Research Topics
| Chun Tao CheSummaryAffiliation: The Chinese University of Hong Kong Country: China Publications
| Collaborators
|
Detail Information
Publications
Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparationSiu Po Ip
School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong SAR, China
Chin Med 5:8. 2010..The procedures developed in the present study will serve as a protocol for other poly-herbal Chinese medicine studies...- Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroliWeihan Zhang
Hutchison Medipharma Ltd, Shanghai, China
Chem Pharm Bull (Tokyo) 51:1009-11. 2003..Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line... - Induction of apoptosis underlies the Radix Rubiae-mediated anti-proliferative action on human epidermal keratinocytes: implications for psoriasis treatmentWai Pui Tse
School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, P R China
Int J Mol Med 20:663-72. 2007..Our experimental results suggest that Radix Rubiae is a promising source from which a herb-based topical agent could be developed for psoriasis treatment... - Vasodilatory actions of xanthones isolated from a Tibetan herb, Halenia ellipticaYan Wang
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China
Phytomedicine 16:1144-50. 2009..The potency and mechanism(s) of the vasorelaxant effects of these xanthones may be relevant to the structure-activity differences in the level and the position of the substituent groups with the primary xanthone structure... - Mechanisms of the vasorelaxant effect of 1-hydroxy-2, 3, 5-trimethoxy-xanthone, isolated from a Tibetan herb, Halenia elliptica, on rat coronary arteryYan Wang
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China
Life Sci 81:1016-23. 2007.... - Long-term treatment with peony glycosides reverses chronic unpredictable mild stress-induced depressive-like behavior via increasing expression of neurotrophins in rat brainQing Qiu Mao
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Behav Brain Res 210:171-7. 2010..The results suggest that the antidepressant-like action of TGP is mediated, at least in part, by increasing the expression of BDNF and NGF in selective brain tissues... - Suppression of low-density lipoprotein oxidation, vascular smooth muscle cell proliferation and migration by a herbal extract of Radix Astragali, Radix Codonopsis and Cortex LyciiJudy Y Chan
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
BMC Complement Altern Med 11:32. 2011..In this study, we want to further investigate the efficacy of SR10 in treating atherosclerosis... - Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-?B activityLin Li Zhou
School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Eur J Pharmacol 670:399-408. 2011.... - [Determination of morusin in cortex mori]Yu Ying Zong
School of Chinese Medicine, The Chinese University of HongKong, Shatin, Hongkong, China
Zhongguo Zhong Yao Za Zhi 32:1038-40. 2007..To determine the contents of morusin in Sangbaipi (Cortex Mori) of different commercial grades and species and obtained from different regions... - Effects of SYJN, a Chinese herbal formula, on chronic unpredictable stress-induced changes in behavior and brain BDNF in ratsQing Qiu Mao
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Ethnopharmacol 128:336-41. 2010..The present study aimed to investigate whether SYJN could produce antidepressant-like effects in chronic unpredictable stress (CUS)-induced depression model in rats and its possible mechanism(s)... - Isoflavanones and their O-glycosides from Desmodium styracifoliumMing Zhao
School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong
Phytochemistry 68:1471-9. 2007..This is for the first time isoflavanone O-glycosides were isolated from a natural source... - Determination of aflatoxins in Chinese medicinal herbs by high-performance liquid chromatography using immunoaffinity column cleanup Improvement of recoverySiu Po Ip
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Chromatogr A 1135:241-4. 2006..The modified method was validated by the analysis of a certified reference material and shown to be useful for the determination of aflatoxins in herbal samples of high acidity... - Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in miceYan Fang Xian
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
Planta Med 77:1977-83. 2011.... - Neonatal maternal separation elevates thalamic corticotrophin releasing factor type 1 receptor expression response to colonic distension in ratYung Wui Tjong
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, China
Neuro Endocrinol Lett 31:215-20. 2010..The aim of our study is to examine the effect of neonatal maternal separation (NMS), an early life stress model, on the brain CRF expression following visceral pain induced by colorectal distension (CRD) stimuli in male rats... - Long-term treatment with a "Yang-invigorating" Chinese herbal formula, Wu-Zi-Yan-Zong-Wan, reduces mortality and liver oxidative damage in chronic alcohol-intoxicated ratsMeng li Chen
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China
Rejuvenation Res 13:459-67. 2010..The results suggest that the suppressive effect of WZ on chronic ethanol-induced oxidative stress and mortality may be attributed to the antioxidant action, particularly in mitochondria... - Geoditin A induces oxidative stress and apoptosis on human colon HT29 cellsFlorence W K Cheung
School of Chinese Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Mar Drugs 8:80-90. 2010..Our results provide a better understanding of the apoptotic properties and chemotherapeutical potential of this marine triterpene... - A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor proteinYan Chen
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China
J Proteome Res 10:299-304. 2011..The results indicate that Sch B triggers the Raf/MEK/ERK signaling pathway, presumably by downregulating RKIP, thereby protecting against carbon tetrachloride-induced cytotoxicity... - Protective effects of an herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: an implication for its treatment of diabetes mellitusJudy Yuet Wa Chan
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR, China
Phytother Res 22:190-6. 2008..The implication of SR10 in treating type 2 diabetes mellitus was discussed... - Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cellsWilliam Ka Kei Wu
Institute of Digestive Diseases, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, P R China
Autophagy 6:228-38. 2010..This discovery may have implications for the application of proteasome-directed therapy for the treatment of cancer... - Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cellsWing Keung Liu
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
J Nat Prod 71:842-6. 2008..Thus, 1 blocked cell cycle progression at the G 1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery... - Stellettin A induces oxidative stress and apoptosis in HL-60 human leukemia and LNCaP prostate cancer cell linesW K Liu
Department of Anatomy and School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, People s Republic of China
J Nat Prod 69:934-7. 2006..All available evidence suggests that 1 induces oxidative cell death through a FasL-caspase-3-apoptotic pathway... - Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell lineWing Keung Liu
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People s Republic of China
Eur J Pharmacol 498:71-8. 2004.... - Jolkinolide B induces neuroendocrine differentiation of human prostate LNCaP cancer cell lineW K Liu
Department of Anatomy, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Shatin, Hong Kong
Biochem Pharmacol 63:951-7. 2002..Taken all data together, jolkinolide B seems to play a role in the regulation of proliferation, differentiation, and apoptosis of LNCaP cells... - Anti-depressant-like effect of peony: a mini-reviewQing Qiu Mao
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Pharm Biol 50:72-7. 2012..The root part of Paeonia lactiflora Pall. (Ranunculaceae), known as peony, is often used in Chinese herbal prescriptions for the treatment of depression-like disorders... - [Chemical constituents and anti-tuberculosis activity of root of Rhodiola kirilowii]Ying Chun Wong
School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong, China
Zhongguo Zhong Yao Za Zhi 33:1561-5. 2008..The 80% (a. q.) EtOH extract, EtOAc-soluble extract, compounds 7 and 8 exhibited in-vitro inhibitory and bactericidal activities against Macobacterium tuberculosis in different extent... - Two new lanostanoids from Ganoderma resinaceumXue Mei Niu
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
J Asian Nat Prod Res 9:659-64. 2007..The structure elucidation was accomplished by spectroscopic methods, especially NMR experiments. Compound 2 showed significant cytotoxic activity with IC(50) value of 2.5 microg/ml in Hep-2 cell line... - Arsenic trioxide, arsenic pentoxide, and arsenic iodide inhibit human keratinocyte proliferation through the induction of apoptosisWai Pui Tse
School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
J Pharmacol Exp Ther 326:388-94. 2008.... - Peony glycosides produce antidepressant-like action in mice exposed to chronic unpredictable mild stress: effects on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factorQing Qiu Mao
School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
Prog Neuropsychopharmacol Biol Psychiatry 33:1211-6. 2009..The results suggest that the antidepressant-like action of TPG is likely mediated by modulating the function of hypothalamic-pituitary-adrenal axis and increasing the expression of BDNF in brain tissues... - Mechanisms of the vasorelaxant effect of 1, 5-dihydroxy-2, 3-dimethoxy-xanthone, an active metabolite of 1-hydroxy-2, 3, 5-trimethoxy-xanthone isolated from a Tibetan herb, Halenia elliptica, on rat coronary arteryYan Wang
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China
Life Sci 82:91-8. 2008..The vasorelaxant effect of HM-5 was mediated through opening of potassium channel (4-AP) and altering intracellular calcium by partial inhibition of Ca2+ influx through L-type voltage-operated Ca2+ channels and intracellular Ca2+ stores... - Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitusJudy Yuet Wa Chan
Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
Phytother Res 23:658-65. 2009..The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host... - Cycloartanes from the red alga Galaxaura spWei-Han Zhang
Hutchison Medipharma Ltd, Shanghai, China
J Asian Nat Prod Res 7:59-65. 2005.... - Cytotoxic acylated triterpene saponins from the husks of Xanthoceras sorbifoliaPui Kwong Chan
Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
J Nat Prod 71:1247-50. 2008..On the basis of the results obtained, it is concluded that a C-3 trisaccharide with a galactose and acylation with an angeloyl group at both C-21 and C-22 are important for cell inhibition activity for this class of compounds... - An aqueous extract of Rubus chingii fruits protects primary rat hepatocytes against tert-butyl hydroperoxide induced oxidative stressMing-Hon Yau
Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, China
Life Sci 72:329-38. 2002..These results suggested that Fructus Rubi was useful in protecting against t-BHP-induced oxidative damage and may also be capable of attenuating cytotoxicity of other oxidants... - Lignanamides and nonalkaloidal components of Hyoscyamus niger seedsCui-Ying Ma
Department of Chemistry, Hong Kong University of Science and Technology, Hong Kong
J Nat Prod 65:206-9. 2002..Grossamide, and cannabisins D and G exhibited moderate cytotoxicity in cultured LNCaP human prostate cancer cells... - New lupane glycosides from Pulsatilla chinensisWencai Ye
Planta Med 68:183-6. 2002..The compounds were evaluated for cytotoxic activities against K-562 human leukemia and HeLa cells... - Constituents of Clerodendrum bungeiHui Yang
Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan
J Asian Nat Prod Res 4:165-9. 2002..The structures of 1 and 2 were elucidated as a perhydrobenzofuran derivative and a peroxide dimer by spectral and chemical evidence. Compounds 3-14 have been obtained from this species for the first time... - New norditerpenoid alkaloids from Aconitum hemsleyanum var. leueanthusLing-yun Li
Mental Health Center, Shantou University, Shantou, People's Republic of China
J Nat Prod 66:269-71. 2003..Four new norditerpenoid alkaloids, leueantines A (1), B (2), C (3), and D (4), were isolated from the roots of Aconitum hemsleyanum var. leueanthus. The structures of 1-4 were established by spectroscopic evidence... - Isoquinoline and isoindole alkaloids from Menispermum dauricumXiaoqi Zhang
Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, China
Phytochemistry 65:929-32. 2004.... - Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytesSiu-Po Ip
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
Planta Med 68:1077-81. 2002..Abbreviations. DTD:DT-diaphorase GSH:glutathione LDH:lactate dehydrogenase MDA:malondialdehyde MTT:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide TBHP: tert-butyl hydroperoxide.. - Treatment of diarrhea-predominant irritable bowel syndrome with traditional Chinese herbal medicine: a randomized placebo-controlled trialWai K Leung
Institute of Digestive Disease, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
Am J Gastroenterol 101:1574-80. 2006..BACKGROUND: The use of this herbal formulation for diarrhea-predominant IBS did not lead to global symptom improvement. Further controlled clinical studies may be necessary to characterize the role of TCM in the management of IBS... - Prenylated phenolics from Ganoderma fornicatumXue-Mei Niu
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, People's Republic of China
J Nat Prod 69:1364-5. 2006..The structure elucidation was achieved by interpretation of spectroscopic data. These compounds exhibited moderate cytotoxic activity with IC(50) values of 15 to 30 microg/mL in Hep-2 cells... - Alisolide, alisols O and P from the rhizome of Alisma orientaleMing Zhao
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong
Phytochemistry 69:527-32. 2008.... - Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri LucidiYan Zhang
Shenzhen Research Institute of the Hong Kong Polytechnic University, State Ky Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, PRC
Br J Nutr 99:494-502. 2008..Our study indicated that FLL extract could improve bone properties in aged rats possibly via its direct action on osteoblastic cells by enhancement of the mineralization process... - Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileumSunny Sun Kin Chan
School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, P R China
Planta Med 74:381-4. 2008..These observations suggest that the magnolol and honokiol contents account for the anti-spasmodic effects of M. officinalis extracts in guinea pig isolated ileum... - Fructus ligustri lucidi extract improves calcium balance and modulates the calciotropic hormone level and vitamin D-dependent gene expression in aged ovariectomized ratsYan Zhang
Shenzhen Research Institute, The Hong Kong Polytechnic University, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, People s Republic of China
Menopause 15:558-65. 2008..In the present study, we aimed to determine whether FLL could regulate calcium balance in aged OVX rats and to study the potential mechanisms that mediate its action in vivo...