Research Topics
| Manuela G NeumanSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Hyaluronic acid signals for repair in ethanol-induced apoptosis in skin cells in vitroManuela G Neuman
Department of Clinical Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M56 1L7
Clin Biochem 43:822-6. 2010..Ethanol is commonly used in cosmetic and pharmaceutical preparations...- In vitro anti-inflammatory effects of hyaluronic acid in ethanol-induced damage in skin cellsManuela G Neuman
Department of Clinical Pharmacology, University of Toronto, Toronto, Ontario, Canada
J Pharm Pharm Sci 14:425-37. 2011..Ethyl alcohol (ethanol) is commonly applied in cosmetic and pharmaceutical preparations, as well as disinfectant for chronic wounds... - The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic reviewJurgen Rehm
Public Health and Regulatory Policies, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
BMC Public Health 9:450. 2009..8%) and 2.2% of global burden of disease (men 2.7%; women 1.7%). The present work portrays accumulated evidence on the association between alcohol consumption and TB with the aim to clarify the nature of the relationship... - Immune dysfunction in inflammatory bowel diseaseManuela G Neuman
Department of Pharmacology and Institute of Drug Research, University of Toronto, Toronto, Ontario, Canada
Transl Res 149:173-86. 2007..Furthermore, this study highlights the potential use of cytokines, anti-cytokine antibodies, and cytokine-related biologic therapies as novel targets for the treatment of IBD... - Apoptosis in ibuprofen-induced Stevens-Johnson syndromeManuela Neuman
In Vitro Drug Safety and Biotechnology Laboratory, University of Toronto, Toronto, Ontario, Canada
Transl Res 149:254-9. 2007..The same is the case with the apoptotic markers Fas, caspase activity, and M30. T-cell cytokines control the pathogenesis of SJS/TEN contributing to apoptotic processes in the liver and in the skin... - Senecio latifolius induces in vitro hepatocytotoxicity in a human cell lineManuela G Neuman
In Vitro Drug Safety and Biotechnology, Department of Pharmacology, Institute of Drug Research, University of Toronto, South Tower of the MaRS Discovery Centre, 101 College Street, Toronto, ON M5G 1L5, Canada
Can J Physiol Pharmacol 85:1063-75. 2007..Cytotoxicity is reduced by supplementation with NAC, which thus prevents GSH depletion. Caspase activation is involved in Senecio-induced apoptosis... - Predicting possible zonisamide hypersensitivity syndromeManuela G Neuman
In Vitro Drug Safety and Biotechnology Laboratory, MaRS Discovery Centre, University of Toronto, Toronto, ON, Canada
Exp Dermatol 17:1045-51. 2008..The second aim was to determine age-related differences in ZNS-induced HSR. LTA was previously validated in patients who received sulphamethoxazole (SMX) or AC... - Immunopathogenesis of hypersensitivity syndrome reactions to sulfonamidesManuela G Neuman
In Vitro Drug Safety and Biotechnology Laboratory, University of Toronto, Toronto, Ontario, Canada
Transl Res 149:243-53. 2007.... - Cytokine--chemokine and apoptotic signatures in patients with hepatitis CManuela G Neuman
In Vitro Drug Safety and Biotechnology, MaRS Discovery Center, 101 College Street, Lab 351, Toronto, Ontario, M5G 1L7 Canada
Transl Res 149:126-36. 2007..In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ... - Role of cytokines in the assessment of the severity of chronic hepatitis C and the prediction of response to therapyManuela G Neuman
Division of Clinical Pharmacology E-240, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
Rom J Gastroenterol 11:97-103. 2002..In addition, it is able to reduce fibrosis as judged both by TGF-beta levels and fibrosis scores as compared to standard therapy... - Inflammation and repair in viral hepatitis CManuela G Neuman
In Vitro Drug Safety and Biotechnology, Department of Pharmacology, Biophysics and Global Health, Institute of Drug Research, University of Toronto, Toronto, ON, Canada
Dig Dis Sci 53:1468-87. 2008..This review will also aim to describe the importance of IFN-alpha-based therapies in HCV infection, ways of monitoring them, and associated complications... - Ethanol signals for apoptosis in cultured skin cellsManuela G Neuman
Departments of Clinical Pharmacology, Dermatology, Medicine, and Laboratory Medicine, University of Toronto, M5S 1A1, Toronto, Ontario, Canada
Alcohol 26:179-90. 2002..Therefore, even at low concentrations, ethanol may induce apoptosis in skin cells by enhancing the effects of TNF-alpha... - Safety of celecoxib in individuals allergic to sulfonamide: a pilot studyLori E Shapiro
Division of Clinical Pharmacology, Drug Safety Research Group, University of Toronto, Toronto, Ontario, Canada
Drug Saf 26:187-95. 2003..To evaluate cross reactivity between sulfonamide antimicrobials and celecoxib in patients with histories of allergies to sulfonamide antimicrobials... - Monitoring adverse drug reactions to sulfonamide antibiotics in human immunodeficiency virus-infected individualsManuela G Neuman
Department of Pharmacology, University of Toronto, Canada
Ther Drug Monit 24:728-36. 2002..Larger patient populations, as well as in vitro studies are needed to further address the reasons for elevated results in immunocompromised patients and to validate the usefulness of the test... - Serum tumour necrosis factor-alpha and transforming growth factor-beta levels in chronic hepatitis C patients are immunomodulated by therapyManuela G Neuman
Division of Clinical Pharmacology, E 240, Sunnybrook and Women s College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
Cytokine 17:108-17. 2002.... - Colorectal polyposis and immune-based therapiesPearl Jacobson-Brown
In Vitro Toxicology Laboratory, Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Ontario
Can J Gastroenterol 18:239-49. 2004..The present review aims to discuss the immunological mechanisms underlying colon tumour progression and the molecular and immune-based therapies that are leading to new methods of prognosis and treatment... - An electron microscopic and morphometric study of ursodeoxycholic effect in primary biliary cirrhosisManuela G Neuman
Division of Clinical Pharmacology, Sunnybrook and Women s Health Sciences Centre, Toronto, Ontario, Canada
Liver 22:235-44. 2002..The study attempted to quantify perisinusoidal collagenization and the number of apoptotic bodies in PBC liver biopsies from patients in a randomized control trial treated with UDCA compared to those who received placebo... - Mechanism of Impila (Callilepis laureola)-induced cytotoxicity in Hep G2 cellsAlpa Popat
Division of Clinical Pharmacology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Clin Biochem 35:57-64. 2002..CONCLUSION: Our results suggest the mechanism of Impila-induced cytotoxicity in Hep G2 cells in vitro involves depletion of cellular GSH. Preventing GSH depletion by supplementing cells with NAC reduces cytotoxicity... - Ibuprofen-induced hypersensitivity syndromeRadu M Nanau
Department of In Vitro Drug Safety and Biotechnology and the Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Transl Res 155:275-93. 2010..Our review presents an ibuprofen-induced clinical manifestation of hypersensitivity syndrome and the necessity of wisely monitoring the patients clinically and by laboratory investigations when prescribing this drug... - HIV-Antiretroviral Therapy Induced Liver, Gastrointestinal, and Pancreatic InjuryManuela G Neuman
Departments of Clinical Pharmacology and Toxicology, and Global Health, University of Toronto, ON, Canada M5G 1X8
Int J Hepatol 2012:760706. 2012.... - Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001Manuela G Neuman
Division of Clinical Pharmacology, Sunnybrook and Women's College Health Sciences Centre, Room E235, 2075 Bayview Ave, Ontario, M4N 3M5, Toronto, Canada
Alcohol 28:117-28. 2002 - Tumor necrosis factor alpha as a noninvasive marker of liver inflammation in patients with viral hepatitis CAsma Ibrahim
Division of Clinical Pharmacology, E-235, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Ave, Toronto, Ontario M4N 3M5, Canada
Am Clin Lab 21:12-5. 2002 - Genetic and immune predictors for hypersensitivity syndrome to antiepileptic drugsManuela G Neuman
In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, Ontario, Canada Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
Transl Res 159:397-406. 2012..There is cross-reactivity between AEDs. Additionally, T-cell cytokines and chemokines control the pathogenesis of SJS/TEN and DILI, contributing to apoptotic processes in the liver and in the skin... - Signaling for inflammation and repair in inflammatory bowel diseaseManuela G Neuman
In Vitro Toxicology Laboratory, Center for Addiction and Mental Health, 33 Russell Street, Room 2035, Toronto, ON M5S 2S1, Canada
Rom J Gastroenterol 13:309-16. 2004..Knowledge of objective evidence of inflammatory activity may allow targeted treatment at an earlier stage to avoid the relapse, as well as assessment of new therapeutic strategies for maintenance of remission... - Synergetic signaling for apoptosis in vitro by ethanol and acetaminophenManuela G Neuman
In Vitro Toxicology Laboratory, Division of Clinical Pharmacology, Sunnybrook and Women's College Health Sciences Centre, Room E235, 2075 Bayview Ave, Toronto, Ontario, Canada M4N 3M5
Alcohol 27:89-98. 2002..The modulation of mitochondrial damage in vitro may have implications for the development of new therapeutic strategies to prevent apoptosis... - Cytokines--central factors in alcoholic liver diseaseManuela G Neuman
In Vitro Toxicology Laboratory in the Kunin-Lunenfeld Applied Research Unit, Baycrest Centre for Geriatric Care, Toronto, Canada
Alcohol Res Health 27:307-16. 2003..Because of their diverse functions, cytokines might make attractive targets in the prevention or treatment of alcoholic liver disease, and researchers already have obtained encouraging results when testing such approaches... - Alcohol Consumption, Progression of Disease and Other Comorbidities, and Responses to Antiretroviral Medication in People Living with HIVManuela G Neuman
Departments of Pharmacology and Toxicology and Global Health, University of Toronto, Toronto, ON, Canada M5S 1A1
AIDS Res Treat 2012:751827. 2012..Our intention was to fully characterize the quality of evidence supporting recommendations, which are reflecting benefit versus risk, and assessing strength or certainty... - Kinetics of serum cytokines reflect changes in the severity of chronic hepatitis C presenting minimal fibrosisManuela G Neuman
Division of Clinical Pharmacology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
J Viral Hepat 9:134-40. 2002..In conclusion, serum TNF-alpha reflects the progression of inflammation as seen in liver biopsies and TGF-beta reflects the degree of fibrosis in HCV patients... - Colon polyps and cytokines: emerging immunological mechanismsPearl Jacobson-Brown
In Vitro Toxicology Laboratory, Division of Clinical Pharmacology, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Rom J Gastroenterol 12:207-14. 2003..This review aims to increase knowledge of the immunological mechanisms underlying colon tumour progression in the hopes that a greater understanding of the molecular pathways will lead to improved methods of prognosis and treatment... - Antiepileptic drug-induced hypersensitivity syndrome reactionsNorberto Krivoy
Department of Medicine B and Clinical Pharmacology Unit, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
Curr Drug Saf 1:289-99. 2006.... - Drug interactions between psychoactive substances and antiretroviral therapy in individuals infected with human immunodeficiency and hepatitis virusesManuela G Neuman
Pan American Health Organization, Washington, DC, USA
Subst Use Misuse 41:1395-463. 2006....