N Lee

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi Diagnosis, management and outcomes of adults hospitalized with influenza
    Nelson Lee
    Division of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Antivir Ther 17:143-57. 2012
  2. ncbi Hypercytokinemia and hyperactivation of phospho-p38 mitogen-activated protein kinase in severe human influenza A virus infection
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Clin Infect Dis 45:723-31. 2007
  3. ncbi Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults
    Nelson Lee
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e26050. 2011
  4. ncbi Factors associated with early hospital discharge of adult influenza patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Antivir Ther 12:501-8. 2007
  5. ncbi Risk factors associated with life-threatening rickettsial infections
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Trop Med Hyg 78:973-8. 2008
  6. ncbi Acute encephalopathy associated with influenza A infection in adults
    Nelson Lee
    Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9 F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People s Republic of China
    Emerg Infect Dis 16:139-42. 2010
  7. ncbi Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Virol 40:333-7. 2007
  8. ncbi Outcomes of adults hospitalised with severe influenza
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Thorax 65:510-5. 2010
  9. ncbi Interferon gamma release assay for differentiating tuberculosis among pneumonia cases in acute healthcare setting
    G Lui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Infect 62:440-7. 2011
  10. ncbi Features discriminating SARS from other severe viral respiratory tract infections
    T H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Rooms 107 113, 1st Floor, Shatin, NT, Hong Kong
    Eur J Clin Microbiol Infect Dis 26:121-9. 2007

Detail Information

Publications64

  1. ncbi Diagnosis, management and outcomes of adults hospitalized with influenza
    Nelson Lee
    Division of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Antivir Ther 17:143-57. 2012
    ....
  2. ncbi Hypercytokinemia and hyperactivation of phospho-p38 mitogen-activated protein kinase in severe human influenza A virus infection
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    Clin Infect Dis 45:723-31. 2007
    ..We postulate that hypercytokinemia plays a role in immunopathogenesis of severe human influenza...
  3. ncbi Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults
    Nelson Lee
    Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Special Administrative Region, People s Republic of China
    PLoS ONE 6:e26050. 2011
    ..Studying cytokine/chemokine responses in severe influenza infections caused by different virus subtypes may improve understanding on pathogenesis...
  4. ncbi Factors associated with early hospital discharge of adult influenza patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Antivir Ther 12:501-8. 2007
    ..Understanding factors affecting length of hospital stay (LOS) in patients with severe influenza may improve their management...
  5. ncbi Risk factors associated with life-threatening rickettsial infections
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Am J Trop Med Hyg 78:973-8. 2008
    ..014). Treatment with fluoroquinolone/clarithromycin did not correlate with clinical outcomes (P > 0.05). Early empirical doxycycline therapy should be considered if clinico-epidemiologic signs of rickettsial infections are present...
  6. ncbi Acute encephalopathy associated with influenza A infection in adults
    Nelson Lee
    Division of Infectious Diseases, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, 9 F Clinical Sciences Building, Department of Medicine and Therapeutics, Shatin, Hong Kong, People s Republic of China
    Emerg Infect Dis 16:139-42. 2010
    ..Patients recovered without sequelae. Hyperactivated cytokine response may play a role in pathogenesis...
  7. ncbi Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    J Clin Virol 40:333-7. 2007
    ..The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown...
  8. ncbi Outcomes of adults hospitalised with severe influenza
    N Lee
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Thorax 65:510-5. 2010
    ..The aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza...
  9. ncbi Interferon gamma release assay for differentiating tuberculosis among pneumonia cases in acute healthcare setting
    G Lui
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    J Infect 62:440-7. 2011
    ..Early diagnosis of smear-negative tuberculosis remains challenging. The role of an interferon-gamma release assay (IGRA) in discriminating active pulmonary tuberculosis (PTB) among cases of 'pneumonia' was investigated...
  10. ncbi Features discriminating SARS from other severe viral respiratory tract infections
    T H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Rooms 107 113, 1st Floor, Shatin, NT, Hong Kong
    Eur J Clin Microbiol Infect Dis 26:121-9. 2007
    ..9-96.9). Certain clinical manifestations and laboratory changes may help to distinguish SARS from other influenza-like illnesses. Scoring systems may help identify patients who should receive more specific tests for influenza or SARS...
  11. ncbi Thin-section CT in patients with severe acute respiratory syndrome following hospital discharge: preliminary experience
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30-32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:810-5. 2003
    ..Patients who are older and have more severe disease during treatment are more likely to develop thin-section CT findings of fibrosis...
  12. ncbi Disease severity prediction for nursing home-acquired pneumonia in the emergency department
    S Y Man
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR
    Emerg Med J 28:1046-50. 2011
    ..0%) and R-ATS (100%) improved greatly with negative likelihood ratios of <0.1. Conclusion PSI and CURB-65 are useful for identification of patients with less severe NHAP...
  13. ncbi Cryptococcosis in apparently immunocompetent patients
    G Lui
    Division of Infectious Diseases, Department of Medicine and Therapeutics, 9/F Clinical Sciences Building, Prince of Wales Hospital, Hong Kong
    QJM 99:143-51. 2006
    ..C. neoformans var. grubii and C. gattii are the common causes. Immunocompetent patients tend to present with localized, indolent neurological disease, with more intense inflammatory responses but better clinical outcomes...
  14. ncbi Cardiovascular complications of severe acute respiratory syndrome
    C M Yu
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong
    Postgrad Med J 82:140-4. 2006
    ..Severe acute respiratory syndrome (SARS) is a virulent viral infection that affects a number of organs and systems. This study examined if SARS may result in cardiovascular complications...
  15. ncbi Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients
    Ignatius T S Yu
    Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, China
    Clin Infect Dis 40:1237-43. 2005
    ..We report the temporal-spatial spread of severe acute respiratory syndrome (SARS) among inpatients in a hospital ward during a major nosocomial outbreak and discuss possible mechanisms for the outbreak...
  16. ncbi Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
    K C Allen Chan
    The Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    BMC Infect Dis 5:26. 2005
    ..Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients...
  17. ncbi Fecal detection of influenza A virus in patients with concurrent respiratory and gastrointestinal symptoms
    Martin C W Chan
    Institute of Digestive Disease, Chinese University of Hong Kong, Hong Kong Special Administrative Region, People s Republic of China
    J Clin Virol 45:208-11. 2009
    ..In seasonal influenza, gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain are sometimes observed, especially among young children. However, fecal excretion of seasonal influenza virus has seldom been studied...
  18. ncbi Clinical management of pandemic 2009 influenza A(H1N1) infection
    David S Hui
    Division of Respiratory Medicine, The Chinese University of Hong Kong, 9 F, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong
    Chest 137:916-25. 2010
    ..Nonpharmacologic measures, such as early case isolation, household quarantine, school/workplace closure, good community hygiene, and restrictions on travel are useful measures in controlling an influenza pandemic at its early phase...
  19. ncbi Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others?
    Ignatius T Yu
    Centre for Emerging Infectious Disease, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
    Clin Infect Dis 44:1017-25. 2007
    ..We systematically analyzed the risk factors for nosocomial outbreaks of SARS among hospital wards in Guangzhou and Hong Kong, China...
  20. ncbi Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections
    Margaret Ip
    Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
    Diagn Microbiol Infect Dis 59:131-6. 2007
    ..857, whereas (CRP x PCT)/neopterin was 0.856. Combination of 2 or all 3 of the biomarkers may improve the discriminatory power in delineating bacterial versus viral etiology in LRTI...
  21. ncbi A comparison of three transarterial lipiodol-based formulations for hepatocellular carcinoma: in vivo biodistribution study in humans
    Simon Chun Ho Yu
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing Street, Shatin, New Territories, Hong Kong
    Cardiovasc Intervent Radiol 31:289-98. 2008
    ..013). This study showed that LEM is associated with a greater embolic effect in intrahepatic HCC at 4 weeks, and a comparable degree of lung shunting and decomposition rates, compared with ethanol-free Lipiodol formulations...
  22. ncbi Diagnostic utility of CRP to neopterin ratio in patients with acute respiratory tract infections
    Timothy H Rainer
    Accident and Emergency Academic Unit, Chinese University of Hong Kong, Prince of Wales Hospital, New Territories, Hong Kong
    J Infect 58:123-30. 2009
    ....
  23. ncbi Failure to confirm HIV infection in two end-stage HIV/AIDS patients using a popular commercial line immunoassay
    Julian W Tang
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR
    J Med Virol 80:1515-22. 2008
    ..This report highlights the utility of having NAT available when diagnosing difficult cases of HIV infection, especially in light of the recent Centers for Disease Control and Prevention move towards more universal, routine, HIV testing...
  24. ncbi Severe acute respiratory syndrome-associated coronavirus infection
    Paul K S Chan
    The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Emerg Infect Dis 9:1453-4. 2003
    ..None of these healthcare workers had antibody to SARS CoV, indicating that subclinical or mild infection attributable to SARS-CoV in adults is rare...
  25. ncbi The spectrum of severe acute respiratory syndrome-associated coronavirus infection
    Timothy H Rainer
    Accident and Emergency Medicine Academic Unit, The Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Ann Intern Med 140:614-9. 2004
    ..Objectives: To describe the spectrum of SARS coronavirus infection in a large outbreak and to compare diagnoses based on clinical judgment with the SARS coronavirus test...
  26. ncbi Immunofluorescence assay for serologic diagnosis of SARS
    Paul K S Chan
    Department of Microbiology, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, People s Republic of China
    Emerg Infect Dis 10:530-2. 2004
    ..Sensitivity and specificity of this assay were both 100%. Immunofluorescence assay can ascertain the status of SARS-CoV infection...
  27. ncbi Laboratory diagnosis of SARS
    Paul K S Chan
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    Emerg Infect Dis 10:825-31. 2004
    ..Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity...
  28. ncbi Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection
    Wai K Leung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Gastroenterology 125:1011-7. 2003
    ..Herein, we describe the clinical, pathologic, and virologic features of the intestinal involvement of this new viral infection...
  29. ncbi Imaging of severe acute respiratory syndrome in Hong Kong
    Gregory E Antonio
    Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, Chinese University of Hong Kong, 30-32 Ngan Shing St, Shatin, Hong Kong, Republic of China
    AJR Am J Roentgenol 181:11-7. 2003
  30. ncbi Human metapneumovirus detection in patients with severe acute respiratory syndrome
    Paul K S Chan
    Faculty of Medicine of the Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    Emerg Infect Dis 9:1058-63. 2003
    ..These widely available HEp-2 cells should be included in conjunction with a molecular method for cell culture followup to detect HMPV, particularly in patients with SARS...
  31. ncbi Seroprevalence of antibody to severe acute respiratory syndrome (SARS)-associated coronavirus among health care workers in SARS and non-SARS medical wards
    Margaret Ip
    Department of Microbiology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Clin Infect Dis 38:e116-8. 2004
    ..Rates for clinical SARS-CoV infection among 742 HCWs on these wards were highest among nurses (11.6%) and health care assistants (11.8%), indicating that these occupations are associated with the highest risks for exposure...
  32. ncbi Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak
    J J Y Sung
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong
    Thorax 59:414-20. 2004
    ..CONCLUSION: The use of high dose pulse methylprednisolone during the clinical course of a SARS outbreak was associated with clinical improvement, but randomised controlled trials are needed to ascertain its efficacy in this condition...
  33. ncbi Role of laboratory variables in differentiating SARS-coronavirus from other causes of community-acquired pneumonia within the first 72 h of hospitalization
    N Lee
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Eur J Clin Microbiol Infect Dis 25:765-72. 2006
    ....
  34. ncbi Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome
    Enders K O Ng
    Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China
    Clin Chem 49:1976-80. 2003
    ..998; P <0.001). CONCLUSION: Plasma/serum SARS-CoV quantification represents a potentially useful early diagnostic and prognostic tool for SARS...
  35. ncbi Fecal viral concentration and diarrhea in norovirus gastroenteritis
    Nelson Lee
    Prince of Wales Hospital, Hong Kong Special Administrative Region, People s Republic of China
    Emerg Infect Dis 13:1399-401. 2007
    ..Higher viral concentration and older age were independently associated with prolonged diarrhea (> or =4 days). These findings provide information on the pathogenesis and transmission of norovirus infections...
  36. ncbi Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period
    Ka-Tak Wong
    Department of Diagnostic Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong, China
    J Comput Assist Tomogr 28:790-5. 2004
    ....
  37. ncbi Allele-specific conventional reverse-transcription polymerase chain reaction as a screening assay for discriminating influenza a H1N1 (H275Y) oseltamivir-resistant and wild-type viruses
    Karry L K Ngai
    Faculty of Medicine, Department of Microbiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administration Region, China
    J Med Virol 82:1295-8. 2010
    ..Further improvement in performance is expected when applied to cell culture isolates with a higher viral titer. These allele-specific cRT-PCR assays can be a simple, low-cost option for large-scale screening of influenza isolates...
  38. ncbi Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China
    J Clin Virol 31:304-9. 2004
    ..CONCLUSION: Our findings suggested "early" corticosteroid treatment was associated with a higher subsequent plasma viral load...
  39. ncbi Preventing healthcare workers from acquiring influenza
    Tak Ching Ng
    Department of Medicine and Therapeutics, Prince of Wales Hospital, and the Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong
    Infect Control Hosp Epidemiol 30:292-5. 2009
    ..56) during high-risk procedures, and failure to receive influenza vaccination (odds ratio, 4.82) were independent risk factors, adjusted for household contacts...
  40. ncbi Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome
    Nelson Lee
    Department of Medicine and Therapeutics, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, 30-32 Ngan Shing Street, Shatin, NT, Hong Kong, PR China
    J Clin Virol 35:179-84. 2006
    ..004), and lymphopenia at presentation (p=0.028). Peak IgG titres also correlated positively with peak LDH levels (Spearman's r=+0.360; p<0.001) among survivors. CONCLUSIONS: Severe SARS is associated with a more robust IgG response...
  41. ncbi Cytokine responses in a severe case of glandular fever treated successfully with foscarnet combined with prednisolone and intravenous immunoglobulin
    Christine Ma
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China
    J Med Virol 81:99-105. 2009
    ..Detailed immunological, virological, haematological and biochemical laboratory parameters are presented to document this patient's severe EBV disease and eventual recovery...
  42. ncbi Viral loads and duration of viral shedding in adult patients hospitalized with influenza
    Nelson Lee
    Department of Medicine and Therapeutics, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Infect Dis 200:492-500. 2009
    ..The goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza...
  43. ncbi Fever, pulmonary haemorrhage, and acute renal failure in a young girl
    F W T Cheng
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 11:408-10. 2005
    ..She presented with fever, hypotension, jaundice, and acute renal failure. She had used well water for bathing and swum in freshwater...
  44. ncbi Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys
    Josette S Y Chor
    School of Public Health and Primary Care, Chinese University of Hong Kong, School of Public Health, Prince of Wales Hospital, Shatin, Hong Kong
    BMJ 339:b3391. 2009
    ..To assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals in Hong Kong and the effect of escalation in the World Health Organization's alert level for an influenza pandemic...
  45. ncbi Development and comparison of molecular assays for the rapid detection of the pandemic influenza A (H1N1) 2009 virus
    Wai Yip Lam
    Faculty of Medicine, Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, People s Republic of China
    J Med Virol 82:675-83. 2010
    ..The newly developed cRT-PCR assay targeting the HA gene allows rapid, specific, and sensitive screening of this novel agent, which can serve as an alternative for laboratories where a real-time PCR machine is not available...
  46. ncbi Role of 'atypical pathogens' among adult hospitalized patients with community-acquired pneumonia
    Grace Lui
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Respirology 14:1098-105. 2009
    ..This study examined the role of these 'atypical pathogens' (AP) among adult hospitalized patients with CAP...
  47. ncbi Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease
    K T Wong
    Department of Diagnostic Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:395-400. 2003
    ..To retrospectively analyze the thin-section computed tomographic (CT) features in patients with severe acute respiratory syndrome (SARS) at the authors' institution...
  48. ncbi Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS)
    G M-K Tse
    Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing Street, Shatin, NT, Hong Kong SAR, China
    J Clin Pathol 57:260-5. 2004
    ....
  49. ncbi Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis
    Raymond S M Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China
    BMJ 326:1358-62. 2003
    ..CONCLUSIONS: Abnormal haematological variables were common among patients with SARS. Lymphopenia and the depletion of T lymphocyte subsets may be associated with disease activity...
  50. ncbi Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients
    K T Wong
    Department of Diagnostic Radiology, Prince of Wales Hospital, Chinese University of Hong Kong, 30 32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 228:401-6. 2003
    ..To retrospectively evaluate the radiographic appearances and pattern of progression of severe acute respiratory syndrome (SARS)...
  51. ncbi Prospective comparison of three predictive rules for assessing severity of community-acquired pneumonia in Hong Kong
    Shin Yan Man
    Accident and Emergency Medicine Academic Unit, Chinese University of Hong Kong, Trauma and Emergency Centre, Prince of Wales Hospital, Shatin, NT, Hong Kong
    Thorax 62:348-53. 2007
    ..Community-acquired pneumonia (CAP) is a leading infectious cause of death throughout the world, including Hong Kong...
  52. ncbi Rates of disease progression among human immunodeficiency virus-infected persons initiating multiple-drug rescue therapy
    Nelson Lee
    British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada
    J Infect Dis 188:137-41. 2003
    ..Over the short-term, patients receiving MDRT had relatively low mortality. After adjustment for baseline prognostic factors, rates of survival were comparable with those in patients initiating triple-drug ART...
  53. ncbi Diagnostic criteria during SARS outbreak in Hong Kong
    Louis Y Chan
    Emerg Infect Dis 10:1168-70. 2004
  54. ncbi Provider bias in the selection of non-nucleoside reverse transcriptase inhibitor and protease inhibitor-based highly active antiretroviral therapy and HIV treatment outcomes in observational studies
    Evan Wood
    BC Centre for Excellence in HIV/AIDS, St Paul's Hospital, Vancouver, Canada
    AIDS 17:2629-34. 2003
    ..As such, it is likely that similar selection factors may explain why our findings contrast with several non-randomized studies showing worse clinical outcomes of patients prescribed nevirapine...
  55. ncbi Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malaria
    Nelson Lee
    Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and School of Population Health, University of Queensland, Queensland, Australia
    J Clin Microbiol 44:2773-8. 2006
    ..These findings support the role of sequence variation as an explanation for variations in the performance of HRP2-based RDTs and point toward possible approaches to improve their diagnostic sensitivities...
  56. ncbi A major outbreak of severe acute respiratory syndrome in Hong Kong
    Nelson Lee
    Department of Medicine, Chinese University of Hong Kong, Hong Kong, China
    N Engl J Med 348:1986-94. 2003
    ..60; 95 percent confidence interval, 1.03 to 2.50; P=0.04). CONCLUSIONS: SARS is a serious respiratory illness that led to significant morbidity and mortality in our cohort...
  57. ncbi Clinical significance of hepatic derangement in severe acute respiratory syndrome
    Henry-Lik-Yuen Chan
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, China
    World J Gastroenterol 11:2148-53. 2005
    ..Chronic hepatitis B was not associated with worse clinical outcomes. CONCLUSION: Reactive hepatitis is a common complication of SARS-coronavirus infection. Those patients with severe hepatitis had worse clinical outcome...
  58. ncbi Penicilliosis: an AIDS-defining disease in Asia
    Nelson Lee
    Hong Kong Med J 14:88-9. 2008
  59. ncbi Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome
    Ka Hing Wong
    Integrated Treatment Centre, Special Preventive Programme, Centre for Health Protection, Department of Health, Kowloon, Hong Kong
    J Microbiol Immunol Infect 40:173-7. 2007
    ..This report describes the case of 2 AIDS patients with EBV-associated SMT and highlights the features and outcome of this rare but potentially important tumor in human immunodeficiency virus management...
  60. ncbi Severe acute respiratory syndrome: correlation between clinical outcome and radiologic features
    David S C Hui
    Department of Diagnostic Radiology and Organ Imaging, The Chinese Univ of Hong Kong, Prince of Wales Hosp, 30-32 Ngan Shing St, Shatin, Hong Kong SAR
    Radiology 233:579-85. 2004
    ..CONCLUSION: More extensive airspace disease at presentation is an independent predictor of adverse outcome in patients with SARS...
  61. ncbi Retrospective analysis of liver function derangement in severe acute respiratory syndrome
    Henry L Y Chan
    Am J Med 116:566-7. 2004
  62. ncbi Chikungunya fever, Hong Kong
    Nelson Lee
    Emerg Infect Dis 12:1790-2. 2006
  63. ncbi Clinical role of beta-lactam/beta-lactamase inhibitor combinations
    Nelson Lee
    Division of Clinical Pharmacology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
    Drugs 63:1511-24. 2003
    ..In certain scenarios, they could even be more cost-effective than conventional combination therapies. With the accumulation of so much clinical experience, their role in the management of infections is now becoming more clearly defined...
  64. ncbi Cytokine profile in fatal human immunodeficiency virus tuberculosis Epstein-Barr virus associated hemophagocytic syndrome
    Chun K Wong
    Arch Intern Med 167:1901-3. 2007