Molecular mechanisms by which dietary isoflavones potentially prevent atherosclerosisAedin Cassidy
Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, University of Reading, Whiteknights, Reading, RG6 6AP, UK
Expert Rev Mol Med 5:1-15. 2003
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- Are herbal remedies and dietary supplements safe and effective for breast cancer patients?
Aedin Cassidy
Hugh Sinclair Human Nutrition Unit, School of Food Biosciences, University of Reading, Reading, UK
Breast Cancer Res 5:300-2. 2003
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- Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production
Wendy L Hall
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, United Kingdom
Am J Clin Nutr 83:592-600. 2006
..However, beneficial effects of isolated isoflavones on lipid biomarkers of cardiovascular disease risk have not yet been shown...
- Effect of circulating forms of soy isoflavones on the oxidation of low density lipoprotein
Rufus Turner
School of Food Biosciences, Hugh Sinclair Human Nutrition Unit, University of Reading, Whiteknights P.O. Box 226, Reading RG6 6AP, UK
Free Radic Res 38:209-16. 2004
..Since almost all isoflavones circulate as conjugates, these data suggest that despite the increased potency produced by some metabolic changes, isoflavones may not be effective antioxidants in vivo unless they are deconjugated again...
- Dietary phytoestrogens and bone health
Aedin Cassidy
Head of Women's Health Biosciences Division, Unilever Research, Colworth, UK
J Br Menopause Soc 9:17-21. 2003
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- Potential risks and benefits of phytoestrogen-rich diets
Aedin Cassidy
Biosciences Division, Unilever Research, Colworth House, Sharnbrook, Bedfordshire, UK, MK 44 ILQ
Int J Vitam Nutr Res 73:120-6. 2003
..However we currently know little about age related differences in exposure to these compounds and there are few guidelines on optimal dose for specific health outcomes...
- Bioavailability of phyto-oestrogens
Ian Rowland
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
Br J Nutr 89:S45-58. 2003
..Factors influencing absorption and metabolism of phyto-oestrogens include diet and gut microflora...
- Monoclonal antibody-based time-resolved fluorescence immunoassays for daidzein, genistein, and equol in blood and urine: application to the Isoheart intervention study
Duncan C S Talbot
Unilever Corporate Research, Sharnbrook, United Kingdom
Clin Chem 53:748-56. 2007
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- Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
Aedin Cassidy
Centre for Metabolic Bone Disease, Hull Royal Infirmary, UK
Proc Nutr Soc 65:76-92. 2006
..Future studies should focus on high-risk post-menopausal women, especially in the areas of diabetes, CVD, breast cancer and bone health...
- Factors affecting the bioavailability of soy isoflavones in humans
Aedin Cassidy
University of East Anglia, School of Medicine, Norwich NR4 7TJ, United Kingdom
J AOAC Int 89:1182-8. 2006
..Available data suggest isoflavones are more bioavailable than other flavonoid subclasses. This review will focus on our current understanding of factors affecting isoflavone absorption and metabolism in humans...
- Comparing the pharmacokinetics of daidzein and genistein with the use of 13C-labeled tracers in premenopausal women
Kenneth D R Setchell
Clinical Mass Spectrometry, Children's Hospital Medical Center, Cincinnati, OH, USA
Am J Clin Nutr 77:411-9. 2003
..The bioavailability of both isoflavones was nonlinear at higher intakes, suggesting that uptake is rate-limiting and saturable...
- Dietary patterns and heritability of food choice in a UK female twin cohort
Birgit Teucher
Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
Twin Res Hum Genet 10:734-48. 2007
..The relatively high heritability of specific dietary components implicates taste perception as a possible target for future genetic studies...
- Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
Aedin Cassidy
School of Medicine, University of East Anglia, Norwich, UK
J Nutr 136:45-51. 2006
..Only 30% of the subjects were equol producers and no differences in equol production with age or gender were observed...
- Daidzein-sulfate metabolites affect transcriptional and antiproliferative activities of estrogen receptor-beta in cultured human cancer cells
Pierangela Totta
Department of Biology, University Roma Tre, I-00146 Rome, Italy
J Nutr 135:2687-93. 2005
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- Absorption of isoflavones in humans: effects of food matrix and processing
Sonia de Pascual-Teresa
Department of Plant Food Sciences and Technology, CSIC, Instituto del Frio, José Anotonio Novais 10, Ciudad Universitaria, Madrid, Spain
J Nutr Biochem 17:257-64. 2006
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- Diet and menopausal health
Aedin Cassidy
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich
Nurs Stand 19:44-52; quiz 54-5. 2005
..This article outlines the evidence for exercise and dietary influences on many of the major disease risks for women around the menopause and after, including cardiovascular diseases, cancer and osteoporosis...
- Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans
Kirty S Solanky
Biological Chemistry, Faculty of Medicine, Imperial College of Science, Technology and Medicine, University of London, South Kensington, SW7 2AZ London, UK
J Nutr Biochem 16:236-44. 2005
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- Urinary isoflavone kinetics: the effect of age, gender, food matrix and chemical composition
Marian S Faughnan
School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
Br J Nutr 91:567-74. 2004
..Further studies are required to examine the effect of higher intake and define the relative influence of these factors in elderly population groups...
- Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile
Kirty S Solanky
Biological Chemistry, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK
Anal Biochem 323:197-204. 2003
..Clear differences in the plasma lipoprotein, amino acid, and carbohydrate profiles were observed following soy intervention, suggesting a soy-induced alteration in energy metabolism...
- UK Food Standards Agency Optimal Nutrition Status Workshop: environmental factors that affect bone health throughout life
Lynn Burns
Food Standards Agency, Aviation House 125 Kingsway, London WC2 6NH, UK
Br J Nutr 89:835-40. 2003
..Other lifestyle factors were also discussed, particularly the effect of physical activity and possible gene-nutrient interactions affecting bone health...
- Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study
Elizabeth Brink
TNO Quality of Life, Business Unit Biosciences, Zeist, Netherlands
Am J Clin Nutr 87:761-70. 2008
..Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to hormone replacement therapy for preventing bone loss during the menopausal transition...
