Research Topics
| M G SwainSummaryAffiliation: University of Calgary Country: Canada Publications
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Detail Information
Publications
Fatigue in liver disease: pathophysiology and clinical managementMark G Swain
University of Calgary, Liver Unit, Health Sciences Centre, Alberta
Can J Gastroenterol 20:181-8. 2006..In conclusion, a reasonable approach to help guide in the management of the fatigued patient with liver disease is presented...- Role of methotrexate in the treatment of chronic cholestatic disordersKerri Novak
Division of Gastroenterology, Liver Unit, University of Calgary, 3330 Hospital Dr, NW, Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
Clin Liver Dis 12:81-96, viii. 2008..In contrast, PSC continues to be an immensely challenging disease to effectively treat, and the role of MTX for treating PSC patients remains dubious... - Hepatic NKT cells: friend or foe?Mark G Swain
Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
Clin Sci (Lond) 114:457-66. 2008.... - I. Stress and hepatic inflammationM G Swain
Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
Am J Physiol Gastrointest Liver Physiol 279:G1135-8. 2000.... - Fatigue in chronic diseaseM G Swain
Liver Unit, Gastroenterlogy Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Clin Sci (Lond) 99:1-8. 2000..Hopefully, a broader understanding of this distressing symptom will lead to the development of specific therapies for treating fatigue in these patients... - Natural killer T cells within the liver: conductors of the hepatic immune orchestraMark G Swain
Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Dig Dis 28:7-13. 2010..This paper highlights the diverse roles played by iNKT cells as master regulators of immune-mediated liver injury... - A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirinMark G Swain
Health Research Innovation Center, University of Calgary, Calgary, Alberta, Canada
Gastroenterology 139:1593-601. 2010..Although small studies have reported that the SVR is durable and lasts for long periods, it has not been conclusively shown... - Downregulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic ratsH Nguyen
Gastrointestinal Research Group, University of Calgary, Calgary, AB, Canada
Neurogastroenterol Motil 20:228-35. 2008.... - A case of coexisting primary biliary cirrhosis and primary sclerosing cholangitis: a new overlap of autoimmune liver diseasesK W Burak
Liver Unit, University of Calgary, Alberta, Canada
Dig Dis Sci 46:2043-7. 2001..This case suggests that PBC, PSC, AIH, and autoimmune cholangitis are part of a spectrum of chronic autoimmune liver disease that develop in response to some yet unidentified antigen... - Augmented interleukin-1beta-induced depression of locomotor activity in cholestatic ratsM G Swain
Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada
Hepatology 28:1561-5. 1998..These findings may explain, at least in part, the high incidence of symptoms such as fatigue, malaise, and lethargy that occur in cholestatic patients and may open novel future avenues for their treatment... - Decreased orexigenic response to neuropeptide Y in rats with obstructive cholestasisK P Rioux
Liver Unit, Gastrointestinal Research Group, University of Calgary, Health Sciences Centre, Calgary, Alberta, Canada T2N 4N1
Am J Physiol Gastrointest Liver Physiol 280:G449-56. 2001.... - Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: a population-based studyRobert P Myers
Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
Hepatology 50:1884-92. 2009..Survival of PBC patients is significantly lower than that of the general population, emphasizing the importance of developing new therapies for this condition... - Validation of coding algorithms for the identification of patients with primary biliary cirrhosis using administrative dataRobert P Myers
Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta
Can J Gastroenterol 24:175-82. 2010..Large-scale epidemiological studies of primary biliary cirrhosis (PBC) have been hindered by difficulties in case ascertainment... - Chemokines as novel therapeutic targets in inflammatory diseasesMaureen N Ajuebor
Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
Biochem Pharmacol 63:1191-6. 2002.... - Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammationCharlotte D'Mello
Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Neurosci 29:2089-102. 2009.... - CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitisMaureen N Ajuebor
Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
Am J Pathol 170:1975-88. 2007..These results highlight the potential profound impact of altered chemokine receptor expression on the innate immune response in the setting of T cell-mediated hepatitis... - A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patientsVincent G Bain
University of Alberta, Liver Unit, Zeidler Ledcor Center, 130 University Campus, Edmonton, Alberta, Canada, T6G 2X8
J Hepatol 44:671-8. 2006..Recombinant human albumin-interferon alfa (alb-IFN) is a novel 85.7-kD recombinant protein consisting of interferon alfa-2b genetically fused to human serum albumin... - Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawalR P Myers
Department of Pathology, University of Calgary Medical Clinical, Calgary, Alberta, Canada
Can J Gastroenterol 15:599-603. 2001..Clinicians should consider the risk of inducing serious flares of hepatic inflammation due to abrupt nucleoside analogue withdrawal in these patients... - Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the ratJ B Meddings
Gastrointestinal Research Group, University of Calgary, Alberta, Canada
Gastroenterology 119:1019-28. 2000..We hypothesized that environmental stress increases gastrointestinal permeability... - Profound suppression of chronic hepatitis C following superinfection with hepatitis B virusCarla S Coffin
Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Liver Int 27:722-6. 2007..Hepatitis B virus (HBV) and hepatitis C virus (HCV) share similar transmission routes; thus, coinfection is frequent. The consequences of acute HBV infection in patients with chronic hepatitis C are unknown... - Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1Claudine S Bonder
Immunology Research Group, Department Physiology and Biophysics, University of Calgary, Alberta, Canada
Immunity 23:153-63. 2005..While this may still be true for neutrophils, Th1 and Th2 cells use alpha(4)-integrin and VAP-1, respectively, to adhere within the liver sinusoids... - Role of chemokines and chemokine receptors in the gastrointestinal tractMaureen N Ajuebor
Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Immunology 105:137-43. 2002..This short review examines the role of chemokines and their receptors in the gastrointestinal tract with an emphasis on their involvement in the regulation of intestinal and hepatic inflammation... - C-C chemokine ligand 2/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouseMaureen N Ajuebor
Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
J Immunol 170:5252-9. 2003..1(+) T cell-derived IL-4 production through direct stimulation of its specific receptor CCR2. These findings may have direct clinical relevance to T cell-mediated hepatitis... - Methotrexate therapy for the symptomatic treatment of primary biliary cirrhosis patients, who are biochemical incomplete responders to ursodeoxycholic acid therapyM A Babatin
Liver Unit, University of Calgary, AB, Canada
Aliment Pharmacol Ther 24:813-20. 2006..CONCLUSIONS: Methotrexate should be considered as a potential additive treatment for symptomatic primary biliary cirrhosis patients who are incomplete biochemical responders to ursodeoxycholic acid therapy... - Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitisK Tjandra
Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
Gut 52:1363-70. 2003..CONCLUSION: We conclude that hepatic T lymphocyte resistance to elevated endogenous glucocorticoid levels in rats with experimental cholangitis appears, in part, to be mediated by decreased GR expression... - CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liverMaureen N Ajuebor
Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Eur J Immunol 34:2907-18. 2004..These findings demonstrate that blockade of the CCL3/MIP-1alpha-CCR1 pathway may represent a novel therapeutic target for treating T cell-mediated liver diseases... - CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitisFeng Zhou
Liver Unit, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
Hepatology 42:372-80. 2005..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)... - Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cellsMaureen N Ajuebor
Gastrointestinal Research Group, Diabetes and Endocrine Research Group, and Department of Histopathology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
J Immunol 174:8027-37. 2005.... - Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in miceTania Santodomingo-Garzon
From the Immunology Research Group, University of Calgary, Calgary, Alberta, Canada
Hepatology 49:1267-76. 2009.... - Liver-brain inflammation axisCharlotte D'Mello
Snyder Institute of Infection, Immunity, and Inflammation, Liver Unit, Department of Medicine, University of Calgary, Alberta, Canada
Am J Physiol Gastrointest Liver Physiol 301:G749-61. 2011..Understanding how the liver communicates with the brain in the setting of chronic inflammatory liver diseases will help delineate novel therapeutic targets that can reduce the burden of symptoms in patients with liver disease... - Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitisClaudine S Bonder
Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
J Immunol 172:45-53. 2004..In summary, the present data support the concept that neutrophils play an important and previously unrecognized role in governing Con A-induced CD4+ T cell recruitment to the liver and the subsequent development of hepatitis... - Increased sensitivity to the locomotor-activating effects of corticotropin-releasing hormone in cholestatic ratsKelly W Burak
Gastrointestinal Research Group, Liver Unit, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Gastroenterology 122:681-8. 2002..CONCLUSIONS: These findings are consistent with defective central CRH neurotransmission contributing to decreased locomotor activity in cholestatic rats and have direct implications for cholestasis-associated fatigue... - CCR5 in T cell-mediated liver diseases: what's going on?Maureen N Ajuebor
Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada
J Immunol 177:2039-45. 2006..Therefore, in this brief review, we highlight the evidence that supports an important role of CCR5 in the pathophysiology of T cell-mediated liver diseases with specific emphasis on autoimmune and viral liver diseases... - TNF-alpha-secreting monocytes are recruited into the brain of cholestatic miceSteven M Kerfoot
Immunology Research Group, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada
Hepatology 43:154-62. 2006..We hypothesize that enhanced TNF-alpha release within the brain may contribute to the development of cholestasis-associated sickness behaviors, including fatigue... - A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: is it safe and useful?Jennifer L Shin
Department of Medicine at University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Hematol 78:85-93. 2005..We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease...