Zhikang Peng

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites
    Zhikang Peng
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, 532 714 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 3P4
    J Allergy Clin Immunol 114:1189-94. 2004
  2. ncbi Mosquito allergy: immune mechanisms and recombinant salivary allergens
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Int Arch Allergy Immunol 133:198-209. 2004
  3. ncbi Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents
    Z Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Exp Allergy 37:1040-8. 2007
  4. ncbi Advances in mosquito allergy
    Zhikang Peng
    Department of Pediatrics and Child Health and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Allergy Clin Immunol 7:350-4. 2007
  5. ncbi Mosquito allergy and mosquito salivary allergens
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Protein Pept Lett 14:975-81. 2007
  6. ncbi Vaccines targeting IgE in the treatment of asthma and allergy
    Zhikang Peng
    Department of Pediatrics and Child Health and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, CA
    Hum Vaccin 5:302-9. 2009
  7. ncbi Evidence for natural desensitization to mosquito salivary allergens: mosquito saliva specific IgE and IgG levels in children
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Ann Allergy Asthma Immunol 93:553-6. 2004
  8. ncbi Expression, purification, characterization and clinical relevance of rAed a 1--a 68-kDa recombinant mosquito Aedes aegypti salivary allergen
    Z Peng
    Department of Pediatrics and Child Health, and Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:1445-52. 2001
  9. ncbi Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis
    Qingdong Guan
    Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Med 17:646-56. 2011
  10. ncbi AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
    Aiping Bai
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 80:1708-17. 2010

Collaborators

Detail Information

Publications27

  1. ncbi Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites
    Zhikang Peng
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, 532 714 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 3P4
    J Allergy Clin Immunol 114:1189-94. 2004
    ..Mosquito bite-induced acute systemic allergic reactions are an increasing clinical concern and have not been optimally characterized immunologically...
  2. ncbi Mosquito allergy: immune mechanisms and recombinant salivary allergens
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Int Arch Allergy Immunol 133:198-209. 2004
    ..These recombinant allergens will significantly improve diagnosis of mosquito allergy and eventually will also improve specific immunotherapy for patients with systemic reactions to mosquito bites...
  3. ncbi Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents
    Z Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Clin Exp Allergy 37:1040-8. 2007
    ..Immunotherapy with anti-IgE antibodies for treatment of allergy is promising but a short half-life and extremely high cost limit its application...
  4. ncbi Advances in mosquito allergy
    Zhikang Peng
    Department of Pediatrics and Child Health and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Curr Opin Allergy Clin Immunol 7:350-4. 2007
    ..Due to the lack of availability of mosquito salivary preparations for use in skin tests and in-vitro tests, allergic reactions to mosquito bites are under diagnosed and under treated...
  5. ncbi Mosquito allergy and mosquito salivary allergens
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Protein Pept Lett 14:975-81. 2007
    ..The use of the recombinant allergens in the diagnosis of mosquito allergy is discussed...
  6. ncbi Vaccines targeting IgE in the treatment of asthma and allergy
    Zhikang Peng
    Department of Pediatrics and Child Health and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, CA
    Hum Vaccin 5:302-9. 2009
    ..This review also discusses concerns with the vaccine strategy...
  7. ncbi Evidence for natural desensitization to mosquito salivary allergens: mosquito saliva specific IgE and IgG levels in children
    Zhikang Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Ann Allergy Asthma Immunol 93:553-6. 2004
    ..There are few epidemiologic data on the prevalence of mosquito allergy, although local reactions to mosquito bites are common...
  8. ncbi Expression, purification, characterization and clinical relevance of rAed a 1--a 68-kDa recombinant mosquito Aedes aegypti salivary allergen
    Z Peng
    Department of Pediatrics and Child Health, and Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:1445-52. 2001
    ....
  9. ncbi Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis
    Qingdong Guan
    Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Mol Med 17:646-56. 2011
    ..This suggests that the vaccine may provide a potential approach for the long-term treatment of Crohn's disease...
  10. ncbi AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
    Aiping Bai
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Biochem Pharmacol 80:1708-17. 2010
    ..AICAR-initiated AMPK activation may act as a central downregulator in ongoing innate and adaptive immune responses of murine colitis, providing a novel therapeutic approach in the treatment of IBD...
  11. ncbi Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis
    Yanbing Ma
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Inflamm Bowel Dis 16:1040-50. 2010
    ....
  12. ncbi Novel anti-inflammatory action of 5-aminoimidazole-4-carboxamide ribonucleoside with protective effect in dextran sulfate sodium-induced acute and chronic colitis
    Aiping Bai
    Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada
    J Pharmacol Exp Ther 333:717-25. 2010
    ..AICAR acts as a central inhibitor in immune responses of experimental colitis. Our data show that AICAR-initiated AMPK activation may represent a promising alternative to our current approaches to suppress intestinal inflammation in IBD...
  13. ncbi Enhancement of IL-10 bioactivity using an IL-10 peptide-based vaccine exacerbates Leishmania major infection and improves airway inflammation in mice
    Gang Zhou
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Vaccine 28:1838-46. 2010
    ..We concluded that the IL-10 vaccine enhances the bioactivity of IL-10 in vitro and in vivo, providing a potential therapeutic approach in diseases associated with insufficient IL-10 production...
  14. ncbi Novel recombinant interleukin-13 peptide-based vaccine reduces airway allergic inflammatory responses in mice
    Yanbing Ma
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Respir Crit Care Med 176:439-45. 2007
    ....
  15. ncbi Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis
    Qingdong Guan
    Dept of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada R3E 3P4
    Vaccine 27:7096-104. 2009
    ..We concluded that IL-12/IL-23p40 vaccines may be a potential therapeutic approach in the treatment of Crohn's disease and other autoimmune diseases...
  16. ncbi A potential immunotherapy approach: mucosal immunization with an IL-13 peptide-based virus-like particle vaccine in a mouse asthma model
    Yanbing Ma
    Department of Pediatrics and Child Health, University of Manitoba, 532 715 McDermot Avenue, Winnipeg, Canada R3E 3P4
    Vaccine 25:8091-9. 2007
    ..In conclusion, mucosal vaccination may be an innovative potential approach in the treatment of asthma...
  17. ncbi A new recombinant mosquito salivary allergen, rAed a 2: allergenicity, clinical relevance, and cross-reactivity
    Z Peng
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada
    Allergy 61:485-90. 2006
    ..CONCLUSIONS: rAed a 2 has identical antigenicity and biologic activity to its native form. It can be used in the diagnosis of mosquito allergy, and is an important species-shared antigen...
  18. ncbi CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice
    Z Peng
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, and Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:3-11. 2001
    ..Strikingly, a transient skin delayed-type hypersensitivity reaction occurred in CpG ODN-treated mice. These observations provide a new insight into the potential therapeutic application of CpG ODN to allergic disorders...
  19. ncbi Mosquito allergy: recombinant mosquito salivary antigens for new diagnostic tests
    F E Simons
    Department of Pediatrics and Child Health, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Int Arch Allergy Immunol 124:403-5. 2001
    ..aegypti bite test reactions. None of 15 A. aegypti bite test-negative subjects had a positive skin test to any of the recombinant antigens. Recombinant mosquito salivary antigens will facilitate the diagnosis of mosquito allergy...
  20. ncbi Production and characterization of monoclonal antibodies to two new mosquito Aedes aegypti salivary proteins
    Z Peng
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Canada
    Insect Biochem Mol Biol 29:909-14. 1999
    ..These mAbs provide a means to purify proteins, to isolate new genes from the salivary gland cDNA library, and to standardise mosquito extracts, facilitating studies of disease transmission by mosquitoes and of mosquito allergy...
  21. ncbi Expression of functional recombinant mosquito salivary apyrase: a potential therapeutic platelet aggregation inhibitor
    Dongfeng Sun
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Manitoba, Canada
    Platelets 17:178-84. 2006
    ....
  22. ncbi Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice
    Y Ma
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    Allergy 62:675-82. 2007
    ..Using interleukin (IL)-4 as a model target, we sought to develop a novel therapeutic strategy by constructing an IL-4 peptide-based vaccine for blocking IL-4 on a persistent basis, and to evaluate its efficacy in a mouse model of asthma...
  23. ncbi Biological therapies of inflammatory bowel disease
    Aiping Bai
    University of Manitoba, Winnipeg, Canada
    Immunotherapy 2:727-42. 2010
    ..This article introduces and discusses these new biological agents that have been used effectively in clinic for IBD patients...
  24. ncbi A sensitive in situ ELISA for quantitative measurements of cytokines and antibodies secreted by culture lymphocytes
    Y Chen
    Department of Paediatrics and Child Health, University of Manitoba, John Buhler Research Centre, Winnipeg, Canada
    J Immunoassay Immunochem 22:353-69. 2001
    ..We conclude that the in situ ELISA is much more sensitive than a conventional ELISA and less costly and easier to perform than ELISPOT, providing a useful tool to quantitatively measure cell-secreted molecules...
  25. ncbi Mosquito saliva-specific IgE and IgG antibodies in 1059 blood donors
    Zhikang Peng
    J Allergy Clin Immunol 110:816-7. 2002
  26. ncbi Comparision of the mosquito saliva-capture enzyme-linked immunosorbent assay and the unicap test in the diagnosis of mosquito allergy
    Qiang Wang
    Ann Allergy Asthma Immunol 99:199-200. 2007
  27. ncbi Early-onset cellulitis after insect bites: allergic inflammation
    F Estelle R Simons
    Ann Allergy Asthma Immunol 93:606; author reply 606-7. 2004