Russell W Chesney

Summary

Publications

  1. ncbi Early animal models of rickets and proof of a nutritional deficiency hypothesis
    Russell W Chesney
    Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA
    J Pediatr Gastroenterol Nutr 54:322-7. 2012
  2. ncbi Environmental factors in Tiny Tim's near-fatal illness
    Russell W Chesney
    Department of Pediatrics, Le Bonheur Children s Hospital, The University of Tennessee Health Science Center, Memphis, TN, USA
    Arch Pediatr Adolesc Med 166:271-5. 2012
  3. ncbi Theobald palm and his remarkable observation: how the sunshine vitamin came to be recognized
    Russell W Chesney
    The Department of Pediatrics, Le Bonheur Children s Hospital, Children s Foundation Research Center, The University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Nutrients 4:42-51. 2012
  4. ncbi Metabolic bone disease in lion cubs at the London Zoo in 1889: the original animal model of rickets
    Russell W Chesney
    Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennesee 38103, USA
    J Biomed Sci 17:S36. 2010
  5. ncbi Taurine and the renal system
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 N, Dunlap, Memphis, Tennessee 38103, USA
    J Biomed Sci 17:S4. 2010
  6. ncbi New thoughts concerning the epidemic of rickets: was the role of alum overlooked?
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap, Memphis, TN, 38103, USA
    Pediatr Nephrol 27:3-6. 2012
  7. ncbi Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
    Pediatrics 122:S233-9. 2008
  8. ncbi Functional TauT protects against acute kidney injury
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Room 301 WPT, Memphis, TN 38103, USA
    J Am Soc Nephrol 20:1323-32. 2009
  9. ncbi Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI)
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 643:105-12. 2009
  10. ncbi Mechanisms of regulation of taurine transporter activity: a complex interplay of regulatory systems
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 583:79-90. 2006

Detail Information

Publications29

  1. ncbi Early animal models of rickets and proof of a nutritional deficiency hypothesis
    Russell W Chesney
    Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA
    J Pediatr Gastroenterol Nutr 54:322-7. 2012
    ..Nonetheless, at the end of these studies, a nutritional deficiency of vitamin D resulting from a poor diet or lack of adequate sunshine was firmly established as a cause of rickets...
  2. ncbi Environmental factors in Tiny Tim's near-fatal illness
    Russell W Chesney
    Department of Pediatrics, Le Bonheur Children s Hospital, The University of Tennessee Health Science Center, Memphis, TN, USA
    Arch Pediatr Adolesc Med 166:271-5. 2012
    ..This component of the innate immune system has strong killing properties for Mycobacterium tuberculosis. The combination of rickets and TB represent a crippling condition that could be reversed by improved vitamin D status...
  3. ncbi Theobald palm and his remarkable observation: how the sunshine vitamin came to be recognized
    Russell W Chesney
    The Department of Pediatrics, Le Bonheur Children s Hospital, Children s Foundation Research Center, The University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Nutrients 4:42-51. 2012
    ..This opened a new era of appreciation for the curative powers of the sun and "the sunshine vitamin". While Palm's observations were in some ways obscure, they had a potent effect on the development of photobiology...
  4. ncbi Metabolic bone disease in lion cubs at the London Zoo in 1889: the original animal model of rickets
    Russell W Chesney
    Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, Tennesee 38103, USA
    J Biomed Sci 17:S36. 2010
    ..Taurine-conjugated bile salts undoubtedly permitted absorption of vitamins A and D, thus preventing the occurrence of metabolic bone disease and rickets...
  5. ncbi Taurine and the renal system
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 N, Dunlap, Memphis, Tennessee 38103, USA
    J Biomed Sci 17:S4. 2010
    ..The role of the kidney in adaptation to variations in dietary taurine intake and the regulation of taurine body pool size are described. Finally, the protective function of taurine against several kidney diseases is reviewed...
  6. ncbi New thoughts concerning the epidemic of rickets: was the role of alum overlooked?
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap, Memphis, TN, 38103, USA
    Pediatr Nephrol 27:3-6. 2012
    ..Namely, alum used as an adulterant in bread in certain locations may have contributed to metabolic bone disease during the great epidemic of rickets...
  7. ncbi Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
    Pediatrics 122:S233-9. 2008
    ..Such recommendations should be evidence-based...
  8. ncbi Functional TauT protects against acute kidney injury
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, Room 301 WPT, Memphis, TN 38103, USA
    J Am Soc Nephrol 20:1323-32. 2009
    ..These data suggest that functional TauT plays a critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway...
  9. ncbi Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI)
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 643:105-12. 2009
    ....
  10. ncbi Mechanisms of regulation of taurine transporter activity: a complex interplay of regulatory systems
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 583:79-90. 2006
  11. ncbi Is TauT an anti-apoptotic gene?
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 583:59-67. 2006
  12. ncbi Stress-responsive gene TauT and acute kidney injury
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, Tennessee, USA
    J Biomed Sci 17:S28. 2010
    ..In the present study, we have investigated how TauT is regulated by p53 and c-Jun and its role during acute kidney injury (AKI)...
  13. ncbi TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center and the Children s Memphis, TN, USA
    Adv Exp Med Biol 643:113-22. 2009
    ..06 mg/dl). However, over-expression of hTauT effectively prevented the progression of cisplatin-induced AKI in hTauT transgenic mice, as measured by the levels of BUN and serum creatininelevels (23 +/- 3.5 mg/dl and 0.6 +/- 0.05 mg/dl)...
  14. ncbi Regulation of taurine transporter gene (TauT) by WT1
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, 50 North Dunlap, Memphis, TN 38103 4909, USA
    FEBS Lett 540:71-6. 2003
    ..Mutation of this WT1 consensus sequence abolished binding of WT1. These results demonstrate that TauT may represent a downstream target gene of WT1 during renal development...
  15. ncbi Transactivation of TauT by p53 in MCF-7 cells: the role of estrogen receptors
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 526:139-47. 2003
  16. ncbi Gating of taurine transport: role of the fourth segment of the taurine transporter
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    Adv Exp Med Biol 526:149-57. 2003
  17. ncbi Rickets in lion cubs at the London Zoo in 1889: some new insights
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Children s Foundation Research Center, Le Bonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatrics 123:e948-50. 2009
    ..However, gum health and the presence of taurine-conjugated bile salts undoubtedly permitted absorption of vitamin A and D, the latter promoting the cure of rickets...
  18. ncbi Who was John Howland and why was an award named after him 50 years ago?
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Medical Center, Memphis, Tennessee 38103, USA
    Pediatr Res 53:523-5. 2003
  19. ncbi The future of pediatric nephrology
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap, Room 306, Memphis, TN 38103, USA
    Pediatr Nephrol 20:867-71. 2005
    ..The International Pediatric Nephrology Association (IPNA), its journal, and pediatric advocates will need to use their energies to take on these challenges...
  20. ncbi American Pediatric Society Presidential Address 2003: the failure of Ockham's razor in 21st century pediatrics
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Le Bonheur Children's Medical Center, 50 N. Dunlap, Room 306-307, Memphis, TN 38103, USA
    Pediatr Res 55:903-7. 2004
  21. ncbi Does taurine deficiency cause metabolic bone disease and rickets in polar bear cubs raised in captivity?
    Russell W Chesney
    The University of Tennessee Health Science Center, USA
    Adv Exp Med Biol 643:325-31. 2009
    ..Higher dietary intake of TAU by free-ranging cubs may influence bile acid conjugation and improve vitamin D absorption...
  22. ncbi Rickets: an old form for a new century
    Russell W Chesney
    Department of Pediatrics, The University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, Memphis, Tennessee 38103-4909, USA
    Pediatr Int 45:509-11. 2003
  23. ncbi Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells
    Xiaobin Han
    Department of Pediatrics, University of Tennessee Health Science Center and the Children s Foundation Research Center at Le Bonheur Children s Medical Center, Memphis, Tennessee 38103, USA
    J Biol Chem 277:39266-73. 2002
    ..Mutation of this p53 consensus sequence abolished binding of p53. These results demonstrate that TauT may represent a downstream target gene of p53 that could link the roles of p53 in renal development and apoptosis...
  24. ncbi Changing requirements for evaluation of pharmacologic agents
    Russell W Chesney
    Department of Pediatrics, Center for Pediatric Pharmacokinetics and Therapeutics, University of Tennessee, Memphis, USA
    Pediatrics 113:1128-32. 2004
    ..This article reviews new laws that govern drug testing in children and the use of children in therapeutic research...
  25. ncbi Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study
    Ron Keren
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 122:S240-50. 2008
    ....
  26. ncbi Women pediatricians: can facts shed light on prejudices and myths?
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Medical Center, Memphis, Tennessee, USA
    J Pediatr 144:413-4. 2004
  27. ncbi Report of an NIH task force on research priorities in chronic kidney disease in children
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap, 38103-4909, USA
    Pediatr Nephrol 21:14-25. 2006
  28. ncbi The development of pediatric nephrology
    Russell W Chesney
    Department of Pediatrics, University of Tennessee College of Medicine, LeBonheur Children s Medical Center, Memphis, Tennessee 38103, USA
    Pediatr Res 52:770-8. 2002
    ..The scientific basis of pediatric nephrology, ongoing patient care needs, and its technical aspects - renal biopsy, dialysis and transplantation - assure its continuing future as a major pediatric discipline on all continents...
  29. ncbi Children as clinical research subjects
    Russell W Chesney
    Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Medical Center, St. Jude Children's Research Hospital, 50 North Dunlap Street, Memphis, TN 38103, USA
    J Pediatr 146:579-80. 2005