Research Topics
| Zhongzhen ZhaoSummaryAffiliation: Hong Kong Baptist University Country: China Publications
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Detail Information
Publications
The formation of daodi medicinal materialsZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Ethnopharmacol 140:476-81. 2012..This review clarifies the concept and rationalizes the formation of daodi medicinal material...
Determination of patchoulic alcohol in Herba Pogostemonis by GC-MS-MSZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong
Chem Pharm Bull (Tokyo) 53:856-60. 2005..cablin. The developed method was found to be convenient and facile in particular to tackle the complicated matrix problems always encountered in the herbs which contain high level of essential oils...
Authentication is fundamental for standardization of Chinese medicinesZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, PR China
Planta Med 72:865-74. 2006..Furthermore, it is proposed that an authority on the authentication of CMM be established, as a physical institution and/or as an electronic database...
Macroscopic identification of Chinese medicinal materials: traditional experiences and modern understandingZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Ethnopharmacol 134:556-64. 2011..This review clarifies the role of macroscopic features in the quality assessment of CMM...
A unique issue in the standardization of Chinese materia medica: processingZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
Planta Med 76:1975-86. 2010..The objective of this paper is to review the literature covering the current situation and problems of CMM processing as well as recent progress in research in this area. A summary of the most urgent work needed is proposed...
Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometryZhitao Liang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
Chin Med 5:29. 2010..The present study investigates the differences in chemistry between raw and processed Radix Polygoni Multiflori...
Application of microscopy in authentication of Chinese patent medicine--Bo Ying compoundZhong Zhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Microsc Res Tech 67:305-11. 2005....
A systematic study on confused species of Chinese materia medica in the Hong Kong marketZhongzhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
Ann Acad Med Singapore 35:764-9. 2006..The current situation in the Hong Kong market and some suggestions for alleviating the problem are also discussed...
Comparative study on the aristolochic acid I content of Herba Asarifor safe useZhong Zhen Zhao
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, PR China
Phytomedicine 15:741-8. 2008..0370.006 microg/g). Therefore, the root portion of Herba Asari was recommended for prescription as a decoction instead of grinding it into powder for oral administration...
Toxicity assessment of nine types of decoction pieces from the daughter root of Aconitum carmichaeli (Fuzi) based on the chemical analysis of their diester diterpenoid alkaloidsGuanghua Lu
Teaching Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Planta Med 76:825-30. 2010....
Quality assessment of Rhizoma et Radix Notopterygii by HPTLC and HPLC fingerprinting and HPLC quantitative analysisGuang Sheng Qian
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
J Pharm Biomed Anal 44:812-7. 2007..Finally, the pharmacologically active marker compounds isoimperatorin, notopterol and bergapten in this herb were quantitatively determined using a validated reverse-phase HPLC method...
Authentication of Chinese Materia Medica decoction dregs. Part II: comparison before and after decoction of four Chinese Materia Medica that mainly comprise storage tissueLailai Wong
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, People s Republic of China
Microsc Res Tech 75:164-75. 2012..These differences could be used to authenticate CMM dregs...
A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potentialZhitao Liang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, PR China
Phytomedicine 15:259-67. 2008..The results suggest that the mechanism of antitumor activity of O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects...
A novel method to identify the Chinese herbal medicine Wuzhimaotao by quantification of laticifersDawn Tung Au
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Microsc Res Tech 72:293-8. 2009..This method is rapid, accurate, and inexpensive...
Ethnobotanical study of medicinal plants used by Hakka in Guangdong, ChinaDawn Tung Au
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Ethnopharmacol 117:41-50. 2008..An ethnobotanical survey was conducted to collect information on the use of medicinal plants by the Hakka living in Guangdong...
Establishment of HPLC-DAD-MS fingerprint of fresh Houttuynia cordataJiang Meng
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Special Administrative Region, PR China
Chem Pharm Bull (Tokyo) 53:1604-9. 2005..cordata is critical to assess and represent its overall quality...
Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromatography coupled with electrospray ionization ion trap mass spectrometry in negative ion modeKim Chung Lee
Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China
Rapid Commun Mass Spectrom 22:2825-34. 2008..Significant variation in the compositions of intact glucosinolates was identified in the cruciferous herbs. This method was applied in the differentiation and quality control of two pairs of easily confused herbs...
Comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysariJing Liu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong
J Biomed Biotechnol 2010:479426. 2010..Polysaccharides comprised the major constituents in RA and HQ. All polysaccharides extract (PE) of the three herbs showed similar levels of immunological effect in both immunological assays...
Establishment of GC-MS fingerprint of fresh Houttuynia cordataJiang Meng
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Special Administrative Region, P. R. China
Chem Pharm Bull (Tokyo) 53:1484-9. 2005..The developed fingerprint can be successfully applied to distinguish between fresh and dry herbs, as well as determining differentiation among different medicinal portions...
Alkaloid profiling in crude and processed Strychnos nux-vomica seeds by matrix-assisted laser desorption/ionization-time of flight mass spectrometryWei Wu
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
J Pharm Biomed Anal 45:430-6. 2007..Experimental results indicated that the direct MALDI-TOFMS analysis allowed rapid screening of the alkaloid components in Strychnos nux-vomica seeds...
Comparative analysis of Oldenlandia diffusa and its substitutes by high performance liquid chromatographic fingerprint and mass spectrometric analysisZhitao Liang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong Special Administrative Region, P R China
Planta Med 73:1502-8. 2007..In conclusion, it is important to use the above three compounds as chemical markers for quality evaluation and chemical authentication of Herba Oldenlandiae and its substitutes...
Characterization of shapes for use in classification of starch grains imagesChong Sze Tong
Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
Microsc Res Tech 71:651-8. 2008....
Identification of starch grains in microscopic images based on granulometric operationsChong Sze Tong
Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Microsc Res Tech 70:724-32. 2007....
Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii)Yong Peng
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Plant Foods Hum Nutr 60:161-4. 2005..The results demonstrated that these methods are reliable and facile techniques for rapid analysis of carotenoids for crude drug and plant-derived food supplements...
Efficacy and safety of herbal medicines for idiopathic Parkinson's disease: a systematic reviewVincent Chung
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Mov Disord 21:1709-15. 2006..Current evidence is insufficient to evaluate the efficacy and safety of various HMs. Further studies with improved trial design and reporting, with assessment on cost-effectiveness, quality of life, and qualitative data are warranted...
Control release effects of binders used in pills of traditional Chinese medicine herbsZhijun Yang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon
Chem Pharm Bull (Tokyo) 54:188-95. 2006..The dissolution profiles indicate that changing the ratio of the binders altered the patterns of dissolution of the API; thus, this ration may be used to control the release of API from the pills...
[Comparative study of wild and cultivated astragali radix in Daqingshan district in Wuchuan of Neimenggu]Jing Liu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China
Zhongguo Zhong Yao Za Zhi 36:1577-81. 2011..To make a comparative study on wild and cultivated Astragali Radix in Wuchuan, Neimenggu where is one of the geo-authentic producing areas of Astragalus membranaceus var. mongholicus...
Direct analysis of alkaloid profiling in plant tissue by using matrix-assisted laser desorption/ionization mass spectrometryWei Wu
Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong SAR, China
J Mass Spectrom 42:58-69. 2007..The rapid collection of information from the direct analysis on plant tissues could be valuable for supporting the discovery of new compounds and for the quality control of medicinal herbs...
[Microscopic identification study of western herbs. Part I: Three Echinacea-species roots]Qin Li
School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China
Zhongguo Zhong Yao Za Zhi 34:2718-20. 2009..To make microscopic identification research of three Echinacea-species roots recorded in the United States Pharmacopeia...
Schisandrol A from Schisandra chinensis reverses P-glycoprotein-mediated multidrug resistance by affecting Pgp-substrate complexesWang Fun Fong
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P R China
Planta Med 73:212-20. 2007..Our results suggest that SCH acts by affecting the normal formation and functioning of the Pgp-substrate complexes...
Quality assessment of radix salviae miltiorrhizaePing Hu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Chem Pharm Bull (Tokyo) 53:481-6. 2005..The HPLC quantitation methods of the three marker compounds were validated and the measurement uncertainty, which is important for setting the proposed content limit of the marker compounds in herbal medicine, were further evaluated...
Multi-component HPLC fingerprinting of Radix Salviae Miltiorrhizae and its LC-MS-MS identificationPing Hu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Chem Pharm Bull (Tokyo) 53:677-83. 2005....
Assay of free ferulic acid and total ferulic acid for quality assessment of Angelica sinensisGuang-Hua Lu
Research and Development Division, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Chromatogr A 1068:209-19. 2005..07 +/- 2.73 (mean +/- SD, n = 10). The chemical assay of DG using total ferulic acid content would be a better choice to assess the herbal quality and was recommended...
Authentication of the 31 species of toxic and potent Chinese Materia medica (T/PCMM) by microscopic technique, part 1: three kinds of toxic and potent animal CMMLi Xia
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People s Republic of China
Microsc Res Tech 70:960-8. 2007..The results demonstrated that it was feasible to use the present microscopic characters for the authentication of the above three animal T/PCMM...
Quantitative determination of four diterpenoids in Radix Salviae Miltiorrhizae using LC-MS-MSPing Hu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Chem Pharm Bull (Tokyo) 53:705-9. 2005..1%, and 95.9% with variation coefficient of 6.0%, 4.3%, 3.7%, and 4.2%, respectively. The established method was successfully applied to the quality assessment of seven batches of RSM samples collected from different regions of China...
Determination of glucosinolates in traditional Chinese herbs by high-performance liquid chromatography and electrospray ionization mass spectrometryKim-Chung Lee
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, People's Republic of China
Anal Bioanal Chem 386:2225-32. 2006..3 to 14.6%. Analysis of the glucosinolates provided scientific evidence enabling differentiation of three pairs of easily confused plants...
Authentication of the 31 species of Toxic and Potent Chinese Materia Medica (T/PCMM) by microscopic technique, part 2: Three species of seed T/PCMMLi Xia
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Microsc Res Tech 71:325-33. 2008....
Application of microscopic techniques in authentication of herbal tea--Ku-Ding-ChaChun-Fung Tam
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Microsc Res Tech 69:927-32. 2006..The method was proven to be quick, handy, simple, and convenient...
DNA-binding affinities and sequence specificities of protoberberine alkaloids and their demethylated derivatives: a comparative studyYong Qin
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Chem Biodivers 4:145-53. 2007..The binding mode of these alkaloids was further confirmed by UV spectroscopic titration experiments. All the compounds bind to double-stranded DNA most probably via an intercalating mode...
Determination of iridoid glucosides for quality assessment of Herba Oldenlandiae by high-performance liquid chromatographyZhi Tao Liang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P R China
Chem Pharm Bull (Tokyo) 54:1131-7. 2006..The analytical method is suitable for quality control of Herba Oldenlandiae and useful in differentiation from its confusable species. The method has been fully validated with satisfactory linearity, accuracy, precision and stability...
[Probe into innovation and development of pattern of quality control and evaluation for Chinese medicine]Xiao He Xiao
PLA Institute of Chinese Meteria Medica, 302 Hospital of PLA, Beijing 100039, China
Zhongguo Zhong Yao Za Zhi 32:1377-81. 2007..Based on geo-authentic medicinal material and bioassay or biopotency detection, a new pattern of quality control for Chinese medicine could be built and applied...
Quantification of ligustilides in the roots of Angelica sinensis and related umbelliferous medicinal plants by high-performance liquid chromatography and liquid chromatography-mass spectrometryGuang-Hua Lu
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
J Chromatogr A 1046:101-7. 2004..The overall analytical procedure is rapid and reproducible which is considered suitable for quantitative analysis of large number of samples...
Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang)Song Lin Li
Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T, Hong Kong SAR
Rapid Commun Mass Spectrom 22:591-602. 2008..Thus, the current finding of the presence of toxic/tumorigenic PAs in S. scandens challenges the safety of using this TCM herb and its proprietary products...
Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopyZhi Tao Liang
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
Microsc Res Tech 69:277-82. 2006..Specially, the wall of endoderm cells of O. diffusa and O. tenelliflora emit autofluorescence, while similar tissue of O. corymbosa does not. Hence, fluorescence microscopy can be helpful in the identification of CMM...
[Determination of ligustilide for quality assessment of Ligusticum chuanxiong]Shi-Qiong Cheng
Sichuan Provincial Institute for Food and Drug Control, Chengdu 610036, China
Zhongguo Zhong Yao Za Zhi 31:1143-6. 2006..The amount of ligustilide in CX samples collected from different cultivation areas was obviously different. However, a relatively higher content of ligustilide was generally found in the CX collected from its main cultivated areas...
[Study on chemical constituents of flavonoids in fresh herb of Houttuynia cordata]Jiang Meng
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Zhongguo Zhong Yao Za Zhi 31:1335-7. 2006..CONCLUSION: Compounds 1, 2 and 5 were separated from H. cordata for the first time...
Macropodumines D and E, two new alkaloids with unusual skeletons from Daphniphyllum macropodum MiqZhen Yu Li
State Key Laboratory of Drug Research, Shanghai Institute of Material Medica, Chinese Academy of Science, Shanghai 201203, People s Republic of China
Org Lett 9:477-80. 2007..The structures including the relative stereochemistry of new compounds 1 and 2 were elucidated on the basis of detailed spectroscopic data analysis...
[Orthogonal experiment using SFE-CO2 in extraction of essential oil from fresh Houttuynia cordata and analysis of essential oil by GC-MS]Jiang Meng
School of Chinese Medicine of Hong Kong Baptist University, Hong Kong, China
Zhongguo Zhong Yao Za Zhi 32:215-7. 2007..To optimize the extraction procedure of essential oil from H. cordata using the SFE-CO2 and analyze the chemical composition of the essential oil...
[Studies on chemical constituents of phenols in fresh Houttuynia cordata]Jiang Meng
Guangdong Pharmaceutical University, Guangzhou 510000, China
Zhongguo Zhong Yao Za Zhi 32:929-31. 2007..To study the aqueous constituents of Houttuynia cordata...
Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric methodJi hua Liu
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
J Agric Food Chem 55:8830-5. 2007..This study introduces the first GC-MS method for the quantitative analysis of polyacetylenes in herbs of the Panax genus...
[Effect of roots of Ficus hirta on cocaine-induced hepatotoxicity and active components]Qing Yuan Cai
Department of Natural Medicines, Peking University School of Pharmaceutical Sciences, Beijing 100083, China
Zhongguo Zhong Yao Za Zhi 32:1190-3. 2007..To investigate the protective effect of the roots of F. hirta against the cocaine-induced hepatotoxicity and it's active components...
[Evaluation of measurement uncertainty for the determination of ginsenosides in Radix ginseng by HPLC]Ping Hu
School of Chemistry and Pharmaceutics, East China University of Science and Technology, Shanghai 200237, China
Yao Xue Xue Bao 40:49-53. 2005..The establishment of the methodology for the evaluation of measurement uncertainty is important to the studies of Chinese materia medica standards...
