Da Yong Lu

Summary

Affiliation: Fudan University
Country: China

Publications

  1. ncbi Effect of anti-cancer drugs on the binding of 125I-Fibrinogen to two leukaemia cell lines in vitro
    D Y Lu
    School of Life Sciences, Shanghai University, Shanghai, People s Republic of China
    J Int Med Res 32:488-91. 2004
  2. ncbi Antimetastatic activities and mechanisms of bisdioxopiperazine compounds
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Anticancer Agents Med Chem 10:564-70. 2010
  3. ncbi Undesired neural side-effects of a drug, a chemical and genetic interrelated problem
    Da Yong Lu
    Shanghai University, Shanghai 200444, PR China
    Cent Nerv Syst Agents Med Chem 10:108-12. 2010
  4. ncbi Anticancer activities and mechanisms of bisdioxopiperazine compounds probimane and MST-16
    Da Yong Lu
    Shanghai University, PR China
    Anticancer Agents Med Chem 10:78-91. 2010
  5. ncbi Sequencing the whole genome of infected human cells obtained from diseased patients--a proposed strategy for understanding and overcoming AIDS or other deadest virus-infected diseases
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Med Hypotheses 68:826-7. 2007
  6. ncbi Treatment of solid tumors and metastases by fibrinogen-targeted anticancer drug therapy
    Da Yong Lu
    School of Life Sciences, Department of Bioengineering, Shanghai University, 99 Shangda Rd, Shanghai 200444, China
    Med Hypotheses 68:188-93. 2007
  7. ncbi Medicinal chemistry of probimane and MST-16: comparison of anticancer effects between bisdioxopiperazines
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Med Chem 2:369-75. 2006
  8. ncbi Individualized cancer chemotherapy integrating drug sensitivity tests, pathological profile analysis and computational coordination - an effective strategy to improve clinical treatment
    Da Yong Lu
    Department of Bioengineering, School of Life Sciences, Shanghai University, 99 Shangda Street, Shanghai 200436, PR China
    Med Hypotheses 66:45-51. 2006
  9. ncbi Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200436, PR China
    BMC Pharmacol 5:11. 2005
  10. ncbi Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
    Da Yong Lu
    Division of Anticancer Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes of Biology Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    BMC Pharmacol 4:32. 2004

Detail Information

Publications13

  1. ncbi Effect of anti-cancer drugs on the binding of 125I-Fibrinogen to two leukaemia cell lines in vitro
    D Y Lu
    School of Life Sciences, Shanghai University, Shanghai, People s Republic of China
    J Int Med Res 32:488-91. 2004
    ..Since these anti-neoplastic drugs do not have anti-coagulant actions, these results provide evidence for the potential of targeting tumour fibrinogen as a new form of cancer chemotherapy...
  2. ncbi Antimetastatic activities and mechanisms of bisdioxopiperazine compounds
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Anticancer Agents Med Chem 10:564-70. 2010
    ..We argue hererin that the systematic exploration of antimetastatic activity and mechanisms of Biz compounds seems to be a shortcut for a final solution of cancer therapy in the future...
  3. ncbi Undesired neural side-effects of a drug, a chemical and genetic interrelated problem
    Da Yong Lu
    Shanghai University, Shanghai 200444, PR China
    Cent Nerv Syst Agents Med Chem 10:108-12. 2010
    ..This review discusses this issue through careful analyzing relevant clinical evidence and published data relating to genetic detection of suffered patients and gives further suggestions to improve...
  4. ncbi Anticancer activities and mechanisms of bisdioxopiperazine compounds probimane and MST-16
    Da Yong Lu
    Shanghai University, PR China
    Anticancer Agents Med Chem 10:78-91. 2010
    ..Therefore, there is a great potential and significance for further investigations...
  5. ncbi Sequencing the whole genome of infected human cells obtained from diseased patients--a proposed strategy for understanding and overcoming AIDS or other deadest virus-infected diseases
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Med Hypotheses 68:826-7. 2007
    ..This might help us to know greatly more about the consequences of virus infection and achieve biotherapy of specifically targeted in future...
  6. ncbi Treatment of solid tumors and metastases by fibrinogen-targeted anticancer drug therapy
    Da Yong Lu
    School of Life Sciences, Department of Bioengineering, Shanghai University, 99 Shangda Rd, Shanghai 200444, China
    Med Hypotheses 68:188-93. 2007
    ..We provide laboratory and clinical evidence supporting the hypothesis and offer proposals for future applications...
  7. ncbi Medicinal chemistry of probimane and MST-16: comparison of anticancer effects between bisdioxopiperazines
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, PR China
    Med Chem 2:369-75. 2006
    ..These findings suggest that Pro is active against more categories of tumors both in vivo and in vitro, which in some circumstances may make it superior to the currently-used anticancer bisdioxopiperazines, including razoxane and MST-16...
  8. ncbi Individualized cancer chemotherapy integrating drug sensitivity tests, pathological profile analysis and computational coordination - an effective strategy to improve clinical treatment
    Da Yong Lu
    Department of Bioengineering, School of Life Sciences, Shanghai University, 99 Shangda Street, Shanghai 200436, PR China
    Med Hypotheses 66:45-51. 2006
    ..Most current cancer chemotherapy is unsatisfactory. There is a trend towards changing the norm for drug selection; one approach is to seek individualized cancer chemotherapy (ICC)...
  9. ncbi Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200436, PR China
    BMC Pharmacol 5:11. 2005
    ..Cytotoxic activities and mechanisms of Raz (+)-steroisomer (ICRF-187, dexrazoxane), Pro and MST-16 against tumor cells were evaluated by MTT colorimetry, flow cytometry and karyotyping...
  10. ncbi Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
    Da Yong Lu
    Division of Anticancer Pharmacology, Shanghai Institute of Materia Medica, Shanghai Institutes of Biology Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    BMC Pharmacol 4:32. 2004
    ..In this work, we evaluated the anti-tumor and anti-metastatic effects of Pro and Raz in vivo against two lung tumor models, one of murine origin (Lewis lung carcinoma, LLC) and one of human origin (LAX-83)...
  11. ncbi Cell biological manifestations of bisdioxopiperazines treatment of human tumor cell lines in culture
    Da Yong Lu
    School of Life Sciences, Shanghai University, Shanghai 200444, P R China
    Anticancer Agents Med Chem 10:657-60. 2010
    ..Pro, ICRF-187 and MST-16 affect the network of actin assembly. We conclude that Biz compounds might inhibit neoplasm metastases via affecting a cascade of GTPases, cell skeleton polarizations and cell movements...
  12. ncbi May genetic factors play a role in the risk of antidepressant-induced suicide?
    Da Yong Lu
    Med Hypotheses 69:1380-1. 2007
  13. ncbi Unsatisfactory design of human AIDS genome research
    Da Yong Lu
    Med Hypotheses 70:900-1. 2008