Jian Xin Li

Summary

Affiliation: Nanjing University
Country: China

Publications

  1. ncbi Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity on osteoclast formation
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P R China
    Planta Med 71:673-9. 2005
  2. ncbi Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
    Curr Med Chem 13:2927-51. 2006
  3. ncbi Triterpenoids from Cimicifugae rhizoma, a novel class of inhibitors on bone resorption and ovariectomy-induced bone loss
    J X Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Maturitas 58:59-69. 2007
  4. ncbi An unusual metabolite of cimicidol-3-O-beta-D-xyloside from Cimicifugae rhizoma by rat intestinal bacteria
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Chem Biodivers 5:290-8. 2008
  5. ncbi Osteoprotective effect of extract from Achyranthes bidentata in ovariectomized rats
    Cui Cui He
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    J Ethnopharmacol 127:229-34. 2010
  6. ncbi Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production
    Peng Teng
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, PR China
    Bioorg Med Chem 19:3096-104. 2011
  7. ncbi Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents
    Jun Feng Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Carbohydr Res 344:599-605. 2009
  8. ncbi Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents
    Peng Teng
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China
    Eur J Med Chem 50:63-74. 2012
  9. ncbi Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina
    Zhang Shuang Deng
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P R China
    Org Lett 10:1119-22. 2008
  10. ncbi Quinoxaline derivative of oleanolic acid inhibits osteoclastic bone resorption and prevents ovariectomy-induced bone loss
    Yu Zhao
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
    Menopause 18:690-7. 2011

Collaborators

  • Mei Geng
  • Lei Zhang
  • Yuan Zhang
  • Gong Chen
  • Ting Chen
  • Peng Li
  • J Liu
  • Xian Mei Zhou
  • Tatsuro Miyahara
  • Ken Tanaka
  • Jian Zhang
  • Cui Cui He
  • Zhang Shuang Deng
  • Peng Teng
  • Qiang Xu
  • Guo Biao Liu
  • Rong Rong Hui
  • Yu Zhao
  • Jian Liang Xu
  • Li li Feng
  • Hai liang Liu
  • Yue Huai
  • Hong Xi Xu
  • Yang Sun
  • Yun Mian He
  • Jie Jin
  • Yong quan Gu
  • Zhang-Shuang Deng
  • Xiao Min Lu
  • Shu-ping Jia
  • Qiao Yun Luo
  • Yun qing Dai
  • Jia Hua
  • Hong juan Chen
  • Zhi Bing Shi
  • Jian Wei Zhao
  • Shigetoshi Kadota
  • Rui Xu
  • Yasuhiro Tezuka
  • Zhong Gao Wang
  • Bing-Xin Ji
  • Shu Wen Zhang
  • Xue Feng Li
  • Yong-quan Gu
  • Xiao Ru Sun
  • Cui-Cui He
  • Shu-wen Zhang
  • Heng xi Yu
  • Tao Luo
  • Bing xin Ji
  • Zhong-gao Wang
  • Li-xing Qi
  • Shi Jun Cui
  • Juan Xu
  • Xiao-Ru Sun
  • Yun-Mian He
  • Xue-Feng Li
  • Heng-xi Yu
  • Shi-jun Cui
  • Lian Rui Guo
  • Li Xing Qi
  • Lian-rui Guo
  • Hong-Wei Yi
  • Jian-Liang Xu
  • Shao Xian Cao
  • Hong Wei Yi
  • Xiao-Min Lu
  • Shao-Xian Cao
  • Zhi-fang Hao
  • Zhi-Yong Yu

Detail Information

Publications22

  1. ncbi Five new oleanolic acid glycosides from Achyranthes bidentata with inhibitory activity on osteoclast formation
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P R China
    Planta Med 71:673-9. 2005
    ..All the oleanolic acid glycosides inhibited the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha,25(OH)2D3 in a co-culture assay system...
  2. ncbi Cimicifugae rhizoma: from origins, bioactive constituents to clinical outcomes
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
    Curr Med Chem 13:2927-51. 2006
    ....
  3. ncbi Triterpenoids from Cimicifugae rhizoma, a novel class of inhibitors on bone resorption and ovariectomy-induced bone loss
    J X Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Maturitas 58:59-69. 2007
    ....
  4. ncbi An unusual metabolite of cimicidol-3-O-beta-D-xyloside from Cimicifugae rhizoma by rat intestinal bacteria
    Jian Xin Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Chem Biodivers 5:290-8. 2008
    ....
  5. ncbi Osteoprotective effect of extract from Achyranthes bidentata in ovariectomized rats
    Cui Cui He
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    J Ethnopharmacol 127:229-34. 2010
    ..The present study is to clarify the fractions responsible for the activity and further explore the osteoprotective effect of the fraction in vivo...
  6. ncbi Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production
    Peng Teng
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, PR China
    Bioorg Med Chem 19:3096-104. 2011
    ..Interestingly, (S)-dimers displayed a better bioactivity than (R)-dimers. These compounds may sever as lead candidates in the development of novel therapeutic drugs for RA treatment...
  7. ncbi Glycoside modification of oleanolic acid derivatives as a novel class of anti-osteoclast formation agents
    Jun Feng Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Carbohydr Res 344:599-605. 2009
    ..The structure-activity relationships of these compounds were also discussed...
  8. ncbi Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents
    Peng Teng
    State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China
    Eur J Med Chem 50:63-74. 2012
    ..Moreover, 3b and 2f significantly alleviated the lipopolysaccharide (LPS)-induced mortality. These two compounds might serve as valuable candidates for anti-inflammatory drug discovery...
  9. ncbi Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina
    Zhang Shuang Deng
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P R China
    Org Lett 10:1119-22. 2008
    ..4 exhibited more potent inhibitory activity on IL-6 production than 1 in human synovial sarcoma cell (SW982), and 5 stimulated IL-6 production...
  10. ncbi Quinoxaline derivative of oleanolic acid inhibits osteoclastic bone resorption and prevents ovariectomy-induced bone loss
    Yu Zhao
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
    Menopause 18:690-7. 2011
    ..The aim of the present study was to evaluate the activities of QOA-8a on bone resorption in vitro and its osteoprotective effect in vivo...
  11. ncbi Synthesis of a novel series of diphenolic chromone derivatives as inhibitors of NO production in LPS-activated RAW264.7 macrophages
    Guo Biao Liu
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    Bioorg Med Chem 18:2864-71. 2010
    ..Furthermore, a computational analysis of physicochemical parameters revealed that the most of the compounds possessed drug-like properties...
  12. ncbi A novel synthetic oleanolic acid derivative with amino acid conjugate suppresses tumour growth by inducing cell cycle arrest
    Xiao Min Lu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing, 210093, China
    J Pharm Pharmacol 59:1087-93. 2007
    ..OA did not show such activities. These results suggest that AOA-GMe may induce growth arrest in tumour cells through regulation of proteins involved in the cell cycle...
  13. ncbi Synthesis and evaluation of a novel series of heterocyclic oleanolic acid derivatives with anti-osteoclast formation activity
    Jun Feng Li
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
    Eur J Med Chem 44:2796-806. 2009
    ..Among the derivatives, compounds 2a and 8a displayed quite a potent activity even at 200 nM. The structure-activity relationships of the derivatives were also discussed...
  14. ncbi pH-dependent, stereoselective dimerization of sinomenine
    Zhang Shuang Deng
    Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China
    Org Lett 10:3879-82. 2008
    ..The bioassay results using human synovial sarcoma cells (SW982) showed that 2 inhibited, while 3 stimulated, IL-6 production...
  15. ncbi Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity
    Guo Biao Liu
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
    Bioorg Med Chem 17:5433-41. 2009
    ....
  16. ncbi Inhibitory effects of citrus extracts on the experimental pulmonary fibrosis
    Xian Mei Zhou
    Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China
    J Ethnopharmacol 126:143-8. 2009
    ..The present study was designed to clarify the active principles responsible for the activity and further explore the anti-pulmonary fibrosis effect in vivo...
  17. ncbi [Isolation and identification of triterpenoids from root of Achyranthes bidentata in Henan]
    Shu-ping Jia
    School of Chemistry and Chemical Engineering, Nanjing University, China
    Zhongguo Zhong Yao Za Zhi 31:1244-7. 2006
    ..CONCLUSION: Compounds 1 and 2 were isolated from the natural resources for the first time...
  18. ncbi Ultrasound-promoted intramolecular direct arylation in a capillary flow microreactor
    Lei Zhang
    State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Ultrason Sonochem 19:250-6. 2012
    ..The ultrasonic irritation not only greatly promoted the conversion and selectivity of the direct arylation, but also solved the clogging problem of the microreactor for solid-forming reaction and made the reaction run smoothly...
  19. ncbi NMR-based metabonomic approach on the toxicological effects of a Cimicifuga triterpenoid
    Cui Cui He
    Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, People s Republic of China
    J Appl Toxicol 32:88-97. 2012
    ..The present study provides a reasonable explanation for the clinical hepatotoxicity of Cimicifuga extract...
  20. ncbi Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation
    Yuan Zhang
    Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University 210093, PR China
    Bioorg Med Chem Lett 15:1629-32. 2005
    ..Derivatives with proline or phenylalanine showed a tendency to enhance the inhibitory activity...
  21. ncbi Structural revision of two flavanonol glycosides from Smilax glabra
    Xiang Zhou
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China
    Planta Med 75:654-5. 2009
    ..The revised structures were determined based on intensive studies of chemical interconversion, NMR spectroscopy, and X-ray crystallographic analysis. The latest NMR data were also summarized...
  22. ncbi Transplantation of autologous bone marrow mononuclear cells for patients with lower limb ischemia
    Yong quan Gu
    Department of Vascular Surgery, Xuanwu Hospital, Institute of Vascular Surgery, Capital Medical University, Beijing, China
    Chin Med J (Engl) 121:963-7. 2008
    ....