Research Topics
| Spencer D ProctorSummaryAffiliation: University of Alberta Country: Canada Publications
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Detail Information
Publications
Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp ratM Miriam Jacome-Sosa
Metabolic and Cardiovascular Diseases Laboratory, University of Alberta, Edmonton, AB, T6G 2P5, Canada
Nutr Metab (Lond) 7:60. 2010..The aim of this study was to evaluate potential additional hypolipidemic effects of purified forms of CLA and VA in an animal model of the metabolic syndrome (the JCR:LA-cp rat)...- Trans-11 vaccenic acid dietary supplementation induces hypolipidemic effects in JCR:LA-cp ratsYe Wang
Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Canada
J Nutr 138:2117-22. 2008..In contrast, dietary VA had substantial hypo-triglyceridemic effects, suggesting a new bioactivity of this fatty acid that is typically found in ruminant-derived food products... - A unique rodent model of cardiometabolic risk associated with the metabolic syndrome and polycystic ovary syndromeDanni Shi
Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, Canada
Endocrinology 150:4425-36. 2009..The results of this study demonstrate that the JCR:LA-cp rodent may be a useful PCOS-like model to study early mechanisms involved in the etiology of cardiometabolic risk factors in the context of both PCOS and the metabolic syndrome... - Metabolic effects of a novel silicate inositol complex of the nitric oxide precursor arginine in the obese insulin-resistant JCR:LA-cp ratSpencer D Proctor
Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, Canada, T6G 2P5
Metabolism 56:1318-25. 2007..This has different beneficial metabolic effects in both sexes of an animal model of insulin resistance and cardiovascular disease, consistent with reduction in end-stage disease... - Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in JCR:LA-cp ratsYe Wang
Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, Canada
J Nutr 139:2049-54. 2009..The appreciable hypolipidemic benefits of VA may be attributed to a reduction in both intestinal CM and hepatic de novo lipogenesis pathways... - Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndromeJames C Russell
Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Canada
Am J Physiol Gastrointest Liver Physiol 299:G507-16. 2010..We conclude that rimonabant improves renal disease and intestinal lipid oversecretion associated with an animal model of the metabolic syndrome that appears to be independent of hyperinsulinemia or macrovascular dysfunction... - Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumptionJohn R Ussher
Department of Pediatrics, University of Alberta, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, Edmonton, Canada
Diabetes 59:2453-64. 2010..We determined the role of de novo ceramide synthesis in mediating muscle insulin resistance... - Hypoxia-induced intrauterine growth restriction increases the susceptibility of rats to high-fat diet-induced metabolic syndromeChristian F Rueda-Clausen
Department of Physiology, University of Alberta, Edmonton, Canada
Diabetes 60:507-16. 2011..Thus, we hypothesized that offspring born with IUGR exhibit permanent metabolic changes that make them more susceptible to HF diet-induced MetS... - Pair feeding-mediated changes in metabolism: stress response and pathophysiology in insulin-resistant, atherosclerosis-prone JCR:LA-cp ratsJames C Russell
Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, Canada
Am J Physiol Endocrinol Metab 294:E1078-87. 2008..Similar stress-related mechanisms may play a role in metabolically induced cardiovascular disease in susceptible human beings... - Overeating by young obesity-prone and lean rats caused by tastes associated with low energy foodsW David Pierce
University of Alberta, Department of Sociology, Tory 5 21, Edmonton, AB, T6G 2H4 Canada
Obesity (Silver Spring) 15:1969-79. 2007..Childhood obesity is a prominent health problem that may involve early learning about tastes and the energy content of foods. We tested the hypothesis that food tastes predictive of low energy content cause overeating in young animals... - Small animal models of cardiovascular disease: tools for the study of the roles of metabolic syndrome, dyslipidemia, and atherosclerosisJames C Russell
Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, Canada T6G 2P5
Cardiovasc Pathol 15:318-30. 2006..This fragmented field would benefit from a consensus on well-characterized appropriate models for the study of different aspects of cardiovascular disease and a renewed emphasis on the biology of underlying diseases... - Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesityRene L Jacobs
Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 285:22403-13. 2010..Thus, de novo synthesis of choline via PEMT has a previously unappreciated role in regulating whole body energy metabolism... - Vaccenic acid favourably alters immune function in obese JCR:LA-cp ratsHeather J Blewett
Alberta Institute for Human Nutrition, Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, T6G 2E1, Canada
Br J Nutr 102:526-36. 2009..These results indicate that dietary VA favourably alters the pro-inflammatory tendency of mesenteric lymphocytes from JCR:LA-cp rats... - Feeding long-chain n-3 polyunsaturated fatty acids to obese leptin receptor-deficient JCR:LA- cp rats modifies immune function and lipid-raft fatty acid compositionMegan R Ruth
Nutrition and Metabolism Research Group, University of Alberta, Edmonton, AB T6G 2P5, Canada
Br J Nutr 101:1341-50. 2009..Feeding FO lowered the ex vivo inflammatory response, without altering IL-2 production from ConA-stimulated splenocytes which may occur independent of leptin signalling... - Intestinal lipid transport and chylomicron production: possible links to exacerbated atherogenesis in a rodent model of the metabolic syndromeDonna F Vine
Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta, Canada
Atheroscler Suppl 9:69-76. 2008..We discuss our findings in the context of a void of knowledge in the understanding of intestinal lipid metabolism, and the potential significance of these pathways in contributing to dyslipidemia in MetS... - Hypersensitivity of prediabetic JCR:LA-cp rats to fine airborne combustion particle-induced direct and noradrenergic-mediated vascular contractionSpencer D Proctor
Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute for Human Nutrition, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
Toxicol Sci 90:385-91. 2006..5) and identify the pathophysiological role of the early prediabetic state in susceptibility to environmentally induced cardiovascular disease. These are important implications for public health and public policy...