Host immune response in sepsis due to ventilator-associated pneumonia: how is it different?Eirini Christaki
Division of Infectious Diseases, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
Crit Care 13:1009. 2009
..A better understanding of the unique pathophysiologic features of VAP is needed in order to develop interventions that target those specific pathways...
- The kinetics of T regulatory cells in shock: beyond sepsis
Eirini Christaki
Division of Infectious Diseases, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
Crit Care 14:132. 2010
..This suppressive function of T regulatory cells could contribute in a similar way to the profound immune dysfunction seen in critical illness whether the latter is due to sepsis or severe injury...
- Immunomodulatory therapy for sepsis: an update
Eirini Christaki
Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
Expert Rev Anti Infect Ther 9:1013-33. 2011
..Antibiotics, statins and other molecules with multipotent immunomodulatory actions have also been studied in the treatment of sepsis...
- A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia
Eirini Christaki
Infectious Disease Division, Memorial Hospital of RI, The Warren Alpert School of Medicine of Brown University, Providence, Rhode Island, USA
Shock 35:492-8. 2011
..Anti-RAGE monoclonal antibody offered a survival advantage to septic mice. This protective role in treated animals is supported by the observed gene expression profile changes of genes involved in sepsis and inflammation...
- Estrogen receptor beta agonism increases survival in experimentally induced sepsis and ameliorates the genomic sepsis signature: a pharmacogenomic study
Eirini Christaki
Infectious Disease Division, Memorial Hospital of Rhode Island, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island, USA
J Infect Dis 201:1250-7. 2010
..Work reported elsewhere has demonstrated that ERbeta agonists have beneficial effects in multiple (but not all) models of inflammatory diseases and also increase survival in experimentally induced sepsis...
- Receptor for advanced glycation end products in bacterial infection: is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis?
Eirini Christaki
aInfectious Diseases Division, Memorial Hospital of Rhode Island, The Alpert School of Medicine of Brown University, Providence, Rhode Island, USA bDepartment of Microbiology, AHEPA Hospital cSecond Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki, Greece
Curr Opin Infect Dis 25:304-11. 2012
..A novel approach is needed in the treatment of sepsis, one that will aim to correct the specific immunologic imbalance that is detrimental to the septic host...
- Is the mortality rate for septic shock really decreasing?
Eirini Christaki
The Infectious Disease Division, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Curr Opin Crit Care 14:580-6. 2008
..To critically examine the mortality rates of septic shock over the last 25 years to determine if significant improvements have been accomplished...
