Research Topics
Genomes and Genes | G Y OuditSummaryAffiliation: University of Alberta Country: Canada Publications
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Publications
Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction: A Critical Role of the Angiotensin II/AT1 Receptor AxisVaibhav B Patel
FRCPC, Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, T6G 2S2, Alberta, Canada
Circ Res 110:1322-35. 2012..Our study demonstrates that ACE2 serves as a protective mechanism against diabetes-induced cardiovascular complications...- Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101--Breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzuEdith Pituskin
University of Alberta, Edmonton, Alberta, Canada
BMC Cancer 11:318. 2011.... - Use of oral proton pump inhibitors is not associated with harm in patients with chronic heart failure in an ambulatory settingGavin Y Oudit
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, 8440 112 Street, Edmonton, Alberta, Canada
Eur J Heart Fail 13:1211-5. 2011..We conducted this study to determine whether PPI use was associated with excess mortality in patients with both ischaemic and non-ischaemic heart failure (HF)... - Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapyGavin Y Oudit
Department of Physiology, Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
Curr Heart Fail Rep 8:176-83. 2011..This review summarizes the beneficial effects of ACE2 in heart disease and the potential use of human recombinant ACE2 as a novel therapy for heart failure... - Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3K? knockout murine modelDanny Guo
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Canada
J Mol Cell Cardiol 50:606-12. 2011.... - Human recombinant ACE2 reduces the progression of diabetic nephropathyGavin Y Oudit
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Diabetes 59:529-38. 2010..Inhibition of ACE2 function accelerates diabetic kidney injury, whereas renal ACE2 is downregulated in diabetic nephropathy. We examined the ability of human recombinant ACE2 (hrACE2) to slow the progression of diabetic kidney injury... - SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARSG Y Oudit
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Eur J Clin Invest 39:618-25. 2009..Patients with SARS also suffered from cardiac disease including arrhythmias, sudden cardiac death, and systolic and diastolic dysfunction... - Cardiac regulation by phosphoinositide 3-kinases and PTENGavin Y Oudit
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Cardiovasc Res 82:250-60. 2009..In this review, we discuss the signalling pathways mediated by PI3K class I isoforms and PTEN and their roles in cardiac structure and function... - Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injuryDenise W Wong
Department of Medicine, Division of Nephrology, University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Pathol 171:438-51. 2007..We conclude that ACE2 plays a protective role in the diabetic kidney, and ACE2 is an important determinant of diabetic nephropathy... - Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunctionJiuchang Zhong
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
Circulation 122:717-28, 18 p following 728. 2010..We hypothesized that ACE2 is a negative regulator of angiotensin II (Ang II)-mediated signaling and its adverse effects on the cardiovascular system... - Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null miceGavin Y Oudit
Division of Cardiology, Department of Medicine, University of Toronto, Canada
Cardiovasc Res 75:29-39. 2007..In this study, we investigate the mechanism for the age-dependent cardiomyopathy in ACE2 null mice... - Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarctionZamaneh Kassiri
Department of Physiology, University of Alberta, Edmonton, Canada
Circ Heart Fail 2:446-55. 2009..We hypothesized that ACE2 deficiency may compromise the cardiac response to myocardial infarction (MI)... - Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent mannerAhmed E Awad
Dept of Physiology, Univ of Alberta, 474 HMRC, Edmonton, AB T6G 2S2, Canada
Am J Physiol Cell Physiol 298:C679-92. 2010.... - Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stressGavin Y Oudit
Division of Cardiology, Department of Medicine, Rm 7326, Medical Sciences Building, One King s College Circle, University of Toronto, Toronto, Canada M5S 1A8
Cardiovasc Res 78:505-14. 2008..We hypothesize that these key changes will halt the development of pathological hypertrophy and the progression to heart failure in response to pressure overload... - Loss of PI3K? enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stressDanny Guo
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
Circ Res 107:1275-89. 2010..Loss of phosphoinositide 3-kinase (PI3K)?, the isoform linked to G protein-coupled receptor signaling, results in increased myocardial contractility, but the response to pressure overload is controversial... - Loss of TIMP3 enhances interstitial nephritis and fibrosisZamaneh Kassiri
Department of Physiology, Cardiovascular Research Group, Room 474, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, T6G 2S2 Canada
J Am Soc Nephrol 20:1223-35. 2009..Taken together, these results provide evidence that TIMP3 is an important mediator of kidney injury, and regulating its activity may have therapeutic benefit for patients with kidney disease... - Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarctionVijay Kandalam
Department of Physiology, University of Alberta, Edmonton, Alberta
Am J Physiol Heart Circ Physiol 299:H1012-23. 2010..Hence, timing of treatments to improve cardiac response to MI may be critical in producing favorable outcome... - TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activationVijay Kandalam
Department of Physiology, Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada
Circ Res 106:796-808. 2010..Hence, it is difficult to predict the function of TIMP2 as protective (MMP-inhibiting) or harmful (MMP-activating) in heart disease... - Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic functionRatnadeep Basu
Department of Physiology, Rm 474, Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
Am J Physiol Heart Circ Physiol 297:H2096-108. 2009..We conclude that early type 1 diabetic cardiomyopathy is characterized by diastolic dysfunction associated with lipotoxic cardiomyopathy with preserved systolic function in the absence of interstitial fibrosis and hypertrophy... - Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney diseaseHeather N Reich
Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
Kidney Int 74:1610-6. 2008..Our results suggest that the kidney disease of patients with type 2 diabetes is associated with a reduction in ACE2 gene and protein expression and this may contribute to the progression of renal injury... - Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinaseP E MacDonald
University of Toronto, Department of Physiology, Toronto, Canada
Endocrinology 145:4078-83. 2004..These surprising results suggest that the G protein-coupled p110gamma isoform of PI3 kinase is not central to the development or maintenance of sufficient beta-cell mass but positively regulates glucose-stimulated insulin secretion... - Role of PI3 kinase gamma in excitation-contraction coupling and heart diseaseGavin Y Oudit
Department of Medicine, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
Cardiovasc Hematol Disord Drug Targets 7:295-304. 2007..In this review article, we discuss the key role of PI3Kgamma gamma in regulating cAMP, Ca(2+) cycling, beta-adrenergic signaling and myocardial structure and function in heart disease... - Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2Jiuchang Zhong
Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
Hypertension 57:314-22. 2011..ACE2 is an important negative regulator of Ang II-induced renal disease and enhancing ACE2 action may have therapeutic potential for patients with kidney disease...