Y Huang

Summary

Affiliation: The Chinese University of Hong Kong
Country: China

Publications

  1. ncbi Relaxing effects of Ligstrum purpurascens extract and purified acteoside in rat aortic rings
    I Y Wong
    Department of Biochemistry, Chinese University of Hong Kong, Hong Kong, China
    Planta Med 67:317-21. 2001
  2. ncbi Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions
    Y Huang
    Department of Physiology, The Chinese University of Hong Kong, Shatin
    Naunyn Schmiedebergs Arch Pharmacol 362:152-9. 2000
  3. ncbi Modulatory effect of protein kinase C activator on contractility of rat vas deferens
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Pharmacology 62:2-9. 2001
  4. ncbi Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, PR China
    Biochem Pharmacol 67:787-94. 2004
  5. ncbi Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Cardiovasc Res 57:824-33. 2003
  6. ncbi Role of endothelium in thapsigargin-induced arterial responses in rat aorta
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Eur J Pharmacol 392:51-9. 2000
  7. ncbi Identification of calcium-activated potassium channels in cultured equine sweat gland epithelial cells
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Exp Physiol 84:881-95. 1999
  8. ncbi Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Faculty of Medicine, Shatin, Hong Kong
    Biochim Biophys Acta 1427:322-8. 1999
  9. ncbi Contribution of nitric oxide and K+ channel activation to vasorelaxation of isolated rat aorta induced by procaine
    Y Huang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, NT
    Eur J Pharmacol 367:231-7. 1999
  10. ncbi Prejunctionally mediated inhibition of neurotransmission by isoprenaline in rat vas deferens
    Y Huang
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Life Sci 63:2107-13. 1998

Collaborators

Detail Information

Publications126 found, 100 shown here

  1. ncbi Relaxing effects of Ligstrum purpurascens extract and purified acteoside in rat aortic rings
    I Y Wong
    Department of Biochemistry, Chinese University of Hong Kong, Hong Kong, China
    Planta Med 67:317-21. 2001
    ..The inhibitory effect on endothelial nitric oxide-mediated relaxation suggests that acteoside could also act on the endothelial cells to reduce nitric oxide release...
  2. ncbi Abolition of endothelium-dependent relaxation in the rat aorta by tetraoctylammonium ions
    Y Huang
    Department of Physiology, The Chinese University of Hong Kong, Shatin
    Naunyn Schmiedebergs Arch Pharmacol 362:152-9. 2000
    ..Changes in contractile force were measured by force transducers and total tissue content of cGMP was measured by radioimmunoassay. Endothelial cytosolic Ca2+ ([Ca2+]i) was assessed by laser scanning confocal microscopy...
  3. ncbi Modulatory effect of protein kinase C activator on contractility of rat vas deferens
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Pharmacology 62:2-9. 2001
    ....
  4. ncbi Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, PR China
    Biochem Pharmacol 67:787-94. 2004
    ..Our results indicate that baicalin and baicalein attenuated NO-mediated aortic relaxation and cyclic GMP increases, likely through inhibition of NO-dependent guanylate cyclase activity...
  5. ncbi Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Cardiovasc Res 57:824-33. 2003
    ..The present study aimed to examine the role of cyclic AMP and Ca(2+)-activated K(+) channels in the relaxant response to urocortin in the isolated endothelium-denuded rat left anterior descending coronary arteries...
  6. ncbi Role of endothelium in thapsigargin-induced arterial responses in rat aorta
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
    Eur J Pharmacol 392:51-9. 2000
    ..Activation of TPA(+)- and Ba(2+)-sensitive but not Ca(2+)-activated or ATP-sensitive K(+) channels may be also involved in thapsigargin-induced relaxation of rat isolated aortic rings...
  7. ncbi Identification of calcium-activated potassium channels in cultured equine sweat gland epithelial cells
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Exp Physiol 84:881-95. 1999
    ..However, the channel could be activated in a regulated manner. The K+ channels may play a role in transepithelial fluid secretion in sweat gland...
  8. ncbi Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Faculty of Medicine, Shatin, Hong Kong
    Biochim Biophys Acta 1427:322-8. 1999
    ..In addition, there may be a causal link between increased Ca2+ levels and nitric oxide release in response to (-)epicatechin...
  9. ncbi Contribution of nitric oxide and K+ channel activation to vasorelaxation of isolated rat aorta induced by procaine
    Y Huang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, NT
    Eur J Pharmacol 367:231-7. 1999
    ..Besides, procaine may directly inhibit both external Ca2+ entry and internal Ca2+ release in aortic smooth muscle cells...
  10. ncbi Prejunctionally mediated inhibition of neurotransmission by isoprenaline in rat vas deferens
    Y Huang
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Life Sci 63:2107-13. 1998
    ..Lack of effect of isoprenaline on agonist-induced contraction does not favour a functional role of beta-adrenoceptors in vas smooth muscle...
  11. ncbi Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT
    Life Sci 63:275-83. 1998
    ..The protein kinase C-dependent contractile pathway and intracellular Ca2+ release may not be involved...
  12. ncbi Urocortin and cardiovascular protection
    Yu Huang
    Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China
    Acta Pharmacol Sin 25:257-65. 2004
    ..This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action...
  13. ncbi Role of endothelium/nitric oxide in vascular response to flavonoids and epicatechin
    Y Huang
    Departments of Physiology and Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Acta Pharmacol Sin 21:1119-24. 2000
    ..To examine the role of endothelium in the vascular responses to flavonoids, baicalein, baicalin, cardamonin, alpinetin, and to purified jasmine green tea (-)epicatechin in the isolated rate mesenteric artery rings...
  14. ncbi Inhibitory effect of tetrabutylammonium ions on endothelium/nitric oxide-mediated vasorelaxation
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, People s Republic of China
    Life Sci 69:1661-72. 2001
    ..The inhibitory effect on pinacidil- and cromakalim-induced relaxation suggests that tetrabutylammonium ions also inhibit ATP-sensitive K+ channels in aortic smooth muscle cells...
  15. ncbi Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels
    Yu Huang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 135:1467-76. 2002
    ..The urocortin-induced endothelium-dependent relaxation appears to be mediated by cyclic GMP-dependent mechanisms...
  16. ncbi Baicalin-induced vascular response in rat mesenteric artery: role of endothelial nitric oxide
    Yu Huang
    Departments of Physiology and Biochemistry, Chinese University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 29:721-4. 2002
    ....
  17. ncbi Beta-adrenoceptor-mediated relaxation inhibited by tetrapentylammonium ions in rat mesenteric artery
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT
    Life Sci 62:PL19-25. 1998
    ..The present results suggest that the activation of TPA+-sensitive K+ channels contributes toward the relaxations mediated through beta- and beta2-adrenoceptor stimulation in rat mesenteric arteries...
  18. ncbi Biological properties of baicalein in cardiovascular system
    Yu Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Curr Drug Targets Cardiovasc Haematol Disord 5:177-84. 2005
    ..The pharmacological findings have highlighted the therapeutic potentials of using plant-derived baicalein and its analogs for the treatment of arteriosclerosis and hypertension...
  19. ncbi Hydroxylamine-induced relaxation inhibited by K+ channel blockers in rat aortic rings
    Y Huang
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, China
    Eur J Pharmacol 349:53-60. 1998
    ..The endothelium is not involved in the aortic response to hydroxylamine...
  20. ncbi Role of endothelium and K+ channels in dobutamine-induced relaxation in rat mesenteric artery
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, China
    Clin Exp Pharmacol Physiol 25:405-11. 1998
    ..Higher concentrations of dobutamine may have a direct, endothelium-independent relaxant effect...
  21. ncbi A protein kinase G-sensitive channel mediates flow-induced Ca(2+) entry into vascular endothelial cells
    X Yao
    Department of Physiology, Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    FASEB J 14:932-8. 2000
    ....
  22. ncbi Endothelium-dependent rhythmic contractions induced by cyclopiazonic acid in rat mesenteric artery
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Eur J Pharmacol 332:167-72. 1997
    ....
  23. ncbi Different role of endothelium/nitric oxide in 17beta-estradiol- and progesterone-induced relaxation in rat arteries
    H Y Chan
    Department of Physiology, Chinese University of Hong Kong, People's Republic of China
    Life Sci 69:1609-17. 2001
    ..Nitric oxide contributes largely to the endothelium-dependent relaxation induced by 17beta-estradiol in the isolated aortas or by progesterone in the mesenteric arteries...
  24. ncbi The relaxant effect of urocortin in rat pulmonary arteries
    Y C Chan
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Regul Pept 121:11-8. 2004
    ..Stimulation of Ba2+-sensitive K+ channel may contribute to urocortin-induced relaxation. Finally, urocortin relaxed pulmonary arteries partly via inhibition of a PKC-dependent contractile mechanism...
  25. ncbi Raloxifene protects endothelial cell function against oxidative stress
    C M Wong
    Institute of Vascular Medicine and Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 155:326-34. 2008
    ..This study tested the hypothesis that raloxifene, a selective oestrogen receptor modulator, can prevent endothelial dysfunction under oxidative stress...
  26. ncbi Effect of 17beta-estradiol exposure on vasorelaxation induced by K(+) channel openers and Ca(2+) channel blockers
    S Y Tsang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, PR China
    Pharmacology 65:26-31. 2002
    ..These results suggest that acute exposure to female sex steroid hormones at near physiological levels may reduce the activity of ATP-sensitive K(+) channels in the rat arteries...
  27. ncbi Therapeutic concentrations of raloxifene augment nitric oxide-dependent coronary artery dilatation in vitro
    F P Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 152:223-9. 2007
    ..This study examines the hypothesis that therapeutic concentrations of raloxifene augment endothelium-dependent relaxation via up-regulation of eNOS expression and activity in porcine coronary arteries...
  28. ncbi Stimulation of chloride secretion by baicalein in isolated rat distal colon
    W H Ko
    Department of Physiology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Am J Physiol Gastrointest Liver Physiol 282:G508-18. 2002
    ..Baicalein may stimulate Cl(-) secretion via a cAMP-independent pathway or have a direct effect on cystic fibrosis transmembrane conductance regulator...
  29. ncbi cGMP abolishes agonist-induced [Ca(2+)](i) oscillations in human bladder epithelial cells
    H Y Kwan
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    Am J Physiol Renal Physiol 281:F1067-74. 2001
    ..Therefore, it is likely that cGMP and PKG may target a signal transduction step(s) linked to IP(3) receptor-mediated Ca(2+) release...
  30. ncbi Tamoxifen dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanisms
    H S Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 149:703-11. 2006
    ..NO activates Na+/K+ -ATPase in vascular smooth muscle, leading to relaxation. These results suggest that tamoxifen is able to modulate eNOS phosphorylation directly...
  31. ncbi BaCl2- and 4-aminopyridine-evoked phasic contractions in the rat vas deferens
    Y Huang
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT
    Br J Pharmacol 115:845-51. 1995
    ..4-Aminopyridine-induced action, however, was largely mediated by neurotransmitters released from the depolarized nerve terminals as a result of blockade of K+ channels...
  32. ncbi Rosuvastatin improves endothelial function in db/db mice: role of angiotensin II type 1 receptors and oxidative stress
    X Y Tian
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Hong Kong, China
    Br J Pharmacol 164:598-606. 2011
    ..The present study aimed to investigate the cellular mechanisms responsible for the therapeutic benefits of rosuvastatin in ameliorating diabetes-associated endothelial dysfunction...
  33. ncbi Studies on vasorelaxation by tetrapentylammonium ions in rat aortic rings
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Life Sci 61:1811-7. 1997
    ..These results indicate that TPA+ could act as a non-selective relaxant in arterial smooth muscle. This vasorelaxant effect is unique for TPA+ since other quaternary ammonium ions did not show the similar action in the rat aorta...
  34. ncbi Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle
    Y Huang
    Department of Physiology, Chinese University of Hong Kong
    Br J Pharmacol 117:533-539. 1996
    ....
  35. ncbi Tea polyphenols benefit vascular function
    L M Yung
    Institute of Vascular Medicine and Department of Physiology, Chinese University of Hong Kong Shatin, NT, Hong Kong
    Inflammopharmacology 16:230-4. 2008
    ..We will briefly discuss the effects of tea on atherosclerosis and hypertension...
  36. ncbi Stretch-sensitive switching among different channel sublevels of an endothelial cation channel
    X Yao
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, PR China
    Biochim Biophys Acta 1511:381-90. 2001
    ..This is the first demonstration showing that mechanostress can change the single channel conductance level of an ion channel in eukaryotic cells...
  37. ncbi Antioxidative activities of phenylethanoid glycosides from Ligustrum purpurascens
    I Y Wong
    Departments of Biochemistry and Physiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China
    J Agric Food Chem 49:3113-9. 2001
    ..The present results suggest that the bitter tea beverage derived from LP contains effective antioxidants that may have an equal benefit as a green tea beverage...
  38. ncbi Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation
    Yau Chi Chan
    Institute of Vascular Medicine, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:992-9. 2010
    ..The present study aimed to examine roles of Ca(2+) influx in endothelium and endothelial nitric oxide synthase (eNOS) activation in dilatations induced by raloxifene, a second-generation SERM in myogenically active arteries...
  39. ncbi Cyclic nucleotides and Ca2+ influx pathways in vascular endothelial cells
    H Y Kwan
    Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China
    Clin Hemorheol Microcirc 37:63-70. 2007
    ..Special emphasis will be placed on the regulation of agonist-induced Ca(2+) influx by protein kinase G (PKG). Flow-induced Ca(2+) influx in relation to vascular dilation and the vasodilator produced will also be discussed...
  40. ncbi Store-operated calcium entry in vascular smooth muscle
    F P Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 153:846-57. 2008
    ..We propose a possible hypothesis for its activation and suggest that SOCE may represent a novel target for pharmacological therapeutic intervention...
  41. ncbi Inhibition of anti-IgE mediated human mast cell activation by NO donors is dependent on their NO release kinetics
    K H Yip
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
    Br J Pharmacol 156:1279-86. 2009
    ..Although the mast cell is a source of nitric oxide (NO), the effect of NO on human mast cells has not been defined. This study investigated if exogenous NO could affect human mast cell activation...
  42. ncbi Separate activation of intracellular Ca2+ release, voltage-dependent and receptor-operated Ca2+ channels in the rat aorta
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Chin J Physiol 39:1-8. 1996
    ..However, Ca2+ influx via ROCCs makes a small contribution to the noradrenaline-induced contractile response...
  43. ncbi Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta
    W T Wong
    Institute of Vascular Medicine and School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Nutr Metab Cardiovasc Dis 21:157-64. 2011
    ..Our aim was to investigate the effects of individual oxidized components at concentrations similar to those in ox-LDL on the impairment of endothelium-dependent relaxation in rat aorta...
  44. ncbi 4-aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery
    Wai San Cheang
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Vascul Pharmacol 53:94-8. 2010
    ..Other potassium channels, Na(+)-K(+) pump or endothelium-derived relaxing factors play little role...
  45. ncbi Endothelium-dependent and -independent coronary relaxation induced by urocortin
    Xiaoqiang Yao
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Card Surg 17:347-9. 2002
    ..The urocortin-induced endothelium-dependent relaxation appears to be cyclic GMP-dependent...
  46. ncbi Raloxifene prevents endothelial dysfunction in aging ovariectomized female rats
    Chi Ming Wong
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Vascul Pharmacol 44:290-8. 2006
    ..These results suggest that chronic oral administration of raloxifene to aging ovariectomized female rats augmented the bioavailability of endothelial nitric oxide in isolated aortic rings without altering eNOS protein levels...
  47. ncbi Cardiovascular actions of berberine
    C W Lau
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cardiovasc Drug Rev 19:234-44. 2001
    ..Its vasodilator activity has been attributed to multiple cellular mechanisms. The cardiovascular effects of berberine suggest its possible clinical usefulness in the treatment of arrhythmias and/or heart failure...
  48. ncbi Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin
    F L Chan
    Department of Anatomy, Basic Medical Sciences Building, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    Cancer Lett 160:219-28. 2000
    ..The results indicate that baicalin has direct anti-tumor effects on human prostate cancer cells...
  49. ncbi Purification of phenylethanoids from Brandisia hancei and the antiproliferative effects on aortic smooth muscle
    Z D He
    Department of Biochemistry, Chinese University of Hong Kong, Shantin, NT, China
    Planta Med 67:520-2. 2001
    ..Inhibition of smooth muscle cell proliferation by phenylethanoids indicates that these compounds may have preventative effects on arteriosclerosis...
  50. ncbi Involvement of endothelium in relaxant action of glibenclamide on the rat mesenteric artery
    Y Huang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Eur J Pharmacol 343:27-33. 1998
    ....
  51. ncbi Attenuated endothelium-mediated relaxation by acteoside in rat aorta: Role of endothelial [Ca2+]i and nitric oxide/cyclic GMP pathway
    Chi-Wai Lau
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Life Sci 75:1149-57. 2004
    ..This novel pharmacological action if occurring in small vessels in vivo, may contribute to the reported anti-inflammatory effect of acteoside against NO-mediated vascular permeability-related acute edema...
  52. ncbi Different role of nitric oxide and endothelium-derived hyperpolarizing factor in endothelium-dependent hyperpolarization and relaxation in porcine coronary arterial and venous system
    Rong-Zhen Zhang
    Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China
    J Cardiovasc Pharmacol 43:839-50. 2004
    ....
  53. ncbi Enhancement of contraction of rat mesenteric artery by acteoside: role of endothelial nitric oxide
    Wing-Yin Tam
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    J Nat Prod 65:990-5. 2002
    ..The present results indicate that acteoside enhanced the evoked vasoconstriction, mainly through inhibition of endothelial NO production/release and inhibition of NO-mediated TEA(+)-sensitive activation of K(+) channels...
  54. ncbi Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging
    Siu Ling Wong
    Institute of Vascular Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Circ Res 104:228-35. 2009
    ..The results support a critical role of COX-2 in endothelium-dependent contractions in this species with an increased importance during aging and, possibly, a similar relevance in humans...
  55. ncbi Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia
    Grace Gar-Lee Yue
    Department of Physiology, The Chinese University of Hong Kong, Shatin, N.T. Hong Kong, China
    J Biol Chem 279:39310-6. 2004
    ....
  56. ncbi Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Vascul Pharmacol 44:299-308. 2006
    ..Thus, the eNOS-dependent H2O2 is likely to be the third mediator of acetylcholine-mediated relaxations in rat femoral arteries...
  57. ncbi Endothelium-independent relaxation to raloxifene in porcine coronary artery
    Hok Sum Leung
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    Eur J Pharmacol 555:178-84. 2007
    ..Raloxifene mainly acts on the vascular smooth muscle cells to induce vasorelaxation by the inhibition of Ca2+ channels and the activation of BK(Ca) channels. The former mechanism appears to play a more significant role...
  58. ncbi Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G
    Hiu Yee Kwan
    Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    J Cell Physiol 207:315-21. 2006
    ....
  59. ncbi Theaflavins in black tea and catechins in green tea are equally effective antioxidants
    L K Leung
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People's Republic of China
    J Nutr 131:2248-51. 2001
    ....
  60. ncbi A mechanosensitive cation channel in endothelial cells and its role in vasoregulation
    X Yao
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Biorheology 40:23-30. 2003
    ..Therefore, it appears that this channel may play a crucial role in the regulation of vascular tone...
  61. ncbi Raloxifene, tamoxifen and vascular tone
    Fung Ping Leung
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
    Clin Exp Pharmacol Physiol 34:809-13. 2007
    ....
  62. ncbi Regulation of TRP channels by phosphorylation
    Xiaoqiang Yao
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
    Neurosignals 14:273-80. 2005
    ..In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases...
  63. ncbi Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries
    Suk Ying Tsang
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, PR China
    Biochem Pharmacol 73:1330-9. 2007
    ..Also, vascular effects of ovariectomy can be reversed by estrogen, tamoxifen or estrogen+tamoxifen treatment, suggesting that tamoxifen confers estrogenic effects in the vascular system...
  64. ncbi Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    Jiu Chang Zhong
    Research Center of Medicine Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, and Department of Physiology, Chinese University of Hong Kong, Shatin, China
    Cardiovasc Res 74:388-95. 2007
    ..Our aim here was to explore the regulatory role of apelin in the aortic vascular tone in diabetic mice...
  65. ncbi Depletion of intracellular Ca2+ stores sensitizes the flow-induced Ca2+ influx in rat endothelial cells
    Hiu-Yee Kwan
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Circ Res 92:286-92. 2003
    ....
  66. ncbi Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i
    Hok Sum Leung
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong, PR China
    Br J Pharmacol 147:55-63. 2006
    ..The Ca(2+) channel-independent effect suggests the usefulness of cilnidipine in the treatment of cardiovascular diseases associated with diminished NO release, such as atherosclerosis...
  67. ncbi Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery
    Cuiling Liu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 147:506-15. 2006
    ..In conclusion, flow-induced dilatation in rat mesenteric arteries can be markedly enhanced by prior depletion of intracellular Ca2+ stores. Furthermore, these data are consistent with a role for H2O2 as the vasodilator involved...
  68. ncbi Exercise, vascular wall and cardiovascular diseases: an update (Part 1)
    Fung Ping Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Sports Med 38:1009-24. 2008
    ....
  69. ncbi Isoproterenol amplifies 17 beta-estradiol-mediated vasorelaxation: role of endothelium/nitric oxide and cyclic AMP
    Hoi Yun Chan
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    Cardiovasc Res 53:627-33. 2002
    ..This enhancement was dependent on the presence of endothelium and abolished by L-NAME via a beta(2)-adrenoceptor-mediated cyclic AMP-dependent mechanism...
  70. ncbi Anti-hypertensive nutraceuticals and functional foods
    Zhen Yu Chen
    Department of Biochemistry, Food and Nutritional Sciences Programme, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    J Agric Food Chem 57:4485-99. 2009
    ....
  71. ncbi Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension
    Wing Tak Wong
    School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Circ Res 107:984-91. 2010
    ..Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension remain elusive...
  72. ncbi A mechanosensitive cation channel in endothelial cells
    Xiaoqiang Yao
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Card Surg 17:340-1. 2002
    ..These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells...
  73. ncbi Differential regulation of K+ and Ca2+ channel gene expression by chronic treatment with estrogen and tamoxifen in rat aorta
    Suk Ying Tsang
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Eur J Pharmacol 483:155-62. 2004
    ....
  74. ncbi Characterization of antioxidants present in bitter tea (Ligustrum pedunculare)
    Zhen Yu Chen
    Food and Nutritional Science Programme, Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
    J Agric Food Chem 50:7530-5. 2002
    ..The present results demonstrate that bitter tea as a beverage contains effective antioxidants that may have benefits similar to those of green tea in terms of antioxidant activity...
  75. ncbi From nitric oxide to endothelial cytosolic Ca2+: a negative feedback control
    Xiaoqiang Yao
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Trends Pharmacol Sci 24:263-6. 2003
    ..Such a negative feedback mechanism could serve to protect the endothelial cells from the detrimental effects of excessive nitric oxide and Ca(2+)...
  76. ncbi Reduced bone perfusion in osteoporosis: likely causes in an ovariectomy rat model
    James F Griffith
    Departments of Diagnostic Radiology and Organ Imaging, Anatomy, Physiology, and Orthopedics and Traumatology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Radiology 254:739-46. 2010
    ..c) RSNA, 2010 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.09090608/-/DC1...
  77. ncbi Vascular effects of a soy leaves (Glycine max) extract and kaempferol glycosides in isolated rat carotid arteries
    Hing Man Ho
    Department of Biochemistry, Chinese University of Hong Kong, Shatin, NT, China
    Planta Med 68:487-91. 2002
    ..Genistein and genistin also caused relaxation, however, the dose range is beyond that of the extract causing relaxation...
  78. ncbi Regulation of canonical transient receptor potential isoform 3 (TRPC3) channel by protein kinase G
    Hiu Yee Kwan
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 101:2625-30. 2004
    ..Taken together, TRPC3 channels could be directly phosphorylated by PKG at position T11 and S263, and this phosphorylation abolished the store-operated Ca2+ influx mediated by TRPC3 channels in HEK293 cells...
  79. ncbi Degradation of green tea catechins in tea drinks
    Z Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, The People s Republic of China
    J Agric Food Chem 49:477-82. 2001
    ..When canned and bottled tea drinks are produced, stored, and transported, the degradation of GTC must be taken into consideration...
  80. ncbi Role of NO and EDHF-mediated endothelial function in the porcine pulmonary circulation: comparison between pulmonary artery and vein
    Rong-Zhen Zhang
    Department of Surgery, The Chinese University of Hong Kong, Block B, Prince of Wales Hospital, Shatin, N.T, Hong Kong SAR, China
    Vascul Pharmacol 44:183-91. 2006
    ..CONCLUSIONS: Both NO and EDHF play an important role in regulation of porcine pulmonary arterial and venous tones. The more significant role of NO and EDHF is revealed in pulmonary arteries than in veins...
  81. ncbi Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
    Yiqun Wang
    Department of Medicine, University of Hong Kong, L8 40, New Laboratory Block, 21 Sassoon Road, Hong Kong, China
    Cardiovasc Res 82:484-92. 2009
    ..The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction...
  82. ncbi TRPC1 associates with BK(Ca) channel to form a signal complex in vascular smooth muscle cells
    Hiu Yee Kwan
    Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China
    Circ Res 104:670-8. 2009
    ..The hyperpolarizing effect of TRPC1-BK(Ca) coupling could serve to reduce agonist-induced membrane depolarization, thereby preventing excessive contraction of VSMCs to contractile agonists...
  83. ncbi Exercise, vascular wall and cardiovascular diseases: an update (part 2)
    Lai Ming Yung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Sports Med 39:45-63. 2009
    ..Overall, more scientific evidence will undoubtedly encourage the widespread advocacy of the clinical benefits of exercise therapy in the prevention and treatment of CVD...
  84. ncbi (-)epicatechin induces and modulates endothelium-dependent relaxation in isolated rat mesenteric artery rings
    Zhen-yu Chen
    Department of Biochemistry, Chinese University of Hong Kong, China
    Acta Pharmacol Sin 23:1188-92. 2002
    ....
  85. ncbi Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats
    Suk-Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong
    Hypertension 44:78-82. 2004
    ..Tamoxifen does not act as an estrogen antagonist; instead, it functions as an estrogen agonist during estrogen deficiency. Thus, tamoxifen may confer beneficial effects similar to estrogen in cerebrovascular vessels...
  86. ncbi CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells
    Hiu Yee Kwan
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, SAR, China
    J Vasc Res 47:148-56. 2010
    ..In the present study, we tested the hypothesis that cyclic nucleotide-gated (CNG) channels also contribute to ATP-induced non-CCE...
  87. ncbi Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    Kenneth K Y Cheng
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 56:1387-94. 2007
    ..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation...
  88. ncbi Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats
    Z Y Chen
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Br J Nutr 86:249-55. 2001
    ....
  89. ncbi CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells
    Kwong Tai Cheng
    Li Ka Shing Institute of Health Sciences and Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, China
    Arterioscler Thromb Vasc Biol 28:913-8. 2008
    ..This study explored the molecular identity of channels that mediate adenosine-induced Ca(2+) influx in vascular endothelial cells...
  90. ncbi Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels
    Bing Shen
    Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
    J Mol Cell Cardiol 45:437-45. 2008
    ..In summary, CNG channels, CNGA2 in particular, mediate beta-adrenoceptor agonist-induced endothelial Ca(2+) influx and subsequent vascular dilation...
  91. ncbi Cyclic nucleotide-gated channels contribute to thromboxane A2-induced contraction of rat small mesenteric arteries
    Yuk Ki Leung
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    PLoS ONE 5:e11098. 2010
    ..This study aims to identify the channels that mediate TxA(2)-induced Ca(2+) influx in vascular smooth muscle cells...
  92. ncbi Functional role of vanilloid transient receptor potential 4-canonical transient receptor potential 1 complex in flow-induced Ca2+ influx
    Xin Ma
    Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China
    Arterioscler Thromb Vasc Biol 30:851-8. 2010
    ..Hemodynamic blood flow is an important physiological factor that modulates vascular tone. One critical early event in this process is a cytosolic Ca(2+) ([Ca(2+)](i)) rise in endothelial cells in response to flow...
  93. ncbi Contribution of K+ channels to relaxation induced by 17beta-estradiol but not by progesterone in isolated rat mesenteric artery rings
    Suk Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Cardiovasc Pharmacol 41:4-13. 2003
    ..The present findings provide pharmacological evidence for an additional mechanism contributing to acute vasorelaxation induced by 17beta-estradiol...
  94. ncbi Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase
    Cui Qing Liu
    Department of Physiology, Hangzhou Normal University, China
    Biochem Pharmacol 78:374-81. 2009
    ....
  95. ncbi Raloxifene relaxes rat intrarenal arteries by inhibiting Ca2+ influx
    Fung Ping Leung
    Dept. of Physiology, Chinese University of Hong Kong, China
    Am J Physiol Renal Physiol 289:F137-44. 2005
    ..There is little sex difference in raloxifene-induced relaxation...
  96. ncbi Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery
    Suk Ying Tsang
    Department of Physiology, Chinese University of Hong Kong, Hong Kong, China
    Br J Pharmacol 138:453-60. 2003
    ..Pinacidil also induces K(+) channel-dependent but VGCCs-independent relaxation. The PKC-mediated cellular pathway may be a target site for pinacidil only in higher concentrations...
  97. ncbi cGMP stimulates endoplasmic reticulum Ca(2+)-ATPase in vascular endothelial cells
    Kin-Ling Lau
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N.T, Hong Kong
    Life Sci 73:2019-28. 2003
    ..Taken together, these data suggest that cGMP may reduce [Ca(2+)](i) level by promoting Ca(2+) uptake through sarcoplasmic/endoplasmic reticulum ATPase and that the effect of cGMP may be mediated by protein kinase G...
  98. ncbi Raloxifene relaxes rat pulmonary arteries and veins: roles of gender, endothelium, and antagonism of Ca2+ influx
    Yau-Chi Chan
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    J Pharmacol Exp Ther 312:1266-71. 2005
    ..Finally, raloxifene induced more relaxation in blood vessels isolated from male than female rats...
  99. ncbi Reactive oxygen species in vascular wall
    Lai Ming Yung
    Department of Physiology, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Cardiovasc Hematol Disord Drug Targets 6:1-19. 2006
    ....
  100. ncbi Expression of TRPC homologs in endothelial cells and smooth muscle layers of human arteries
    Ham Yip
    Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, China
    Histochem Cell Biol 122:553-61. 2004
    ..These results suggest a ubiquitous role of TRPC homologs in regulating blood supply to different regions and in controlling arterial blood pressure...
  101. ncbi Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers
    Jin Ze Xu
    Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China
    Br J Nutr 91:873-81. 2004
    ..It was concluded that the epimerisation reaction occurring in manufacturing canned and bottled tea drinks would not significantly affect antioxidant activity and bioavailability of total tea polyphenols...