Nhu An Pham

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    BMC Cancer 8:43. 2008
  2. ncbi Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models
    Nhu An Pham
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Pancreas 35:e16-26. 2007
  3. ncbi Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma
    Nikolina Radulovich
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada
    Mol Cancer 9:24. 2010
  4. ncbi Oxidative stress is generated via the mitochondrial respiratory chain during plant cell apoptosis
    Iona E Weir
    Division of Experimental Therapeutics, Department of Medical Oncology and Haematology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Cytometry A 54:109-17. 2003
  5. ncbi Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures
    Yuhong Wei
    Program in Molecular Structure and Function, Hospital for Sick Children, University Health Network, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    J Proteome Res 10:161-74. 2011
  6. ncbi The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    Nicole G Chau
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Head Neck Oncol 3:11. 2011
  7. ncbi A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer
    Srikala S Sridhar
    Princess Margaret Hospital, Toronto, ON, Canada
    Am J Clin Oncol 33:609-13. 2010
  8. ncbi Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo
    Jörg Schwock
    Department of Laboratory Medicine and Pathobiology, University of Toronto, 610 University Ave, 5th Floor, Rm 203, M5G 2M9, Toronto, ON, Canada
    Cancer Chemother Pharmacol 61:669-81. 2008
  9. ncbi Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models
    Nhu An Pham
    Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada
    Int J Cancer 124:280-6. 2009
  10. ncbi The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    Nhu-An Pham
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Cancer Ther 3:1239-48. 2004

Collaborators

Detail Information

Publications10

  1. ncbi Immunohistochemical analysis of changes in signaling pathway activation downstream of growth factor receptors in pancreatic duct cell carcinogenesis
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    BMC Cancer 8:43. 2008
    ..This study was performed to gain a better understanding of the abnormal signaling that occurs in PDAC compared with normal duct epithelia...
  2. ncbi Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models
    Nhu An Pham
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Pancreas 35:e16-26. 2007
    ..To understand the impact of protein kinase B (PKB; Akt) signaling on growth and protection from apoptosis in pancreatic ductal adenocarcinoma models demonstrating differences in PKB activity...
  3. ncbi Differential roles of cyclin D1 and D3 in pancreatic ductal adenocarcinoma
    Nikolina Radulovich
    Ontario Cancer Institute and Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2M9, Canada
    Mol Cancer 9:24. 2010
    ..The cyclin D1 (CCND1) and cyclin D3 (CCND3) are frequently co-overexpressed in pancreatic ductal adenocarcinoma (PDAC). Here we examine their differential roles in PDAC...
  4. ncbi Oxidative stress is generated via the mitochondrial respiratory chain during plant cell apoptosis
    Iona E Weir
    Division of Experimental Therapeutics, Department of Medical Oncology and Haematology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    Cytometry A 54:109-17. 2003
    ..We present evidence that in plant cells DNA damage induced by the topoisomerase trapping drug camptothecin induces oxidative stress via the mitochondrial respiratory chain...
  5. ncbi Primary tumor xenografts of human lung adeno and squamous cell carcinoma express distinct proteomic signatures
    Yuhong Wei
    Program in Molecular Structure and Function, Hospital for Sick Children, University Health Network, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Canada
    J Proteome Res 10:161-74. 2011
    ..These findings illustrate the potential to develop a comprehensive MS-based platform in oncologic pathology for better classification and potentially treatment of NSCLC patients...
  6. ncbi The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    Nicole G Chau
    Division of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Head Neck Oncol 3:11. 2011
    ....
  7. ncbi A multicenter phase II clinical trial of lapatinib (GW572016) in hormonally untreated advanced prostate cancer
    Srikala S Sridhar
    Princess Margaret Hospital, Toronto, ON, Canada
    Am J Clin Oncol 33:609-13. 2010
    ..This Phase II multicenter clinical trial is the first to evaluate Lapatinib in early stage, hormonally untreated recurrent or metastatic prostate cancer...
  8. ncbi Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo
    Jörg Schwock
    Department of Laboratory Medicine and Pathobiology, University of Toronto, 610 University Ave, 5th Floor, Rm 203, M5G 2M9, Toronto, ON, Canada
    Cancer Chemother Pharmacol 61:669-81. 2008
    ..In this study we investigated the response of a panel of cervical carcinoma cell lines in vitro and in vivo to determine potential factors that might influence the sensitivity towards Hsp90 inhibition...
  9. ncbi Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models
    Nhu An Pham
    Ontario Cancer Institute, Princess Margaret Hospital, and Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario, Canada
    Int J Cancer 124:280-6. 2009
    ..These results show that signaling pathways are responsive to tumor hypoxia in vivo, although the effects appear to differ between individual tumor types...
  10. ncbi The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    Nhu-An Pham
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Cancer Ther 3:1239-48. 2004
    ..Our findings suggest that, in addition to the known effects on cancer prevention, sulforaphane may have activity in established pancreatic cancer...