Xiuwei Yang

Summary

Affiliation: Peking University
Country: China

Publications

  1. ncbi [GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:227-31. 2007
  2. ncbi The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model
    Xiu Wei Yang
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China
    Planta Med 76:1587-91. 2010
  3. ncbi [The biotransformation of kaempferitrin by human intestinal flora]
    Xiu Wei Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 40:717-21. 2005
  4. ncbi Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Bioorg Med Chem Lett 17:1107-11. 2007
  5. ncbi [GC-MS analysis of essential oils from Radix Angelicae Pubescentis]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:663-6. 2006
  6. ncbi [Toxicological assessment on safety of water and 70% ethanolic extracts of nearly ripe fruit of Evodia rutaecarpa]
    Xiu Wei Yang
    Department of Natural Medicines, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 33:1317-21. 2008
  7. ncbi [Studies on chemical constituents in fruits of Eucalyptus globulus]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:496-500. 2007
  8. ncbi [Discovery strategy for effective and active constituents of Chinese material medica based on processes of metabolism and disposition in intra-body]
    Xiu Wei Yang
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:365-70. 2007
  9. ncbi [Study on excretion of ginsenoside Rg2 in rats]
    Xiuwei Yang
    School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:1281-4. 2009
  10. ncbi [Key foundational science problem in experimental medicine study of Chinese materia medica: ascertainment of active and toxic constituents from Chinese materia medica]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Medical and Health Analysis Center, Peking University, Beijing 100083, China
    Zhong Xi Yi Jie He Xue Bao 3:154-9. 2005

Collaborators

Detail Information

Publications71

  1. ncbi [GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:227-31. 2007
    ....
  2. ncbi The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model
    Xiu Wei Yang
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, China
    Planta Med 76:1587-91. 2010
    ..Among them, eight neolignans were transported mainly VIA passive diffusion. These findings indicate that the 8- O-4'-type neolignans are well-absorbed compounds and can be used as oral leading compounds in drug discovery...
  3. ncbi [The biotransformation of kaempferitrin by human intestinal flora]
    Xiu Wei Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 40:717-21. 2005
    ..To study the biotransformation of kaempferitrin, a major chemical principle of the fruits of Siraitia grosvenori (Swingle) C. Jeffery, with human intestinal flora...
  4. ncbi Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Bioorg Med Chem Lett 17:1107-11. 2007
    ..M-A and M-B appear to accumulate in the epithelial cells. The intestinal absorption of M-A, M-B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent...
  5. ncbi [GC-MS analysis of essential oils from Radix Angelicae Pubescentis]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:663-6. 2006
    ..To analyze the constituents of the essential oils from Radix Angelicae Pubescentis planted in a GAP base of the Chinese medica materials, and provide the scientific basis for quality control...
  6. ncbi [Toxicological assessment on safety of water and 70% ethanolic extracts of nearly ripe fruit of Evodia rutaecarpa]
    Xiu Wei Yang
    Department of Natural Medicines, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 33:1317-21. 2008
    ..To study the acute toxicity and mutagenic risk of the water extracts (ERWE) and 70% ethanol extracts (EREE) from the nearly ripe fruit of Evodia rutaecarpa, and provide experimental basis for safety evaluation of ones...
  7. ncbi [Studies on chemical constituents in fruits of Eucalyptus globulus]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:496-500. 2007
    ..To study the chemical constituents in the fruits of Eucalyptus globulus Labill...
  8. ncbi [Discovery strategy for effective and active constituents of Chinese material medica based on processes of metabolism and disposition in intra-body]
    Xiu Wei Yang
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:365-70. 2007
    ....
  9. ncbi [Study on excretion of ginsenoside Rg2 in rats]
    Xiuwei Yang
    School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:1281-4. 2009
    ..To determine the ginsenoside Rg2 and study its excretion in bile, feces and urine of rat...
  10. ncbi [Key foundational science problem in experimental medicine study of Chinese materia medica: ascertainment of active and toxic constituents from Chinese materia medica]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Medical and Health Analysis Center, Peking University, Beijing 100083, China
    Zhong Xi Yi Jie He Xue Bao 3:154-9. 2005
    ..This method is also an important research assignment in the field of experimental medicine study of Chinese materia medica...
  11. ncbi [Studies on the chemical constituents from herba anoectochili]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhong Yao Cai 30:797-800. 2007
    ..To study the chemical constituents in the whole herb of Anoectochiluts roxburghii (Wall) Lindl...
  12. ncbi The permeability and the efflux of alkaloids of the Evodiae fructus in the Caco-2 model
    Xiu Wei Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Phytother Res 23:56-60. 2009
    ..The data support the involvement for multidrug resistance-associated proteins (MRPs) in the intestinal transcellular efflux of WZYB...
  13. ncbi [Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhong Xi Yi Jie He Xue Bao 5:634-41. 2007
    ..To establish Caco-2 (a human colon adenocarcinoma cell line) cell monolayer model and the standard operation procedure for studying and assessing intestinal absorption of chemical components of traditional Chinese medicine...
  14. ncbi [Studies on chemical constituents from whole plants of Crossostephium chinense]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 33:905-8. 2008
    ..Compounds 3-8 were isolated from the plant for the first time...
  15. ncbi Three new triterpenoid saponins from the seeds of Aesculus turbinata
    Xiu Wei Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing, China
    J Asian Nat Prod Res 10:259-65. 2008
    ....
  16. ncbi [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model]
    Xiu Wei Yang
    Department of Natural Medicines, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhong Xi Yi Jie He Xue Bao 6:392-8. 2008
    ..biserrata) in the human Caco-2 cell monolayer model...
  17. ncbi [New neolignan from seed of Myristica fragrans]
    Xiu Wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 33:397-402. 2008
    ..To study the chemical constituents in the nutmeg (seed of Myristica fragrans)...
  18. ncbi [Biotransformation of mogroside III by human intestinal bacteria]
    Xiu Wei Yang
    Department of Natural Medicines, Peking University School of Pharmaceutical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 39:657-62. 2007
    ....
  19. ncbi [Establishment of model and standard operation procedure for biotransformation of chemical constituents of traditional Chinese medicine by human intestinal bacteria]
    Xiuwei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 36:19-26. 2011
    ..To establish human intestinal bacteria biotransformation model and the standard operation procedure for studying and assessing intestinal biotransformation of chemical constituents of traditional Chinese medicine (TCM)...
  20. ncbi The efflux of flavonoids morin, isorhamnetin-3-O-rutinoside and diosmetin-7-O-beta-D-xylopyranosyl-(1-6) -beta-D-glucopyranoside in the human intestinal cell line caco-2
    XiaoJuan Tian
    Department of Chemical Biology and State Key Laboratories of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, People's Republic of China
    Pharm Res 23:1721-8. 2006
    ..CONCLUSION: These data support a role for MRPs in the intestinal transcellular efflux of morin, IRR, DXG and possibly other hydrophilic flavonoid aglycons and glycosides...
  21. ncbi Cinnabar is not converted into methylmercury by human intestinal bacteria
    Xinrui Zhou
    State Key Laboratories of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China
    J Ethnopharmacol 135:110-5. 2011
    ..As for the toxicity of cinnabar, one important assumption is that cinnabar may be transformed into highly toxic methylmercury by gastrointestinal flora. There is no evidence in humans to support this assumption...
  22. ncbi Differential cytotoxic effects of denitroaristolochic acid II and aristolochic acids on renal epithelial cells
    Qing Liu
    School of Public Health, Peking University, Beijing 100083, China
    Toxicol Lett 184:5-12. 2009
    ..The results suggest that the nitro group plays an important role in AA-mediated cytotoxicity in MDCK cells and increased intracellular ROS levels may be associated, at least in part, with the cell injury observed in MDCK cells...
  23. ncbi [Bioactivity guided isolation of alpha-glucosidase inhibitor from whole herbs of Crossostephium chinense]
    Qi Wu
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:2206-11. 2009
    ..To investigate the chemical constituents of 70% aqueous ethanol extract from the whole plant of Crossostephium chinense for inhibitory activity against alpha-glucosidase...
  24. ncbi [GC-MS analysis of essential oil of the flower of the Chrysanthemum morifolium by the different processing methods]
    Ying Wang
    The State Key Laboratory of Natural and Biomimetic Drugs, School Sciences of Pharmaceutical of Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 31:456-9. 2006
    ..260%, and that from the braised sample was 0.108%. The former is 1.5 times higher than the latter. There are differences between the constitutions of the two samples...
  25. ncbi [GC-MS analysis of essential oil from nutmeg processed by different traditional methods]
    Xin Hang
    Department of Natural Medicines and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:1669-75. 2007
    ....
  26. ncbi [GC-MS analysis of essential oil of honeyed red ginseng]
    Wei Xu
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University
    Zhongguo Zhong Yao Za Zhi 34:591-5. 2009
    ..To investigate the constituents of essential oil of honeyed red ginseng, and provide scientific basis for its quality evaluation...
  27. ncbi Antiviral flavonoid-type C-glycosides from the flowers of Trollius chinensis
    Shao Qing Cai
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Chem Biodivers 3:343-8. 2006
    ..All compounds were identified by HR-ESI-MS and in-depth NMR-spectroscopic analyses. In antiviral assays, compound 3 was found to be moderately active towards influenza virus A...
  28. ncbi [Raman spectroscopic analysis of cinnabar as a traditional Chinese medicine]
    Qi Wang
    School of Public Health, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:1527-9. 2009
    ..To develop a new quality control method for cinnabar, in order to ensure the safety application of cinnabar...
  29. ncbi [Absorption and transportation characteristic of alkaloids from herba ephedra in model of Caco-2 cells monolayer]
    Yin Liao
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 35:3010-5. 2010
    ..To study the absorption and transportation characteristic of 1-ephedrine (LEP), d-pseudoephedrine (DPEP), d-norpseudoephedrine (DNPE) isolated from Herba Ephedrae, which were classified the alkaloids, in human intestinal epithelium...
  30. ncbi [A new flavonoid glucoside from Huanglianjiedutang decoction]
    Zhaotang Ma
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:1097-100. 2009
    ....
  31. ncbi [Effects of chemical constituents of Crossostephium chinense on insulin secretion in rat islets in vitro]
    Lei Zou
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing10l091, China
    Zhongguo Zhong Yao Za Zhi 34:1401-5. 2009
    ..To investigate the effects of the chemical constituents of the whole herbs of Crossostephium chinense on insulin secretion in rat islets...
  32. ncbi [O-methylnotopterol, a new natural product from the roots and rhizomes of Notopterygium incisum]
    Guifengl Kou
    1 State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 35:1134-6. 2010
    ..To study the chemical constituents of ethyl acetate-soluble fraction from methanolic extract of the roots and rhizomes of Notopterygium incisum ...
  33. ncbi [Chemical constitutents from pre-formulation of lonicerae japonicae flos in shuanghuanglian lyophilized powder for injection]
    Nan Wang
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 36:1613-9. 2011
    ....
  34. ncbi Quantification of myrislignan in rat plasma by solid-phase extraction and reversed-phase high-performance liquid chromatography
    Fei Li
    The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People s Republic of China
    Biomed Chromatogr 22:601-5. 2008
    ..Intra- and inter-day precisions were 2.4-7.5 and 1.3-5.7%, respectively. The extraction recovery from plasma was more than 90%. This assay method has been successfully used to study the pharmacokinetics of myrislignan in rats...
  35. ncbi Isolation and identification of metabolites from dihydromyricetin
    Yansong Zhang
    Department of Natural Medicines and State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, No 38 Xueyuan Road, Beijing 100083, P R China
    Magn Reson Chem 45:909-16. 2007
    ..These seven metabolites were formed through familiar metabolic reactions. Dihydromyricetin-O-5-beta-D-glucuronide (5) is a new compound. The (13)C-NMR data of (2) and (4) are reported for the first time...
  36. ncbi New spirobenzofuranoid dibenzocyclooctadiene lignans from Kadsura oblongifolia
    Haitao Liu
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Fitoterapia 82:731-4. 2011
    ..Their structures were elucidated on the basis of spectral evidences and comparisons with literatures. Compounds 3-7 were isolated from this plant for the first time...
  37. ncbi [Assay of andrographolide bulk drug by HPLC]
    Wei Xu
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 35:2113-5. 2010
    ..To establish a method for the determination of andrographolide bulk drug by HPLC...
  38. ncbi [Chalcones from Bauhinia glauca subsp. pernervosa]
    Zengbao Wu
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:1676-8. 2009
    ..To study the chemical constituents of Bauhinia glauca subsp. pernervosa...
  39. ncbi [GC-MS analysis of essential oils from seeds of Myristica fragrans in Chinese market]
    Ying Wang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 29:339-42. 2004
    ..RESULT: 95-118 compounds were separated respectively. 79 Compounds being identified which were 95.18%-98.70% of the total essential oil. CONCLUSION: Myristicin (39.63%) and terpene series were the main compounds...
  40. ncbi [GC-MS analysis of essential oil from root of Angelica dahurica cv. Qibaizhi]
    Aihong Zhao
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 36:603-7. 2011
    ..Essential oil from root of Angelica dahurica cv. Qibaizhi were studied...
  41. ncbi [Liposolubility constituents from leaves of Aquilaria sinensis]
    Jie Feng
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 36:2092-5. 2011
    ..To study the chemical constituents of the leaves of Aquilaria sinensis...
  42. ncbi Evidence of gastro-intestinal system as an active and toxic target of sasanqua saponins extract
    Jia Shen
    Laboratory of Pharmaceutical Sciences, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China
    Exp Toxicol Pathol 60:43-9. 2008
    ..The excretion time of feces was significantly prolonged by the oral SSE treatment. These results indicate that SSE is a kind of extract of a narrow active window and the its active and toxic target could be gastro-intestinal system...
  43. ncbi The anxiolytic effect of cinnabar involves changes of serotonin levels
    Qi Wang
    School of Public Health, Peking University, Beijing 100083, P R China
    Eur J Pharmacol 565:132-7. 2007
    ..The cinnabar showed no effects on 5-HT metabolism pathway. The results suggested the potential importance of the brain serotonergic system. The 5-HT metabolism pathway may be not involved in the anxiolytic effects of cinnabar...
  44. ncbi [New dibenzofuran and anthraquinone from Usnea longissima]
    Jie Feng
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
    Zhongguo Zhong Yao Za Zhi 34:852-3. 2009
    ..To study the chemical constituents of Usnea longissima...
  45. ncbi Two new lanostane triterpenoids from Poria cocos
    Yan Zheng
    State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University, Beijing, China
    J Asian Nat Prod Res 10:323-8. 2008
    ..Wolf. Their structures were determined by extensive spectroscopic analyses, including IR, UV, ESITOF-MS, HRESI-MS, 1D and 2D NMR data (1H NMR, 13C NMR, 1H-1H COSY, NOESY, HSQC and HMBC)...
  46. ncbi A new ellagic acid derivative from the fruits of Eucalyptus globulus Labill
    Qing-mei Guo
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing, China
    Pharmazie 60:708-10. 2005
    ..It is alsoassignment the 13C NMR signals of 3-O-methylellagic acid 4'-O-alpha-L-rhamnopyranoside for the first...
  47. ncbi [Characteristics of uptake, transport and efflux of Z- and E-ajoenes in Caco-2 cell monolayers in vitro]
    Li Tian
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Yao Xue Xue Bao 42:87-92. 2007
    ..The metabolism might be in correlation with cytochrome P450 drugs metabolism enzymes in Caco-2 cell monolayers...
  48. ncbi [Analysis of fatty acids in the seeds of Sterculia lychnophora by GC-MS]
    Ru Feng Wang
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 28:533-5. 2003
    ..To analyze and identify fatty acids in the seeds of Sterculia lychnophora...
  49. ncbi [Studies on the chemical constituents in herbs of ethanolic extract from herbs of Dicliptera chinensis]
    Yu-tao Gao
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 31:985-7. 2006
    ..CONCLUSION: All the compounds except 6 were obtained from the plants of Dicliptera for the first time...
  50. ncbi [Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I]
    Xiu-wei Yang
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100083, China
    Beijing Da Xue Xue Bao 36:31-5. 2004
    ..Desacylescin I as a biotransformation product showed potentially inhibitory effects on mouse tumor, and a potential candidate for anti tumor agents...
  51. ncbi Four new triterpene saponins from the seeds of Aesculus chinensis
    Jing Zhao
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences of Peking University, Beijing 100083, China
    J Asian Nat Prod Res 5:197-203. 2003
    ..Their structures were established on the basis of spectroscopic and chemical evidence...
  52. ncbi [Bioactive constituents inhibiting TNF-alpha production in fresh rhizome of Pinellia ternata]
    Mei Hua Han
    State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 32:1755-9. 2007
    ..To study the bioactive constituents of the fresh rhizome of Pinellia ternata, and provide the scientific basis for quality control...
  53. ncbi Determination and pharmacokinetic study of nodakenin in rat plasma by RP-HPLC method
    Peng Zhang
    The State Key Laboratory of Natural and Biomimetic Drugs, and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People s Republic of China
    Biomed Chromatogr 22:758-62. 2008
    ..This assay method has been successfully applied to the study of the pharmacokinetics of nodakenin in rats...
  54. ncbi Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches
    Yashu Liu
    The National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    Mol Cell Proteomics 7:1737-47. 2008
    ..Our work provided useful clues to understanding the molecular mechanism underlying liver dysfunction in senescence-accelerated mouse...
  55. ncbi [Triterpenoid saponins from bark Mitragyna inermis]
    Zhi Hong Cheng
    National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 27:274-7. 2002
    ..To study the constituents of Mitragyna inermis that have an anti-tumor activity on Bel-7402 of hepatic carcinoma...
  56. ncbi [Pilot study on the mechanisms of growth inhibitory effect of cinobufagin on HeLa cells]
    Li Wang
    National Research Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing, 100083 China
    Zhonghua Zhong Liu Za Zhi 27:717-20. 2005
    ..It may lead to cell cycle arrest of HeLa cells at G(2)/M phase. It can also change the expression of some small molecular acidic proteins in HeLa cells...
  57. ncbi [Studies on the chemical constituents in herb of Ludwigia octovalvis]
    Jing Yan
    National Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    Zhongguo Zhong Yao Za Zhi 30:1923-6. 2005
    ..CONCLUSION: Compounds 3, 4, 6-13 were isolated from the plant for the first time. And compounds 3, 4, 6, 10, 12 were obtained from the genus for the first time...
  58. ncbi Trollioside, a new compound from the flowers of Trollius chinensis
    Ru-Feng Wang
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China
    J Asian Nat Prod Res 6:139-44. 2004
    ..The isolation and structural determination of these compounds are discussed...
  59. ncbi Two new acylgluconic acids from the nearly ripe fruits of Evodia rutaecarpa
    Meng Yao Zhao
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
    J Asian Nat Prod Res 10:769-73. 2008
    ..Benth. Their structures were determined by spectroscopic methods, including IR, UV, ESITOFMS, HRSIMS, 1D and 2D NMR spectral analyses...
  60. ncbi Alkaloids from the seeds of Sterculia lychnophora (Pangdahai)
    Ru Feng Wang
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No 38, Xueyuan Road, Beijing 100083, PR China
    Phytochemistry 63:475-8. 2003
    ..Their structures were elucidated by NMR, UV, IR and MS spectroscopic analysis...
  61. ncbi A new limonoid from the fruits of Evodia rutaecarpa (Juss.) Benth
    Jie Teng
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing, China
    Pharmazie 61:1038-40. 2006
    ..Shihulimonin A of known structure was also isolated from the unripe fruits of Evodia rutaecarpa for the first time...
  62. ncbi Biotransformation of myrislignan by rat liver microsomes in vitro
    Fei Li
    The State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China
    Phytochemistry 69:765-71. 2008
    ..Seven metabolites were produced by liver microsomes from rats pre-treated with sodium phenobarbital. These were identified, using spectroscopic methods, as myrislignanometins A-G (2-8), respectively...
  63. ncbi Simultaneous determination of diastereomers (+)-licarin A and isolicarin A from Myristica fragrans in rat plasma by HPLC and its application to their pharmacokinetics
    Fei Li
    Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, People s Republic of China
    Planta Med 74:880-4. 2008
    ..05 and 0.25 microg/mL for (+)-licarin A, and 0.05 and 0.10 microg/mL for isolicarin A, respectively. This assay method was successfully applied to study the pharmacokinetics of diastereomers (+)-licarin A and isolicarin A in rat plasma...
  64. ncbi Poriacosones A and B: two new lanostane triterpenoids from Poria cocos
    Yan Zheng
    State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
    J Asian Nat Prod Res 10:645-51. 2008
    ..The structures of the new compounds were established as 3alpha,16alpha-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (8) and 3beta,16alpha-dihydroxy-24-oxolanost-7,9(11)-dien-21-oic acid (9)...
  65. ncbi Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method
    Fang Jin Gui
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Medical and Healthy Analysis Center, Peking University, Beijing 100083, China
    J Chromatogr B Analyt Technol Biomed Life Sci 850:1-6. 2007
    ..A pharmacokinetic study in rat plasma indicated that the enantiomers were rapidly absorbed and eliminated. These assay results are necessary for the evaluation of the metabolism of ginsenoside-Rg2 in vivo...
  66. ncbi [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]
    Xiu Wei Yang
    The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100083, China
    Zhong Xi Yi Jie He Xue Bao 5:56-60. 2007
    ..To screen antitumor active compounds, drug-like or leading compounds from Chinese traditional and herbal drugs...
  67. ncbi Extremely low bioavailability of magnesium lithospermate B, an active component from Salvia miltiorrhiza, in rat
    Ying Zhang
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Planta Med 70:138-42. 2004
    ..04 %) after oral dosing. These findings suggest that extensive metabolism, including a first-pass effect, and wide distribution of LSB besides the poor absorption contributed significantly to the extremely low systemic bioavailability...
  68. ncbi New triterpenoid saponins from the roots of Sinocrassula asclepiadea
    Jing Zhao
    Department of Metabolic Engineering, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Chem Pharm Bull (Tokyo) 52:230-7. 2004
    ..Sinocrassulosides VI (4) and V (5) also contained a novel A-seco aglycone in their structures. All of the structures were determined on the basis of spectroscopic and physicochemical evidence...
  69. ncbi [GC-MS analysis of essential oil from Xiaoboju processed by aeration-desiccation and sulfur-burnin fumigation]
    Ya Jun Wang
    Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China
    Zhongguo Zhong Yao Za Zhi 32:808-13. 2007
    ....
  70. ncbi Magnesium lithospermate B is excreted rapidly into rat bile mostly as methylated metabolites, which are potent antioxidants
    Ying Zhang
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
    Drug Metab Dispos 32:752-7. 2004
    ..The rapid and high biliary excretion levels of these metabolites suggested that they could undergo enterohepatic circulation in rats and that they might thereby be largely responsible for the pharmacological effects of MLB...
  71. ncbi 27-Nor-triterpenoid glycosides from Mitragyna inermis
    Zhi Hong Cheng
    Department of Complex Presection of CMM, China Pharmaceutical University, 210038, Nanjing, People s Republic of China
    Phytochemistry 61:379-82. 2002
    ....