Research Topics
Species | Mark D RobinsonSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clustersLani F Wu
Rosetta Inpharmatics, Kirkland, Washington, USA
Nat Genet 31:255-65. 2002..We present experimental validation confirming the involvement of several of these proteins in ribosomal RNA processing. Our methodology can be applied to a variety of genomics data types and organisms...- FunSpec: a web-based cluster interpreter for yeastMark D Robinson
Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
BMC Bioinformatics 3:35. 2002.... - Identifying transcription factor functions and targets by phenotypic activationGordon Chua
Banting and Best Department of Medical Research, University of Toronto, 160 College Street, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 103:12045-50. 2006..The general strategy outlined here presents a straightforward approach to discovery of TF activities and mapping targets that could be adapted to any organism with transgenic technology... - Genome-wide analysis of mouse transcripts using exon microarrays and factor graphsBrendan J Frey
Electrical and Computer Engineering, University of Toronto, 10 King s College Rd, Toronto, Ontario M5S 3G4, Canada
Nat Genet 37:991-6. 2005..GenRate also detected tens of thousands of potential new exons and reconciled discrepancies in current cDNA databases by 'stitching' new transcribed regions into previously annotated genes... - Transcriptional networks: reverse-engineering gene regulation on a global scaleGordon Chua
Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Room 307, Toronto, Ontario M5G 1L6, Canada
Curr Opin Microbiol 7:638-46. 2004..The results indicate that a complete and comprehensive yeast transcriptional network will ultimately be achieved... - The functional landscape of mouse gene expressionWen Zhang
Banting and Best Department of Medical Research, University of Toronto, 1 King s College Circle, Toronto, ON M5S 1A8, Canada
J Biol 3:21. 2004.... - Global landscape of protein complexes in the yeast Saccharomyces cerevisiaeNevan J Krogan
Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, Ontario M5S 3E1, Canada
Nature 440:637-43. 2006..The data (all of which are available online) will help future studies on individual proteins as well as functional genomics and systems biology... - High-definition macromolecular composition of yeast RNA-processing complexesNevan J Krogan
Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario M5G 1L6, Canada
Mol Cell 13:225-39. 2004..This study provides a high-resolution overview of the modular topology of noncoding RNA-processing machinery... - The promise of functional genomics: completing the encyclopedia of a cellTimothy R Hughes
Banting and Best Department of Medical Research, University of Toronto, 112 College St, Room 307, Toronto, ON, M5G 1L6, Canada
Curr Opin Microbiol 7:546-54. 2004..This task seems increasingly feasible; however, progress to date suggests that increased interaction between systematic efforts and individual investigators will be critical to completing the encyclopedia of the yeast cell... - The synthetic genetic interaction spectrum of essential genesArmaity P Davierwala
Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ontario, M5G 1L6, Canada
Nat Genet 37:1147-52. 2005.... - High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiae deletion mutantsPaul Jorgensen
Department of Medical Genetics and Microbiology, University of Toronto, Ontario M5S 1A8, Canada
Genetics 162:1091-9. 2002..In principle, SGAM should be applicable to the analysis of multigenic traits. Large-scale construction of ordered mutations in other model organisms would broaden the application of this approach... - A panoramic view of yeast noncoding RNA processingWen Tao Peng
Banting and Best Department of Medical Research, University of Toronto, 112 College Street, M5G 1L6, Toronto, Ontario, Canada
Cell 113:919-33. 2003..These data present a global view of yeast noncoding RNA processing and confirm that many currently uncharacterized yeast proteins are involved in biogenesis of noncoding RNA... - A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experimentsMark D Robinson
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
BMC Bioinformatics 8:419. 2007..Automated retention time correction is particularly important in non-targeted profiling studies... - Moderated statistical tests for assessing differences in tag abundanceMark D Robinson
Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
Bioinformatics 23:2881-7. 2007.... - Small-sample estimation of negative binomial dispersion, with applications to SAGE dataMark D Robinson
Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, and Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
Biostatistics 9:321-32. 2008..The impact of dispersion estimation on hypothesis testing is studied. We derive an "exact" test that outperforms the standard approximate asymptotic tests... - Definition and characterization of a "trypsinosome" from specific peptide characteristics by nano-HPLC-MS/MS and in silico analysis of complex protein mixturesThierry Le Bihan
Protana Inc, 251 Attwell Drive, Toronto, Ontario, Canada M9W 7H4
J Proteome Res 3:1138-48. 2004..This approach is based on experimentally derived data to calibrate the method and therefore may theoretically be applied to any HPLC-MS/MS system on which data are being generated... - A comparison of Affymetrix gene expression arraysMark D Robinson
Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050, Australia
BMC Bioinformatics 8:449. 2007..In this study, we use publicly available data from Affymetrix to gauge the performance of three human gene expression arrays: Human Genome U133 Plus 2.0 (U133), Human Exon 1.0 ST (HuEx) and Human Gene 1.0 ST (HuGene)...