Francisca C Bronfman

Summary

Country: Chile

Publications

  1. ncbi Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
    Oscar M Lazo
    Department of Physiology, Neurobiology Unit, Center of Ageing and Regeneration CARE, Nucleus Millennium in Regenerative Biology MINREB, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, CP 8331010, Santiago, Chile
    Mol Neurodegener 5:5. 2010
  2. ncbi Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology Joaquin V Luco, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Neurochem 103:91-100. 2007
  3. ncbi Commuting within the cell-mind the GAPs. Workshop on Systems Dynamics of Intracellular Communication: overcoming Distance in Signalling Networks
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology (CRCP, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    EMBO Rep 8:1011-5. 2007
  4. ncbi Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Dev Neurobiol 67:1183-203. 2007
  5. ncbi TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
    Soledad Urra
    Department of Physiology, Center for Cellular Regulation and Pathology Joaquin V Luco, Faculty of Biological Sciences, Pontificia Universidad Catolica, Alameda 340, Santiago 8320000, Chile
    J Biol Chem 282:7606-15. 2007
  6. ncbi Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells
    Karen M Fuenzalida
    Centro de Regulación Celular y Patología and Millennium Institute for Fundamental and Applied Biology, Faculty of Biological Sciences, P Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    J Biol Chem 280:9604-9. 2005
  7. ncbi Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology, Department of Physiological Science, Faculty of Biological Sciences, P Catholic University of Chile, Alameda 340, Santiago, Chile
    EMBO Rep 5:867-71. 2004
  8. ncbi Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease
    Alejandra R Alvarez
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile
    FASEB J 22:3617-27. 2008
  9. ncbi Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
    Francisca C Bronfman
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 23:3209-20. 2003
  10. ncbi The p75 neurotrophin receptor interacts with multiple MAGE proteins
    Marianna Tcherpakov
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 277:49101-4. 2002

Collaborators

  • Mike Fainzilber
  • Alejandra R Alvarez
  • Alex Kruttgen
  • Nibaldo C Inestrosa
  • J Weis
  • M V Chao
  • E Arenas
  • Oscar M Lazo
  • Soledad Urra
  • Karen M Fuenzalida
  • Marianna Tcherpakov
  • Claudia A Pissani
  • Jocelyn C Mauna
  • Fernanda Lisbona
  • Edgardo Allende
  • Niccolo Zampieri
  • Jose I Parraguez
  • Paulina Covarrubias
  • Wim Annaert
  • Claudia A Escudero
  • Patricio Ramos
  • Mauricio C Aguilera
  • Patricio C Ramos
  • Miguel Bronfman
  • Veronica Quinones
  • Daniela G Piderit
  • Atilio Rigotti
  • David Contador
  • Anna Vaskovsky
  • Kazuaki Yoshikawa
  • Michio Niinobe
  • Silvestro G Conticello
  • Zehava Levy

Detail Information

Publications10

  1. ncbi Axotomy-induced neurotrophic withdrawal causes the loss of phenotypic differentiation and downregulation of NGF signalling, but not death of septal cholinergic neurons
    Oscar M Lazo
    Department of Physiology, Neurobiology Unit, Center of Ageing and Regeneration CARE, Nucleus Millennium in Regenerative Biology MINREB, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, CP 8331010, Santiago, Chile
    Mol Neurodegener 5:5. 2010
    ..The principal aim of this study was to evaluate, using modern quantitative confocal microscopy, neurodegenerative changes in septal cholinergic neurons after axotomy and to assess their response to delayed infusion of NGF in rats...
  2. ncbi Metalloproteases and gamma-secretase: new membrane partners regulating p75 neurotrophin receptor signaling?
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology Joaquin V Luco, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Neurochem 103:91-100. 2007
    ..In this review, we argue that both sheddases and gamma-secretase are key membrane components regulating p75-mediated signaling transduction; therefore, further attention should be paid to their roles as p75 signaling regulators...
  3. ncbi Commuting within the cell-mind the GAPs. Workshop on Systems Dynamics of Intracellular Communication: overcoming Distance in Signalling Networks
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology (CRCP, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    EMBO Rep 8:1011-5. 2007
  4. ncbi Endosomal transport of neurotrophins: roles in signaling and neurodegenerative diseases
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology, Department of Physiology, Faculty of Biological Sciences, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Dev Neurobiol 67:1183-203. 2007
    ..In this article, we review the mechanisms of internalization and endocytic trafficking of neurotrophin receptors, and discuss the potential roles of perturbations in neurotrophin trafficking in a number of neurodegenerative diseases...
  5. ncbi TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain
    Soledad Urra
    Department of Physiology, Center for Cellular Regulation and Pathology Joaquin V Luco, Faculty of Biological Sciences, Pontificia Universidad Catolica, Alameda 340, Santiago 8320000, Chile
    J Biol Chem 282:7606-15. 2007
    ..Moreover, we show similar structural requirements for gamma-secretase processing of p75 and amyloid precursor protein-derived CTFs. Thus, NGF-induced endocytosis regulates both signaling and proteolytic processing of p75...
  6. ncbi Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells
    Karen M Fuenzalida
    Centro de Regulación Celular y Patología and Millennium Institute for Fundamental and Applied Biology, Faculty of Biological Sciences, P Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    J Biol Chem 280:9604-9. 2005
    ....
  7. ncbi Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
    Francisca C Bronfman
    Center for Cellular Regulation and Pathology, Department of Physiological Science, Faculty of Biological Sciences, P Catholic University of Chile, Alameda 340, Santiago, Chile
    EMBO Rep 5:867-71. 2004
    ..We therefore argue that cell-biology-driven approaches are now required to make sense of p75 signalling...
  8. ncbi Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease
    Alejandra R Alvarez
    Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Casilla 114 D, Santiago, Chile
    FASEB J 22:3617-27. 2008
    ....
  9. ncbi Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome
    Francisca C Bronfman
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Neurosci 23:3209-20. 2003
    ..These data suggest that signaling endosomes containing activated p75 are involved in neurotrophin signaling, and that such endosomes may be temporally and spatially distinct from those containing trk receptors...
  10. ncbi The p75 neurotrophin receptor interacts with multiple MAGE proteins
    Marianna Tcherpakov
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 277:49101-4. 2002
    ..These findings indicate that diverse MAGE family members can interact with the p75 receptor and highlight type II MAGE proteins as a potential family of interactors for signaling proteins containing type II death domains...