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Species | Zhi bin LinSummaryAffiliation: Peking University Country: China Publications
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Publications
[The pharmacological study of Ganoderma spores and their active components]Zhi bin Lin
Department of Pharmacology, Peking University School of Basic Medical Sciences, Beijing 100083, China
Beijing Da Xue Xue Bao 38:541-7. 2006..The possible problems and their solutions in this research area are also discussed...- Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidumZhi bin Lin
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center
J Pharmacol Sci 99:144-53. 2005..However, whole animal experiments are still needed to further establish the mechanism of the immuno-modulating effects by G. lucidum. Evidence-based clinical trials are also needed... - Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanismsZhi bin Lin
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Acta Pharmacol Sin 25:1387-95. 2004..Preliminary study indicated that antiangiogenic effect may be involved antitumor activity of G lucidum... - Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitroLi Zhen Cao
Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
Acta Pharmacol Sin 24:321-6. 2003..To study the regulatory effects of Ganoderma lucidum polysaccharides (Gl-PS) on cytotoxicity and mechanism of specific cytotoxic T-lymphocytes (CTL) induced by dendritic cells (DC) in vitro during the stage of antigen presentation... - Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cellsLi Xin Sun
Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
J Pharm Pharmacol 63:725-35. 2011..The purpose of this study was to determine the antagonistic effects of Gl-PS on the suppression induced by B16F10 melanoma cell culture supernatant (B16F10-CS) on lymphocytes... - Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in miceGuo Liang Zhang
Department of Pharmacology, School of Basic Medical Sciences, Beijing University, Beijing 100083, China
World J Gastroenterol 8:728-33. 2002..To examine the effect of ganoderma lucidum polysaccharide (GLP) on the immune liver injury induced by BCG infection, and investigate the relationship between degrees of hepatic damage and NO production in mice... - Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed miceXiao Ling Zhu
Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China xiaolingzhu88yahoo com cn
J Ethnopharmacol 111:219-26. 2007.... - [Immunopharmacological action of sinomenine, an alkaloid isolated from Sinomenium acutum, and its mechanism of action in treating rheumatoid arthritis]Ji Hong Liu
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
Yao Xue Xue Bao 40:127-31. 2005..To observe the effects of sinomenine on the immune functions and apoptosis of murine lymphocyte as well as on human synovial fibroblast proliferation... - Dynamic effects of leflunomide on IL-1, IL-6, and TNF-alpha activity produced from peritoneal macrophages in adjuvant arthritis ratsWei Dong Li
Department of Pharmacology, Health Science Center of Peking University, Beijing 100083, China
Acta Pharmacol Sin 23:752-6. 2002.... - Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to activate lymphocytesLi Xin Sun
Department of Pharmacology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Basic Clin Pharmacol Toxicol 108:149-54. 2011.... - [Comparison of the immunomodulatory effects of spore polysaccharides and broken spore polysaccharides isolated from Ganoderma lucidum on murine splenic lymphocytes and peritoneal macrophages in vitro]Peng-yun Wang
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
Beijing Da Xue Xue Bao 37:569-74. 2005..CONCLUSION: Gl-SP and Gl-BSP have similar immunomodulatory effects in vitro, as though the immunomodulatory effects of Gl-BSP are stronger than that of Gl-SP... - Ganoderma lucidum polysaccharides reduce methotrexate-induced small intestinal damage in mice via induction of epithelial cell proliferation and migrationLi Hua Chen
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Acta Pharmacol Sin 32:1505-12. 2011..To study the effects of Ganoderma lucidum polysaccharides (Gl-PS) on methotrexate (MTX)-induced small intestinal damage in mice and the underlying mechanisms... - Immune receptors for polysaccharides from Ganoderma lucidumBao-Mei Shao
Department of Immunology, Peking University Health Science Center, School of Basic Medical Sciences, Beijing, China
Biochem Biophys Res Commun 323:133-41. 2004..Our results may have important implications for our understanding on the molecular mechanisms of immunopotentiating polysaccharides from traditional Chinese medicine... - Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cellQi zhen Cao
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100083, China
Life Sci 78:1457-63. 2006.... - Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptideQi-Zhen Cao
Department of Pharmacology, Health Science Center, Peking University, Beijing 100083, China
Acta Pharmacol Sin 25:833-8. 2004..4 %, 15.6 %, and 40.4 %, respectively. CONCLUSION: GLPP has antitumor and anti-angiogenic activity. The anti-angiogenesis of GLPP may be a new mechanism underlying its anti-tumor effects... - Effects of Ganoderma lucidum polysaccharide on CYP2E1, CYP1A2 and CYP3A activities in BCG-immune hepatic injury in ratsXin Wang
Department of Pharmacology, Basic Medical School, Beijing Peking University, Beijing 100083, P R China
Biol Pharm Bull 30:1702-6. 2007.... - [Advances of pharmacological effects of triterpenes from Ganoderma lucidum]Jun Luo
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100083, China
Yao Xue Xue Bao 37:574-8. 2002 - Comparison of the effects of polysaccharides from wood-cultured and bag-cultured Ganoderma lucidum on murine spleen lymphocyte proliferation in vitroLi-Zhen Cao
Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China
Yao Xue Xue Bao 38:92-7. 2003..No significant difference was observed between these two kinds of polysaccharides in selected concentrations. CONCLUSION: Gl-PS-WC and Gl-PS-BC showed similar effects on the proliferation activities of murine spleen lymphocytes in vitro... - Regulation on maturation and function of dendritic cells by Ganoderma lucidum polysaccharidesLi-Zhen Cao
Department of Pharmacology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, People's Republic of China
Immunol Lett 83:163-9. 2002..Gl-PS was shown to promote not only the maturation of cultured murine bone marrow derived DC in vitro, but also the immune response initiation induced by DC... - Promotion of Myelopoiesis in Myelosuppressed Mice by Ganoderma lucidum PolysaccharidesXiao Ling Zhu
Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center Beijing, China
Front Pharmacol 3:20. 2012.... - Effects of Ganoderma lucidum polysaccharides on IEC-6 cell proliferation, migration and morphology of differentiation benefiting intestinal epithelium healing in vitroLi Xin Sun
Department of Pharmacology, Basic Medical School, Peking University Health Science Center, Beijing Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province Changsha Medical University, Changsha, Hunan Province Tianjing Medical University, Tianjing, China
J Pharm Pharmacol 63:1595-603. 2011..Conclusions? These results suggest the potential usefulness of Gl-PS to cure intestinal disorders characterized by injury and ineffective repair of the intestinal mucosa... - Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocationWei Dong Li
Department of Pharmacology, Health Science Center, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
Int Immunopharmacol 6:1243-50. 2006..These observations suggested that the inhibitory effects of DHA on TNF-alpha production may result from the block in the NF-kappaB signaling pathway upstream of IkappaB degradation... - Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanismQing Ping Chu
Department of Pharmacology, Peking University, School of Basic Medical Science, 38 Xueyuan Lu, Beijing 100083, China
Pharmacol Biochem Behav 86:693-8. 2007..Significant effect was also observed with GLE on delta activity during non-REM sleep and flumazenil did not block this effect. In conclusion, GLE may be a herb having benzodiazepine-like hypnotic activity at least in part... - Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147Yang qiong Ou
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
Acta Pharmacol Sin 30:435-41. 2009..Sinomenine is a pure alkaloid extracted from the Chinese medical plant Sinomenium acutum... - Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen speciesYu-hong You
Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100083, China
Acta Pharmacol Sin 23:787-91. 2002..Under the electron microscope it was found that GLPP (100 mg/kg, ip, for 5 d) could protect the organelle such as mitochondria against injury by tBOOH. CONCLUSION: GLPP had significant scavenging ROS and antioxidant effects... - Effect of 2-amino-2-(2-(4-octylphenyl) ethyl) propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in miceJing-Hua He
Department of Pharmacology, Basic Medical School, Peking University Health Science Center, Beijing 100083, China
World J Gastroenterol 11:573-6. 2005.... - In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damageHui-na Zhang
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, PR China
Life Sci 73:2307-19. 2003.... - Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cellsXiao-ling Zhu
Department of Pharmacology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100083, China
Acta Pharmacol Sin 26:1130-7. 2005..CONCLUSION: Gl-PS was shown to be a promising biological response modifier and immune potentiator. The effect of Gl-PS on CIK cells is possibly mediated primarily through complement receptor type 3... - Hypoglycemic effect of Ganoderma lucidum polysaccharidesHui-na Zhang
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083, China
Acta Pharmacol Sin 25:191-5. 2004..CONCLUSION: Gl-PS possesses the hypoglycemic effect on normal mice; one mechanism is through its insulin-releasing activity due to a facilitation of Ca2+ inflow to the pancreatic beta cells... - Reversal effect of Ganoderma lucidum polysaccharide on multidrug resistance in K562/ADM cell lineWei Dong Li
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100083, China
Acta Pharmacol Sin 29:620-7. 2008..To investigate the reversal effect of Ganoderma lucidum polysaccharides (Gl-PS) on multidrug resistance (MDR) in the adriamycin (ADM)-resistant leukemic cell line K562/ADM... - Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/reoxygenation injuryHong-Bo Zhao
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, P.R. China
Life Sci 76:1027-37. 2005..These findings demonstrated that GS(1) is the main component in GS; and play a critical role in the neuroprotective effect of GS against H/R... - The effect of 7-nitroindazole on the acquisition and expression of D-methamphetamine-induced place preference in ratsSu-Min Li
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, 100083, Beijing, PR China
Eur J Pharmacol 435:217-23. 2002..These findings indicate that nitric oxide (NO) is involved in the rewarding properties of methamphetamine and suggest that selective nNOS inhibitors maybe useful in the management of methamphetamine abuse... - [Antioxidant effect of Ganoderma polysaccharide peptide]Yu-hong You
Department of Pharmacology, School of Basic Medical Sciences, Health Science Center, Peking University, Beijing 100083, China
Yao Xue Xue Bao 38:85-8. 2003..The catalase(CAT) levels were not significantly changed by GLPP. CONCLUSION: GLPP showed antioxidant effect by scavenging ROS or enhancing the enzyme activity of GSHpx in vivo and in vitro... - Polysaccharide extract isolated from ganoderma lucidum protects rat cerebral cortical neurons from hypoxia/reoxygenation injuryHong-Bo Zhao
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
J Pharmacol Sci 95:294-8. 2004..These findings suggest that Gl-PS might be useful in treating H/R-induced oxidative stress and Mn-SOD might play a critical role in the neuroprotective effect of Gl-PS against H/R injury... - [Establishment of immune insulin resistance model in the rats by i.v. injection of BCG]Yu-xiao Guo
Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing 100083, China
Yao Xue Xue Bao 37:321-5. 2002..mL-1, P < 0.05] and insulin [(31 +/- 5) vs (36 +/- 5) mu.L-1, P > 0.05] increased. CONCLUSION: This novel model of immune insulin resistance is completely and constantly established... - [Effects of leflunomide and its active metabolite on the production and mRNA expression of TNF-alpha in peritoneal macrophages and synovial cells with adjuvant arthritis in rats]Wei-Dong Li
Department of Pharmacology, School of Basic Medical Sciences, Medical Center of Peking University, Beijing 100083, China
Yao Xue Xue Bao 37:767-70. 2002..It might be involved in the mechanisms of its anti-inflammation and immunosupression... - Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Bel7402/5-FU cellsYu-Xiu Li
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100083, China
Acta Pharmacol Sin 25:76-82. 2004..CONCLUSION: These results indicated that the wt p53 gene transfection not only induced suppression of cell growth, but also increased the sensitivity of Bel7402/5-FU cells to 5-FU, vincristine, and doxorubicin... - Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barleyWing Keung Chan
Department of Paediatrics and Adolescent Medicine, Hong Kong Jockey Club Clinical Research Center, Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China
Int Immunol 19:891-9. 2007..Our study also provides a reproducible biological platform for comparing the potential therapeutic effects of different herbal-derived polysaccharides in the future... - [Grasps favorable opportunity to search for truth]Zhi-bin Lin
Sheng Li Ke Xue Jin Zhan 36:1-5. 2005 - Analysis of genetic diversity in Ganoderma population with a novel molecular marker SRAPShu-Jing Sun
College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, People's Republic of China
Appl Microbiol Biotechnol 72:537-43. 2006..It also suggested SRAP marker could be used in the taxonomic analysis of fungi. To our knowledge, this is the first application of SRAP marker on the systematics of Ganoderma strains within basidiomycetes...