Research Topics
Species | D E SpanerSummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Toll-like receptor-7 tolerizes malignant B cells and enhances killing by cytotoxic agentsYonghong Shi
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada
Cancer Res 67:1823-31. 2007..This property of the TLR7-tolerized state may potentially be exploited in the treatment of B cell cancers...- Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimodDavid E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Leuk Lymphoma 46:935-9. 2005..These observations extend the therapeutic spectrum of imiquimod to cutaneous B-cell lymphomas and suggest the use of TLR-7/8 agonists in CLL immunotherapy... - Enhanced viral and tumor immunity with intranodal injection of canary pox viruses expressing the melanoma antigen, gp100David E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Cancer 106:890-9. 2006.... - A phase I/II trial of oxidized autologous tumor vaccines during the "watch and wait" phase of chronic lymphocytic leukemiaDavid E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, ON, Canada M4N 3M5
Cancer Immunol Immunother 54:635-46. 2005..Toxicity was minimal. Vaccination with oxidized autologous tumor cells appears worthy of further investigation and may be a potential alternative to a "watch and wait" strategy for selected CLL patients... - Effect of IL-2R beta-binding cytokines on costimulatory properties of chronic lymphocytic leukaemia cells: implications for immunotherapyDavid E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto M4N 3M5, Canada
Br J Haematol 127:531-42. 2004..IL-15 had similar effects on the costimulatory properties of CLL cells. These results suggest a role for IL-2, or IL-15, in immunotherapeutic strategies for CLL... - Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cellsDavid E Spaner
Division of Molecular and Cellular Biology, Research Institute, S 116A, Research Building, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
J Leukoc Biol 76:338-51. 2004.... - Immunomodulatory effects of Toll-like receptor-7 activation on chronic lymphocytic leukemia cellsD E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Leukemia 20:286-95. 2006..Normal B cells also responded to TLR7 activation by increasing costimulatory molecule expression and cytokine production. These findings suggest a potential role for TLR7 agonists in CLL immunotherapy... - Aberrant regulation of superantigen responses during T-cell reconstitution and graft-versus-host disease in immunodeficient miceDavid Spaner
Division of Molecular and Cellular Biology, Research Institute S 116A, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
Blood 100:2216-24. 2002.... - A role for perforin in activation-induced T cell death in vivo: increased expansion of allogeneic perforin-deficient T cells in SCID miceD Spaner
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Canada
J Immunol 162:1192-9. 1999..The results are compatible with a model of a defective activation-induced cell death (AICD) pathway, controlled by perforin, accounting for the increased expansion of alloreactive pko T cells... - Acute intestinal graft-versus-host disease in a syngeneic bone marrow transplant recipientD Spaner
Toronto Sunnybrook Regional Cancer Center, Department of Medicine, University of Toronto, Ontario, Canada
Transplantation 66:1251-3. 1998..We report a case of intestinal graft-versus-host disease (GVHD) in a syngeneic bone marrow transplant patient... - A role for perforin in activation-induced cell deathD Spaner
Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, Canada
J Immunol 160:2655-64. 1998..The results suggest a model in which perforin acts internally to cause a form of activation-induced T cell death distinct from that caused by members of the TNFR superfamily... - Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cellsS P Shaha
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook Health Sciences Center, Toronto, Canada
Clin Exp Immunol 158:186-98. 2009..Use of PKC agonists and microtubule inhibitors to mimic TLR-signalling, and increase the immunogenicity of CLL cells, has implications for the design of chemo-immunotherapeutic strategies... - Chronic lymphocytic leukemia-reactive T cells during disease progression and after autologous tumor cell vaccinesElena Gitelson
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, M4N 3M5 Canada
Clin Cancer Res 9:1656-65. 2003.... - Amplification of virus-induced antimelanoma T-cell reactivity by high-dose interferon-alpha2b: implications for cancer vaccinesIgor Astsaturov
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada
Clin Cancer Res 9:4347-55. 2003..CONCLUSIONS: The finding that high-dose IFN recalls previously activated tumor-reactive T cells with potent killing ability suggests a strategy to maintain antitumor responses initiated by cancer vaccines... - Differential immune responses mediated by adenovirus- and lentivirus-transduced DCs in a HER-2/neu overexpressing tumor modelT C Felizardo
Campbell Family Cancer Research Institute and Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
Gene Ther 18:986-95. 2011..Our results suggest that not only the target antigen but also the virus system may determine the nature and magnitude of antitumor immunity by DC vaccination... - Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cellsCaitlin Hammond
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women's College Health Sciences Center, 2075 Bayview Avenue, Toronto, Canada M4N 3M5
J Immunother (1997) 28:28-39. 2005..The observation that CLL cells can acquire features of dendritic cells that promote type 1 immunity may find clinical application in immunotherapeutic strategies for this disease... - Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemiaY Shi
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada
Leukemia 24:1588-98. 2010..These findings suggest that intracellular O-GlcNAcylation is associated with the pathogenesis of CLL, which could potentially have therapeutic implications... - The scid mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host diseaseR A Phillips
Division of Immunology and Cancer Research, Hospital for Sick Children, Toronto, Canada
Immunol Rev 124:63-74. 1991 - Toll-like receptor agonists in the treatment of chronic lymphocytic leukemiaD E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
Leukemia 21:53-60. 2007.... - Extracellular calcium sensing promotes human B-cell activation and functionCaitlin M Hammond
Division of Molecular and Cellular Biology, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Blood 110:3985-95. 2007..These findings suggest a means by which B cells prepare to engage in immune responses by responding to calcium fluctuations in their environment... - The role of CD200 in immunity to B cell lymphomaKarrie K Wong
Institute of Medical Science, University Health Network, University of Toronto, Rm 2 805, MaRS Tower, 101 College St, Toronto, ON, Canada, M5G1L7
J Leukoc Biol 88:361-72. 2010..Killing was mediated by CD8+ cytotoxic T cells, and CD4+ T cells play an important role in CD200-mediated suppression of CTL responses. Our data suggest that CD200 blockade may represent a novel approach to clinical treatment of CLL... - Obstacles to effective Toll-like receptor agonist therapy for hematologic malignanciesD E Spaner
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
Oncogene 27:208-17. 2008..Accordingly, concomitant use of agents to counter this intrinsic microenvironmental inhibition, together with TLR agonists, may prove to be an effective treatment strategy for the hematologic malignancies... - Sensitization of IL-2 signaling through TLR-7 enhances B lymphoma cell immunogenicityJelena Tomic
Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
J Immunol 176:3830-9. 2006..These findings suggest that TLR-7 "licenses" human B cells to respond to cytokines of the adaptive immune system (such as IL-2) and provide a strategy to increase the immunogenicity of lymphoma cells for therapeutic purposes...