Sheng Di Chen

Summary

Country: China

Publications

  1. ncbi The neuroprotection of prodromal transient ischaemic attack on cerebral infarction
    Y Fu
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur J Neurol 15:797-801. 2008
  2. ncbi DJ-1 can inhibit microtubule associated protein 1 B formed aggregates
    Zhiquan Wang
    Laboratory of Neurodegenerative Diseases and key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mol Neurodegener 6:38. 2011
  3. ncbi Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes
    S Chen
    Department of Neurology, Clinical and Research Center for Parkinson Disease, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, People s Republic of China
    Parkinsonism Relat Disord 9:S91-7. 2003
  4. ncbi Microglia in the aging brain: relevance to neurodegeneration
    Xiao Guang Luo
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Mol Neurodegener 5:12. 2010
  5. ncbi P2Y6 receptor and immunoinflammation
    Gui Dong Liu
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China
    Neurosci Bull 25:161-4. 2009
  6. ncbi Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease
    Wei Guo Liu
    Department of Neurology and Neuroscience Institute, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Mol Neurodegener 2:19. 2007
  7. ncbi The role of synphilin-1 in the pathogenesis of Parkinson's disease
    Rui Zheng
    Department of Neurology and Institute of Neurology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China E mail
    Neurosci Bull 22:239-43. 2006
  8. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
  9. ncbi Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease
    Wei Guo Liu
    Department of Neurology, Clinical and Research Center for Parkinson Disease and Movement Disorders, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Parkinsonism Relat Disord 13:77-88. 2007
  10. ncbi Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China
    Alzheimer Dis Assoc Disord 25:283-5. 2011

Collaborators

Detail Information

Publications68

  1. ncbi The neuroprotection of prodromal transient ischaemic attack on cerebral infarction
    Y Fu
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Eur J Neurol 15:797-801. 2008
    ..To evaluate the potential neuroprotection against subsequent cerebral infarction conferred by a prodromal transient ischaemic attack (TIA)...
  2. ncbi DJ-1 can inhibit microtubule associated protein 1 B formed aggregates
    Zhiquan Wang
    Laboratory of Neurodegenerative Diseases and key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Mol Neurodegener 6:38. 2011
    ..abstract:..
  3. ncbi Behavioral correction of Parkinsonian rats following the transplantation of immortalized fibroblasts genetically modified with TH and GCH genes
    S Chen
    Department of Neurology, Clinical and Research Center for Parkinson Disease, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, People s Republic of China
    Parkinsonism Relat Disord 9:S91-7. 2003
    ..This work demonstrates that the co-transplantation of immortalized fibroblasts genetically modified by TH and GCH genes may be developed as a valuable approach to the treatment of Parkinson's disease...
  4. ncbi Microglia in the aging brain: relevance to neurodegeneration
    Xiao Guang Luo
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Mol Neurodegener 5:12. 2010
    ..In Parkinson's disease and Alzheimer's disease, over-activation of microglia may play an active role in the pathogenesis because microglia senescence primes them to be neurotoxic during the development of the diseases...
  5. ncbi P2Y6 receptor and immunoinflammation
    Gui Dong Liu
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China
    Neurosci Bull 25:161-4. 2009
    ..Itos proposed that purinoceptor P2Y6 may play a role in neuroinflammation in CNS, although further research is still required...
  6. ncbi Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease
    Wei Guo Liu
    Department of Neurology and Neuroscience Institute, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Mol Neurodegener 2:19. 2007
    ..In this study, we transplanted NTN-c17.2 into the striatum of the 6-hydroxydopamine (6-OHDA) PD model to further determine the regenerative effect of NTN-c17.2 on the rat models of PD...
  7. ncbi The role of synphilin-1 in the pathogenesis of Parkinson's disease
    Rui Zheng
    Department of Neurology and Institute of Neurology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China E mail
    Neurosci Bull 22:239-43. 2006
    ..It is widely accepted that synphilin-1 is involved in the pathogenic process of PD. This review will provide an overall view of the role of synphilin-1 in the pathogenesis of Parkinson's disease and the latest findings in this field...
  8. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    ....
  9. ncbi Dopaminergic neuroprotection by neurturin-expressing c17.2 neural stem cells in a rat model of Parkinson's disease
    Wei Guo Liu
    Department of Neurology, Clinical and Research Center for Parkinson Disease and Movement Disorders, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Parkinsonism Relat Disord 13:77-88. 2007
    ..2 and Mock-c17.2 groups. Taken together, our results suggest that transplantation of NTN-secreting NSCs exerted protective on PD rat models...
  10. ncbi Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China
    Alzheimer Dis Assoc Disord 25:283-5. 2011
    ..To assess genetic variations of GAB2 as a risk factor for developing Alzheimer disease (AD)...
  11. ncbi Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice
    Zhen Hong
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 China
    Eur J Neurosci 26:1500-8. 2007
    ..These data demonstrate a neuroprotective action of TW397 in vivo against MPTP toxicity, with important implications for the treatment of PD...
  12. ncbi A single nucleotide polymorphism in LRP2 is associated with susceptibility to Alzheimer's disease in the Chinese population
    Li ling Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Clin Chim Acta 412:268-70. 2011
    ....
  13. ncbi Malnutrition and associated factors in Chinese patients with Parkinson's disease: Results from a pilot investigation
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Parkinsonism Relat Disord 16:119-23. 2010
    ..This study was conducted to evaluate the prevalence of malnutrition among patients with Parkinson's disease (PD) and determine the associations between malnutrition and non-motor symptoms (NMS)...
  14. ncbi Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease
    Min Ye
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine SJTUSM, Shanghai 200025, China
    Brain Res 1142:206-16. 2007
    ....
  15. ncbi K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways
    Jing Pan
    Department of Neurology and Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Mol Pharmacol 72:1607-18. 2007
    ....
  16. ncbi Mitogen activated protein kinase and protein kinase C activation mediate promotion of sAPPalpha secretion by deprenyl
    Hong Qi Yang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Neurochem Int 50:74-82. 2007
    ....
  17. ncbi CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population
    Pei Jing Cui
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Alzheimers Dis 19:31-5. 2010
    ..The allelic frequencies of the AD patients and control subjects were found to be significantly different. Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han...
  18. ncbi Neuroprotective effects of PACAP27 in mice model of Parkinson's disease involved in the modulation of K(ATP) subunits and D2 receptors in the striatum
    Gang Wang
    Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Neuropeptides 42:267-76. 2008
    ....
  19. ncbi New protein kinase C activator regulates amyloid precursor protein processing in vitro by increasing alpha-secretase activity
    Hong Qi Yang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P R China
    Eur J Neurosci 26:381-91. 2007
    ..Our data indicate that TPPB could direct APP processing towards the non-amyloidogenic pathway by increasing alpha-secretase activity, and suggest its therapeutic potential in AD...
  20. ncbi Effect of transplantation of c17.2 cells transfected with interleukin-10 gene on intracerebral immune response in rat model of Parkinson's disease
    Xi jin Wang
    Department of Neurology and Neuroscience Institute, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, PR China
    Neurosci Lett 423:95-9. 2007
    ..The reduction in ED1 immunostaining in the rats treated with IL-10-c17.2 cells remained significant until day 60 after transplantation. Our results suggest the potential application value of IL-10 in the transplantation treatment of PD...
  21. ncbi Four novel mutations in the GCH1 gene of Chinese patients with dopa-responsive dystonia
    Li Cao
    Department of Neurology and Institute of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Mov Disord 25:755-60. 2010
    ....
  22. ncbi Lack of association between ATP13A2 Ala746Thr variant and Parkinson's disease in Han population of mainland China
    Qing Zhou Fei
    Department of Neurology and Institute of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Lett 475:61-3. 2010
    ..The results suggested that Ala746Thr variant was not a major susceptible factor for PD in Han Chinese people...
  23. ncbi Starvation triggers Abeta42 generation from human umbilical vascular endothelial cells
    Jian fang Ma
    Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    FEBS Lett 584:3101-6. 2010
    ..These results suggest that starvation-induced Abeta(42) secretion might contribute to the formation of CAA and hence vascular degeneration in AD...
  24. ncbi Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid
    Zhi Kun Sun
    Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    J Neurosci Res 86:3018-27. 2008
    ..This study provides new molecular insight into the neuroprotective effect of Epo and suggests its possible therapeutic role in the management of AD...
  25. ncbi Transthyretin-related hereditary amyloidosis in a Chinese family with TTR Y114C mutation
    Yu Zhang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Neurodegener Dis 8:187-93. 2011
    ..Corresponding to the various transthyretin gene mutations and a wide range of geographical distribution, transthyretin-related hereditary amyloidosis presents diverse characteristics in genotype-phenotype correlation...
  26. ncbi CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease
    Shi Zhang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, P R China
    J Neuroinflammation 8:154. 2011
    ..Thus, further in vivo evidence is needed to elucidate the role of malfunction of CD200-CD200R signalling in the pathogenesis of PD...
  27. ncbi Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells
    Qing Yun Li
    Lab of Neurodegenerative Diseases and Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS, and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Lett 481:154-8. 2010
    ....
  28. ncbi Sleep disorders in Chinese patients with Parkinson's disease: validation study of a Chinese version of Parkinson's disease sleep scale
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to the Medical School of Shanghai Jiaotong University 20025, China
    J Neurol Sci 271:153-7. 2008
    ..The Chinese version of PDSS met some basic standards required for sleep disorders measures. It could lead to better understanding the sleep disorders of PD of China in future studies...
  29. ncbi [The relationship between the five beta-fibrinogen gene polymorphisms and cerebral infarction]
    Yi Fu
    Department of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 44:914-7. 2005
    ..To investigate the relationship among beta-fibrinogen (Fg) concentration, related gene polymorphisms (including -148C/T, -249C/T, -455G/A, 448G/A, 1689T/G) and cerebral infarction...
  30. ncbi Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease
    Jing Pan
    Department of Neurology and Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Neurosci Lett 428:82-7. 2007
    ..This indicates that the 6-OHDA-induced activation of Fas signaling pathway is mediated by JNK and that FasL may be a promising target in the therapeutic approach for PD patients...
  31. ncbi Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer's disease
    Yue Huang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Curr Alzheimer Res 8:765-70. 2011
    ..e., in APOE non ?4 allele carriers, SIGMAR1 2P variant had increased cognitive dysfunction and more advanced stages of NFT. Our data demonstrate that SIGMAR1 and APOE interact to influence AD severity across ethnic populations...
  32. ncbi The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population
    Pei Jing Cui
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 2nd Rui Jin Road, Shanghai 200025, China
    J Clin Neurosci 19:745-9. 2012
    ..007, OR=0. 358, 95% CI=0.170-0.752 for rs4646958; adjusted p=0.001, OR=0. 368, 95% CI=0.199-0.679 in rs1887922). In the context of APOE?4-negative status, both variants were significantly associated with AD in some genetic models...
  33. ncbi Association study of clusterin polymorphism rs11136000 with late onset Alzheimer's disease in Chinese Han population
    Jian fang Ma
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, China
    Am J Alzheimers Dis Other Demen 26:627-30. 2011
    ..We conducted a case-control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer's disease in Chinese Han population...
  34. ncbi PPARgamma agonist curcumin reduces the amyloid-beta-stimulated inflammatory responses in primary astrocytes
    Hong Mei Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    J Alzheimers Dis 20:1189-99. 2010
    ..Furthermore, GW9662, a PPARgamma antagonist, can abolish the anti-inflammatory effect of curcumin. These results show that curcumin might act as a PPARgamma agonist to inhibit the inflammation in Abeta-treated astrocytes...
  35. ncbi Gene polymorphisms and risk of adult early-onset ischemic stroke: A meta-analysis
    Xiao yu Xin
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China
    Thromb Res 124:619-24. 2009
    ..Through meta-analysis, this study was conducted to determine the genetic risk contributed by each susceptibility gene polymorphism, particularly in adult early-onset ischemic stroke patients...
  36. ncbi Proteasome inhibitor lactacystin induces cholinergic degeneration
    Hai Yan Zhou
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Can J Neurol Sci 37:229-34. 2010
    ..In our present study, we attempt to figure out what effect the failure of ubiquitin proteasome function would execute on cholinergic cells in culture...
  37. ncbi Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia
    Xi jin Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurochem Int 50:39-50. 2007
    ..Our work provides new evidence for the involvement of the immune/inflammatory system in PD and helpful clues for studying the combined effect of antibody and complement on microglia...
  38. ncbi Altered regulation of CD200 receptor in monocyte-derived macrophages from individuals with Parkinson's disease
    Xiao Guang Luo
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong Univeristy School of Medicine, Shanghai, LuWan District, China
    Neurochem Res 35:540-7. 2010
    ..These results suggest an intrinsic abnormality in the CD200-CD200R signaling in MDMs during aging and, especially, in PD. We speculate that in the PD brain,microglia might undergo abnormalities similar to MDMs...
  39. ncbi Heat shock proteins reduce alpha-synuclein aggregation induced by MPP+ in SK-N-SH cells
    Guo Hua Fan
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, No 197 Rui Jin Er Road, Shanghai 200025, China
    FEBS Lett 580:3091-8. 2006
    ..These findings suggest that HSPs may inhibit the MPP+-induced alpha-synuclein expression, accelerate alpha-synuclein degradation, thereby reducing the amount of alpha-synuclein protein and accordingly preventing its aggregation...
  40. ncbi Downregulation of parkin damages antioxidant defenses and enhances proteasome inhibition-induced toxicity in PC12 cells
    Hui Yang
    Department of Neurology and Neuroscience Institute, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Neuroimmune Pharmacol 2:276-83. 2007
    ..These results indicate that downregulation of Parkin may damage the antioxidation defenses of dopaminergic cells and increase their susceptibility to proteasome inhibitor-induced toxicity...
  41. ncbi Restless legs syndrome in Chinese elderly people of an urban suburb in Shanghai: a community-based survey
    Jian fang Ma
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No 197 Rd Ruijin Second, Shanghai 200025, China
    Parkinsonism Relat Disord 18:294-8. 2012
    ..The aim of the study is to investigate the prevalence rate of restless legs syndrome (RLS) in elderly Chinese people over 50 years of age in an urban suburb of Shanghai by a community-based study...
  42. ncbi The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
    Ru jing Ren
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Neurol Sci 308:32-4. 2011
    ..829, 95% CI: 1.277-2.619, P=0.001), and the results were influenced by APOE status. Our data revealed that the allele (A) of the rs11754661 polymorphism within MTHFD1L gene may contribute to AD risk in the Chinese Han population...
  43. ncbi Blockade of the translocation and activation of c-Jun N-terminal kinase 3 (JNK3) attenuates dopaminergic neuronal damage in mouse model of Parkinson's disease
    Jing Pan
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    Neurochem Int 54:418-25. 2009
    ....
  44. ncbi The metric properties of Zarit caregiver burden scale: validation study of a Chinese version
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Medical School of Shanghai Jiaotong University, Shanghai, China
    Alzheimer Dis Assoc Disord 22:321-6. 2008
    ..To evaluate the Chinese version of the Zarit Burden Interview (ZBI) as an instrument for measuring strain in Chinese caregivers of elderly people with dementia...
  45. ncbi Apolipoprotein E promoter polymorphisms and risk of Alzheimer's disease: evidence from meta-analysis
    Xiao yu Xin
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Alzheimers Dis 19:1283-94. 2010
    ..Our results confirm a significant but modest association between APOE promoter -491A/T and -219T/G polymorphisms and AD susceptibility...
  46. ncbi 2-methoxyestradiol attenuates autophagy activation after global ischemia
    Xiao yu Xin
    Department of Neurology and Institute of Neurology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Can J Neurol Sci 38:631-8. 2011
    ..In the present study, we aimed to test the hypothesis that post-ischemic HIF-1? up-regulation might promote autophagy activation; thereby, HIF-1? inhibitor 2ME2 might prevent neurons from ischemic injury through inhibiting autophagy...
  47. ncbi Economic impact of dementia in developing countries: an evaluation of Alzheimer-type dementia in Shanghai, China
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Medical School of Shanghai Jiaotong University, Shanghai, China
    J Alzheimers Dis 15:109-15. 2008
    ..With the increase in the number of persons at risk for developing AD, the economic burden of AD patients in China is significantly heavy...
  48. ncbi Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway
    Gang Wang
    Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China
    Biochem Biophys Res Commun 374:204-9. 2008
    ..3. Our studies provide an entry point for understanding the novel roles of Kir2.3 in cell models of PD, and they offer clues for the common mechanisms underlying different neurodegenerative conditions...
  49. ncbi Validation of the Chinese non-motor symptoms scale for Parkinson's disease: results from a Chinese pilot study
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to the Medical School of Shanghai Jiaotong University, Shanghai 200025, China
    Clin Neurol Neurosurg 111:523-6. 2009
    ..To evaluate a Chinese version of the Non-Motor Symptoms Scale (NMSS) in Parkinson's disease (PD) as an instrument for measuring non-motor symptoms (NMSs) in Chinese patients with Parkinson's disease...
  50. ncbi Cognitive impairment and associated factors among the elderly in the Shanghai suburb: findings from a low-education population
    Yu Hui Yao
    Department of Neurology, Ruijin Hospital affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Neuroepidemiology 34:245-52. 2010
    ..Our purpose was to investigate the prevalence of cognitive impairment and associated factors among elderly people in the Shanghai suburb...
  51. ncbi Serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with multiple sclerosis
    Ying Chun Chen
    Department of Neurology, Ruijin Hospital, Medical School of Shanghai Jiao Tong University, Shanghai, China
    J Neuroimmunol 243:56-60. 2012
    ..775, P=0.041). Our data suggest that all IL-18, IL-23 and IL-17 may be involved in the pathogenesis of MS. However, the relationships of the three cytokines and clinical characteristics of MS need to be further investigated in the future...
  52. ncbi Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias
    Jun ling Wang
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China
    Brain 134:3493-3501. 2011
    ..Thus, we have identified PRRT2 as the first causative gene of paroxysmal kinesigenic dyskinesias, warranting further investigations to understand the pathogenesis of this disorder...
  53. ncbi Identification of glial-cell-line-derived neurotrophic factor-regulated proteins of striatum in mouse model of Parkinson disease
    Zhen Hong
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, P R China
    Proteomics Clin Appl 3:1072-83. 2009
    ..These data will provide some clues for understanding the mechanisms by which GDNF promotes the survival of dopaminergic neurons...
  54. ncbi CD200-CD200R regulation of microglia activation in the pathogenesis of Parkinson's disease
    Xi jin Wang
    Department of Neurology and Institute of Neurology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    J Neuroimmune Pharmacol 2:259-64. 2007
    ..Finally, we discuss the status of current studies on the regulation of microglia activation in PD and strongly suggest that it is very promising to regulate microglia activation in PD via targeting CD200-CD200R signaling pathways...
  55. ncbi Verification of expressions of Kir2 as potential peripheral biomarkers in lymphocytes from patients with Parkinson's disease
    Ya Xing Gui
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Lett 505:104-8. 2011
    ..2 mRNA between PD patients and healthy controls. We proposed that the Kir2 potassium channels mRNA on blood lymphocytes may be regarded as a potential biomarker for PD screening...
  56. ncbi The iPS technique provides hope for Parkinson's disease treatment
    Liang Xu
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Rui Jin Er Road, Shanghai, 200025, China
    Stem Cell Rev 6:398-404. 2010
    ..In addition, differentiated iPS cells are now close to be used in clinical practice. Here we review the progress of iPS technique and the possible application in the area of Parkinson's disease treatment...
  57. ncbi Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?
    Xiao Kun Liu
    Department of Neurology and Institute of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Bull 26:265-71. 2010
    ..Besides, whether modulation of SK channels could be a potential target for PD treatment was also discussed...
  58. ncbi Lingo2 variants associated with essential tremor and Parkinson's disease
    Yi Wen Wu
    Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Hum Genet 129:611-5. 2011
    ..Our study demonstrated for the first time that rs7033345 is associated with PD and ET and rs10812774 with ET among Asians, suggesting that LINGO2 might act as a susceptibility gene for both conditions...
  59. ncbi ATP-sensitive potassium channels: novel potential roles in Parkinson's disease
    Jie Zeng
    Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Neurosci Bull 23:370-6. 2007
    ....
  60. ncbi PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro
    Hong Qi Yang
    Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Neurochem Res 34:528-35. 2009
    ..These results indicated that PMS777 could modulate APP processing in vitro and that decreasing Abeta generation might demonstrate its therapeutic potential in AD...
  61. ncbi The Gab2 in signal transduction and its potential role in the pathogenesis of Alzheimer's disease
    Xiao Ling Pan
    Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Neurosci Bull 26:241-6. 2010
    ..This review mainly focuses on the structure and function of Gab2 protein and its role in the pathogenesis of AD...
  62. ncbi GIGYF2 Asn56Ser mutation is rare in Chinese Parkinson's disease patients
    Yu Zhang
    Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neurosci Lett 463:172-5. 2009
    ..The result showed that the GIGYF2 Asn56Ser mutation was not present in all subjects. Our finding suggests that the GIGYF2 Asn56Ser mutation is rare in Chinese PD patients...
  63. ncbi The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target?
    Li ling Wang
    Department of Neurology and Institute of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Med Hypotheses 78:398-401. 2012
    ..This review focuses on the recent findings regarding the role of miR-146 in modulating immune response and its subsequent effects in the pathogenesis of AD...
  64. ncbi [The linkage disequilibrium of four loci in hepatic lipase promoter gene of cerebral infarction patients in Shanghai]
    Yi Fu
    Department of Neurology, Ruijin Hospital, Department of Medical Laboratory, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    Zhonghua Yi Xue Za Zhi 87:2203-8. 2007
    ..To investigate the single nucleotide polymorphism (SNP), the distribution of their haplotypes and linkage disequilibrium of hepatic lipase (HL) gene promoter 250G/A, 514C/T, 710T/C and 763A/G in cerebral infarction patients of Shanghai...
  65. ncbi Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor
    Yu Yan Tan
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People s Republic of China
    Mol Cell Biochem 318:109-15. 2008
    ..Moreover, we provide a new cell model for studying the roles of UCH-L1 in Parkinson's disease...
  66. ncbi Genetic predisposition to inflammation: a new risk factor of Alzheimer's disease
    Ying Wan
    Department of Neurology Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    Neurosci Bull 24:314-22. 2008
    ..Hence we present a hypothesis that the inflammation genotypes may contribute to AD susceptibility. This may provide a new orientation both for future identification of individuals at risk and for personalized medication...
  67. ncbi Diffusion tensor imaging changes correlate with cognition better than conventional MRI findings in patients with subcortical ischemic vascular disease
    Qun Xu
    Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, PR China
    Dement Geriatr Cogn Disord 30:317-26. 2010
    ..To investigate whether diffusion tensor imaging (DTI) is more sensitive than conventional MRI at detecting cognitive deterioration in patients with subcortical ischemic vascular disease (SIVD)...
  68. ncbi Phosphoproteome study reveals Hsp27 as a novel signaling molecule involved in GDNF-induced neurite outgrowth
    Zhen Hong
    Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
    J Proteome Res 8:2768-87. 2009
    ....