otitis media (AOM) treatment failure (AOMTF)... - An international serotype 3 clone causing pediatric noninvasive infections in Israel, Costa Rica, and LithuaniaNurith Porat
Pediatric Infectious Disease Unit, Soroka University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Pediatr Infect Dis J 27:709-12. 2008..The present study was aimed to evaluate the importance of serotype 3 clones in noninvasive infections in Israel, Costa Rica, and Lithuania... - Activity of faropenem against middle ear fluid pathogens from children with acute otitis media in Costa Rica and IsraelKimberley Clawson Stone
Replidyne Inc, 1450 Infinite Drive, Louisville, CO 80027, USA
Antimicrob Agents Chemother 51:2230-5. 2007..Faropenem was also active against Moraxella catarrhalis and Streptococcus pyogenes... - Pharmacokinetics of cefprozil in plasma and middle ear fluid: in children undergoing treatment for acute otitis mediaDavid P Nicolau
Center for Anti Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102 5037, USA
Paediatr Drugs 9:119-23. 2007..Despite the wide-scale use of cefprozil for acute otitis media (AOM), there are only limited data available regarding the pharmacokinetic profile of this agent in the pediatric population... - Pharmacokinetics and pharmacodynamics of gatifloxacin in children with recurrent otitis media: application of sparse sampling in clinical developmentChristopher M Rubino
Institute for Clinical Pharmacodynamics, Ordway Research Institute, Albany, NY 12206, USA
Diagn Microbiol Infect Dis 59:67-74. 2007..In conclusion, population pharmacokinetic/pharmacodynamic methods allowed estimation of drug exposure using one sample per patient... - Comparative study of levofloxacin in the treatment of children with community-acquired pneumoniaJohn S Bradley
Children s Hospital and Health Center, San Diego, CA, USA
Pediatr Infect Dis J 26:868-78. 2007..Levofloxacin has established efficacy and safety in the treatment of community-acquired pneumonia (CAP) in adults, and its use as an alternative therapy for children with CAP has been proposed... - Gatifloxacin therapy for children: turn on the lightRoger Echols
Clin Infect Dis 41:1824-5. 2005