Research Topics
Species | Luigi DevotoSummaryAffiliation: Universidad de Chile Country: Chile Publications
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Detail Information
Publications
The human corpus luteum: life cycle and function in natural cyclesLuigi Devoto
Instituto de Investigaciones Materno Infantil, Departamento de Obstetricia y Ginecologia, Hospital Clinico San Borja Arriaran, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Fertil Steril 92:1067-79. 2009....
Neuroendocrinology and ovarian agingLuigi Devoto
Instituto de Investigaciones Materno Infantil, Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Universidad de Chile, Hospital San Borja Arriaran, Santiago, Chile
Gynecol Endocrinol 28:14-7. 2012..In this review, we aim to further the discussion of neuroendocrine changes taking place during the ovarian aging process that may impact reproductive function...
Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulationLuigi Devoto
Universidad de Chile, Hospital Clinico San Borja Arriaran, Santiago, Chile
Reprod Biomed Online 18:19-24. 2009..The current trend towards simple stimulation protocols and the use of single-embryo transfers provide further opportunity to revisit HCG administration as luteal support...
Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-mug tablets or as 30-microg minipillsLuigi Devoto
Instituto de Investigaciones Materno Infantil and Departamento de Obstetricia y Ginecologia, Universidad de Chile, Santiago, Chile
Fertil Steril 88:976-7. 2007..These findings suggest that levonorgestrel-containing minipills can be considered as an alternative to standard levonorgestrel tablets for use in emergency contraception...
Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5-mg dose by the oral and vaginal routeLuigi Devoto
Instituto de Investigaciones Materno Infantil, Departamento de Obstetricia y Ginecologia, Medical Faculty, Hospital San Borja Arriaran, University of Chile, Santiago, Chile
Fertil Steril 84:46-51. 2005..To determine the pharmacokinetics and endometrial tissue levels of levonorgestrel when taken as a single dose of 1.5 mg either orally or vaginally by healthy women in the periovulatory phase of their menstrual cycle...
The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phasePaulina Kohen
Instituto de Investigaciones Materno Infantil y Departamento de Obstetricia y Ginecología, Facultad de Medicina, Universidad de Chile, Hospital Clinico San Borja Arriaran, Santiago
J Clin Endocrinol Metab 88:3421-30. 2003....
Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycleLuigi Devoto
Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Hospital Clinico San Borja Arriaran, Instituto de Investigaciones Materno Infantil IDIMI, Universidad de Chile, PO Box 226 3, Santiago, Chile
J Reprod Immunol 55:11-20. 2002..hCG increased both the level of StAR expression and the level of anti-apoptotic protein Bcl-2 within the late CL. We conclude that mRNA and protein expression of StAR and bcl-2 are important target elements for hCG during the CL rescue...
Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory periodVictor Garcia
Institute for Maternal and Child Research, IDIMI, and Department of Obstetrics and Gynecology, Faculty of Medicine, San Borja Arriaran Clinical Hospital, University of Chile, Santiago, Chile
Fertil Steril 97:707-13.e1. 2012..To study in vivo the progesterone receptor (PR) expression levels in human granulosa cells (GCs) during the periovulatory period and the affect of the protein kinase A (PKA) pathway on PR expression and cathepsin-L expression-activation...
Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patientsReinaldo Gonzalez-Ramos
Departamento de Obstetricia y Ginecologia, Instituto de Investigaciones Materno Infantil, Hospital San Borja Arriaran, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Fertil Steril 97:645-51. 2012..To evaluate nuclear factor kappaB (NF-?B) activation and NF-?B-p65 subunit activation, immunolocalization, and expression in the endometrium of healthy women and endometriosis patients throughout the menstrual cycle...
Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clomiphene citrateW Alberto Palomino
Institute for Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile
Fertil Steril 83:587-93. 2005..To assess the effect of clomiphene citrate (CC) on endometrial epithelial integrins and P receptors (PR) during the window of implantation...
Features of natural and gonadotropin-releasing hormone antagonist-induced corpus luteum regression and effects of in vivo human chorionic gonadotropinFelipe Del Canto
Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Hospital Clinico San Borja Arriaran, Universidad de Chile, Santiago 3, Chile
J Clin Endocrinol Metab 92:4436-43. 2007..The natural process of luteolysis and luteal regression is induced by withdrawal of gonadotropin support...
A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expression of the L-selectin ligand or molecular markers of endometrial receptivityWilder Alberto Palomino
Instituto de Investigaciones Materno Infantil, Universidad de Chile, Santiago de Chile, Chile
Fertil Steril 94:1589-94. 2010..To examine the effects of a single-dose of 1.5 mg of levonorgestrel (commonly used as emergency contraceptive) on endometrial receptivity biomarkers through the oral or vaginal route...
Assessment of diagnostic competence of plasmatic androgens on polycystic ovary syndrome based on receiver operator characteristic curvesClaudio Villarroel
Instituto de Investigaciones Materno Infantil IDIMI, Facultad de Medicina, Universidad de Chile, Hospital Clinico San Borja Arriaran, Santiago, Chile
Gynecol Endocrinol 26:600-6. 2010..This study was designed to assess the diagnostic potency of different androgens in hyperandrogenaemia criterion on polycystic ovary syndrome (PCOS) based on receiver operator characteristic (ROC) curves analysis...
Control of human luteal steroidogenesisLuigi Devoto
Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Instituto de Investigaciones Materno Infantil, IDIMI y Universidad de Chile, PO Box 226 3, Santiago, Chile
Mol Cell Endocrinol 186:137-41. 2002....
Tumor necrosis factor-alpha activates nuclear factor-kappaB but does not regulate progesterone production in cultured human granulosa luteal cellsFlor Gonzalez-Navarrete
Institute of Maternal and Child Research, Department of Obstetrics and Gynecology, Hospital San Borja Arriaran, Santiago, Chile
Gynecol Endocrinol 23:377-84. 2007..Our aim was to examine the steroidogenic response, together with the simultaneous expression and activation of nuclear factor-kappaB (NF-kappaB), in cultured human granulosa luteal cells (GLCs) following administration of TNF-alpha...
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivityAlejandro Tapia
Instituto de Investigaciones Materno Infantil, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Reprod Biol Endocrinol 9:14. 2011....
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumorsTeresa Tapia
Department of Cell and Molecular Biology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
Epigenetics 3:157-63. 2008..Moreover, a number of biopsies with absence of expression on BRCA1 showed negative detection of estrogen and progesterone receptors, a similar phenotype to BRCA1 mutated breast tumors...
Clomiphene citrate and ovulation inductionHugo Sovino
Instituto de Investigación Materno Infantil, Departamento de Obstetricia y Ginecologia, Unidad de Medicina Reproductiva, Campus Centro, Universidad de Chile, Hospital Clinico San Borja Arriaran, Chile
Reprod Biomed Online 4:303-10. 2002..Other adverse effects include multiple pregnancies, an increase in the rate of multiple births, ovarian hyperstimulation and unsubstantiated claims of ovarian cancer...
Men's participation in psychologic counseling services offered during in vitro fertilization treatmentsIrene Furman
Instituto de Investigaciones Materno Infantil, Hospital Clinico San Borja Arriaran, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Fertil Steril 94:1460-4. 2010..To assess frequency of male participation in psychologic support services during IVF treatments...
Involvement of the nuclear factor-?B pathway in the pathogenesis of endometriosisReinaldo Gonzalez-Ramos
Instituto de Investigaciones Materno Infantil, Departamento de Obstetricia y Ginecologia, Hospital Clinico San Borja Arriaran, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Fertil Steril 94:1985-94. 2010..To evaluate the role of nuclear factor-?B (NF-?B) in the pathogenesis of endometriosis...
[Association between motherhood postponement and socioeconomic status]Ariel Fuentes
Instituto de Investigaciones, Materno Infantil, Facultad de Medicina, Universidad de Chile, Chile
Rev Med Chil 138:1240-5. 2010..In Chile the National Institute of Statistics established that this age has remained around 23 years for more than two decades. Motherhood postponement may be modulated by socioeconomic status...
Cholesterol transport and steroidogenesis by the corpus luteumLane K Christenson
Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, PA 19104, USA
Reprod Biol Endocrinol 1:90. 2003..The key factors involved in luteal steroidogenesis and several new exciting observations regarding regulation of luteal steroidogenic function are discussed in this review...
Luteal phase physiology and its relevance for steroids and human chorionic gonadotropin treatmentLuigi Devoto
Gynecol Endocrinol 24:237-8. 2008
Activation of Cl- channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesisPablo Olivero
Centro de Estudios Moleculares de la Célula and Instituto de Ciencias Biomédicas, Escuela de Medicina, Universidad de Valparaiso, Valparaiso, Chile
Endocrinology 149:4680-7. 2008..It is concluded that human granulosa cells express functional the volume-sensitive outwardly rectifying Cl(-) channels that are activated by hCG, which are critical for plasma membrane potential changes, Ca2+ influx, and P4 production...
Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cellsWalter D Sierralta
Laboratorio de Estructuras, INTA Universidad de Chile, Macul 5540, PO Box 138, Santiago 11, Chile
Mol Cell Endocrinol 242:103-10. 2005....
