Tianzi Jiang

..Moreover, a quantitative description of such a functional modulation has also been presented...

..Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD...

..The changes of connectivity in simulated data are closely identical with the truth and the results of two pairs of gene expression data show that our method has successfully demonstrated the dynamic connectivity between genes. CONTACT: ...

..Our findings suggest that COMT val158met may contribute to intelligence by affecting the association between IQ and the white matter architecture in the prefrontal lobe and the hippocampal formation...

..These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients...

..Anatomical parcellation process is proved useful to improve classification rate by a control experiment. The discriminative model shows its ability to reveal abnormal brain functional activities and identify people with schizophrenia...

..Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind...

..The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated...

..Our findings suggest that COMT haplotypes can nonlinearly modulate the intelligence-related white matter integrity of the prefrontal lobes by more significantly influencing prefrontal dopamine variations than does val158met...

..Detection and estimation of these alterations could prove helpful for understanding the pathophysiological mechanism as well as for evaluation of the severity of schizophrenia...

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..In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks...

..This method can also be used to quantitatively analyze other white matter fiber tracts between two definite anatomic landmarks in many neurological or psychiatric diseases...

..Our findings suggest that early deprivation of a single sensory modality induces alterations of functional connectivity between the deprived functional area and other associated brain areas...

..Our findings indicate that changes in the functional connectivities in the resting state may be an integrated reflection of general loss and compensatory plasticity when a single sensory modality is deprived...

..Our findings suggest that the efficiency of brain structural organization may be an important biological basis for intelligence...

..Our findings suggest that default network connectivity that involves the prefrontal cortex is modulated by COMT val(158)met through differential effects on prefrontal dopamine levels...

..We validate our method using synthetic data, phantom data and real data. Our method works well in all experiments, especially for the data with low SNR, low anisotropy and non-exponential decay...

..Finally, we summarize the main results and some prospects for future work...

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..Our results suggest that functional dysconnectivity associated with the DLPFC exists in schizophrenia during rest. This may be partially related to disturbance in the intrinsic brain activity...

..Interestingly, higher anisotropy of the right-hander than the left-hander was found in the bilateral cingulum bundles. No significant handedness-by-side interaction was obtained in the present study, however...

..We suggested the damaged functional integrations of the DMN in the GTCS epilepsy patients even during the resting state, which could help to understand the neural correlations of the impaired consciousness of GTCS epilepsy patients...

..This study highlights the importance of paying attention to the influence of the stabilities of NCOBSs in related studies and establishes the need for further studies on NCOBSs...

..This confirmation supports the perspective that brain is a system intrinsically operating on its own, and sensory information interacts with rather than determines the operation of the system...

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..ReHo can consider as a complementary method to model-driven method, and it could help reveal the complexity of the human brain function. More work is needed to understand the neural mechanism underlying ReHo...

..The high accuracy and robustness of the algorithm indicate that it is promising for gel image alignment...

..For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers...

..We suggest these abnormally more significant functional connectivities in the ADHD patients may indicate the abnormality of autonomic control functions in them...

..This could provide a new perspective for understanding the neural basis of intelligence...

..As a result of these features, the algorithm is also suitable for estimating the FD of fractals in addition to that of the cerebral cortex...

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..Spherical Polar Fourier Imaging (SPFI) was proposed for ODF and Ensemble Average Propagator (EAP) estimation from arbitrary sampled signals without any assumption...

..Our results demonstrate that the systems biology-based approach enables to identify common survival-associated genes...

..e. Riemannian coordinates, is robust and linear. Moreover it should be noted that our theoretical results can be used for any probability density function (PDF) under an orthonormal basis representation...

..By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group...

..The purpose of the current paper is to use a scale-free measure, fractal information dimension (FID), to assess the prefrontal cortical convolution complexity and asymmetry in ADHD patients...

..Experimental results show that the occurrence of misalignment is dramatically reduced and that registration accuracy is greatly improved at the same time, leading to enhanced matching performance...

..Finally, our study indicated that regional brain atrophy could be an important consideration in functional imaging studies of neurodegenerative diseases...

..In addition, we examined the effectiveness and usefulness of our method on real experimental data...

..05) than did the varepsilon4 carriers. These findings suggest that the different alleles of the APOE gene have distinct neuroanatomic effects in elderly healthy subjects and may play specific roles in the development of AD...

..Experimental results show that our method successfully detected expected activated regions and has advantages over the other two methods...

..However, white matter fibers connecting these cerebral areas may also be abnormal...

..In this paper, we attempt to introduce a combinational feature selection method in conjunction with ensemble neural networks to generally improve the accuracy and robustness of sample classification...

..Compared with the original temporal self-correlation method, the proposed method shows a significant improvement. In addition, a technique for quantitative comparison of different fMRI data analysis methods is proposed...

..The results confirm the functional deficits of the PFC and impaired planning ability in first-episode schizophrenia patients and suggest that NIRS may be a useful clinical tool for evaluating PFC activation in psychiatric disorders...

..The results provide a quantitative support for the hypothesis that schizophrenia may arise from the disrupted functional integration of widespread brain areas...

..Thus, questions were raised about whether existing compensatory theories could adequately describe individual risky decisions...

..These results suggest that our region growing method can serve as a reliable analysis of fMRI data...

..The present study investigated the potential contribution of NRG1 variation to anterior cingulum abnormalities in participants with schizophrenia...

..More interestingly, a significant left-greater-than-right asymmetry pattern was obtained in most segments of cingulum bundle (-50-25 degrees), except in the most posterior portion of cingulum (25-50 degrees)...

..These findings reveal patterns in recombination rates of microRNAs that could help in understanding the function, evolution, and disease-related roles of microRNAs...

..Spontaneous thought processes (STPs), also called daydreaming or mind-wandering, occur ubiquitously in daily life. However, the functional significance of STPs remains largely unknown...

..2% for FA). In conclusion, the proposed method on the basis of combined features is more effective for classification than those merely using the features separately, and it may be helpful in differentiating RNMO from RRMS patients...

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..From the results of this research, we conclude that the proposed multicentered mode could advance the performance of rDOI both in image quality and practical convenience...

..We have also conducted preliminary numerical studies to demonstrate and evaluate the reconstruction properties of the derived chord-based algorithms for curved detectors...

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..And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies...

..We also found correlations between the modularity and functional genomics as well as its connection to drug-target associations...

..As the number of new genomes has dramatically increased over recent years, a reliable and efficient system to predict protein subcellular location is urgently needed...

..We demonstrate that the method successfully overcomes numerical instability and is capable of generating an accurate and robust anatomic descriptor for complex objects in the human brain, such as the lateral ventricles...

..Experimental results on both real MR images and simulated volumetric MR data show that MCFC outperforms the classic fuzzy c-means (FCM) as well as other segmentation methods that deal with intensity inhomogeneities...

..We speculate that this may provide a neural basis for the phenomenon that future losses are discounted less steeply than future gains...

..Our results indicate that abnormal brain activity of schizophrenia may exist in a resting state and the regional homogeneity may be potentially helpful in understanding the resting state of schizophrenia...

..We suggest that these negative correlations between the extrinsic and intrinsic systems may explain the phenomenon that externally and internally oriented processes can always disturb or even interrupt each other...

..The method is demonstrated to have low sensitivity to noise at various noise levels. Moreover, with the PAR method, the detectability of an object located both at the center and near the peripheral regions has been increased largely...

..As compared to the controls, the ADHD patients exhibited more significant resting-state activities in basic sensory and sensory-related cortices. This finding was in accordance with ADHD symptoms of inattention...

..The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder...

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..This study also supports the perspective that experience-dependent plasticity occurs not only in the cortical areas but also in the white matter fiber tracts...

..Our findings suggest that neurophysiological alterations and memory performance deficit have developed in acute severe PTSD...

..This study indicate that MR patients show extensive damage in the integrity of the brain white matter tracts, and the right UF is an important neural basis of human intelligence...

..These results suggested that white matter integrity of the whole brain was disrupted in early illness onset of schizophrenia...

..Moreover, these findings suggest that resting-state fMRI might be an appropriate approach for studying pathophysiological changes in early AD...