Min Zhuo

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
  2. ncbi Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-? (PI3K?)
    Bolam Lee
    Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Pain 7:96. 2011
  3. ncbi Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
  4. ncbi Pavlovian fear memory induced by activation in the anterior cingulate cortex
    Jianrong Tang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Medical Sciences Building, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:6. 2005
  5. ncbi Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  6. ncbi Hit a new high
    Min Zhuo
    Mol Pain 4:4. 2008
  7. ncbi A transcription factor for cold sensation!
    Susan J Kim
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:11. 2005
  8. ncbi CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
    Hushan Ao
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 2:15. 2006
  9. ncbi Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
  10. ncbi Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
    Fuxing Zhang
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:15. 2008

Research Grants

  1. SEROTONERGIC REGULATION OF SENSORY TRANSMISSION
    Min Zhuo; Fiscal Year: 2002
  2. Synaptic change in cingulate cortex after amputation
    Min Zhuo; Fiscal Year: 2006

Detail Information

Publications109 found, 100 shown here

  1. ncbi Rapid synaptic potentiation within the anterior cingulate cortex mediates trace fear learning
    Giannina Descalzi
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 5:6. 2012
    ....
  2. ncbi Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-? (PI3K?)
    Bolam Lee
    Department of Brain and Cognitive Sciences, Seoul National University, Seoul 151 747, Korea
    Mol Pain 7:96. 2011
    ..Our findings indicate that PI3K? selectively contributes to behavioral itching induced by histamine and PAR-2 agonist, but not chloroquine agonist...
  3. ncbi Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 7:47. 2011
    ..Our results will help to understand the neuronal mechanism of itch and aid future treatment for patients with pruritic disease...
  4. ncbi Pavlovian fear memory induced by activation in the anterior cingulate cortex
    Jianrong Tang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Medical Sciences Building, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:6. 2005
    ..Our results provide strong evidence that the excitatory activity in the ACC contribute to pain-related fear memory as well as descending facilitatory modulation of spinal nociception...
  5. ncbi Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  6. ncbi Hit a new high
    Min Zhuo
    Mol Pain 4:4. 2008
    ..From this calculation, we have found that Molecular Pain is now ranked at the top among pain journals in the world...
  7. ncbi A transcription factor for cold sensation!
    Susan J Kim
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Mol Pain 1:11. 2005
    ..Our results provide strong evidence that the first transcription factor NGFIB determines the ability of animals to respond to cold stimulation...
  8. ncbi CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain
    Hushan Ao
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 2:15. 2006
    ..Our findings suggest that constitutively active CREB phosphorylation is important for the survival of mammalian cells in the brain...
  9. ncbi Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
    ..Molecular Pain, an Open Access, peer-reviewed, online journal, will provide a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field...
  10. ncbi Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse
    Fuxing Zhang
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:15. 2008
    ..Our results provide strong evidence that nerve injury primarily activates microglia in the spinal cord of adult mice, and pain-related cortical plasticity is likely mediated by neurons...
  11. ncbi Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 5:4. 2009
    ....
  12. ncbi Spinal microglial motility is independent of neuronal activity and plasticity in adult mice
    Tao Chen
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:19. 2010
    ....
  13. ncbi Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 20201, USA
    Mol Pain 4:28. 2008
    ..We propose a synaptic model for explaining the roles of Erk activity during different phases of chronic pain. Our findings suggest that cortical activation of Erk may contribute to both induction and expression of chronic pain...
  14. ncbi Hot receptors in the brain
    Hendrik W Steenland
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada
    Mol Pain 2:34. 2006
    ..In addition, some regions of the brain utilize the TRPV1 receptor for functions apparently unrelated to pain...
  15. ncbi Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice
    Shanelle W Ko
    Department of Physiology, University of Toronto, Centre for the Study of Pain, Faculty of Medicine, Medical Science Building, Room 3342, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:10. 2005
    ..Our results provide a new approach for investigating the molecular mechanism for emotional vocalization in mice and suggest that CaMKIV dependent signaling pathways play an important role in the emotional response to pain and fear...
  16. ncbi Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
    Shanelle W Ko
    Department of Physiology, University of Toronto, University of Toronto Centre for the Study of Pain, Canada
    Mol Brain 1:2. 2008
    ....
  17. ncbi Welcome to molecular brain
    Lin Mei
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Brain 1:1. 2008
    ..It will be a premier platform for neuroscientists to exchange their ideas with researchers from around the world to help improve our understanding of the molecular mechanisms of the brain and mind...
  18. ncbi Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats
    Xue Han Zhang
    Institutes of Brain Science, Fudan University, Shanghai, PR China
    Mol Brain 1:9. 2008
    ..Pre-training intra-CA1 infusion of ifenprodil or Ro25-6981 impaired the contextual fear memory induced by five CS-US pairings, with no effect on the memory induced by one CS-US pairing...
  19. ncbi Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety
    Kun Xia
    State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China
    Mol Brain 3:23. 2010
    ..Our study suggests that KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission, and drugs that act on KChIP1 may help to treat patients with mood disorders including anxiety...
  20. ncbi Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice
    Ming Gao Zhao
    School of Pharmacy, Fourth Military Medical University, 17 Changle West Road, Xi an 710032, Shaanxi, PR China
    Mol Brain 2:11. 2009
    ..Our findings provide the first evidence that NMDA NR2B receptors play an important role in experience-dependent synaptic potentiation within the ACC in wild mice as previously reported in laboratory mice...
  21. ncbi Molecular mechanisms of pain in the anterior cingulate cortex
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci Res 84:927-33. 2006
    ....
  22. ncbi Neuronal and microglial mechanisms of neuropathic pain
    Min Zhuo
    Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi an Jiaotong University, Xi an, China
    Mol Brain 4:31. 2011
    ..In this review, we present recent progress in the study of neuronal and microglial mechanisms underlying neuropathic pain. We propose that activity-dependent neuronal plasticity is a key target for treatment in neuropathic pain...
  23. ncbi Forebrain NMDA receptors contribute to neuronal spike responses in adult mice
    Guo Du Wang
    Department of Physiology, University of Toronto Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada E mail
    Sheng Li Xue Bao 58:511-20. 2006
    ....
  24. ncbi Cortical plasticity as a new endpoint measurement for chronic pain
    Min Zhuo
    Center for Neuron and Disease, Frontier Institute for Science and Technology, Xian Jiaotong University, China
    Mol Pain 7:54. 2011
    ..I hope that these new cortical endpoint measurements will facilitate our search for new, and more effective, pain medicines, and help to reduce false lead drug targets...
  25. ncbi Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    Curr Pharm Des 13:1597-605. 2007
    ..Recent genetic and pharmacological studies suggest that kainate receptors can regulate nociceptive responses. These results highlight kainate receptors as a target for the development of new treatments for chronic pain...
  26. ncbi Neuronal mechanism for neuropathic pain
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 3:14. 2007
    ..I propose that neuropathic pain as a major brain disease, rather being a clinic problem due to peripheral injury...
  27. ncbi A synaptic model for pain: long-term potentiation in the anterior cingulate cortex
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, Toronto, Ontario, Canada
    Mol Cells 23:259-71. 2007
    ..Understanding signaling pathways related to ACC LTP may help us to identify novel drug target for various mental disorders...
  28. ncbi Cortical excitation and chronic pain
    Min Zhuo
    Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
    Trends Neurosci 31:199-207. 2008
    ..This review paper will critically examine the current literature and propose a cortical network model for chronic pain...
  29. ncbi Plasticity of NMDA receptor NR2B subunit in memory and chronic pain
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:4. 2009
    ..A positive feedback control of NR2B receptor subunit is proposed to explain cortical sensitization involved in chronic pain, but not learning and memory...
  30. ncbi Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:17. 2009
    ..This discovery provides key molecular insights for cholinergic dependent cognitive function, and mAChR-LTD can serve as a useful cellular model for studying the roles of cholinergic mechanism in learning and memory...
  31. ncbi Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortex
    Xiaoyan Cao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mol Pain 6:52. 2010
    ..Our results suggest that GRP receptor is an important regulator of inhibitory circuits in forebrain areas...
  32. ncbi Targeting central plasticity: a new direction of finding painkillers
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Curr Pharm Des 11:2797-807. 2005
    ..In this review, I provide review of evidence related to these new progresses, from human brain imaging to work from genetically mutant mice...
  33. ncbi Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 2:e167. 2007
    ..Our results suggest that GluR5 is a key regulator of inhibitory circuits in the amygdala and highlight the potential use of GluR5-specific drugs in the treatment of pathological anxiety...
  34. ncbi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKM? in the ACC acts to maintain neuropathic pain. PKM? could thus be a new therapeutic target for treating chronic pain...
  35. ncbi Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
    Sci Transl Med 3:65ra3. 2011
    ..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain...
  36. ncbi Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
    Learn Mem 14:304-12. 2007
    ..Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation...
  37. ncbi Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 26:8923-30. 2006
    ..Our findings provide strong evidence that presynaptic alterations caused by peripheral inflammation contribute to memory impairments after injury...
  38. ncbi Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons
    Bo Gong
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Eur J Neurosci 26:275-88. 2007
    ..AC1 plays a subtype selective role in this process by coupling signals from L-type Ca(2+) channels to downstream signalling pathways...
  39. ncbi Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
    Ming Gao Zhao
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:7385-92. 2005
    ..This suggests that synaptic plasticity in the ACC and amygdala of FMR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome...
  40. ncbi Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
    Yuze Shang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 111:635-46. 2009
    ....
  41. ncbi Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurosci 28:7445-53. 2008
    ..AC1 thus may serve as a potential therapeutic target for treating neuropathic pain...
  42. ncbi Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Neurobiol 67:498-509. 2007
    ..Our results demonstrate that the GluR1 subunit is essential for synaptic plasticity in the ACC and may play critical roles under physiological and pathological conditions...
  43. ncbi Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injury
    Xiao Yan Cao
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 5:73. 2009
    ....
  44. ncbi Evidence for a role of CaMKIV in the development of opioid analgesic tolerance
    Shanelle W Ko
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Medical Sciences Building Rm3342, Toronto, Canada, M5S 1A8
    Eur J Neurosci 23:2158-68. 2006
    ..Our results provide novel evidence for the role of CaMKIV in the development of opioid analgesic tolerance but not physical dependence...
  45. ncbi Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 3:36. 2007
    ..Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions...
  46. ncbi Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 94:1805-13. 2005
    ..Our results show that KA receptors contribute to synaptic transmission in adult ACC pyramidal neurons and provide a synaptic basis for the physiology and pathology of KA receptors in ACC-related functions...
  47. ncbi Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:11107-16. 2005
    ..Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation...
  48. ncbi Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
    J Cell Physiol 211:336-43. 2007
    ....
  49. ncbi Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1923-32. 2008
    ..Our results provide strong evidence that forebrain CaMKIV contributes to trace fear memory by enhancing synaptic potentiation in the ACC...
  50. ncbi Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice
    Susan S Kim
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
    Mol Brain 4:6. 2011
    ..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders...
  51. ncbi Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa
    Hui Xu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 2:29. 2006
    ..GluR5-containing KARs are thus important for spinal sensory transmission/modulation in the spinal cord...
  52. ncbi Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 282:1507-17. 2007
    ..Our findings provide direct evidence that AC1 plays an important role in neuronal excitotoxicity and may serve as a therapeutic target for preventing excitotoxicity in stroke and neurodegenerative diseases...
  53. ncbi Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, Toronto, Ontario, Canada M5S 1A8
    Dev Neurobiol 67:146-57. 2007
    ..Our results suggest the somatodendritic, but not presynaptic GluR5, in modulation of GABA release. The endogenous GluR5 activation and the subsequent tonic GABA current may play an inhibitory role in ACC-related brain functions...
  54. ncbi Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Mol Pain 3:11. 2007
    ..These results suggest that NVP-AAM007 shows great preference for NR2A subunit and could be used as a selective antagonist for NR2A-containing NMDARs in the ACC...
  55. ncbi Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia
    Feng Wei
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, University of Toronto, Toronto, M5S 1A8, Canada
    Mol Pain 2:21. 2006
    ..Our results suggest that neuronal CaMKII activity in the forebrain plays a role in persistent pain...
  56. ncbi FMRP acts as a key messenger for dopamine modulation in the forebrain
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
    Neuron 59:634-47. 2008
    ..Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome...
  57. ncbi Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex
    Jason Liauw
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 94:878-82. 2005
    ..Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP...
  58. ncbi Resting microglial motility is independent of synaptic plasticity in mammalian brain
    Long Jun Wu
    Department of Physiology, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Neurophysiol 99:2026-32. 2008
    ..Our results suggest that microglia are highly reserved for neuronal protective function but not synaptic plasticity in the brain...
  59. ncbi Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 28:4385-97. 2008
    ..Our study has provided the first evidence for a molecular link between group I mGluRs and FMRP in ACC neurons and may help us to understand the pathogenesis of fragile X syndrome...
  60. ncbi CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep
    Hendrik W Steenland
    Department of Physiology, University of Toronto, Centre for the Study of Pain, Toronto, Ontario, Canada
    Mol Brain 3:16. 2010
    ..Our data emphasize the role of CaMKIV in controlling learning and sleep-related oscillations and suggest that oscillatory activity during wakefulness may be a relevant predictor of subsequent memory consolidation...
  61. ncbi Predicting aversive events and terminating fear in the mouse anterior cingulate cortex during trace fear conditioning
    Hendrik W Steenland
    Department of Physiology, University of Toronto, Medical Sciences Building, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 32:1082-95. 2012
    ..Collectively, our findings indicate that the ACC is involved in predicting future aversive events and terminating fear during trace fear...
  62. ncbi A new assay of thermal-based avoidance test in freely moving mice
    Hoi-Ki Ding
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:411-6. 2005
    ..The measure of escape responses might be useful in the assessment of memory defects, evaluation of drug therapies, and the behavioral characterization of transgenic mice...
  63. ncbi Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
    Mol Pain 5:46. 2009
    ..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC...
  64. ncbi Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 4:40. 2008
    ..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation...
  65. ncbi Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 22:485-94. 2005
    ..Furthermore, our studies provide direct physiological evidence that both NR2A and NR2B subunits are involved in the induction of LTD in the ACC...
  66. ncbi Neurabin contributes to hippocampal long-term potentiation and contextual fear memory
    Long Jun Wu
    Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
    PLoS ONE 3:e1407. 2008
    ..Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons...
  67. ncbi In vivo whole-cell patch-clamp recording of sensory synaptic responses of cingulate pyramidal neurons to noxious mechanical stimuli in adult mice
    Kohei Koga
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 6:62. 2010
    ..Our studies provide the first in vivo characterization of ACC neurons in adult mice, and demonstrate that ACC neurons are indeed nociceptive. These findings support the critical roles of ACC in nociception, from mice to humans...
  68. ncbi Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases
    Kunjumon I Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, ON, Canada
    Mol Pain 2:7. 2006
    ..Muscle pain is different from cutaneous pain in its characteristics as well as conducting fibers. Therefore, we conducted the present work to test the role of AC1 and AC8 in both acute persistent and chronic muscle pain...
  69. ncbi Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice
    Shanelle Ko
    Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 25:977-84. 2005
    ..Selectively targeting different KAR subtypes may provide a useful strategy for treating persistent pain and fear-related mental disorders...
  70. ncbi Roles of fragile X mental retardation protein in dopaminergic stimulation-induced synapse-associated protein synthesis and subsequent alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) receptor internalization
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 285:21888-901. 2010
    ..Our study thus provides further insights into FMRP involvement in DA modulation and may help to reveal the molecular mechanisms underlying impaired learning and memory in fragile X syndrome...
  71. ncbi ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Glia 55:810-21. 2007
    ..Our results provide strong evidence that P2Y receptor-associated outward potassium channels and the phosphoinositide 3-kinase pathway are important for ATP-induced microglial motility in acute brain slices...
  72. ncbi Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex
    Hansen Wang
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:18953-62. 2009
    ..Our study has provided strong evidence for CaMKIV as a molecular link between Group I mGluRs and FMRP in ACC neurons and may help us to elucidate the pathogenesis of fragile X syndrome...
  73. ncbi Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
    Hiroki Toyoda
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 3:27. 2010
    ..Our results reveal in the first time a transcription- and translation-dependent component of early synaptic LTP in adult ACC synapses, and demonstrate that CaMKIV enhances early synaptic potentiation by activating new protein synthesis...
  74. ncbi DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Brain 3:3. 2010
    ..By contrast, sensory responses to noxious stimuli were not affected. Our results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory...
  75. ncbi Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV
    Fanny W F Shum
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Mol Pain 1:22. 2005
    ..In addition, CaMKIV(-/-) mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior...
  76. ncbi Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:32. 2009
    ..Moreover, reciprocal connections exist in all four types of paired neurons. Our results provide the first key evidence of functional excitatory and inhibitory connections in the ACC...
  77. ncbi A behavioral model of neuropathic pain induced by ligation of the common peroneal nerve in mice
    Kunjumon Ittira Vadakkan
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:747-56. 2005
    ..Here we report a less invasive procedure to ligate common peroneal nerve of leg to induce neuropathic pain with least motor defects...
  78. ncbi Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortex
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Brain 2:9. 2009
    ..Our results present direct evidence of the critical role of the ACC in sexual attraction, and long-term increases in glutamate mediated excitatory transmission may contribute to sexual attraction between male and female mice...
  79. ncbi Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 1:34. 2005
    ..It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord...
  80. ncbi Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression
    Rochelle M Hines
    Department of Psychiatry, Brain Research Centre, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 28:6055-67. 2008
    ..These findings may provide the neural basis for E/I imbalance and altered behavior associated with neurodevelopmental disorders...
  81. ncbi Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Neurotherapeutics 6:693-702. 2009
    ..The NMDA receptors, in particular NR2B-containing NMDA receptors, serve as promising targets for treatment of neuropathic pain...
  82. ncbi Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, Medical Science Building, Room no 3342, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    J Mol Med (Berl) 89:847-55. 2011
    ..We propose that targeting PKM?, or its up- or downstream signaling proteins, in the ACC may provide novel clinical treatment for chronic pain...
  83. ncbi Molecular targets of anxiety: from membrane to nucleus
    Long Jun Wu
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Neurochem Res 33:1925-32. 2008
    ..Studies on the interactions between these molecules will help elucidate the cellular mechanisms of anxiety, and will provide molecular targets for treating the disorders...
  84. ncbi Selective contribution of Egr1 (zif/268) to persistent inflammatory pain
    Shanelle W Ko
    Department of Physiology, University of Toronto, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
    J Pain 6:12-20. 2005
    ..Egr1 knockout mice showed reduced nociceptive behaviors to persistent inflammatory pain and inflammation increased Egr1 expression in the anterior cingulate cortex of wild-type mice...
  85. ncbi Presynaptic and postsynaptic cortical mechanisms of chronic pain
    Giannina Descalzi
    Department of Physiology, University of Toronto Centre for the Study of Pain, University of Toronto, Ontario, Canada
    Mol Neurobiol 40:253-9. 2009
    ..Understanding presynaptic and postsynaptic mechanisms for ACC potentiation may help us to treat chronic pain in near future...
  86. ncbi Central plasticity in pathological pain
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada
    Novartis Found Symp 261:132-45; discussion 145-54. 2004
    ..Our studies suggest distinct signalling pathways are responsible for physiological responses to the injury, including behavioural, emotional and memory...
  87. ncbi Endogenous facilitation: from molecular mechanisms to persistent pain
    Daphne A Robinson
    Department of Physiology, 1 King's College Circle, University of Toronto, Toronto, Canada M5S 1A8
    Curr Neurovasc Res 1:11-20. 2004
    ..We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain...
  88. ncbi Fragile X mental retardation protein in learning-related synaptic plasticity
    Valentina Mercaldo
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Mol Cells 28:501-7. 2009
    ..We hypothesize that alterations in ACC-related plasticity and synaptic modulation may contribute to various forms of cognitive deficits associated with FXS...
  89. ncbi Interplay of amygdala and cingulate plasticity in emotional fear
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Neural Plast 2011:813749. 2011
    ....
  90. ncbi NMDA receptor-dependent long-term depression in the anterior cingulate cortex
    Hiroki Toyoda
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Rev Neurosci 17:403-13. 2006
    ..Here, we review recent studies and present new experimental data on the roles of NMDA receptors during synaptic depression in the ACC. Furthermore, we consider the physiological and pathological significance of LTD in the ACC...
  91. ncbi Canadian Association of Neuroscience review: Cellular and synaptic insights into physiological and pathological pain. EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health lecture
    Min Zhuo
    Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, ON, Canada
    Can J Neurol Sci 32:27-36. 2005
    ..Our results provide important synaptic and molecular insights into physiological responses to injury...
  92. ncbi Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice
    Frank Blaeser
    Department of Pediatrics, The David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Mol Cell Biol 26:9105-15. 2006
    ..These results demonstrate a selective role for CaMKKalpha in contextual fear memory and suggest that different combinations of upstream and downstream components of the CaMK cascade may serve distinct physiological functions...
  93. ncbi Presynaptic suppression of dorsal horn inhibitory transmission by mu-opioid receptors
    Geoffrey A Kerchner
    Washington University Pain Center and Departments of Anesthesiology, Anatomy and Neurobiology, and Psychiatry, Washington University School of Medicine, St. Louis, Missouri, 63110, USA
    J Neurophysiol 88:520-2. 2002
    ..These data identify mu-opioid receptors as important presynaptic modulators of dorsal horn inhibitory transmission...
  94. ncbi Calcium calmodulin-dependent protein kinase IV is required for fear memory
    Feng Wei
    Washington University Pain Center, Departments of Anesthesiology, Anatomy, and Neurobiology and Psychiatry, St Louis, Missouri 63110, USA
    Nat Neurosci 5:573-9. 2002
    ..We propose that cognitive memory related to a noxious shock can be disassociated from behavioral responses to tissue injury and inflammation...
  95. ncbi Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat
    Min Zhuo
    Department of Pharmacology, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Gastroenterology 122:1007-19. 2002
    ..CONCLUSIONS: Spinal visceral nociceptive reflexes are subject to facilitatory modulation from the RVM, providing the basis for a mechanism by which visceral sensations can be enhanced from supraspinal sites...
  96. ncbi GluR3 subunit regulates sleep, breathing and seizure generation
    Hendrik W Steenland
    Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Eur J Neurosci 27:1166-73. 2008
    ..Finally, this is the first study to demonstrate the feasibility of direct diaphragm electromyogram recordings in freely behaving mice...
  97. ncbi Glutamate receptors and persistent pain: targeting forebrain NR2B subunits
    Min Zhuo
    Department of Anesthesiology, Washington University School of Medicine, Campus Box 8054, 660 S Euclid Ave, St Louis, MO 63110, USA
    Drug Discov Today 7:259-67. 2002
    ..Drugs targeting NMDA NR2B subunits in the forebrain could serve as a new class of medicine for controlling persistent pain in humans...
  98. ncbi Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice
    Feng Wei
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Neurosci 26:851-61. 2006
    ....
  99. ncbi Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord
    Long Jun Wu
    Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031
    J Biol Chem 279:43716-24. 2004
    ..These results support the idea that the ASICs of dorsal horn neurons participate in central sensory transmission/modulation under physiological conditions and may play important roles in inflammation-related persistent pain...
  100. ncbi A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval
    Carolina Isiegas
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:6220-30. 2008
    ....

Research Grants8

  1. SEROTONERGIC REGULATION OF SENSORY TRANSMISSION
    Min Zhuo; Fiscal Year: 2002
    ..The proposed studies will generate synaptic mechanisms for fast glutamatergic transmission as well as 5-HT regulation in the spinal cord. This information will be important for understanding central pain transmission and modulation. ..
  2. Synaptic change in cingulate cortex after amputation
    Min Zhuo; Fiscal Year: 2006
    ..This information will provide a potential neuronal basis for understanding phantom limb sensation and phantom pain. ..