Nibaldo C Inestrosa

Summary

Country: Chile

Publications

  1. ncbi Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile, Santiago, Chile
    Curr Alzheimer Res 1:249-54. 2004
  2. ncbi Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco and MIFAB, Chile
    Neural Dev 4:41. 2009
  3. ncbi Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
    Oscar M Lazo
    Department of Physiology, Neurobiology Unit, Center of Ageing and Regeneration CARE, Nucleus Millennium in Regenerative Biology MINREB, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, CP 8331010, Santiago, Chile
    Mol Neurodegener 5:5. 2010
  4. ncbi Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
    Waldo Cerpa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Neurodegener 5:3. 2010
  5. ncbi Emerging roles of Wnts in the adult nervous system
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Nat Rev Neurosci 11:77-86. 2010
  6. ncbi Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, Instituto Milenio MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 5:4. 2010
  7. ncbi The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Neurodegener 3:9. 2008
  8. ncbi Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
    Nibaldo C Inestrosa
    CRCP Biomedical Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
    FEBS J 275:625-32. 2008
  9. ncbi c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis
    Mary C Vázquez
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontifical Catholic University of Chile, Santiago, Chile
    J Cell Physiol 220:136-43. 2009
  10. ncbi Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    Karen Fuenzalida
    Centro de Regulación Celular y Patologia Joaquín V Luco and Millennium Institute for Fundamental and Applied Biology, Department of Cellular and Molecular Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Biol Chem 282:37006-15. 2007

Collaborators

Detail Information

Publications71

  1. ncbi Acetylcholinesterase (AChE)--amyloid-beta-peptide complexes in Alzheimer's disease. the Wnt signaling pathway
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile, Santiago, Chile
    Curr Alzheimer Res 1:249-54. 2004
    ..Compounds that mimic the Wnt signaling or modulate the cross-talking with this pathway could be used as neuroprotective agents for therapeutic strategies in AD patients...
  2. ncbi Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco and MIFAB, Chile
    Neural Dev 4:41. 2009
    ..Some Wnt signaling components are localized at central synapses, and it is thus possible that this pathway could be activated at the synapse...
  3. ncbi Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
    Oscar M Lazo
    Department of Physiology, Neurobiology Unit, Center of Ageing and Regeneration CARE, Nucleus Millennium in Regenerative Biology MINREB, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, CP 8331010, Santiago, Chile
    Mol Neurodegener 5:5. 2010
    ..The principal aim of this study was to evaluate, using modern quantitative confocal microscopy, neurodegenerative changes in septal cholinergic neurons after axotomy and to assess their response to delayed infusion of NGF in rats...
  4. ncbi Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
    Waldo Cerpa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Mol Neurodegener 5:3. 2010
    ..Abeta oligomers block hippocampal long-term potentiation (LTP) and impair rodent spatial memory. Wnt signaling plays an important role in neural development, including synaptic differentiation...
  5. ncbi Emerging roles of Wnts in the adult nervous system
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Nat Rev Neurosci 11:77-86. 2010
    ..Here, the latest insights into the function of Wnt signalling in the adult nervous system and therapeutic opportunities for neurodegenerative diseases such as Alzheimer's and Parkinson's disease are discussed...
  6. ncbi Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Abeta peptide. Implications for the pathogenesis of Alzheimer's disease
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, Instituto Milenio MIFAB, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    Mol Neurodegener 5:4. 2010
    ..From a therapeutic point of view, activation of the Wnt signaling pathway, as well as NMDAR inhibition may be important factors to protect neurons under Abeta-AChE attack...
  7. ncbi The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease
    Nibaldo C Inestrosa
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V, Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Neurodegener 3:9. 2008
    ..In conclusion the activation of the Wnt signaling pathway could be proposed as a therapeutic target for the treatment of AD...
  8. ncbi Amyloid-cholinesterase interactions. Implications for Alzheimer's disease
    Nibaldo C Inestrosa
    CRCP Biomedical Center, Pontificia Universidad Catolica de Chile, Santiago, Chile
    FEBS J 275:625-32. 2008
    ..Recent studies also indicate that acetylcholinesterase induces the aggregation of prion protein with a similar dependence on the peripherical anionic site...
  9. ncbi c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis
    Mary C Vázquez
    Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Pontifical Catholic University of Chile, Santiago, Chile
    J Cell Physiol 220:136-43. 2009
    ....
  10. ncbi Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
    Karen Fuenzalida
    Centro de Regulación Celular y Patologia Joaquín V Luco and Millennium Institute for Fundamental and Applied Biology, Department of Cellular and Molecular Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Biol Chem 282:37006-15. 2007
    ..Altogether, these data suggest that PPARgamma supports survival in neurons in part through a mechanism involving increased expression of Bcl-2...
  11. ncbi Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway
    Macarena S Arrázola
    Centro Basal de Excelencia para el Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V Luco CRCP and MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 221:658-67. 2009
    ..We conclude that CaMKIV is regulated by the Wnt signaling pathway and that its expression could play a role in the neuroprotective function of the Wnt signaling against the Alzheimer's amyloid peptide...
  12. ncbi Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons
    Loreto Cuitino
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 30:8411-20. 2010
    ..Therefore, we postulate that Wnt-5a, by activation of CaMKII, induces the recycling of functional GABA(A)-Rs on the mature hippocampal neurons...
  13. ncbi Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Neurobiol Aging 26:1023-8. 2005
    ..Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD...
  14. ncbi Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurodegener Dis 5:149-52. 2008
    ..The cellular mechanism by which beta-amyloid peptide (Abeta) affects synapses remains unclear. Abeta oligomers target synapses in cultured rat hippocampal neurons suggesting that they play a key role in the regulation of synapses...
  15. ncbi Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss
    Ariel E Reyes
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute of Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Am J Pathol 164:2163-74. 2004
    ..Our studies are consistent with the notion that Abeta-AChE complexes are more toxic than Abeta fibrils and that AChE triggered some of the neurodegenerative changes observed in Alzheimer's disease brains...
  16. ncbi STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits
    Gonzalo I Cancino
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Brain 131:2425-42. 2008
    ..These results are consistent with the role of the c-Abl/p73 signalling pathway in Abeta neurodegeneration, and suggest that STI571-like compounds would be effective in therapeutic treatments of Alzheimer disease...
  17. ncbi Peroxisomal proliferation protects from beta-amyloid neurodegeneration
    Manuel J Santos
    , , , Casilla 114-D, Santiago, Chile
    J Biol Chem 280:41057-68. 2005
    ..Our data suggest, for the first time, a direct link between peroxisomal proliferation and neuroprotection from Abeta-induced degenerative changes...
  18. ncbi Induction of cellular prion protein gene expression by copper in neurons
    Lorena Varela-Nallar
    CRCP, Biomedical Center, P Catholic Univ of Chile, Alameda 340, Santiago, Chile
    Am J Physiol Cell Physiol 290:C271-81. 2006
    ..These findings demonstrate that Prnp expression is upregulated by copper in neuronal cells by an MTF-1-independent mechanism, and suggest a metal-specific modulation of Prnp in neurons...
  19. ncbi Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway
    Rodrigo A Quintanilla
    , Millennium Institute of Fundamental and Applied Biology, , , Casilla 114-D, Santiago, Chile
    J Biol Chem 280:11615-25. 2005
    ..Our results suggest that control of oxidative stress, regulation of cytoplasmic calcium, and activation of Wnt signaling may prevent A beta neurotoxicity...
  20. ncbi Copper brain homeostasis: role of amyloid precursor protein and prion protein
    Nibaldo C Inestrosa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    IUBMB Life 57:645-50. 2005
    ..Results with transgenic and other animal models have established the relation between these pathogenic proteins and copper. In particular, APP transgenic models, suggest a beneficial effect for copper in AD...
  21. ncbi Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons
    Alejandra R Alvarez
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 297:186-96. 2004
    ..Our results support the hypothesis that a loss of function of Wnt signaling may play a role in the progression of neurodegenerative diseases such as Alzheimer's disease...
  22. ncbi Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
    Waldo Cerpa
    Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, 8331010 Santiago, Chile
    J Biol Chem 283:5918-27. 2008
    ..These results indicate that the presynaptic function of rat hippocampal neurons is modulated by the canonical Wnt signaling...
  23. ncbi PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes
    Alejandro D Roth
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    J Neurosci Res 72:425-35. 2003
    ..Our data suggest a relevant role for PPARgamma in oligodendrocyte lipid metabolism and differentiation...
  24. ncbi The hyperforin derivative IDN5706 occludes spatial memory impairments and neuropathological changes in a double transgenic Alzheimer's mouse model
    W Cerpa
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Alzheimer Res 7:126-33. 2010
    ..We conclude that the hyperforin derivative, IDN5706, has therapeutic potential for prevention and treatment of AD...
  25. ncbi Frizzled-1 is involved in the neuroprotective effect of Wnt3a against Abeta oligomers
    Marcelo A Chacón
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, Instituto Milenio MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 217:215-27. 2008
    ....
  26. ncbi Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons
    Ginny G Farías
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Instituto Milenio, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, P O Box 8331150, Santiago, Chile
    J Biol Chem 284:15857-66. 2009
    ..Our studies indicate that the Wnt-5a/JNK pathway modulates the postsynaptic region of mammalian synapse directing the clustering and distribution of the physiologically relevant scaffold protein, PSD-95...
  27. ncbi M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway
    Ginny G Farías
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurobiol Dis 17:337-48. 2004
    ..We conclude that the cross-talk between the muscarinic signaling and Wnt components underlie the neuroprotective effect of the M1 mAChR activation...
  28. ncbi Genome-wide identification of new Wnt/beta-catenin target genes in the human genome using CART method
    Christian Hodar
    Laboratorio de Bioinformatica y Expresion Genica, INTA, Universidad de Chile, Santiago, Chile
    BMC Genomics 11:348. 2010
    ..In this article, we construct a classification tool that uses the transcription factor binding site motifs composition of some gene promoters to identify new Wnt/beta-catenin pathway target genes potentially involved in brain diseases...
  29. ncbi Overexpression of amyloid precursor protein increases copper content in HEK293 cells
    Miriam Suazo
    INTA, Laboratorio de Bioinformatica y Expresion Genica, Universidad de Chile, Macul, Santiago, Chile
    Biochem Biophys Res Commun 382:740-4. 2009
    ..We conclude that Cu(2+) reduction activity of APP facilitates copper uptake and may represent an early step in cellular copper homeostasis...
  30. ncbi Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation
    Karen Perez de Arce
    Laboratorio de Señalización Celular, Departmento de Biologia Celular y Molecular, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 30:3728-38. 2010
    ..Our results indicate that c-Abl regulates synapse formation by mediating tyrosine phosphorylation and clustering of PSD-95...
  31. ncbi Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
    Nibaldo C Inestrosa
    Centro FONDAP de Regulación Celular y Patología Joaquín V Luco, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Exp Cell Res 304:91-104. 2005
    ..More important, the fact that the activation of PPAR gamma attenuated A beta-dependent neurodegeneration opens the possibility to fight AD from a new therapeutic perspective...
  32. ncbi Heparin activates Wnt signaling for neuronal morphogenesis
    Marcela Colombres
    Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cell Physiol 216:805-15. 2008
    ..Changes in the expression of specific HSPGs were observed upon differentiation of N2a cells. Taken together, our findings suggest that HSPGs may modulate canonical Wnt signaling for neuronal morphogenesis...
  33. ncbi Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile
    Proc Natl Acad Sci U S A 107:21164-9. 2010
    ..We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system...
  34. ncbi Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations
    Ginny G Farías
    Centro de Envejecimiento y Regeneración CARE, Instituto Milenio MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Dev Dyn 239:94-101. 2010
    ..We also elaborate on the idea that Wnt signaling pathways are a target for the treatment of neurodegenerative diseases that affect synaptic integrity, such as Alzheimer's disease...
  35. ncbi Methionine sulfoxide reductase A expression is regulated by the DAF-16/FOXO pathway in Caenorhabditis elegans
    Alicia N Minniti
    Centro de Envejecimiento y Regeneración, Centro de Regulación Celular y Patología Joaquín V Luco, Santiago, Chile
    Aging Cell 8:690-705. 2009
    ..This repair mechanism, rather than the general decreased of radical oxygen species levels, could be one of the main determinants of organisms' lifespan...
  36. ncbi Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease
    Rodrigo A Fuentealba
    , MIFAB, , , Santiago, Chile
    Brain Res Brain Res Rev 47:275-89. 2004
    ....
  37. ncbi Inclusion body myositis: a view from the Caenorhabditis elegans muscle
    Daniela L Rebolledo
    Centro de Envejecimiento y Regeneración CARE, Centro de Regulación Celular y Patología Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Neurobiol 38:178-98. 2008
    ..as well as anatomical, physiological, and behavioral characteristics add to the value of this model. In the present work, we review evidence that supports the use of Caenorhabditis elegans as a biological model for IBM...
  38. ncbi Structure-function implications in Alzheimer's disease: effect of Abeta oligomers at central synapses
    Waldo Cerpa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, Millennium Institute MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Curr Alzheimer Res 5:233-43. 2008
    ..Here we review recent progress about Abeta structure and function, from the formation of amyloid fibrils and some molecular chaperones which modulate the amyloidogenesic process to synaptic damage induce by Abeta oligomers...
  39. ncbi The role of Wnt signaling in neuroprotection
    Waldo Cerpa
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Drug News Perspect 22:579-91. 2009
    ..The study of the Wnt pathway is a promising approach in the search for possible targets to fight the deleterious effects of neurodegenerative conditions such as AD...
  40. ncbi The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
    Waldo F Cerpa
    , MIFAB, , , Santiago, Chile
    FASEB J 18:1701-3. 2004
    ..We also found that Cu2+ neurotoxicity is associated with an increase in nitrotyrosine immunofluorescence as well as with a decrease in Cu2+ uptake. The CuBD of APP therefore may play a role in the detoxification of brain Cu...
  41. ncbi Copper reduces A? oligomeric species and ameliorates neuromuscular synaptic defects in a C. elegans model of inclusion body myositis
    Daniela L Rebolledo
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute of Fundamental and Applied Biology, Centro de Envejecimiento y Regeneración, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 31:10149-58. 2011
    ..Our findings emphasize the importance of neuromuscular synaptic dysfunction and the relevance of modulating the amyloidogenic component as an alternative therapeutic approach for this debilitating disease...
  42. ncbi Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons
    Ginny G Farías
    Centro de Regulación Celular y Patología Joaquín V Luco, Millennium Institute for Fundamental and Applied Biology, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, 8331010 Santiago, Chile
    J Neurosci 27:5313-25. 2007
    ..Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses...
  43. ncbi Structural and functional organization of synaptic acetylcholinesterase
    Rebeca Aldunate
    , MIFAB, , , 114-D Santiago, Chile
    Brain Res Brain Res Rev 47:96-104. 2004
    ..These mutations determine end-plate acetylcholinesterase deficiency and induce one type of synaptic functional disorders observed in Congenital Myasthenic Syndromes (CMSs)...
  44. ncbi Is there a role for copper in neurodegenerative diseases?
    Waldo Cerpa
    , MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    Mol Aspects Med 26:405-20. 2005
    ..Here, we review the evidence that supports both, the role of beta-APP and PrP(C), in copper metabolism and the putative role of copper in neurodegenerative diseases...
  45. ncbi The synaptic protein neuroligin-1 interacts with the amyloid ?-peptide. Is there a role in Alzheimer's disease?
    Margarita C Dinamarca
    Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
    Biochemistry 50:8127-37. 2011
    ..In conclusion, our results show that NL-1 interacts with A? increasing the formation of A? oligomers, suggesting that this interaction could triggers the targeting of A? oligomer to the postsynaptic regions of excitatory synapses...
  46. ncbi Wnt signaling in neuroprotection and stem cell differentiation
    Enrique M Toledo
    Centro de Envejecimiento y Regeneración CARE, Instituto Milenio MIFAB, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Prog Neurobiol 86:281-96. 2008
    ....
  47. ncbi Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
    Margarita C Dinamarca
    Centro de Regulación Celular y Patología Joaquín V Luco, Centro de Envejecimiento y Regeneración CARE, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Chile
    Chem Biol Interact 175:142-9. 2008
    ..Altogether this gathered evidence indicates the important role of AChE in the neurotoxicity of Abeta plaques and finding new compounds which decrease the AChE-Abeta interaction may be a putative therapeutic agent to fight the disease...
  48. ncbi Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway
    Nibaldo C Inestrosa
    FONDAP Biomedical Center, P Catholic University of Chile, P O Box 114 D, Santiago, Chile
    Curr Alzheimer Res 2:301-6. 2005
    ....
  49. ncbi The functional links between prion protein and copper
    Lorena Varela-Nallar
    , MIFAB, , , Santiago, Chile
    Biol Res 39:39-44. 2006
    ..Here we address some of the evidence that support a physiological link between PrPC and copper. Also, in vivo experiments suggesting the physiological relevance of PrPC interaction with heparan sulfate proteoglycans are discussed...
  50. ncbi Adult hippocampal neurogenesis in aging and Alzheimer's disease
    Lorena Varela-Nallar
    Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Birth Defects Res C Embryo Today 90:284-96. 2010
    ..Finally, we focus on hippocampal neurogenesis in Alzheimer's disease, reviewing animal models of the disease used for the study of this process and the conclusions that have been drawn in this context...
  51. ncbi Acetylcholinesterase interaction with Alzheimer amyloid beta
    Nibaldo C Inestrosa
    FONDA-Biomedical Center, P Catholic University of Chile, Santiago, Chile
    Subcell Biochem 38:299-317. 2005
    ....
  52. ncbi The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action
    Ramón A Lorca
    Centro de Regulación Celular y Patología, J V Luco Instituto MIFAB, Departamento de Fisiologia, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 85:709-16. 2003
    ..Our findings highlight the role of PrP in copper homeostasis and hint at its possible role as a modulator of synapses regulated by this trace metal...
  53. ncbi Structure and function of amyloid in Alzheimer's disease
    Carlos Morgan
    , MIFAB, , , P.O. Box 114-D, Santiago, Chile
    Prog Neurobiol 74:323-49. 2004
    ..This review is focused on Alzheimer's amyloid fibrils in general and has been divided into two parts dealing with the structure and function of amyloid...
  54. ncbi Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target
    Nibaldo C Inestrosa
    Centro de Regulacion Celular y Patologia Joaquin V Luco CRCP, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    IUBMB Life 59:316-21. 2007
    ....
  55. ncbi Acetylcholinesterase induces the expression of the beta-amyloid precursor protein in glia and activates glial cells in culture
    Rommy von Bernhardi
    Departamento de Neurologia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Neurobiol Dis 14:447-57. 2003
    ..As a whole, we found that AChE has additional effects that could result in an increased synthesis of Abeta, both by increasing beta-APP expression of astrocytes and by further activating glial cells...
  56. ncbi Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus
    Marcelo A Chacón
    Centro de Regulación Celular y Patología Dr Joaquín V Luco, MIFAB, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Neurochem 87:195-204. 2003
    ....
  57. ncbi Blood cells cholinesterase activity in early stage Alzheimer's disease and vascular dementia
    Rommy von Bernhardi
    Department of Neurology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    Dement Geriatr Cogn Disord 19:204-12. 2005
    ....
  58. ncbi The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors
    Ramón A Lorca
    Departamento de Fisiologia, Centro de Envejecimiento y Regeneración CARE, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile, Santiago 8331150, Chile
    Int J Alzheimers Dis 2011:706576. 2011
    ..Thus, our observations suggest a role for PrP(C) in modulating synaptic activity through binding of extracellular Cu(2+)...
  59. ncbi Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)
    Carlos Opazo
    , Departamento de Biologia Celular y Molecular, , , Santiago 114-D, Chile
    J Biol Chem 277:40302-8. 2002
    ..Cu. Therefore, microregional catalytic H(2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value...
  60. ncbi Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation
    Juan Carlos Casar
    Centro de Regulación Celular y Patología, Facultad de Ciencias Biologicas, MIFAB, P Universidad Catolica de Chile, Santiago, Chile
    J Cell Sci 117:73-84. 2004
    ..These data constitute the first in vivo evidence suggesting the requirement of a specific heparan sulfate proteoglycan for successful skeletal muscle regeneration...
  61. ncbi ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association
    Loreto Cuitino
    FONDAP Center for Cell Regulation and Pathology, , Department of Cell and Molecular Biology, Faculty of Biological Sciences, , Santiago, Chile
    Traffic 6:820-38. 2005
    ..These studies indicate that apoER2 internalizes through a clathrin-mediated pathway and that its association with caveolar and noncaveolar rafts does not determine its endocytosis...
  62. ncbi Ethanol specifically decreases peroxisome proliferator activated receptor beta in B12 oligodendrocyte-like cells
    Andrea V Leisewitz
    , , , Millenium Institute for Fundamental and Applied Biology, , Santiago, Chile
    J Neurochem 85:135-41. 2003
    ..Our results suggest a possible link between PPARbeta function and ethanol-induced abnormal myelination in oligodendrocytes...
  63. ncbi Copper reduction by copper binding proteins and its relation to neurodegenerative diseases
    Carlos Opazo
    , MIFAB, , , Santiago, Chile
    Biometals 16:91-8. 2003
    ..Moreover, protein-metal complexes could be the catalytic centers for the formation of reactive oxygen species involved in the oxidative damage present both in Alzheimer's and Prion disease...
  64. ncbi An overview of the current and novel drugs for Alzheimer's disease with particular reference to anti-cholinesterase compounds
    Marcela Colombres
    , , MIFAB, , , Santiago, Chile
    Curr Pharm Des 10:3121-30. 2004
    ....
  65. ncbi Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide
    Carlos Morgan
    Departamento de Biologia Celular y Molecular, MIFAB, Facultad de Ciencias Biologicas, Centro de Regulación Celular y Patología, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Peptides 23:1229-40. 2002
    ....
  66. ncbi Vitamin E but not 17beta-estradiol protects against vascular toxicity induced by beta-amyloid wild type and the Dutch amyloid variant
    Francisco J Muñoz
    Unitat de Senyalització Cel lular, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona E 08003, Spain
    J Neurosci 22:3081-9. 2002
    ..Our data indicate that vitamin E attenuated significantly the Abeta-mediated cytotoxicity on vascular cells, although 17beta-estradiol and vitamin C failed to inhibit the cytotoxicity induced by Abeta fibrils...
  67. ncbi Two different heparin-binding domains in the triple-helical domain of ColQ, the collagen tail subunit of synaptic acetylcholinesterase
    Paola Deprez
    Centro de Regulación Celular y Patología Dr Joaquín V Luco, Instituto Milenio de Biología Fundamental y Aplicada, Facultad de Ciencias Biologicas, P Universidad Catolica de Chile
    J Biol Chem 278:23233-42. 2003
    ..We hypothesize that these binding sites coordinate acetylcholinesterase positioning within the organized architecture of the neuromuscular junction basal lamina...
  68. ncbi Role of copper in prion diseases: deleterious or beneficial?
    Lorena Varela-Nallar
    , ,
    Curr Pharm Des 12:2587-95. 2006
    ..Which of these predominates might vary under distinct conditions that need to be defined before deciding on the feasibility of either incorporating or avoiding metal influences in prion disease therapies...
  69. ncbi Stepwise construction of triple-helical heparin binding sites using peptide models
    Ellen Doss-Pepe
    Department of Biochemistry, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Biochim Biophys Acta 1698:187-95. 2004
    ..The model peptides for the C-terminal binding site show a greater heparin affinity than the peptide models for the N-terminal binding site only when residues surrounding the consensus sequence are included...