Research Topics
Genomes and Genes | B SinghSummaryAffiliation: University of Saskatchewan Country: Canada Publications
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Publications
Pulmonary intravascular macrophages and lung health: what are we missing?David Schneberger
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Am J Physiol Lung Cell Mol Physiol 302:L498-503. 2012..We provide a review of PIM biology to make an argument for increased emphasis and better focus on the study of human PIMs to better understand their potential role in the pathophysiology and mechanisms of pulmonary diseases...- Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsivenessChandrashekhar Charavaryamath
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, S7N 5B4, Canada
Respir Res 6:50. 2005..Therefore, we tested a hypothesis in a rat model that multiple interrupted exposures to the barn air will cause chronic lung inflammation and decline in lung function... - Role of pulmonary intravascular macrophages in endotoxin-induced lung inflammation and mortality in a rat modelSukhjit S Gill
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK S7N5B4, Canada
Respir Res 9:69. 2008..We tested a hypothesis that recruited PIMs promote endotoxin-induced mortality in a rat model... - Lipopolysaccharide induced inflammation in the perivascular space in lungsThomas Tschernig
Dept, of Functional and Applied Anatomy 4120, Medical School of Hannover, Carl Neuberg Str, 1, 30625, Hannover, Germany
J Occup Med Toxicol 3:17. 2008.... - Strain-specific differences in perivascular inflammation in lungs in two murine models of allergic airway inflammationB Singh
Department Veterinary Biomedical Sciences, Immunology Research Group, University of Saskatchewan, SK S7N 5B4, Canada
Clin Exp Immunol 141:223-9. 2005..VAP-1 staining was generally observed throughout the pulmonary arterial wall in chronic lung inflammation. These data show that periarterial inflammation is influenced by the genetic background, and may be partially regulated by VAP-1... - Depletion of pulmonary intravascular macrophages inhibits acute lung inflammationBaljit Singh
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada SK S7N 5B4
Am J Physiol Lung Cell Mol Physiol 286:L363-72. 2004..These data may also be relevant to humans due to our ability to recruit PIMs... - Expression of integrin alphavbeta3 in pig, dog and cattleB Singh
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
Histol Histopathol 16:1037-46. 2001..Restriction of the integrin to absorptive epithelia of small intestine and kidney may suggest its putative role in endocytosis. Because the integrin is a receptor for adenovirus, these data may be relevant to gene therapy studies... - Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungsBaljit Singh
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Virchows Arch 442:491-5. 2003..Furthermore, since VAP-1 is expressed over a longer period of time in inflamed lungs, it may even be a suitable target for drug delivery and therapeutic manipulations... - An aerobiological perspective of dust in cage-housed and floor-housed poultry operationsNatasha Just
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
J Occup Med Toxicol 4:13. 2009..Further understanding of the source and aerosolization of dust in poultry operations will aid in the development of management practices to reduce worker exposure and response... - Lung inflammation following a single exposure to swine barn airLakshman Nihal Angunna Gamage
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
J Occup Med Toxicol 2:18. 2007..We hypothesized that barn exposure induces recruitment of PIMMs and increases susceptibility for acute lung inflammation with a secondary challenge... - Nanotechnology-based drug delivery systemsSarabjeet Singh Suri
Department of Veterinary Biomedical Sciences and Immunology Research Group, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada
J Occup Med Toxicol 2:16. 2007.... - Lung responses to secondary endotoxin challenge in rats exposed to pig barn airChandrashekhar Charavaryamath
Immunology and Infectious Disease Research Group, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
J Occup Med Toxicol 3:24. 2008..Therefore, we tested a hypothesis that single or multiple exposures to barn air will result in exaggerated lung inflammation in response to a secondary insult with Escherichia coli LPS (E. coli LPS)... - Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor in canine cutaneous fibrosarcomasA N Al-Dissi
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
J Comp Pathol 141:229-36. 2009..The potential for autocrine activity for VEGF exists in canine cutaneous fibrosarcomas, as VEGF and VEGFR-2 expression was found in most tumours... - Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattleA Wassef
Immunology Research Group, Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Histol Histopathol 19:1201-8. 2004..These are the first immunocytochemical data on TLR4 expression in domestic animal species and show similarity in TLR4 staining in macrophages, epithelium and vascular endothelium among dog, pig and cattle... - Expression and function of endothelial monocyte-activating polypeptide-II in acute lung inflammationW Shane Journeay
Immunology Research Group, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B4
Inflamm Res 56:175-81. 2007.... - Toll like receptor-4 expression in lipopolysaccharide induced lung inflammationK S Janardhan
Immunology Research Group, Department of Veterinary Biomedical Sciences, Saskatchewan Cancer Agency, College of Medicine, University of Saskatchewan, Saskatoon, Canada
Histol Histopathol 21:687-96. 2006..Nuclear localization of TLR4 was confirmed with Western blots on lung nuclear extracts. We conclude that TLR4 expression in lung is sustained up to 36 hours and that TLR4 and LPS are localized in the cytoplasm and nuclei of lung cells... - The role of RGD-tagged helical rosette nanotubes in the induction of inflammation and apoptosis in human lung adenocarcinoma cells through the P38 MAPK pathwaySarabjeet S Suri
Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 1L7, Canada
Biomaterials 30:3084-90. 2009..These results suggest that the RNTs could be used as a drug to induce apoptosis in cancer cells or as a versatile platform to deliver a variety of biologically active molecules for cancer therapy... - Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 in canine simple mammary gland adenocarcinomasAhmad N Al-Dissi
Department of Veterinary Pathology, University of Saskatchewan, Canada
Can Vet J 51:1109-14. 2010..05). Vascular endothelial growth factor may stimulate tumor cell proliferation through an autocrine loop, since VEGF and VEGFR-2 were expressed in most tumors... - Localization of integrin alpha(v)beta3 and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in cutaneous and oral melanomas of dogN G Rawlings
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
Histol Histopathol 18:819-26. 2003..These data demonstrate expression and co-localization of integrin alpha(v)beta3 and VEGFR-2 in cutaneous and oral melanomas of dogs... - Role of Toll-like receptor 4 in lung inflammation following exposure to swine barn airChandrashekhar Charavaryamath
Immunology Research Group, and Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada
Exp Lung Res 34:19-35. 2008..These data show different roles of TLR4 in lung inflammation and AHR in mice exposed to swine barn air... - Macrophage inflammatory response to self-assembling rosette nanotubesW Shane Journeay
Immunology Research Group Department of Veterinary Biomedical Sciences Western College of Veterinary Medicine University of Saskatchewan 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada
Small 5:1446-52. 2009..These data indicate that RNT-K do not induce a robust inflammatory response or cytotoxicity in the U937 human macrophage cell line, and therefore could be used for biomedical applications... - Rosette nanotubes show low acute pulmonary toxicity in vivoW Shane Journeay
Immunology Research Group, Toxicology Graduate Program and Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada
Int J Nanomedicine 3:373-83. 2008..This study also demonstrates that water-soluble rosette nanotube structures represent low pulmonary toxicity, likely due to their biologically inspired design, and their self-assembled architecture... - Pulmonary intravascular macrophages and endotoxin-induced pulmonary pathophysiology in horsesKarin Aharonson-Raz
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
Can J Vet Res 74:45-9. 2010..Within the context of the broader picture of endotoxemia and lung injury, we offer a perspective on the roles of pulmonary intravascular macrophages in endotoxin-induced lung inflammation in horses... - Depletion of pulmonary intravascular macrophages partially inhibits lipopolysaccharide-induced lung inflammation in horsesOm P Parbhakar
Department of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada
Vet Res 36:557-69. 2005..05). Immuno-electron microscopy localized TNF-alpha and IL-1beta in PIMs. These new data show that PIMs endocytose LPS and contain TNF-alpha and IL-1beta and their depletion partially inhibits LPS-induced pulmonary inflammatory responses... - Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor associated with tumor cell proliferation in canine cutaneous squamous cell carcinomas and trichoepitheliomasA N Al-Dissi
Department of Veterinary Pathology, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada
Vet Pathol 44:823-30. 2007..An autocrine pathway for VEGF probably operates in canine SCCs and TCPs, as VEGF and VEGFR-2 expression was found in most tumors and was associated with evidence for tumor cell proliferation... - Pulmonary intravascular monocytes/macrophages in a rat model of sepsisChandrashekhar Charavaryamath
Immunology Research Group and Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Anat Rec A Discov Mol Cell Evol Biol 288:1259-71. 2006..coli and LPS compared with those treated with only LPS or E. coli (P<0.05). We conclude that ED-1-positive PIMMs are recruited in this model of sepsis and contain TNF-alpha, IL-10, and TGF-beta2... - Rosette nanotubes inhibit bovine neutrophil chemotaxisMinh Hong Anh Le
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
Vet Res 41:75. 2010..001). We conclude that RGDSK/K-RNT inhibit phosphorylation of ERK1/2 and p38 MAPK and inhibit chemotaxis of bovine neutrophils... - Expression of integrin subunits alphav and beta3 in acute lung inflammationKyathanahalli S Janardhan
Immunology Research Group, Departments of Veterinary Biomedical Sciences and Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, SK S7N 5B4, Saskatoon, Canada
Histochem Cell Biol 121:383-90. 2004..These data lay the foundation for further characterization of these integrin subunits in neutrophil migration specifically in S. pneumoniae infection that utilizes molecules other than beta2 integrins for neutrophil recruitment... - Expression and activity of N-myristoyltransferase in lung inflammation of cattle and its role in neutrophil apoptosisAnuraag Shrivastav
Department of Pathology and Laboratory Medicine, College of Medicine and Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, SK, Canada
Vet Res 41:9. 2010..NMT knockdown increased apoptosis in activated neutrophils. This is the first report demonstrating expression of NMT in normal and inflamed lungs and a novel role for NMT in regulation of neutrophil lifespan... - Low inflammatory activation by self-assembling Rosette nanotubes in human Calu-3 pulmonary epithelial cellsW Shane Journeay
Immunology Research Group, Toxicology Graduate Program and Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan 52 Campus Drive, Saskatoon, SK, S7N 5B4, Canada
Small 4:817-23. 2008..In summary, RNT-K neither reduces cell viability at moderate doses nor does it induce a time-dependent inflammatory response in pulmonary epithelial cells in vitro... - Neutrophil depletion inhibits early and late monocyte/macrophage increase in lung inflammationKyathanahalli S Janardhan
Immunology Research Group, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
Front Biosci 11:1569-76. 2006..These findings show that increase in monocytes/macrophages in lung occurs in two, early and late phases, both being dependent on neutrophils but not on MCP-1... - Patterns of expression of steroidogenic enzymes during the first wave of the ovine estrous cycle as compared to the preovulatory follicleR Duggavathi
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Anim Reprod Sci 91:345-52. 2006.... - Macroscopic and microvascular blood supply of the canine common calcaneal tendonP J Gilbert
Western College of Veterinary Medicine, University of Saskatchewan, Small Animal Clinical Sciences, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada
Vet Comp Orthop Traumatol 23:81-6. 2010..Atraumatic handling and minimal manipulation should be used during the surgical approach and debridement to preserve the remaining blood supply in ruptured tendons... - Expression of toll-like receptor 9 in horse lungsDavid Schneberger
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Anat Rec (Hoboken) 292:1068-77. 2009..The increase in TLR9 mRNA is eliminated by depletion of PIMs, implicating these cells as a major source of TLR9 in the equine lung... - Localization and regulation of bovine eye calmodulin-dependent cyclic nucleotide phosphodiesterase by cyclic AMP-dependent protein kinaseRajendra K Sharma
Department of Pathology, College of Medicine, University of Saskatchewan and Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
Int J Mol Med 10:17-23. 2002.... - Immunophenotypic characterization and depletion of pulmonary intravascular macrophages of horsesOm P Parbhakar
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada
Vet Res 35:39-51. 2004..These data show that MAC-387 is a reliable marker for PIMs and GC is a safe tool to reduce the number of PIMs... - Expression of angiostatin, integrin alphavbeta3, and vitronectin in human lungs in sepsisBaljit Singh
Immunology Research Group and Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Exp Lung Res 31:771-82. 2005..Because all these molecules can have significant influence on inflammation, the data reported in this manuscript create a need for further investigation... - Localization and characterization of calcineurin in bovine eyeDallas P Seitz
Department of Pathology, College of Medicine, University of Saskatchewan, and Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada
Invest Ophthalmol Vis Sci 43:15-21. 2002..Further in vivo studies of CaN function are necessary to understand the contributions of CaN to ocular physiology... - Angiostatin and integrin alphavbeta3 in the feline, bovine, canine, equine, porcine and murine retina and corneaJacqueline W Pearce
Immunology Research Group, Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Vet Ophthalmol 10:313-9. 2007.... - Expression of toll-like receptor 4 and 2 in horse lungsSarabjeet Singh Suri
Immunology Research Group, Departments of Veterinary Biomedical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N5B4, Canada
Vet Res 37:541-51. 2006..These data provide evidence that PIM are equipped with TLR4 to handle and rapidly respond to circulating endotoxins... - Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungsChandrashekhar Charavaryamath
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada
Exp Lung Res 35:729-47. 2009..These results show that expression of myristoyltransferase and calcineurin in lung epithelium and endothelium and a cell-specific increase in immunohistochemical expression... - Feline mammary adenocarcinoma: tumor size as a prognostic indicatorJodi R Viste
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4
Can Vet J 43:33-7. 2002.... - Expression, localization, and correlation of N-myristoyltransferase and its inhibitor in bovine eyeAnuraag Shrivastav
Department of Pathology and Cancer Research Unit, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
Invest Ophthalmol Vis Sci 45:1674-9. 2004..These findings indicate that NMT and NIP are present in various regions of the eye and will lead to further understanding of visual signaling in ocular cells... - High-aspect ratio nanoparticles in nanotoxicologyW Shane Journeay
University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Integr Environ Assess Manag 4:128-9. 2008..However, more systematic toxicity studies are required to determine the role of specific nanomaterial properties relative to biological responses... - Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situM Silvina Frech
Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA
Cancer Res 65:681-5. 2005.... - Accurate genotyping from paraffin-embedded normal tissue adjacent to breast cancerBin Xie
Cancer Genetics and Epidemiology Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20007-1465, USA
Carcinogenesis 27:307-10. 2006..Although this study only used breast tumor samples, and may be applicable only to breast cancer studies, we expect the results to be applicable to other types of cancers also... - Role of cadmium in the regulation of AR gene expression and activityMary Beth Martin
Department of Biochemistry and Molecular Biology, Lombardi Cancer Center, E411 Research Building, 3970 Reservoir Road NW, Washington, D.C. 20007
Endocrinology 143:263-75. 2002..97- to 3-fold) and the seminal vesicle complex (approximately 1.5-fold) and increased the expression of the androgen-regulated gene, probasin (27-fold). The in vivo effects were also blocked by an antiandrogen... - Breast cancer in young womenDeborah Axelrod
Department of Surgery, New York University School of Medicine, New York, NY, USA
J Am Coll Surg 206:1193-203. 2008