Guang Ning

Summary

Affiliation: Shanghai Institutes for Biological Sciences
Country: China

Publications

  1. ncbi Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis
    Guang Ning
    Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Intern Med 155:368-74. 2011
  2. ncbi The influence of Lys3Asn polymorphism in the osteoprotegerin gene on bone mineral density in Chinese postmenopausal women
    Hong Yan Zhao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Second Medical University, 197 Ruijin Er Road, 200025, Shanghai, China
    Osteoporos Int 16:1519-24. 2005
  3. ncbi Serum fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese
    Yu Xu
    State Key Laboratory of Medical Genomics, E Institute of Shanghai Universities, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Atherosclerosis 216:180-6. 2011
  4. ncbi Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese
    Yaohua Wu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, 197 Rui Jin 2nd Road, Shanghai, China
    J Diabetes 3:217-24. 2011
  5. ncbi The interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses
    Jie Hong
    Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin 2nd Road, Shanghai, 200025, PR China
    Endocrine 31:93-9. 2007
  6. ncbi Elevated serum ?-glutamyltransferase predicts the development of impaired glucose metabolism in middle-aged and elderly Chinese
    Yu Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
    Endocrine 40:265-72. 2011
  7. ncbi Prevalence of metabolic syndrome and its association with obesity indices in a Chinese population
    Yun Huang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 1:57-64. 2009
  8. ncbi [Study of the impact of candidate genes on bone mineral density in postmenopausal women]
    Hong Yan Zhao
    Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Fu Chan Ke Za Zhi 40:803-7. 2005
  9. ncbi The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population
    Ze Fei Zhao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, Shanghai, 200025, PR China
    Endocrine 32:143-7. 2007
  10. ncbi IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University Medical School, 197 Shanghai Rui jin Er Road, Shanghai 200025, China
    J Bone Miner Metab 26:159-64. 2008

Collaborators

Detail Information

Publications98

  1. ncbi Relationship of urinary bisphenol A concentration to risk for prevalent type 2 diabetes in Chinese adults: a cross-sectional analysis
    Guang Ning
    Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Ann Intern Med 155:368-74. 2011
    ..Greater bisphenol A exposure has been shown to be associated with a higher risk for self-reported adverse health outcomes, including diabetes...
  2. ncbi The influence of Lys3Asn polymorphism in the osteoprotegerin gene on bone mineral density in Chinese postmenopausal women
    Hong Yan Zhao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Second Medical University, 197 Ruijin Er Road, 200025, Shanghai, China
    Osteoporos Int 16:1519-24. 2005
    ..The Lys3Asn polymorphism in the OPG gene is associated with L2-4 BMD in postmenopausal women. The Lys-allele is associated with lower BMD and an increased risk for osteoporosis...
  3. ncbi Serum fetuin-A is correlated with metabolic syndrome in middle-aged and elderly Chinese
    Yu Xu
    State Key Laboratory of Medical Genomics, E Institute of Shanghai Universities, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Atherosclerosis 216:180-6. 2011
    ..Fetuin-A is an important player in the enhancement of insulin resistance. We aimed to investigate the association of serum fetuin-A and metabolic syndrome (MetS) in a community based Chinese population...
  4. ncbi Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese
    Yaohua Wu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, 197 Rui Jin 2nd Road, Shanghai, China
    J Diabetes 3:217-24. 2011
    ....
  5. ncbi The interplay of insulin resistance and beta-cell dysfunction involves the development of type 2 diabetes in Chinese obeses
    Jie Hong
    Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin 2nd Road, Shanghai, 200025, PR China
    Endocrine 31:93-9. 2007
    ..It indicates that obese subjects with different glucose tolerances have a similar degree of insulin resistance but differ in insulin secretion in Chinese Han population...
  6. ncbi Elevated serum ?-glutamyltransferase predicts the development of impaired glucose metabolism in middle-aged and elderly Chinese
    Yu Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
    Endocrine 40:265-72. 2011
    ..Serum GGT concentration, even within its normal range, is a risk marker for developing impaired glucose metabolism in middle-aged and elderly Chinese...
  7. ncbi Prevalence of metabolic syndrome and its association with obesity indices in a Chinese population
    Yun Huang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 1:57-64. 2009
    ....
  8. ncbi [Study of the impact of candidate genes on bone mineral density in postmenopausal women]
    Hong Yan Zhao
    Department of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Fu Chan Ke Za Zhi 40:803-7. 2005
    ..To investigate the impact of multiple candidate genes on bone mineral density in postmenopausal women...
  9. ncbi The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population
    Ze Fei Zhao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, Shanghai, 200025, PR China
    Endocrine 32:143-7. 2007
    ..242; chi2 = 1.127, P = 0.288). The genotype-phenotype correlation was not identified either. Therefore we were unable to find the association of A946T polymorphism of the IFIH1 gene with the development of GD in a Chinese population...
  10. ncbi IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University Medical School, 197 Shanghai Rui jin Er Road, Shanghai 200025, China
    J Bone Miner Metab 26:159-64. 2008
    ..17, P < 0.001). In conclusion, measurement of serum IGF-1 in young women may help in the early identification of those at risk for developing low bone mass and osteoporosis...
  11. ncbi The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population
    Qiaorui Liu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Department of Endocrine and Metabolic Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Endocrine 34:62-7. 2008
    ..01). Thus, the TAAAAn polymorphism in SHBG gene was not a determinant of PCOS in this population of Chinese women, whereas, serum SHBG was significantly associated with BMI and insulin resistance in these PCOS patients...
  12. ncbi Cross-sectional and longitudinal association of serum alanine aminotransaminase and ?-glutamyltransferase with metabolic syndrome in middle-aged and elderly Chinese people
    Yu Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 3:38-47. 2011
    ....
  13. ncbi Insulin sensitivity and first-phase insulin secretion in obese Chinese with hyperglycemia in 30 and/or 60 min during glucose tolerance tests
    Jie Hong
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Division of Endocrine and Metabolic Diseases, Shanghai Jiao Tong University Medical School, Shanghai, People s Republic of China
    Endocrine 34:75-80. 2008
    ..In conclusion, our present results demonstrated that the pathophysiological basis of obese subjects with PLH were clearly insulin resistance and defective in first-phase insulin secretion as that in IGT subjects in Chinese population...
  14. ncbi Glycated hemoglobin A1c, fasting plasma glucose, and two-hour postchallenge plasma glucose levels in relation to carotid intima-media thickness in chinese with normal glucose tolerance
    Yun Huang
    Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road, Shanghai 200025, China
    J Clin Endocrinol Metab 96:E1461-5. 2011
    ..The association between hyperglycemic markers and cardiovascular risk is not consistent in nondiabetic subjects. Even less are the data regarding the associations in subjects with normal glucose tolerance (NGT)...
  15. ncbi Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves' disease
    Li Qun Gu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 197 Rui Jin Er Road, Shanghai, 200025, People s Republic of China
    Endocrine 39:266-71. 2011
    ..Future studies may determine the usefulness of these two biomarkers to detect early signs of endothelial dysfunction, vascular stiffness, and fluid volume in GD patients...
  16. ncbi Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes
    Yi Sheng Yang
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University Medical School, Shanghai 200025, China
    Endocrine 32:297-302. 2007
    ..These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance...
  17. ncbi MEN1 mutation analysis in Chinese patients with multiple endocrine neoplasia type 1
    Xiao hua Jiang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism and Chinese French Laboratory of Genomics and Life Sciences, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China
    Endocr Relat Cancer 14:1073-9. 2007
    ..In conclusion, MEN1 heterozygous mutations are associated with LOH and menin absence, which are present in MEN1-associated endocrine tumours...
  18. ncbi Androgen receptor gene CAG(n) trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome
    Qiaorui Liu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Endocrine 33:165-70. 2008
    ..05, respectively), but not with total testosterone, body mass index, waist and hip circumferences. The CAG(n) repeat length polymorphism may not be a major determinant of PCOS, but it may influence the lipid metabolism of PCOS patients...
  19. ncbi Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women
    Qun Yan
    Shanghai Key Laboratory for Endocrine Tumors, Shanghai Institute of Endocrine and metabolic Disease, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Lu, 200025 Shanghai, People s Republic of China
    Endocrine 36:377-82. 2009
    ..In conclusions, the rs9939609 variant in the FTO gene is associated with PCOS susceptibility in the Chinese population, probably because of its effect on BMI...
  20. ncbi Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves' disease
    Li Qun Gu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, PR China
    Clin Biochem 43:223-7. 2010
    ..Tumor necrosis factor alpha (TNF-alpha) may play a central role in the development of Graves' disease (GD). The aim of this study was to investigate the association of TNF-alpha polymorphisms with GD in Chinese population...
  21. ncbi Different association of circulating levels of adipocyte and epidermal fatty acid-binding proteins with metabolic syndrome and coronary atherosclerosis in Chinese adults
    Jie Hong
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E Institutes of Shanghai Universities EISU and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Atherosclerosis 217:194-200. 2011
    ..In the present study, we investigated the different association of A-FABP and E-FABP with metabolic syndrome (MetS) and coronary artery disease (CAD) in Chinese adults...
  22. ncbi Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Endocrinol Metab 95:E112-20. 2010
    ..However, none of these has been fully investigated in Han Chinese populations...
  23. ncbi Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women
    Lin Zhao
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, People s Republic of China
    Menopause 18:1018-25. 2011
    ..It is still unclear whether osteoporosis susceptibility genes are also associated with AAM, ANM, and maximal height in Chinese women...
  24. ncbi The novel compound heterozygous mutations, V434del and W666X, in WFS1 gene causing the Wolfram syndrome in a Chinese family
    Jie Hong
    Department of Endocrine and Metabolic Diseases, Shanghai Key Laboratory for Endocrine Tumors, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, People s Republic of China
    Endocrine 35:151-7. 2009
    ..Four cases with heterozygotes had been found through screening for the mutation V434del and five cases for the mutation W666X in the whole family. This is the first report of WFS with the mutation V434del and W666X in the WFS1 gene...
  25. ncbi Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients
    Shu Wang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China
    Endocrine 31:114-8. 2007
    ..In order to study the association of G241R polymorphism of ICAM-1 gene with an earlier onset of Graves' disease (GD) and the susceptibility of K469E polymorphism to Graves' ophthalmopathy (GO) in Chinese population...
  26. ncbi Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease
    Xue Jiang Gu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China
    Clin Immunol 127:298-302. 2008
    ..013). In conclusion, IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population...
  27. ncbi Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis
    Yichuan Xiao
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine SJTUSM and Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and SJTUSM, Shanghai 200025, China
    Glia 58:932-42. 2010
    ..Our results build up a link between lipid metabolic regulation and immune functions, and the modulation of the expression of SRC-3 or PPAR-beta may hopefully has therapeutic modality in MS and possibly other neurodegenerative diseases...
  28. ncbi Characteristics of ectopic adrenocorticotropic hormone syndrome due to thymic carcinoid and analysis of the molecular mechanism
    Yu-fang Bi
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Chin Med J (Engl) 121:667-70. 2008
  29. ncbi Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance
    Tiange Wang
    Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 97:E223-7. 2012
    ..Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited...
  30. ncbi Association of arterial stiffness with HbA1c in 1,000 type 2 diabetic patients with or without hypertension
    Yuhong Chen
    Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People s Republic of China
    Endocrine 36:262-7. 2009
    ..Ba-PWV positively correlated with HbA1c and duration of diabetes in subjects with diabetes and hypertension, suggesting the importance of early glycemic control in the prevention of arterial stiffness and vascular complications...
  31. ncbi Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies
    Min Xu
    State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 5:e14022. 2010
    ..We aimed to determine the association of 11 known loci with T2DM and impaired glucose regulation (IGR), individually and in combination, in Chinese...
  32. ncbi Prehypertension is associated with atherosclerosis in Type 2 diabetes
    Jiao Rong Tan
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 2:56-63. 2010
    ..However, the association between prehypertension and atherosclerosis in Type 2 diabetes mellitus (T2DM) has not been evaluated. In the present study, we investigated the impact of prehypertension on atherosclerosis in T2DM...
  33. ncbi Impact of the metabolic syndrome and its individual components on risk and severity of coronary heart disease
    Yifei Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E Institutes of Shanghai Universities EISU and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, People s Republic of China
    Endocrine 36:233-8. 2009
    ..Clinical focus should remain on establishing optimum-risk algorithms for CHD...
  34. ncbi Low-grade albuminuria is associated with carotid intima-media thickness in Chinese type 2 diabetic patients
    Yun Huang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Endocrinol Metab 95:5122-8. 2010
    ..Our present study showed a significant association between low-grade urinary albumin-to-creatinine ratio (ACR) and elevated carotid intima-media thickness (CIMT) in type 2 diabetic patients...
  35. ncbi The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis
    Nan Liu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Hum Immunol 71:397-401. 2010
    ..70, p = 0.002) and GO (OR = 0.65, p = 0.02). The results confirmed that the rs1800587 (IL-alpha, T-889 C) and rs16944 (IL-1beta, A-511 G) polymorphisms may confer susceptibility to GD and GO in Asian population...
  36. ncbi [The relationships between changes of serum osteoprotegerin, nuclear factor-kappa B ligand receptor activator, and age, menopause, bone biochemical markers and bone mineral densities in women aged 20 - 75]
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 43:447-50. 2004
    ....
  37. ncbi [The relationship between body composition measured with bioelectric impedance analysis and bone mass in female]
    Hong Yan Zhao
    Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 43:506-9. 2004
    ..To investigate the effect of fat mass and fat-free mass on bone mineral density (BMD) in pre- and postmenopausal women...
  38. ncbi [Prevalence and predictors of microalbuminuria in persons with various glucose tolerance levels]
    Li Huo
    Department of Endocrinology, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Zhonghua Yi Xue Za Zhi 87:2537-40. 2007
    ..To investigate the prevalence of microalbuminuria in persons with various glucose tolerance levels and the risk factors for the development of microalbuminuria...
  39. ncbi Serum C-reactive protein (CRP) and microalbuminuria in relation to fasting and 2-h postload plasma glucose in a Chinese population
    Xiao Ying Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Division of Endocrinology and Metabolism, E Institutes of Shanghai Universities, Shanghai, China
    Clin Endocrinol (Oxf) 70:691-7. 2009
    ..The association of these factors of cardiovascular risk with fasting and 2-h postload plasma glucose in a group of Chinese subjects was investigated...
  40. ncbi Relationships between C-reactive protein, white blood cell count, and insulin resistance in a Chinese population
    Yu Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, The State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, China
    Endocrine 39:175-81. 2011
    ..Both CRP and WBC were significantly associated with risks of IR. CRP might be a more effective biomarker in terms of the association with IR...
  41. ncbi L-selectin gene polymorphisms in Graves' disease
    Hao Yan Chen
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Clin Endocrinol (Oxf) 67:145-51. 2007
    ..However, the impact of L-selectin polymorphisms on GD has not yet been investigated. The aim of the present study was to elucidate whether L-selectin gene polymorphisms were associated with the development of GD...
  42. ncbi p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration
    Rui xin Liu
    Shanghai Key Laboratory for Endocrine Tumors, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    Endocrine 38:38-47. 2010
    ..Activation of JNK pathway was also detected in thymic carcinoid with high level of PAK3 expression. Our findings suggested a potential role of PAK3 in the progression of ACTH-producing thymic carcinoid...
  43. ncbi Elevated serum levels of interleukin-18 are associated with insulin resistance in women with polycystic ovary syndrome
    Yi Fei Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197 Ruijin 2nd Road, 200025, Shanghai, P R China
    Endocrine 29:419-23. 2006
    ..It indicates that IL-18 may be a contributing factor linking inflammation and insulin resistance in PCOS women...
  44. ncbi Association of WBC count and glucose metabolism among Chinese population aged 40 years and over
    Jing Yan Tian
    Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 197 Ruijin Er Lu, Shanghai 200025, China
    Diabetes Res Clin Pract 82:132-8. 2008
    ..WBC count was associated with lipid metabolism in males and with various components of the metabolic syndrome in females and subjects who never smoked...
  45. ncbi Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients
    Menglei Chao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E Institutes of Shanghai Universities, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People s Republic of China
    Endocrine 36:268-74. 2009
    ..No severe side effect was found in TCM group. TCM can ameliorate insulin resistance in type 2 diabetes and it is safe and effective in newly diagnosed diabetic patients...
  46. ncbi Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis
    Xinran Ma
    Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine SJTUSM, 225 South Chongqing Road, Shanghai 200025, China
    J Hepatol 55:445-52. 2011
    ..We sought to determine the influence of SRC-3 on hepatic steatosis and the mechanism beneath...
  47. ncbi [The clinical patterns and RET proto-oncogene in fifteen multiple endocrine neoplasia type 2A pedigrees]
    Yu Lin Zhou
    Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 46:466-70. 2007
    ..To detect the phenotype and rearranged mutations during transfection of RET proto-oncogene in fifteen multiple endocrine neoplasia type 2A (MEN2A) probands and their family members...
  48. ncbi Gene expression profiles of thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome reveal novel molecular mechanism
    Yu fang Bi
    Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Endocr Relat Cancer 16:1273-82. 2009
    ..Hence, this study has provided not only a detailed comprehension of the molecular pathogenesis of thymic carcinoids with ectopic ACTH syndrome, but also a road map to approach thymic NETs at the system level...
  49. ncbi Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults
    Aiyun Song
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 6:e19228. 2011
    ..We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older...
  50. ncbi Serum uric acid associates with the incidence of type 2 diabetes in a prospective cohort of middle-aged and elderly Chinese
    Tiange Wang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Endocrine 40:109-16. 2011
    ..Serum uric acid was an independent predictor of incident type 2 diabetes in middle-aged and elderly Chinese...
  51. ncbi The association of serum chemerin level with risk of coronary artery disease in Chinese adults
    Qun Yan
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China
    Endocrine 41:281-8. 2012
    ..05). Higher serum chemerin levels were associated with increased risk of CAD and metabolic parameters in Chinese adults. Chemerin may represent a novel link between metabolic signals and atherosclerosis...
  52. ncbi Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus
    Yifei Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E Institutes of Shanghai Universities EISU and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui Jin Hospital, Shanghai, 200025, China
    Endocrine 38:181-7. 2010
    ....
  53. ncbi Aberrant expression and modification of silencing mediator of retinoic acid and thyroid hormone receptors involved in the pathogenesis of tumoral cortisol resistance
    Jingjing Jiang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Endocrinology 151:3697-705. 2010
    ..These results suggested that aberrant expression and modification of SMRT might be involved in the pathogenesis of tumoral cortisol resistance. A therapeutic approach targeting SMRT SUMOylation might be developed for EAS patients...
  54. ncbi Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese
    Jie Xiang
    Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 93:4107-12. 2008
    ....
  55. ncbi GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes
    Hong Gao
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai, 200025, China
    Endocrine 32:90-5. 2007
    ..These results indicate that GLP-1 and its analogue exendin-4 can amplify insulin signaling in 3T3-L1 adipocytes by up-regulation of some crucial insulin signaling molecules...
  56. ncbi Association between alcohol consumption and metabolic syndrome in 19,215 middle-aged and elderly Chinese
    Lina Jin
    Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Diabetes Res Clin Pract 92:386-92. 2011
    ..To assess the association of alcohol consumption with metabolic syndrome (Mets) in a Chinese population...
  57. ncbi Obesity and its associations with hypertension and type 2 diabetes among Chinese adults age 40 years and over
    Yan Hong He
    School of Public Health, Shanghai Jiao Tong University, Shanghai, China
    Nutrition 25:1143-9. 2009
    ....
  58. ncbi PTH inhibition rate is useful in the detection of early-stage primary hyperparathyroidism
    Lin Zhao
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China
    Clin Biochem 44:844-8. 2011
    ..This study was to establish biochemical thresholds for the intravenous calcium suppression test in the early diagnosis of primary hyperparathyroidism (PHPT)...
  59. ncbi Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
    Li Qun Gu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China
    Clin Endocrinol (Oxf) 72:248-55. 2010
    ..Furthermore, we evaluated the influences these SNPs have on the risk and severity of GD...
  60. ncbi A population-based study examining calcaneus quantitative ultrasound and its optimal cut-points to discriminate osteoporotic fractures among 9352 Chinese women and men
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Clin Endocrinol Metab 97:800-9. 2012
    ..No generally accepted thresholds for quantitative ultrasound (QUS) parameters to screen individuals at high risk of osteoporotic fractures have been defined...
  61. ncbi The change points of HbA(1C) for detection of retinopathy in Chinese type 2 diabetic patients
    Jia Ning Hou
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai, China
    Diabetes Res Clin Pract 91:401-5. 2011
    ..To investigate the change points of HbA(1C) for detection of retinopathy in Chinese type 2 diabetic patients...
  62. ncbi Progress in diabetes research in China
    Guang Ning
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    J Diabetes 1:163-72. 2009
    ....
  63. ncbi GnRH secretion is inhibited by adiponectin through activation of AMP-activated protein kinase and extracellular signal-regulated kinase
    Xiao Bing Cheng
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Key Laboratory of Endocrine and Metabolic Diseases of Chinese Health Ministry, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Endocrine 39:6-12. 2011
    ..Furthermore, we found that activated AMPK by adiponectin reduced ERK phosphorylation, which possibly impaired GnRH secretion in GT1-7 cells...
  64. ncbi Association between higher serum fetuin-A concentrations and abnormal albuminuria in middle-aged and elderly chinese with normal glucose tolerance
    Mian Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Diabetes Care 33:2462-4. 2010
    ..To study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT)...
  65. ncbi SRC-3 deficient mice developed fat redistribution under high-fat diet
    Lingyan Xu
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS, Shanghai, China
    Endocrine 38:60-6. 2010
    ..Our results presented in vivo evidence that SRC-3 deficiency could lead to fat redistribution under HFD in mice and provided new clues to researches on the pathogenesis of fat redistribution...
  66. ncbi Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family
    Li Hao Sun
    Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
    Endocrine 36:25-9. 2009
    ..We found a novel frame shift mutation in exon 11 of the GNAS gene identified in both of the two boys and their mother. This report provides another example of a Gs-alpha mutation leading to PHP...
  67. ncbi Differences between measurements of bone mineral densities by quantitative ultrasound and dual-energy X-ray absorptiometry in type 2 diabetic postmenopausal women
    Bei Tao
    Department of Endocrine and Metabolic Diseases, Shanghai Rui Jin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, China
    J Clin Endocrinol Metab 93:1670-5. 2008
    ..Quantitative ultrasound (QUS) may be more helpful than dual-energy X-ray absorptiometry (DXA) in detecting bone deficits in patients with type 2 diabetes mellitus (T2DM)...
  68. ncbi Variations in the promoter of CYP21A2 gene identified in a Chinese patient with simple virilizing form of 21-hydroxylase deficiency
    Hui jie Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Clin Endocrinol (Oxf) 70:201-7. 2009
    ..The present study aims to verify that the variations in the promoter of CYP21A2 relate to the classical form of 21OHD...
  69. ncbi Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy
    Yun Ze Xu
    Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, No 197, Ruijin Er Road, Shanghai, 200025, China
    Endocrine 40:445-51. 2011
    ..001; r_s = 0.834, P < 0.001). In conclusion, these results suggest that angiogenesis of human ACC maybe mediated by these proteins and they could represent selective targets for the molecularly targeted treatments of ACC...
  70. ncbi Diagnosis and therapy for Cushing's disease with negative dynamic MRI finding: a single-centre experience
    Yuhao Sun
    Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Department of Neurology, Wuxi NO 3 People s Hospital, Wuxi Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Clin Endocrinol (Oxf) 76:868-76. 2012
    ..Conclusions? Based on the findings outlined, MRI-negative CD may be a surgically remediable syndrome, with a pathophysiological basis that primarily involves a pituitary cause of the hypercortisolaemia...
  71. ncbi Protective effect of andrographolide against concanavalin A-induced liver injury
    Guojun Shi
    Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, No 197 Rui Jin 2nd Road, Shanghai, 200025, China
    Naunyn Schmiedebergs Arch Pharmacol 385:69-79. 2012
    ..The hepatic protective effect of Ag indicates that Ag supplementation may be beneficial in the treatment of immune-mediated liver injury...
  72. ncbi A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese
    Bin Cui
    Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 6:e22353. 2011
    ..Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited...
  73. ncbi A novel SRD5A2 mutation with loss of function identified in Chinese patients with hypospadias
    Manna Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Horm Res Paediatr 76:44-9. 2011
    ..To investigate the functional change of SRD5A2 gene mutations identified in patients with 5?-reductase type 2 deficiency...
  74. ncbi Two unusual cases of intractable hyperthyroidism responsive to octreotide: Munchausen syndrome or not?
    Jian min Liu
    Department of Endocrine and Metabolic Diseases, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China
    Clin Chim Acta 412:1155-60. 2011
    ..The effective treatment for patients with resistant hyperthyroidism is difficult...
  75. ncbi Heparanase-1 and Cyclooxygenase-2: prognostic indicators of malignancy in pheochromocytomas
    Yu Zhu
    Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Endocrine 38:93-9. 2010
    ..Heparanase-1 and Cyclooxygenase-2 combined is better than their own to be used as a marker to distinguish malignant from benign pheochromocytoma...
  76. ncbi Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine
    Yifei Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, People s Republic of China
    J Clin Endocrinol Metab 93:2559-65. 2008
    ..The potential glucose-lowering effect of berberine was noted when it was used for diarrhea in diabetic patients. In vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia...
  77. ncbi Multiple endocrine neoplasia type 1 simultaneous with various types of enteropancreatic endocrine tumors: one case report: lessons learned
    Guangwen Zhou
    Department of Surgery, RuijinHospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Pancreas 39:680-3. 2010
    ..She was treated by means of several surgical strategies, resulting in improvement of the frequency and severity of the hypoglycemic episodes and a better quality of life...
  78. ncbi Andrographolide attenuates tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes
    Lina Jin
    Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mol Cell Endocrinol 332:134-9. 2011
    ..These findings are helpful in understanding the anti-diabetic properties of AG and can be of interest for the therapeutic application of AG in glucose controlling...
  79. ncbi Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes
    Libin Zhou
    Shanghai Institute of Endocrine and metabolic Disease, Department of Endocrine and Metabolic Disease, Shanghai Clinical Center for Endocrine and Metabolic Disease, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Biochim Biophys Acta 1812:527-35. 2011
    ..These results suggest that berberine exerts an antilipolytic effect mainly by reducing the inhibition of PDE, leading to a decrease in cAMP and HSL phosphorylation independent of AMPK pathway...
  80. ncbi GPR48 increases mineralocorticoid receptor gene expression
    Jiqiu Wang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E Institute of Shanghai Universities, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Am Soc Nephrol 23:281-93. 2012
    ..Taken together, our data demonstrate that GPR48 enhances aldosterone responsiveness by activating MR expression, suggesting that GPR48 contributes to homeostasis of electrolytes and BP and may be a candidate gene for PHA1...
  81. ncbi Association of XIAP and P2X7 receptor expression with lymph node metastasis in papillary thyroid carcinoma
    Li Qun Gu
    Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, People s Republic of China
    Endocrine 38:276-82. 2010
    ..001). Our results suggested that XIAP and P2X7 receptor expression may predict the aggressiveness of PTC...
  82. ncbi G protein-coupled receptor 48 upregulates estrogen receptor alpha expression via cAMP/PKA signaling in the male reproductive tract
    Xiao Ying Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
    Development 137:151-7. 2010
    ..In conclusion, Gpr48 participates in the development of the male epididymis and efferent ducts through regulation of ERalpha expression via the cAMP/PKA signaling pathway...
  83. ncbi An assessment of the use of quantitative ultrasound and the Osteoporosis Self-Assessment Tool for Asians in determining the risk of nonvertebral fracture in postmenopausal Chinese women
    Bei Tao
    Department of Endocrine and Metabolic Diseases, Shanghai Rui Jin Hospital, Jiaotong University, School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China
    J Bone Miner Metab 26:60-5. 2008
    ....
  84. ncbi A genome-wide association study identifies two new risk loci for Graves' disease
    Xun Chu
    State Key Laboratory of Medical Genomics, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Nat Genet 43:897-901. 2011
    ..Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease...
  85. ncbi Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity
    Qidi Wang
    Shanghai Key Laboratory for Endocrine Tumors and Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 6:e21006. 2011
    ..The present study is to determine whether BAT activity can be independently stimulated by elevated catecholamines levels in adult human, and whether it is associated with their adiposity...
  86. ncbi High sensitive C-reactive protein, adiponectin, and urine albumin excretion rate in Chinese coronary artery disease patients with different glucose tolerance status
    Ming Hui Gui
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Chin Med J (Engl) 121:2509-16. 2008
    ....
  87. ncbi Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults
    Yifei Zhang
    State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Endocrine and Metabolic E Institutes of Shanghai Universities, and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Am J Cardiol 106:1461-5. 2010
    ..In conclusion, our data indicate that serum osteocalcin level was associated with decreased risk of CHD and protective metabolic changes in Chinese adults...
  88. ncbi DAX1 suppresses FXR transactivity as a novel co-repressor
    Jin Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Biochem Biophys Res Commun 412:660-6. 2011
    ..In addition, our study characterized that DAX1 suppresses FXR transactivation via competing with co-activators such as SRC-1 and PGC-1?. In conclusion, DAX1 acts as a co-repressor to negatively modulate FXR transactivity...
  89. ncbi The expression and pathophysiological role of osteopontin in graves' disease
    Lingyan Xu
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, and Department of Endocrine and Metabolic Diseases, Rui Jin Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China
    J Clin Endocrinol Metab 96:E1866-70. 2011
    ..OPN could affect GD development through NF-?B activation and the subsequent changes in inflammatory milieu. OPN could serve as a novel biomarker for GD as well as a potential target for GD treatment...
  90. ncbi Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease
    Chaoming Mao
    Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Immunol 186:4734-43. 2011
    ..Collectively, uGD-derived DCs through pDC polarization and elevated thyroid hormones act in concert to impair the regulatory capacity of Treg cells, facilitating the production of TSHR autoantibodies in the pathogenesis of GD...
  91. ncbi Assessment of bilateral inferior petrosal sinus sampling in the diagnosis and surgical treatment of the ACTH-dependent Cushing's syndrome: a comparison with other tests
    Xiuhua Shi
    Department of Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Neuro Endocrinol Lett 32:865-73. 2011
    ..As a result, we investigated whether such invasive test compared other noninvasive tests may affect the efficacy and accuracy of diagnosis and TSS treatment in ACTH-dependent CS...
  92. ncbi Seven novel DAX1 mutations with loss of function identified in Chinese patients with congenital adrenal hypoplasia
    Na Li
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Clin Endocrinol Metab 95:E104-11. 2010
    ..The correlation of clinical features with genetic and functional alterations of the gene was investigated in detail in AHC patients...
  93. ncbi Ginsenoside Re reduces insulin resistance through inhibition of c-Jun NH2-terminal kinase and nuclear factor-kappaB
    Zhiguo Zhang
    Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin 2nd Road, Shanghai 200025, China
    Mol Endocrinol 22:186-95. 2008
    ..In conclusion, Re reduces insulin resistance in 3T3-L1 adipocytes and HFD rats through inhibition of JNK and NF-kappaB activation...
  94. ncbi Expression of IFNalpha-inducible genes and modulation of HLA-DR and thyroid stimulating hormone receptors in Graves' disease
    Miao Kuang
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University Medical School, Shanghai, China
    Mol Cell Endocrinol 319:23-9. 2010
    ..Taken together, these data indicated that in GD patients, IFNalpha can function on thyroid tissue to induce a number of genes, particularly MHC class II molecules which may enhance autoantigen presentation of TSHR on thyrocytes...
  95. ncbi Gut hormones and the brain
    Yifei Zhang
    Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E Institutes of Shanghai Universities, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Diabetes 2:138-45. 2010
    ..Results from further clinical studies with related therapies will help us determine the role of these treatments in the management of energy homeostasis...
  96. ncbi Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential
    Jun Ping Wen
    Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Key Laboratory of Endocrine Tumors, Endocrine and Metabolic Division, Shanghai Jiao Tong University School of Medicine, China
    Biochem Biophys Res Commun 371:756-61. 2008
    ..GnRH secretion was inhibited via activation of AMP-activated protein kinase (AMPK). Moreover, we revealed that hyperpolarization of plasma membrane potentials and reduction of calcium influx was also caused by adiponectin...
  97. ncbi Selective ?1-adrenoceptor antagonist (controlled release tablets) in preoperative management of pheochromocytoma
    Yu Zhu
    Department of Urology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China
    Endocrine 38:254-9. 2010
    ..Although phenoxybenzamine provided better arterial pressure control, patients pretreated with DOX experienced more stable perioperative hemodynamic changes, shorter preoperative management periods and more simple medication...
  98. ncbi Loss of steroid receptor co-activator-3 attenuates carbon tetrachloride-induced murine hepatic injury and fibrosis
    Xinran Ma
    Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Lab Invest 89:903-14. 2009
    ..Our results established an essential involvement of SRC-3 in liver fibrogenesis, which might provide new clues to the future treatment of hepatic fibrosis...