Zhenguo Zhang

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. ncbi Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
    Zhenguo Zhang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, PR China
    BMC Biol 7:23. 2009
  2. ncbi Divergence of exonic splicing elements after gene duplication and the impact on gene structures
    Zhenguo Zhang
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, 225 South Chong Qing Road, Shanghai 200025, PR China
    Genome Biol 10:R120. 2009
  3. ncbi Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation
    Zhenguo Zhang
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China China
    Mol Syst Biol 6:442. 2010
  4. ncbi Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases
    Yang Liu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    PLoS Genet 7:e1001338. 2011
  5. ncbi SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell
    Li Zhou
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, People s Republic of China
    J Cell Mol Med 15:783-95. 2011
  6. ncbi Novel association strategy with copy number variation for identifying new risk Loci of human diseases
    Xianfeng Chen
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 5:e12185. 2010
  7. ncbi Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes
    Ping Wang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, 225 South Chong Qing Road, Shanghai 200025, PR China
    Genome Biol 9:R169. 2008
  8. ncbi Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts
    Heng Xu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chong Qing Road, Shanghai 200025, China
    Cell Res 20:445-57. 2010

Collaborators

Detail Information

Publications8

  1. ncbi Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
    Zhenguo Zhang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, PR China
    BMC Biol 7:23. 2009
    ..Alternatively, nonsense-mediated decay can be regulated under certain conditions so the presence of a premature termination codon can be a means to up-regulate transcripts needed when nonsense-mediated decay is suppressed...
  2. ncbi Divergence of exonic splicing elements after gene duplication and the impact on gene structures
    Zhenguo Zhang
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, 225 South Chong Qing Road, Shanghai 200025, PR China
    Genome Biol 10:R120. 2009
    ..Here we examine a novel way that new gene structures could originate, namely through the evolution of new alternative splicing isoforms after gene duplication...
  3. ncbi Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation
    Zhenguo Zhang
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China China
    Mol Syst Biol 6:442. 2010
    ..Translational inefficiency is flexible, such that NMD targets have increased TE upon starvation. We propose that the low TE predisposes to NMD and/or that it is part of a mechanism for regulation of NMD transcripts...
  4. ncbi Genome-wide interaction-based association analysis identified multiple new susceptibility Loci for common diseases
    Yang Liu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    PLoS Genet 7:e1001338. 2011
    ..In addition, our PIAM program was capable of handling very large GWAS datasets that are likely to be produced in the future...
  5. ncbi SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell
    Li Zhou
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai, People s Republic of China
    J Cell Mol Med 15:783-95. 2011
    ....
  6. ncbi Novel association strategy with copy number variation for identifying new risk Loci of human diseases
    Xianfeng Chen
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 5:e12185. 2010
    ..Copy number variations (CNV) are important causal genetic variations for human disease; however, the lack of a statistical model has impeded the systematic testing of CNVs associated with disease in large-scale cohort...
  7. ncbi Evidence for common short natural trans sense-antisense pairing between transcripts from protein coding genes
    Ping Wang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, 225 South Chong Qing Road, Shanghai 200025, PR China
    Genome Biol 9:R169. 2008
    ....
  8. ncbi Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts
    Heng Xu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, 225 South Chong Qing Road, Shanghai 200025, China
    Cell Res 20:445-57. 2010
    ..Interestingly, dual-coding transcripts were significantly enriched for transcripts from the zinc-finger protein family, which are usually DNA-binding proteins involved in regulation of the transcription process...