Lan Shen

Summary

Affiliation: Fourth Military Medical University
Country: China

Publications

  1. ncbi NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity
    Lan Shen
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Cell Mol Life Sci 67:1371-81. 2010
  2. ncbi RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
  3. ncbi Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines
    Na Liu
    Department of Biochemistry and Molecular Biology, The Center of Molecular Medicine, The Fourth Military Medical University, The State Key Laboratory of Cancer Biology, 17 Changle Western Road, 710032 Xi an, People s Republic of China
    Biochem Biophys Res Commun 358:164-9. 2007
  4. ncbi [Construction of cblN/Zap and its down-regulating effect on TCRzeta protein in Jurkat cells]
    Xia Li
    Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:437-41. 2005
  5. ncbi Degradation of HER2 by Cbl-based chimeric ubiquitin ligases
    Xia Li
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Cancer Res 67:8716-24. 2007
  6. ncbi Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia/reperfusion injury
    Zhongchan Sun
    Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Histochem Cell Biol 135:27-35. 2011
  7. ncbi RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer
    Guodong Yang
    The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Gastroenterology 138:231-40.e1-5. 2010
  8. ncbi Spatial-temporal expression of NDRG2 in rat brain after focal cerebral ischemia and reperfusion
    Yan Li
    Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Brain Res 1382:252-8. 2011
  9. ncbi The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
    Lan Shen
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, The People s Republic of China
    Clin Cancer Res 18:1561-7. 2012
  10. ncbi Immunohistochemical detection of Ndrg2 in the mouse nervous system
    Lan Shen
    The Institute of Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Neuroreport 19:927-31. 2008

Collaborators

Detail Information

Publications11

  1. ncbi NDRG2 is highly expressed in pancreatic beta cells and involved in protection against lipotoxicity
    Lan Shen
    Department of Biochemistry and Molecular Biology, The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Cell Mol Life Sci 67:1371-81. 2010
    ..Collectively, these data indicate that NDRG2 acts as a key molecule in pancreatic beta cells and is involved in the Akt-mediated protection of beta cells against lipotoxicity...
  2. ncbi RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line
    Wei Lin
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University and The State Key Laboratory of Cancer Biology, Xi an, The People s Republic of China
    J Cell Mol Med 13:4608-22. 2009
    ..In summary, our data highlight the importance of MSP58 in glioma progression and provided a biological basis for MSP58 as a novel candidate target for treatment of glioma...
  3. ncbi Promoter methylation, mutation, and genomic deletion are involved in the decreased NDRG2 expression levels in several cancer cell lines
    Na Liu
    Department of Biochemistry and Molecular Biology, The Center of Molecular Medicine, The Fourth Military Medical University, The State Key Laboratory of Cancer Biology, 17 Changle Western Road, 710032 Xi an, People s Republic of China
    Biochem Biophys Res Commun 358:164-9. 2007
    ..Unexpectedly, changes in the NDRG2 gene were not observed. Here, we describe for the first time, the mechanisms involved in NDRG2 gene down-regulation...
  4. ncbi [Construction of cblN/Zap and its down-regulating effect on TCRzeta protein in Jurkat cells]
    Xia Li
    Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 21:437-41. 2005
    ..To construct the chimeric cblN/Zap molecule, and to observe its effect on TCRzeta protein in pcDNA3.1(+)-cblN/Zab transfected Jurkat cells...
  5. ncbi Degradation of HER2 by Cbl-based chimeric ubiquitin ligases
    Xia Li
    State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Cancer Res 67:8716-24. 2007
    ..Collectively, our findings suggest that the Cbl-based chimeric ubiquitin ligases designed in the present study may represent a novel approach for the targeted therapy of HER2-overexpressing cancers...
  6. ncbi Variation of NDRG2 and c-Myc expression in rat heart during the acute stage of ischemia/reperfusion injury
    Zhongchan Sun
    Department of Cardiovascular Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Histochem Cell Biol 135:27-35. 2011
    ..This stress response might be involved in the novel mechanism of myocardial apoptosis induced by I/R injury in rat...
  7. ncbi RNA-binding protein quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer
    Guodong Yang
    The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, China
    Gastroenterology 138:231-40.e1-5. 2010
    ..Here we studied the role of RNA-binding protein quaking (QKI) in colon cancer...
  8. ncbi Spatial-temporal expression of NDRG2 in rat brain after focal cerebral ischemia and reperfusion
    Yan Li
    Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Brain Res 1382:252-8. 2011
    ..In conclusion, NDRG2 expression is up-regulated in ischemic penumbra following transient focal cerebral ischemia. NDRG2 expression in astrocytes may play important pathological roles in cell apoptosis after stroke...
  9. ncbi The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
    Lan Shen
    Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi an, The People s Republic of China
    Clin Cancer Res 18:1561-7. 2012
    ....
  10. ncbi Immunohistochemical detection of Ndrg2 in the mouse nervous system
    Lan Shen
    The Institute of Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China
    Neuroreport 19:927-31. 2008
    ..Taken together, these findings suggest that Ndrg2 is possibly associated with glial cell proliferation and differentiation based on its immunolocalization in this study...
  11. ncbi The physical and functional interaction of NDRG2 with MSP58 in cells
    Jing Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, China 710032, China
    Biochem Biophys Res Commun 352:6-11. 2007
    ..Furthermore, the modulation of Ndrg2 level influences the cell cycle process together with MSP58. In conclusion, the findings offered a novel insight into the physiological roles of Ndrg2...