Research Topics
Genomes and GenesSpecies | Long Jun WuSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of ratsXue Han Zhang
Institutes of Brain Science, Fudan University, Shanghai, PR China
Mol Brain 1:9. 2008..Pre-training intra-CA1 infusion of ifenprodil or Ro25-6981 impaired the contextual fear memory induced by five CS-US pairings, with no effect on the memory induced by one CS-US pairing...- Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortexLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 4:40. 2008..The present study provides the first evidence linking enhanced presynaptic glutamate release in the ACC to behavioral sensitization caused by peripheral inflammation... - Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance PLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 1:34. 2005..It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord... - Sexual attraction enhances glutamate transmission in mammalian anterior cingulate cortexLong Jun Wu
Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Brain 2:9. 2009..Our results present direct evidence of the critical role of the ACC in sexual attraction, and long-term increases in glutamate mediated excitatory transmission may contribute to sexual attraction between male and female mice... - Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortexLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Mol Pain 3:11. 2007..These results suggest that NVP-AAM007 shows great preference for NR2A subunit and could be used as a selective antagonist for NR2A-containing NMDARs in the ACC... - Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recordingLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Brain 2:32. 2009..Moreover, reciprocal connections exist in all four types of paired neurons. Our results provide the first key evidence of functional excitatory and inhibitory connections in the ACC... - Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout miceLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 2:e167. 2007..Our results suggest that GluR5 is a key regulator of inhibitory circuits in the amygdala and highlight the potential use of GluR5-specific drugs in the treatment of pathological anxiety... - Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortexLong Jun Wu
Department of Physiology, University of Toronto, Medical Sciences Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 94:1805-13. 2005..Our results show that KA receptors contribute to synaptic transmission in adult ACC pyramidal neurons and provide a synaptic basis for the physiology and pathology of KA receptors in ACC-related functions... - Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndromeMing Gao Zhao
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
J Neurosci 25:7385-92. 2005..This suggests that synaptic plasticity in the ACC and amygdala of FMR1 KO mice plays an important role in the expression of behavioral phenotypes similar to the symptoms of fragile X syndrome... - Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic painMing Gao Zhao
Department of Physiology, Faculty of Medicine, and Centre for the Study of Pain, University of Toronto, Toronto, Ontario, Canada M5S 1A8
J Neurosci 26:8923-30. 2006..Our findings provide strong evidence that presynaptic alterations caused by peripheral inflammation contribute to memory impairments after injury... - Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichmentFanny W F Shum
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, University of Toronto, Toronto, Canada
Learn Mem 14:304-12. 2007..Our findings suggest that exposure to EE alters physiological properties within the ACC which results in enhanced responses to inflammation... - Evidence for a role of CaMKIV in the development of opioid analgesic toleranceShanelle W Ko
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Medical Sciences Building Rm3342, Toronto, Canada, M5S 1A8
Eur J Neurosci 23:2158-68. 2006..Our results provide novel evidence for the role of CaMKIV in the development of opioid analgesic tolerance but not physical dependence... - Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory painHansen Wang
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario M5S1A8, Canada
Sci Transl Med 3:65ra3. 2011..Our study thus shows that AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain... - Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortexHiroki Toyoda
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
J Cell Physiol 211:336-43. 2007.... - Interplay of amygdala and cingulate plasticity in emotional fearHiroki Toyoda
Department of Physiology, University of Toronto, Toronto, ON, Canada
Neural Plast 2011:813749. 2011.... - Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortexHiroki Toyoda
Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 3:36. 2007..Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions... - Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortexJason Liauw
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Bldg, Rm 3342, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
J Neurophysiol 94:878-82. 2005..Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP... - Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammationLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, M5S 1A8, Canada
J Neurosci 25:11107-16. 2005..Our results demonstrate that the upregulation of NR2B receptors in the ACC contributes to behavioral sensitization caused by inflammation... - Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult miceSusan S Kim
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, ON, Canada
Mol Brain 4:6. 2011..These findings reveal novel roles of the ACC in anxiety disorders, and provide a new therapeutic target for the treatment of anxiety disorders... - Characterization of intrinsic properties of cingulate pyramidal neurons in adult mice after nerve injuryXiao Yan Cao
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 5:73. 2009.... - Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiationHiroki Toyoda
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Dev Neurobiol 67:498-509. 2007..Our results demonstrate that the GluR1 subunit is essential for synaptic plasticity in the ACC and may play critical roles under physiological and pathological conditions... - Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosaHui Xu
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 2:29. 2006..GluR5-containing KARs are thus important for spinal sensory transmission/modulation in the spinal cord... - Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult miceLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Science Building, Toronto, Ontario, Canada M5S 1A8
Dev Neurobiol 67:146-57. 2007..Our results suggest the somatodendritic, but not presynaptic GluR5, in modulation of GABA release. The endogenous GluR5 activation and the subsequent tonic GABA current may play an inhibitory role in ACC-related brain functions... - Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortexHui Xu
Department of Physiology, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
J Neurosci 28:7445-53. 2008..AC1 thus may serve as a potential therapeutic target for treating neuropathic pain... - Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IVLong Jun Wu
Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
Eur J Neurosci 27:1923-32. 2008..Our results provide strong evidence that forebrain CaMKIV contributes to trace fear memory by enhancing synaptic potentiation in the ACC... - Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptorsHansen Wang
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
J Neurosci 28:4385-97. 2008..Our study has provided the first evidence for a molecular link between group I mGluRs and FMRP in ACC neurons and may help us to understand the pathogenesis of fragile X syndrome... - Facilitation of the inhibitory transmission by gastrin-releasing peptide in the anterior cingulate cortexXiaoyan Cao
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Mol Pain 6:52. 2010..Our results suggest that GRP receptor is an important regulator of inhibitory circuits in forebrain areas... - FMRP acts as a key messenger for dopamine modulation in the forebrainHansen Wang
Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON M5S1A8, Canada
Neuron 59:634-47. 2008..Our study has identified FMRP as a key messenger for DA modulation in the forebrain and may provide insights into the cellular and molecular mechanisms underlying fragile X syndrome... - DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memoryLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
Mol Brain 3:3. 2010..By contrast, sensory responses to noxious stimuli were not affected. Our results demonstrate that DREAM plays a novel role in postsynaptic modulation of the NMDA receptor, and contributes to synaptic plasticity and behavioral memory... - Resting microglial motility is independent of synaptic plasticity in mammalian brainLong Jun Wu
Department of Physiology, University of Toronto Centre for the Study of Pain, Toronto, Ontario, Canada
J Neurophysiol 99:2026-32. 2008..Our results suggest that microglia are highly reserved for neuronal protective function but not synaptic plasticity in the brain... - Neurabin contributes to hippocampal long-term potentiation and contextual fear memoryLong Jun Wu
Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
PLoS ONE 3:e1407. 2008..Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons... - ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currentsLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Glia 55:810-21. 2007..Our results provide strong evidence that P2Y receptor-associated outward potassium channels and the phosphoinositide 3-kinase pathway are important for ATP-induced microglial motility in acute brain slices... - Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic painLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto Centre for Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Neurotherapeutics 6:693-702. 2009..The NMDA receptors, in particular NR2B-containing NMDA receptors, serve as promising targets for treatment of neuropathic pain... - Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouseFuxing Zhang
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for Study of Pain, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Pain 4:15. 2008..Our results provide strong evidence that nerve injury primarily activates microglia in the spinal cord of adult mice, and pain-related cortical plasticity is likely mediated by neurons... - Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortexLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario, Canada
Curr Pharm Des 13:1597-605. 2007..Recent genetic and pharmacological studies suggest that kainate receptors can regulate nociceptive responses. These results highlight kainate receptors as a target for the development of new treatments for chronic pain... - Hot receptors in the brainHendrik W Steenland
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Canada
Mol Pain 2:34. 2006..In addition, some regions of the brain utilize the TRPV1 receptor for functions apparently unrelated to pain... - Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic toleranceShanelle W Ko
Department of Physiology, University of Toronto, University of Toronto Centre for the Study of Pain, Canada
Mol Brain 1:2. 2008.... - Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortexHiroki Toyoda
Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, 1 King s College Circle, Ontario, Canada
Mol Pain 5:46. 2009..Our results demonstrate that AMPA receptor subunit GluA1 is a key mechanism for the expression of ACC LTP and inflammation-induced long-term plastic changes in the ACC... - Molecular targets of anxiety: from membrane to nucleusLong Jun Wu
Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
Neurochem Res 33:1925-32. 2008..Studies on the interactions between these molecules will help elucidate the cellular mechanisms of anxiety, and will provide molecular targets for treating the disorders... - Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampusLong Jun Wu
Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
Mol Brain 2:17. 2009..This discovery provides key molecular insights for cholinergic dependent cognitive function, and mAChR-LTD can serve as a useful cellular model for studying the roles of cholinergic mechanism in learning and memory... - Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neuronsYan-Fang Li
Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China
J Physiol 552:73-87. 2003..Taken together, the results support a "conformational coupling" model for H+ modulation of the GlyR and suggest that H+ may act as a novel modulator for inhibitory neurotransmission in the mammalian spinal cord... - Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cordLong Jun Wu
Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031
J Biol Chem 279:43716-24. 2004..These results support the idea that the ASICs of dorsal horn neurons participate in central sensory transmission/modulation under physiological conditions and may play important roles in inflammation-related persistent pain... - Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memoryMing Gao Zhao
Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, 220 Han Dan Road, Shanghai 200433, China
Neuron 47:859-72. 2005..Our results demonstrate that the NR2B subunit of the NMDA receptor in the prefrontal cortex is critically involved in both LTP and contextual memory... - A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrievalCarolina Isiegas
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:6220-30. 2008.... - The role of hippocampal GluR1 and GluR2 receptors in manic-like behaviorJing Du
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20878, USA
J Neurosci 28:68-79. 2008..These studies provide novel insights into the role of hippocampal GluR1/2 receptors in mediating facets of the manic syndrome and offer avenues for the development of novel therapeutics for these disorders... - Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and miceFeng Wei
Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
J Neurosci 26:851-61. 2006.... - Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feedingHongkui Zeng
Nura, Inc, Seattle, WA 98104, USA
Mol Cell Biol 26:9352-63. 2006..They suggest that NMUR2 plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding... - Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neuronsYong Li
Department of Neurobiology and Biophysics, University of Science and Technology of China, Hefei 230027, China
J Biol Chem 278:38637-45. 2003.... - Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neuronsLong-Jun Wu
Laboratory of Receptor Pharmacology, Department of Neurobiology and Biophysics, School of Life Science, University of Science and Technology of China P.O. Box 4 Hefei 230027, PR China
Neuroreport 13:977-81. 2002..This interaction may contribute to sensory processing such as nociception in the mammalian deep dorsal horn under physiological and/or pathological conditions... - Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivityBo Duan
Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
J Neurosci 27:11139-48. 2007..Specific blockade of Ca2+-permeable ASIC1a channels thus may have antinociceptive effect by reducing or preventing the development of central sensitization induced by inflammation... - Properties of the proton-evoked currents and their modulation by Ca2+ and Zn2+ in the acutely dissociated hippocampus CA1 neuronsJun Gao
School of Life Sciences, University of Science and Technology of China, Hefei
Brain Res 1017:197-207. 2004.... - Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with agingHotaka Fukushima
Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156 8502, Japan
J Neurosci 28:9910-9. 2008..Our findings suggest that the level of CaMKIV expression correlates positively with the ability to form long-term memory and implicate the decline of CaMKIV signaling mechanisms in age-related memory deficits...